The document is a series of repeated lines containing the website address "www.BiochemDen.in", suggesting it is related to immunology content on that site but does not contain any other substantive information.
Hybridoma
Hybridomas are cells that have been engineered to produce a desired antibody in large amounts, to produce monoclonal antibodies.
Monoclonal antibodies can be produced in specialized cells through a technique now popularly known as hybridoma technology.
Hybridoma technology was discovered in 1975 by two scientists, G. Kohler and C. Milstein, were awarded Noble prize for physiology and medicine in 1984.
B cells are lymphocytes that play a key role in humoral immunity by producing antibodies. B cell development occurs in the bone marrow, progressing from pro-B cells to immature B cells that express IgM, and then to mature B cells that express IgM and IgD. Activation of B cells leads to proliferation and differentiation into plasma cells in secondary lymphoid organs. Defects in B cell development or function can cause immunodeficiencies characterized by poor antibody production and recurrent bacterial infections. Some examples of B cell immunodeficiencies include X-linked agammaglobulinemia caused by mutations in BTK, IgA deficiency, and common variable immunodeficiency.
The ELISA (enzyme-linked immunosorbent assay) is a test that uses antibodies and color change to identify a substance. It involves using an enzyme to detect antigen-antibody binding, which converts a colorless substrate into a colored product. There are several types of ELISA including indirect, direct, sandwich, and competitive ELISA. ELISA can provide quantitative or qualitative results and has applications like screening donated blood and measuring hormone levels.
This document discusses antigens and their classification. It defines antigens as substances that can induce an immune response. Antigens are classified as either exogenous (external) or endogenous (internal) antigens. Exogenous antigens enter the body from the external environment, while endogenous antigens are further divided into xeno-genic, allogenic, and autologous antigens based on their origin. The document also discusses the properties of immunogens and antigens, as well as factors that contribute to immunogenicity.
The document summarizes the JAK-STAT signaling pathway. It discusses how the pathway consists of receptors, Janus kinases (JAKs), and Signal Transducers and Activators of Transcription (STATs). When a ligand binds to a receptor, it activates associated JAKs which phosphorylate STATs. Phosphorylated STATs form dimers and translocate to the nucleus to regulate gene transcription. The pathway is negatively regulated by phosphatases, suppressors of cytokine signaling, and protein inhibitors of activated STATs. Experiments using STAT knockout cells and mice have helped elucidate the specific roles and regulation of the pathway.
This document discusses antigens, haptens, and adjuvants. It defines antigens as molecules capable of inducing an immune response, and notes they are usually proteins or polysaccharides. Haptens are small molecules that are not antigenic alone but can become antigenic when bonded to a carrier molecule. Adjuvants are substances that can enhance the immune response to antigens when mixed with a vaccine. The document provides examples and mechanisms of action for each.
This document discusses the B cell receptor (BCR) and its role in chronic lymphocytic leukemia (CLL). The BCR is composed of immunoglobulin and Igα/Igβ proteins that transmit signals into cells. CLL results when too many B cells become abnormal lymphocytes. In CLL, tonic BCR signaling provides growth signals and plays a key role in disease progression. New drugs target proteins in the BCR pathway like Btk and Syk to block this signaling and stop cancer cell growth and division. Ibrutinib is an approved treatment that inhibits the BCR complex and brings hope to CLL patients.
1. Allograft rejection occurs when tissue is transferred between genetically different members of the same species. The immune system recognizes the foreign tissue as non-self and mounts an immune response.
2. Allograft rejection displays specificity and memory. The rate of rejection varies by tissue, and previously exposed tissues will be rejected faster upon second exposure due to immunological memory.
3. Graft rejection occurs via two main stages - a sensitization stage where T cells recognize foreign antigens on the graft cells, and an effector stage where the immune system destroys the graft through cell-mediated responses. Different types of rejection reactions can also occur on different timescales from hyperacute to chronic.
Hybridoma
Hybridomas are cells that have been engineered to produce a desired antibody in large amounts, to produce monoclonal antibodies.
Monoclonal antibodies can be produced in specialized cells through a technique now popularly known as hybridoma technology.
Hybridoma technology was discovered in 1975 by two scientists, G. Kohler and C. Milstein, were awarded Noble prize for physiology and medicine in 1984.
B cells are lymphocytes that play a key role in humoral immunity by producing antibodies. B cell development occurs in the bone marrow, progressing from pro-B cells to immature B cells that express IgM, and then to mature B cells that express IgM and IgD. Activation of B cells leads to proliferation and differentiation into plasma cells in secondary lymphoid organs. Defects in B cell development or function can cause immunodeficiencies characterized by poor antibody production and recurrent bacterial infections. Some examples of B cell immunodeficiencies include X-linked agammaglobulinemia caused by mutations in BTK, IgA deficiency, and common variable immunodeficiency.
The ELISA (enzyme-linked immunosorbent assay) is a test that uses antibodies and color change to identify a substance. It involves using an enzyme to detect antigen-antibody binding, which converts a colorless substrate into a colored product. There are several types of ELISA including indirect, direct, sandwich, and competitive ELISA. ELISA can provide quantitative or qualitative results and has applications like screening donated blood and measuring hormone levels.
This document discusses antigens and their classification. It defines antigens as substances that can induce an immune response. Antigens are classified as either exogenous (external) or endogenous (internal) antigens. Exogenous antigens enter the body from the external environment, while endogenous antigens are further divided into xeno-genic, allogenic, and autologous antigens based on their origin. The document also discusses the properties of immunogens and antigens, as well as factors that contribute to immunogenicity.
The document summarizes the JAK-STAT signaling pathway. It discusses how the pathway consists of receptors, Janus kinases (JAKs), and Signal Transducers and Activators of Transcription (STATs). When a ligand binds to a receptor, it activates associated JAKs which phosphorylate STATs. Phosphorylated STATs form dimers and translocate to the nucleus to regulate gene transcription. The pathway is negatively regulated by phosphatases, suppressors of cytokine signaling, and protein inhibitors of activated STATs. Experiments using STAT knockout cells and mice have helped elucidate the specific roles and regulation of the pathway.
This document discusses antigens, haptens, and adjuvants. It defines antigens as molecules capable of inducing an immune response, and notes they are usually proteins or polysaccharides. Haptens are small molecules that are not antigenic alone but can become antigenic when bonded to a carrier molecule. Adjuvants are substances that can enhance the immune response to antigens when mixed with a vaccine. The document provides examples and mechanisms of action for each.
This document discusses the B cell receptor (BCR) and its role in chronic lymphocytic leukemia (CLL). The BCR is composed of immunoglobulin and Igα/Igβ proteins that transmit signals into cells. CLL results when too many B cells become abnormal lymphocytes. In CLL, tonic BCR signaling provides growth signals and plays a key role in disease progression. New drugs target proteins in the BCR pathway like Btk and Syk to block this signaling and stop cancer cell growth and division. Ibrutinib is an approved treatment that inhibits the BCR complex and brings hope to CLL patients.
1. Allograft rejection occurs when tissue is transferred between genetically different members of the same species. The immune system recognizes the foreign tissue as non-self and mounts an immune response.
2. Allograft rejection displays specificity and memory. The rate of rejection varies by tissue, and previously exposed tissues will be rejected faster upon second exposure due to immunological memory.
3. Graft rejection occurs via two main stages - a sensitization stage where T cells recognize foreign antigens on the graft cells, and an effector stage where the immune system destroys the graft through cell-mediated responses. Different types of rejection reactions can also occur on different timescales from hyperacute to chronic.
This document contains lecture notes on major histocompatibility complex (MHC) and related topics from a biotechnology course. It discusses antigen-presenting cells, the structure and function of MHC class I and II molecules, similarities and differences between the two classes, MHC-associated genes, and important immune signaling molecules like cytokines, interleukins, interferons, and chemokines. Diagrams are included to illustrate MHC pathway and types of interferons. The notes provide an overview of key concepts in MHC and immunology for students in the biotechnology course.
Transfection is a technique used to insert foreign nucleic acids like DNA or RNA into cells to alter their properties. There are various biological, chemical, and physical methods to accomplish transfection, either transiently or stably. In stable transfection, the foreign DNA integrates into the cellular genome and is passed to daughter cells, while transient transfection only expresses the DNA for a short time without integration. Genetic engineering techniques are used to transfer genes between organisms, like retrovirus-mediated gene transfer where the retrovirus acts as a vector to deliver transgenes into host cells. Embryonic stem cell-mediated gene transfer involves introducing DNA into stem cells that can integrate randomly or through homologous recombination and be passed to offspring. Liposome
Interferons and interleukins are cytokines that play an important role in the immune system. Interferons are proteins produced by cells in response to viral infections that activate immune responses in other cells. The three main types are alpha, beta, and gamma interferons. Interleukins are cytokines that are primarily produced by lymphocytes and macrophages to mediate communication between immune cells. There are over 30 identified interleukins that activate immune responses. Both interferons and interleukins have therapeutic applications for treating viral infections and cancers by enhancing immune activation. They are administered through intravenous or subcutaneous injection.
Cytokines are cell signaling molecules that allow communication between cells of the immune system. They can be classified into six families based on structural similarities and functions. The interleukin (IL) family includes pro-inflammatory cytokines like IL-1 and IL-2 that are secreted by macrophages and T cells respectively to induce immune responses. Chemokines are a subgroup of cytokines that mobilize immune cells between tissues by influencing cytoskeletal proteins and adhesion molecules. Cytokines can have pleiotropic, redundant, synergistic or antagonistic effects on different target cells. Their localized release and cell surface receptor binding allows for precise communication between immune cells.
This document summarizes antigen processing and presentation. It discusses that antigen presenting cells such as macrophages, dendritic cells, and B cells express class II MHC molecules and provide co-stimulatory signals to activate T helper cells. These cells internalize antigens through phagocytosis or endocytosis, degrade them into peptides, and present the peptides bound to class II MHC on their surface. The document also describes the major histocompatibility complex and the roles of class I and class II MHC molecules in antigen presentation to T cells. It outlines the exogenous and endogenous antigen processing pathways, how exogenous antigens are presented by class II MHC and endogenous antigens by class I MHC.
1. The document presents information about T cells and B cells, including their development, activation, and functions.
2. T cells develop in the thymus gland and have roles in direct killing of infected cells and regulating the immune response. B cells mature in the bone marrow and produce antibodies to help fight pathogens.
3. Activation of both T and B cells involves interaction with antigen-presenting cells and costimulatory signals, leading to cell proliferation and differentiation into effector and memory cells.
Immune response during bacterial, parasitic and viral infection.pptxVanshikaVarshney5
1) The innate immune response to viruses involves interferon production which stimulates antiviral proteins to block viral replication. Natural killer cells also help destroy infected cells.
2) The adaptive immune response involves humoral immunity with antiviral antibodies that neutralize viruses and prevent infection of cells. Cell-mediated immunity uses cytotoxic T-cells and macrophages to directly kill infected cells.
3) Viruses have evolved mechanisms to evade the immune response, such as reducing MHC expression to avoid detection by T-cells, direct immunosuppression, and antigenic variation for influenza virus.
The document discusses cytokines, their properties, classification, receptors, and signaling pathways. It notes that cytokines exhibit pleiotropy, redundancy, synergy and antagonism. Major cytokine families include hematopoietins, interferons, chemokines, and TNF. Cytokine receptors include Ig superfamily, class 1, class 2, TNF and chemokine receptors. Cytokine binding induces receptor dimerization and JAK/STAT pathway activation. Cytokines play essential roles in hematopoiesis and immunity, but imbalances can lead to disease.
Central tolerance refers to deletion of self-reactive T and B cells in the thymus and bone marrow during maturation. T cells that recognize self antigens undergo apoptosis in the thymus. Peripheral tolerance uses backup mechanisms like clonal deletion through activation-induced cell death, clonal anergy from lack of co-stimulation, and suppression by regulatory T cells. These mechanisms help prevent autoimmune disease by silencing self-reactive cells that escape central tolerance.
The document discusses the major histocompatibility complex (MHC), which are surface proteins that play an important role in identifying antigens and presenting them to T cells. It covers the different classes of MHC molecules, their structures, functions in immunity, and examples in humans (HLA) and mice (H-2 complex). MHC molecules present peptide fragments on their surface and interact specifically with T cells through anchor residues on the peptides. They are essential for self/non-self discrimination, defense against infection, and transplantation compatibility.
The JAK-STAT signaling pathway transmits signals from extracellular chemicals to the nucleus, activating transcription of target genes. It consists of a cell surface receptor, associated Janus kinases (JAKs), and signal transducers and activators of transcription (STATs). When a ligand binds the receptor, JAKs phosphorylate STATs, which form dimers and translocate to the nucleus to regulate gene expression. The Ras/MAPK pathway similarly relays signals from cell surface receptors via Ras, Raf, MEK, and MAPK proteins to influence transcription. Both pathways are tightly regulated and important for processes like cell growth, differentiation, and apoptosis, with dysregulation contributing to diseases.
Haptens are small molecules that are antigenic but not immunogenic on their own. They are unable to induce an immune response because they cannot activate helper T cells due to their inability to bind MHC proteins or activate B cells directly as they are univalent. However, when haptens are covalently bound to a carrier protein, they form immunogenic conjugates that can induce an immune response by activating helper T cells and B cells. Pioneering work by Karl Landsteiner demonstrated that antibodies produced against hapten-carrier conjugates were specific for the hapten and carrier epitopes. Common examples of haptens include drug molecules, peptides, and steroids. Hapten-protein conjugates can cause drug
Immunoelectron microscopy is a technique that uses antibodies tagged with electron-dense markers like gold particles to locate specific proteins or antigens within cells and tissues at the ultrastructural level under an electron microscope. It bridges the gap between biochemical and molecular studies and traditional electron microscopy by allowing visualization of macromolecular functions in their cellular context. Key aspects include using primary antibodies that bind to antigens of interest and secondary antibodies tagged with gold particles of varying sizes. This technique has various applications like studying subcellular protein localization, host-parasite interactions, plant virus detection, and phytoplasma diagnosis at high resolution. Quantitative immunoelectron microscopy also allows statistical analysis of antigen distributions across cellular compartments.
There are 5 major antibody isotypes - IgM, IgD, IgG, IgE, and IgA - which differ based on their heavy chain. The heavy chain determines the isotype and can be mu, delta, gamma, epsilon, or alpha. Light chains can be either kappa or lambda with any isotype. IgG is the most abundant in humans while IgE is the least. Isotypes are located in the constant region of the heavy and light chains. Allotypes are specified by allelic forms of immunoglobulin genes and are also in the constant regions. Idiotypes are unique epitopes located in the variable regions of individual antibody molecules.
Antigens are substances that induce a specific immune response and react with the products of that response. They stimulate the immune system to produce antibodies and each antigen has a distinct epitope. Antigens can be proteins, lipids, carbohydrates or nucleic acids and are generally found on bacteria, viruses, fungi or in allergens. They cause diseases or allergic reactions. Epitopes are the immunologically active regions of antigens that antibodies or lymphocytes bind to. Antigens can be exogenous (external), endogenous (internal) or autoantigens involved in autoimmune diseases.
This document discusses humoral immunity and antibodies. It describes how antibodies are produced by B cells and plasma cells in response to antigens. The primary role of antibodies is protection against reinfection by binding to pathogens and marking them for destruction or neutralization. The document provides details on antibody structure, classes, properties, functions, and role in immune responses.
Hypersensitivity refers to excessive or harmful immune reactions. There are four main types:
I. Type I is an immediate reaction mediated by IgE antibodies binding to mast cells. Common examples include allergic reactions.
II. Type II involves IgG or IgM binding to cells, activating complement and causing cell lysis. Examples include hemolytic anemia.
III. Type III occurs when antigen-antibody complexes are deposited in tissues, activating complement and attracting inflammatory cells. Examples include serum sickness.
IV. Type IV is delayed hypersensitivity mediated by T cells. The tuberculin skin test detects exposure to tuberculosis bacteria.
This document provides an overview of hypersensitivity reactions. It begins with an introduction to immune responses and defines hypersensitivity as an inappropriate or exaggerated immune response that causes tissue damage. It then summarizes the four main types of hypersensitivity reactions: Type I is an immediate, IgE-mediated allergy; Type II involves antibody-mediated cell destruction; Type III occurs via immune complex deposition; and Type IV is a delayed, cell-mediated response. Each type is described in 1-2 sentences with examples given for Type I such as anaphylaxis and atopy.
Hunt, French Revolution and Human RightsJosiah Eck
This document contains a list of codes that appear to be student identification numbers for a history class during the winter of 2011. The codes range from Winter2011HIS10B-85 to Winter2011HIS10B-92, suggesting there were approximately 8 students in the class.
This document contains lecture notes on major histocompatibility complex (MHC) and related topics from a biotechnology course. It discusses antigen-presenting cells, the structure and function of MHC class I and II molecules, similarities and differences between the two classes, MHC-associated genes, and important immune signaling molecules like cytokines, interleukins, interferons, and chemokines. Diagrams are included to illustrate MHC pathway and types of interferons. The notes provide an overview of key concepts in MHC and immunology for students in the biotechnology course.
Transfection is a technique used to insert foreign nucleic acids like DNA or RNA into cells to alter their properties. There are various biological, chemical, and physical methods to accomplish transfection, either transiently or stably. In stable transfection, the foreign DNA integrates into the cellular genome and is passed to daughter cells, while transient transfection only expresses the DNA for a short time without integration. Genetic engineering techniques are used to transfer genes between organisms, like retrovirus-mediated gene transfer where the retrovirus acts as a vector to deliver transgenes into host cells. Embryonic stem cell-mediated gene transfer involves introducing DNA into stem cells that can integrate randomly or through homologous recombination and be passed to offspring. Liposome
Interferons and interleukins are cytokines that play an important role in the immune system. Interferons are proteins produced by cells in response to viral infections that activate immune responses in other cells. The three main types are alpha, beta, and gamma interferons. Interleukins are cytokines that are primarily produced by lymphocytes and macrophages to mediate communication between immune cells. There are over 30 identified interleukins that activate immune responses. Both interferons and interleukins have therapeutic applications for treating viral infections and cancers by enhancing immune activation. They are administered through intravenous or subcutaneous injection.
Cytokines are cell signaling molecules that allow communication between cells of the immune system. They can be classified into six families based on structural similarities and functions. The interleukin (IL) family includes pro-inflammatory cytokines like IL-1 and IL-2 that are secreted by macrophages and T cells respectively to induce immune responses. Chemokines are a subgroup of cytokines that mobilize immune cells between tissues by influencing cytoskeletal proteins and adhesion molecules. Cytokines can have pleiotropic, redundant, synergistic or antagonistic effects on different target cells. Their localized release and cell surface receptor binding allows for precise communication between immune cells.
This document summarizes antigen processing and presentation. It discusses that antigen presenting cells such as macrophages, dendritic cells, and B cells express class II MHC molecules and provide co-stimulatory signals to activate T helper cells. These cells internalize antigens through phagocytosis or endocytosis, degrade them into peptides, and present the peptides bound to class II MHC on their surface. The document also describes the major histocompatibility complex and the roles of class I and class II MHC molecules in antigen presentation to T cells. It outlines the exogenous and endogenous antigen processing pathways, how exogenous antigens are presented by class II MHC and endogenous antigens by class I MHC.
1. The document presents information about T cells and B cells, including their development, activation, and functions.
2. T cells develop in the thymus gland and have roles in direct killing of infected cells and regulating the immune response. B cells mature in the bone marrow and produce antibodies to help fight pathogens.
3. Activation of both T and B cells involves interaction with antigen-presenting cells and costimulatory signals, leading to cell proliferation and differentiation into effector and memory cells.
Immune response during bacterial, parasitic and viral infection.pptxVanshikaVarshney5
1) The innate immune response to viruses involves interferon production which stimulates antiviral proteins to block viral replication. Natural killer cells also help destroy infected cells.
2) The adaptive immune response involves humoral immunity with antiviral antibodies that neutralize viruses and prevent infection of cells. Cell-mediated immunity uses cytotoxic T-cells and macrophages to directly kill infected cells.
3) Viruses have evolved mechanisms to evade the immune response, such as reducing MHC expression to avoid detection by T-cells, direct immunosuppression, and antigenic variation for influenza virus.
The document discusses cytokines, their properties, classification, receptors, and signaling pathways. It notes that cytokines exhibit pleiotropy, redundancy, synergy and antagonism. Major cytokine families include hematopoietins, interferons, chemokines, and TNF. Cytokine receptors include Ig superfamily, class 1, class 2, TNF and chemokine receptors. Cytokine binding induces receptor dimerization and JAK/STAT pathway activation. Cytokines play essential roles in hematopoiesis and immunity, but imbalances can lead to disease.
Central tolerance refers to deletion of self-reactive T and B cells in the thymus and bone marrow during maturation. T cells that recognize self antigens undergo apoptosis in the thymus. Peripheral tolerance uses backup mechanisms like clonal deletion through activation-induced cell death, clonal anergy from lack of co-stimulation, and suppression by regulatory T cells. These mechanisms help prevent autoimmune disease by silencing self-reactive cells that escape central tolerance.
The document discusses the major histocompatibility complex (MHC), which are surface proteins that play an important role in identifying antigens and presenting them to T cells. It covers the different classes of MHC molecules, their structures, functions in immunity, and examples in humans (HLA) and mice (H-2 complex). MHC molecules present peptide fragments on their surface and interact specifically with T cells through anchor residues on the peptides. They are essential for self/non-self discrimination, defense against infection, and transplantation compatibility.
The JAK-STAT signaling pathway transmits signals from extracellular chemicals to the nucleus, activating transcription of target genes. It consists of a cell surface receptor, associated Janus kinases (JAKs), and signal transducers and activators of transcription (STATs). When a ligand binds the receptor, JAKs phosphorylate STATs, which form dimers and translocate to the nucleus to regulate gene expression. The Ras/MAPK pathway similarly relays signals from cell surface receptors via Ras, Raf, MEK, and MAPK proteins to influence transcription. Both pathways are tightly regulated and important for processes like cell growth, differentiation, and apoptosis, with dysregulation contributing to diseases.
Haptens are small molecules that are antigenic but not immunogenic on their own. They are unable to induce an immune response because they cannot activate helper T cells due to their inability to bind MHC proteins or activate B cells directly as they are univalent. However, when haptens are covalently bound to a carrier protein, they form immunogenic conjugates that can induce an immune response by activating helper T cells and B cells. Pioneering work by Karl Landsteiner demonstrated that antibodies produced against hapten-carrier conjugates were specific for the hapten and carrier epitopes. Common examples of haptens include drug molecules, peptides, and steroids. Hapten-protein conjugates can cause drug
Immunoelectron microscopy is a technique that uses antibodies tagged with electron-dense markers like gold particles to locate specific proteins or antigens within cells and tissues at the ultrastructural level under an electron microscope. It bridges the gap between biochemical and molecular studies and traditional electron microscopy by allowing visualization of macromolecular functions in their cellular context. Key aspects include using primary antibodies that bind to antigens of interest and secondary antibodies tagged with gold particles of varying sizes. This technique has various applications like studying subcellular protein localization, host-parasite interactions, plant virus detection, and phytoplasma diagnosis at high resolution. Quantitative immunoelectron microscopy also allows statistical analysis of antigen distributions across cellular compartments.
There are 5 major antibody isotypes - IgM, IgD, IgG, IgE, and IgA - which differ based on their heavy chain. The heavy chain determines the isotype and can be mu, delta, gamma, epsilon, or alpha. Light chains can be either kappa or lambda with any isotype. IgG is the most abundant in humans while IgE is the least. Isotypes are located in the constant region of the heavy and light chains. Allotypes are specified by allelic forms of immunoglobulin genes and are also in the constant regions. Idiotypes are unique epitopes located in the variable regions of individual antibody molecules.
Antigens are substances that induce a specific immune response and react with the products of that response. They stimulate the immune system to produce antibodies and each antigen has a distinct epitope. Antigens can be proteins, lipids, carbohydrates or nucleic acids and are generally found on bacteria, viruses, fungi or in allergens. They cause diseases or allergic reactions. Epitopes are the immunologically active regions of antigens that antibodies or lymphocytes bind to. Antigens can be exogenous (external), endogenous (internal) or autoantigens involved in autoimmune diseases.
This document discusses humoral immunity and antibodies. It describes how antibodies are produced by B cells and plasma cells in response to antigens. The primary role of antibodies is protection against reinfection by binding to pathogens and marking them for destruction or neutralization. The document provides details on antibody structure, classes, properties, functions, and role in immune responses.
Hypersensitivity refers to excessive or harmful immune reactions. There are four main types:
I. Type I is an immediate reaction mediated by IgE antibodies binding to mast cells. Common examples include allergic reactions.
II. Type II involves IgG or IgM binding to cells, activating complement and causing cell lysis. Examples include hemolytic anemia.
III. Type III occurs when antigen-antibody complexes are deposited in tissues, activating complement and attracting inflammatory cells. Examples include serum sickness.
IV. Type IV is delayed hypersensitivity mediated by T cells. The tuberculin skin test detects exposure to tuberculosis bacteria.
This document provides an overview of hypersensitivity reactions. It begins with an introduction to immune responses and defines hypersensitivity as an inappropriate or exaggerated immune response that causes tissue damage. It then summarizes the four main types of hypersensitivity reactions: Type I is an immediate, IgE-mediated allergy; Type II involves antibody-mediated cell destruction; Type III occurs via immune complex deposition; and Type IV is a delayed, cell-mediated response. Each type is described in 1-2 sentences with examples given for Type I such as anaphylaxis and atopy.
Hunt, French Revolution and Human RightsJosiah Eck
This document contains a list of codes that appear to be student identification numbers for a history class during the winter of 2011. The codes range from Winter2011HIS10B-85 to Winter2011HIS10B-92, suggesting there were approximately 8 students in the class.
ERP-Systeme gewinnbringend einsetzen, Einführungsprojekte erfolgreich gestalten,
Geschäftsprozesse optimieren und mit der Software unterstützen, Erfolgsfaktoren bei der Software-Auswahl, Lieferanten und Kunden einbinden
Diese Präsentation beinhaltet einen Überblick über alle wichtigen Schritte der CCC Zertifizierung, den möglichen Zertifizierungsproblemen und den zuständige Zertifizierungsbehörden. Diese Informationen sind wichtig, da bei fehlerhaften CCC-Zertifizierungen Ihre Produkte trotz CCC-Zertifikat vom chinesischen Zoll einbehalten werden können.
- Die Berufsbildung im Überblick
- Das Berufsbildungssystem der Schweiz
- Eine Aufgabe - drei Partner
- Die Lernorte
- Der Lehrstellenmarkt
- Die Berufsbildung in Zahlen
- Berufsbildung international
- Weiterführende Informationen
Beim Essure Eingriff wird eine weiche Mikrospirale durch die Gebärmutter während einer Gebärmutterspiegelung in jeden Eileiter eingesetzt.
Der Eingriff dauert ungefähr 5 Minuten und erfolgt in örtlicher Betäubung oder Vollnarkose. Die meisten Frauen können die Tagesklinik nach 45 Minuten verlassen und gehen am nächsten Tag wieder ihrer Arbeit nach.
Für den Essure-Eingriff sind keine Einschnitte des Körpers notwendig, die Eileiter werden nicht durchgeschnitten oder mit Klipps versehen.
Während der drei Monate nach dem Eingriff arbeitet der Körper und die Mikrospirale zusammen, indem sie eine Gewebebarriere aufbauen, die die Spermien daran hindert, das Ei zu erreichen. Die Mikrospiralen enthalten keine Hormone.
Text Version is Available at: http://www.biochemden.in/2014/11/anthrone-method-carbohydrate-determination.html
Carbohydrates are very important component of Storage and structural materials in the plants. The carbohydrates are stored as free sugars and polysaccharides. The basic units of carbohydrates are Monosaccharides. When hydrolyse the carbohydrates, gives monosaccharides, but when hydrolyse monosaccharides it can not be split into more simpler sugars. The hydrolysed product of Polysaccharide are estimating by the resultant monosaccharides.
What is Immunity? Explain the types of Immunity? (Presentation)Biochemistry Den
The document provides an overview of immunology, including definitions and key concepts. It discusses the immune system's innate and acquired immunity. Innate immunity provides immediate protection through physical barriers, chemicals, proteins and cells. Acquired immunity develops from exposure through active immunity from natural infection or vaccination, or passive immunity from maternal antibodies or antibody treatments. The immune system uses recognition and response to protect against pathogens through a variety of interrelated components.
This document is a list of web page references to www.BiochemDen.in that spans 12 lines. It provides URL references but no other contextual information about the content or purpose of the referenced pages.
Stem cells can develop into red blood cells, lymphocytes, or myeloid cells. Lymphocytes include T cells, B cells, and null cells such as natural killer cells. T cells regulate cell-mediated immunity while B cells produce antibodies. Myeloid cells include granulocytes like neutrophils, eosinophils, and basophils, which defend against pathogens. Monocytes develop into macrophages and dendritic cells, which process and present antigens to lymphocytes. Together, these immune cells protect the body through innate and adaptive immune responses.
Immunology: Immunity - What is Aquired immunity?Biochemistry Den
This document discusses acquired immunity, also known as specific immunity. When a foreign substance like a bacterium or virus enters the body, the immune system produces antibodies that specifically recognize and eliminate that substance. If the pathogen is encountered again later, the immune system can quickly produce those same antibodies to fight it off, conferring long-lasting protection against that specific pathogen.
This document discusses immunology and is comprised of 24 numbered sections from www.BiochemDen.in covering various topics within immunology. The document provides an overview of immunological concepts but does not go into detail about any specific topic.
Immunology: Complememt system and its types, MechanismBiochemistry Den
The document discusses the three pathways of the complement system - the classical pathway, alternative pathway, and lectin pathway. The classical pathway is activated by antigen-antibody complexes and involves C1, C4, C2, and C3. The alternative pathway involves spontaneous activation of C3 and forms the C3 convertase C3bBb. The lectin pathway is activated upon recognition of mannose residues on microbial surfaces by mannose-binding lectin or ficolins, activating MASPs and forming the C3 convertase C4bC2a.
This document is a list of website URLs for www.BiochemDen.in that spans 10 lines. It contains repeated references to the same website across multiple lines without any other visible text or context.
Communicating effectively and consistently with students can help them feel at ease during their learning experience and provide the instructor with a communication trail to track the course's progress. This workshop will take you through constructing an engaging course container to facilitate effective communication.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
This document provides an overview of wound healing, its functions, stages, mechanisms, factors affecting it, and complications.
A wound is a break in the integrity of the skin or tissues, which may be associated with disruption of the structure and function.
Healing is the body’s response to injury in an attempt to restore normal structure and functions.
Healing can occur in two ways: Regeneration and Repair
There are 4 phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This document also describes the mechanism of wound healing. Factors that affect healing include infection, uncontrolled diabetes, poor nutrition, age, anemia, the presence of foreign bodies, etc.
Complications of wound healing like infection, hyperpigmentation of scar, contractures, and keloid formation.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
Philippine Edukasyong Pantahanan at Pangkabuhayan (EPP) CurriculumMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏)-𝐏𝐫𝐞𝐥𝐢𝐦𝐬
𝐃𝐢𝐬𝐜𝐮𝐬𝐬 𝐭𝐡𝐞 𝐄𝐏𝐏 𝐂𝐮𝐫𝐫𝐢𝐜𝐮𝐥𝐮𝐦 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐡𝐢𝐥𝐢𝐩𝐩𝐢𝐧𝐞𝐬:
- Understand the goals and objectives of the Edukasyong Pantahanan at Pangkabuhayan (EPP) curriculum, recognizing its importance in fostering practical life skills and values among students. Students will also be able to identify the key components and subjects covered, such as agriculture, home economics, industrial arts, and information and communication technology.
𝐄𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐞 𝐍𝐚𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐒𝐜𝐨𝐩𝐞 𝐨𝐟 𝐚𝐧 𝐄𝐧𝐭𝐫𝐞𝐩𝐫𝐞𝐧𝐞𝐮𝐫:
-Define entrepreneurship, distinguishing it from general business activities by emphasizing its focus on innovation, risk-taking, and value creation. Students will describe the characteristics and traits of successful entrepreneurs, including their roles and responsibilities, and discuss the broader economic and social impacts of entrepreneurial activities on both local and global scales.