Answer: Cellular respiration: We breathe in O2 and breathe out CO2. Nowhere did we see O2 and CO2 in the same metabolic pathway, yet these two molecules are related and these molecules are interrelated when a glucose molecule oxidized in the presence of oxygen in eukaryotic cell finally release CO2 where carbon is going to get the oxygen from glucose. The remaining carbon skeleton in the metabolic pathways such as glycolysis followed by citric acid cycle finally \"oxidative phopshorylation\" are performed to generate metabolic energy Cellular respiration is the utilization of oxygen by the cell for the synthesis of metabolic products such as sugars, fats, proteins etc. In humans, cellular respiration takes place in cytosol & in the mitochondria (power hoses of the cell), in which the most of the metabolic processes takes place. Blood carries the oxygen to each cell in the body and again collects the carbon dioxide. The primary function of cellular respiration is to generate ATP, which traps some of the chemical energy of food molecules in its high- energy bonds (adenosine triphosphate). The process of generation of ATP is via glycolysis and Krebs’s cycle finally through oxidative phosphorylation. The overall balanced reaction of cellular respiration is: CHO+ 6O 6CO+ 6HO + ATP Glucose + oxygen carbon dioxide + water + energy In this reaction, glucose oxidized and oxygen reduced to CO2. Carbonic- Acid - Bicarbonate Blood buffer system & lungs: The bicarbonate buffering system of In the cellular respiration, involves an acid & base homeostatic mechanism further involving the equilibrium balance of carbonic acid(H2CO3), bicarbonate ion (HCO3-), and carbon dioxide (CO2) in order to maintain isotonic pH (7.4) in the blood and duodenum, among other tissues, to enable appropriate metabolic function. This reaction is catalyzed by carbonic anhydrase, when cellular carbon dioxide (CO2) (lungs) reacts with water (H2O) to form carbonic acid (H2CO3), which in turn rapidly dissociates to form a hydrogen ion (exists in the solution as hydronium ion, H3O+) and bicarbonate ion (HCO3) The first step in cellular respiration is glycolysis. Glycolysis is an anaerobic process & takes place in cytosol, through which one glucose molecules is breakdown into two molecules of three-carbon pyruvate. The glycolysis of each glucose molecule generates 2 ATP molecules. ATP synthesis from anaerobic process is via glycolysis of glucose in the presence of various enzymes. Glucose + 2 NAD+ + 2 Pi + 2 ADP 2 pyruvate + 2 NADH + 2 ATP + 2 H+ + 2 H2O + heat Citric acid cycle: The pyruvate generated by the glycolysis is converted into acetyl-CoA that enters into the citric acid cycle. Citric acid cycle involves a series of reactions that occur in the presence of \"oxygen\" & metabolic output is \"CO2\". Citric acid cycle generates NADH, which enters into the oxidative phosphorylation process. This cycle occurs in mitochondrial matrix and generates one ATP molecule only. Acetyl co-A +.