ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR
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The document contains 20 frequently asked questions about angiotensin receptor-neprilysin inhibitors (ARNI). The questions cover topics such as the role of digoxin in heart failure, why ARNI was not used in the PARADIGM-HF trial, how ARNI should be monitored, its use in pregnancy and heart failure with preserved ejection fraction, dosing and safety. The document provides answers from Professor Dr. Md.Toufiqur Rahman, a cardiologist, about the role and use of ARNI in treating heart failure.
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Pulmonary hypertension (PH) is a complex and progressive
condition characterised by high blood pressure in the lungs, leading
to significant health challenges. This book is dedicated to unravelling
the intricacies of PH, encompassing its pathophysiology, diagnosis,
management and emerging research trends. It is designed to serve
as a comprehensive guide for clinicians, researchers and students
in the field of cardiology and respiratory medicine, as well as a
valuable resource for patients and their families seeking to deepen
their understanding of this condition.
The chapters of this book are structured to provide a detailed
insight into the various facets of PH. Starting with the basic
pathophysiology and classification systems, I delve into the
clinical presentation, diagnostic criteria and the nuances of
managing this condition, including both pharmacological and
non-pharmacological approaches. Special attention is given to
the unique challenges posed by pediatric PH, PH in pregnancy
and the management of co-morbidities and complications.
Recognizing the rapid advancements in the field, this book also
dedicates a significant portion to discussing current research
trends, future therapeutic targets and evolving diagnostic
techniques. Real-world case studies and patient testimonies are
included to provide a practical perspective, highlighting the
impact of PH on patients’ lives and the importance of a patient-
centered approach to care.
The field of pulmonary hypertension is one of dynamic change
and I growing understanding. Through this book, we aim to
provide a thorough and up-to-date resource that reflects the
current state of knowledge and practice in the field of PH, while
also offering a glimpse into the future directions of research and
treatment. It is my hope that this book will not only enhance the
understanding of PH among healthcare professionals but also offer
support and information to patients and their families navigating
this challenging condition.The Pulmonary Paradox : Navigating the Challenges of Pulmonary Hypertension ...
The Pulmonary Paradox : Navigating the Challenges of Pulmonary Hypertension ...PROFESSOR DR. MD. TOUFIQUR RAHMAN
Recommended
Pulmonary hypertension (PH) is a complex and progressive
condition characterised by high blood pressure in the lungs, leading
to significant health challenges. This book is dedicated to unravelling
the intricacies of PH, encompassing its pathophysiology, diagnosis,
management and emerging research trends. It is designed to serve
as a comprehensive guide for clinicians, researchers and students
in the field of cardiology and respiratory medicine, as well as a
valuable resource for patients and their families seeking to deepen
their understanding of this condition.
The chapters of this book are structured to provide a detailed
insight into the various facets of PH. Starting with the basic
pathophysiology and classification systems, I delve into the
clinical presentation, diagnostic criteria and the nuances of
managing this condition, including both pharmacological and
non-pharmacological approaches. Special attention is given to
the unique challenges posed by pediatric PH, PH in pregnancy
and the management of co-morbidities and complications.
Recognizing the rapid advancements in the field, this book also
dedicates a significant portion to discussing current research
trends, future therapeutic targets and evolving diagnostic
techniques. Real-world case studies and patient testimonies are
included to provide a practical perspective, highlighting the
impact of PH on patients’ lives and the importance of a patient-
centered approach to care.
The field of pulmonary hypertension is one of dynamic change
and I growing understanding. Through this book, we aim to
provide a thorough and up-to-date resource that reflects the
current state of knowledge and practice in the field of PH, while
also offering a glimpse into the future directions of research and
treatment. It is my hope that this book will not only enhance the
understanding of PH among healthcare professionals but also offer
support and information to patients and their families navigating
this challenging condition.The Pulmonary Paradox : Navigating the Challenges of Pulmonary Hypertension ...
The Pulmonary Paradox : Navigating the Challenges of Pulmonary Hypertension ...PROFESSOR DR. MD. TOUFIQUR RAHMAN
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ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR
- 1. Professor Dr. Md.Toufiqur Rahman MBBS, FCPS, MD, FACC, FESC, FRCP, FSCAI, FCCP,FAPSC, FAPSIC, FAHA,FACP Professor of Cardiology National Institute of Cardiovascular Diseases Sher-e-Bangla Nagar, Dhaka-1207 Consultant, Medinova, Malibagh branch. drtoufiq19711@yahoo.com Frequent Asked Questions about ARNI
- 2. • 1. what is the role of digoxin in HF? • 2. Why ACEI not used in PARADIGM-HF? • 3. Why ARB must be added to Sacubitril to make ARNI? • 4. Any role of ARNI in acute HF? • 5. After starting ARNI how should I understand the improvement of HF? • 6. Why ARNI should be started after 36 hr stopping ACEI?
- 3. • 7. What are the mode of death in HF patients? • 8. How ARNI patients should be monitored? • 9. ARNI can be used in pregnancy? • 10. ARNI can be used in HFpEF? • 11. Patients with HF & low blood pressure can ARNI is given? • 12. Why Valsartan is chosen with Sacubitril why not other ARB? • 13. Why Sacubitril-Valsartan is given 24/26, 49/51 & 97/103 mg strength? • 14. Long term safety & efficacy of ARNI
- 4. • 15. Renal & Hepatic dose adjustment of ARNI • 16. Contraindication of ARNI • 17. why increased chance of angioedema if ARNI an ACEI used together? • 18. Uses of ARNI to control HTN? PARAMETER study. • 19. Effect of ARNI on renal function? • 20. Use of ARNI in renal imparment?