This document presents AMSTAR 2, a critical appraisal tool for systematically evaluating the quality of systematic reviews that include randomized or non-randomized studies of healthcare interventions. It consists of 16 items addressing aspects such as whether the review had clearly defined objectives and inclusion criteria, conducted a comprehensive literature search and study selection process, assessed risk of bias in individual studies, and appropriately synthesized results. The tool provides criteria for rating reviews as high, moderate, low or critically low quality based on how well they address each item. It aims to provide a reliable and valid measurement of the quality of systematic reviews.