This document summarizes the products and services of AllCells, a leading provider of human primary cells. It offers over 800 healthy and diseased primary cell products that are used in areas like drug discovery, stem cell research, and regenerative medicine. AllCells has a supply chain and tissue collection clinic that enables efficient procurement of these cells. It provides a variety of normal and diseased primary cells and tissues, as well as custom processing and isolation services. AllCells aims to advance scientific research through its high quality and biologically relevant primary cell products.
Are you considering banking your child’s cord blood? Let Americord answer all your questions about cord blood, from the cost of cord blood banking to what conditions can be treated with banked cord blood and stem cells.
Stem cells are one of the important cells present in both plant and animals. these cells have ability to regenerate any part of the body work similarily as meristem cells in plant. The advances in the stem cell technology has open a new era in medical field. the advances in this technology has been presented here and their important application has been included in this present in this presentation.
Are you considering banking your child’s cord blood? Let Americord answer all your questions about cord blood, from the cost of cord blood banking to what conditions can be treated with banked cord blood and stem cells.
Stem cells are one of the important cells present in both plant and animals. these cells have ability to regenerate any part of the body work similarily as meristem cells in plant. The advances in the stem cell technology has open a new era in medical field. the advances in this technology has been presented here and their important application has been included in this present in this presentation.
ReeLabs is a zero debt, presently 10 crore company with a working capital of 100 crores that has recently
ventured into cord blood banking and stem cell research and therapy.
Cell Storage Best Practices: Techniques to Ensure Greater Research Resultsallcells
Featuring: Cryopreservation Specialist, Michael George
This webinar will introduce cell storage equipment and techniques in order to provide the most up-to-date trends in research today. There will be special emphasis on human primary cell storage, cryopreservation, and transportation.
Topics to be covered in the webinar:
• Background on life science storage methods
• Advantages/disadvantages of storage equipment
• What not to do (common mistakes/misconceptions)
• Interview with James Lee, Associate Director of Production, AllCells
• Q&A
Get information of what are stem cells, sources of stem cells, what is umbilical cord and the umbilical cord blood, what us HLS matching etc and many more.
Selecting a model system is usually one of the first and most challenging steps in exploring a clinical hypothesis, validating a technology, or understanding a biological process. Although cell lines have served the needs of biomedical research for decades, increasingly, grant and publication reviewers as well as agencies regulating drug development, are requesting researchers to reproduce their results in more representative or “clinically relevant” models. This webinar will introduce human and animal-derived primary cells and explain how they currently serve diverse biomedical clinical and research applications as biologically-relevant, species-specific, and simple to use biological systems.
What process is used to obtain cells from bone marrow and normal peripheral blood?
What is the best cell counting and viability method for primary cells?
AllCells, your primary cells research partner, and Nexcelom Bioscience, your cell counting experts, have joined together in an exclusive collaboration to host a free webinar to help educate researchers and present data from their own experiences.
Cord blood (umbilical cord blood) is the blood that remains in the placenta and in the attached umbilical cord after childbirth. Cord blood is collected because it contains stem cells, which can be used to ... Blood · Childbirth ·
In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologically and genetically part of the fetus and, (in humans), normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta. Conversely, the fetal heart pumps deoxygenated, nutrient-depleted blood through the umbilical arteries back to the placenta.
The blood within the umbilical cord, known as cord blood, is a rich and readily available source of primitive, undifferentiated stem cells (of type CD34-positive and CD38-negative). These cord blood cells can be used for bone marrow transplant.
Some parents choose to have this blood diverted from the baby's umbilical blood transfer through early cord clamping and cutting, to freeze for long-term storage at a cord blood bank should the child ever require the cord blood stem cells (for example, to replace bone marrow destroyed when treating leukemia).
In the future, cord blood-derived embryonic-like stem cells (CBEs) may be banked and matched with other patients, much like blood and transplanted tissues. The use of CBEs could potentially eliminate the ethical difficulties associated with embryonic stem cells (ESCs).
Total Pregnancy Care is an online guide for pregnancy, childbirth and motherhood related information. Women wanting to conceive, pregnant women, expecting parents, and new mothers can use this pregnancy portal for a healthy pregnancy, fulfilling childbirth and joyful motherhood. With pregnancy at its core, this portal covers various important aspects and especially addresses those matters that the Indian Woman always wanted to know but did not know whom to ask. Visit www.totalpregnancycare.com
ReeLabs is a zero debt, presently 10 crore company with a working capital of 100 crores that has recently
ventured into cord blood banking and stem cell research and therapy.
Cell Storage Best Practices: Techniques to Ensure Greater Research Resultsallcells
Featuring: Cryopreservation Specialist, Michael George
This webinar will introduce cell storage equipment and techniques in order to provide the most up-to-date trends in research today. There will be special emphasis on human primary cell storage, cryopreservation, and transportation.
Topics to be covered in the webinar:
• Background on life science storage methods
• Advantages/disadvantages of storage equipment
• What not to do (common mistakes/misconceptions)
• Interview with James Lee, Associate Director of Production, AllCells
• Q&A
Get information of what are stem cells, sources of stem cells, what is umbilical cord and the umbilical cord blood, what us HLS matching etc and many more.
Selecting a model system is usually one of the first and most challenging steps in exploring a clinical hypothesis, validating a technology, or understanding a biological process. Although cell lines have served the needs of biomedical research for decades, increasingly, grant and publication reviewers as well as agencies regulating drug development, are requesting researchers to reproduce their results in more representative or “clinically relevant” models. This webinar will introduce human and animal-derived primary cells and explain how they currently serve diverse biomedical clinical and research applications as biologically-relevant, species-specific, and simple to use biological systems.
What process is used to obtain cells from bone marrow and normal peripheral blood?
What is the best cell counting and viability method for primary cells?
AllCells, your primary cells research partner, and Nexcelom Bioscience, your cell counting experts, have joined together in an exclusive collaboration to host a free webinar to help educate researchers and present data from their own experiences.
Cord blood (umbilical cord blood) is the blood that remains in the placenta and in the attached umbilical cord after childbirth. Cord blood is collected because it contains stem cells, which can be used to ... Blood · Childbirth ·
In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologically and genetically part of the fetus and, (in humans), normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta. Conversely, the fetal heart pumps deoxygenated, nutrient-depleted blood through the umbilical arteries back to the placenta.
The blood within the umbilical cord, known as cord blood, is a rich and readily available source of primitive, undifferentiated stem cells (of type CD34-positive and CD38-negative). These cord blood cells can be used for bone marrow transplant.
Some parents choose to have this blood diverted from the baby's umbilical blood transfer through early cord clamping and cutting, to freeze for long-term storage at a cord blood bank should the child ever require the cord blood stem cells (for example, to replace bone marrow destroyed when treating leukemia).
In the future, cord blood-derived embryonic-like stem cells (CBEs) may be banked and matched with other patients, much like blood and transplanted tissues. The use of CBEs could potentially eliminate the ethical difficulties associated with embryonic stem cells (ESCs).
Total Pregnancy Care is an online guide for pregnancy, childbirth and motherhood related information. Women wanting to conceive, pregnant women, expecting parents, and new mothers can use this pregnancy portal for a healthy pregnancy, fulfilling childbirth and joyful motherhood. With pregnancy at its core, this portal covers various important aspects and especially addresses those matters that the Indian Woman always wanted to know but did not know whom to ask. Visit www.totalpregnancycare.com
Các nguyên nhân răng miệng thường gặp gây đau răng bao gồm sâu răng, áp xe răng, bệnh nướu, kích thích chân răng, hội chứng răng nứt, bệnh khớp thái dương hàm, răng mọc kẹt và răng đang mọc.
This is already slated to be a sold out conference! Confirm your attendee, sponsorship or exhibitor spot early or be left out!
Keynote Speakers include:
Stuart Crabb (Facebook)
Keith Ferrazzi
James Key Lim
Robert Van Arlen
Stedman Graham
The AZSHRM Annual Conference is the largest human resource-focused conference in the state of Arizona. It provides fantastic keynote speakers, great educational sessions, networking opportunities, and exposure to the newest HR products, techniques and services. Open to all HR professionals looking for an affordable, dynamic program that can help you earn re-certification credits. Business owners and managers can learn from top keynote speakers and leading experts nationwide.
This years conference is being held at the Sheraton Wild Horse Pass.
Full Conference Early Bird Rate $545.00 (Includes Pre-conference day)
Regular Conference Early Bird Rate $365.00 (Does not include Pre-conference day)
(Visit the fees page for more information & rate details)
AZSHRM HOTEL Rate: $115/night + charges & taxes
Colt is an international IT services company. We help businesses perform better by removing the complexity around delivering and integrating network, data centre and IT services. We have developed a new business opportunity to enter specific market segments via the franchising concept. This brochure explains how you can be part of this new business opportunity in the ICT market.
5 myths you should know about dog and cat foodsTom Musbach
Webinar on dog and cat nutrition featuring Dr. Roger Welton, a veterinarian on Pearl.com.
The slide show addresses common myths and offers tips for selecting the right pet food.
Learn what we can do for you. This presentation gives an overview of our capabilities as well as detailing some of the specific applications where our products are used.
switch~ is an energy entertainment event using 5min pecha-kucha talk format to inspire or humor a sustainability geek audience. This talk was given at eTown Hall fall of 2014 by Chuck Ray addressing the struggle between regulated monopoly electric delivery and market side entrepreneurs. switch-energy.org
A presentation on the Stem Cells 21 - IntelliHealthPlus medical center in Bangkok, Thailand. Information on Umbilical cord mesenchymal stem cells and Cd34+ cells, also the companies Ultrasound adipose stem cell separation.
What is Stem Cell ?
History of Stem Cells ?
Stages of Embryogenesis
Blastocyst Diagram
Three types of stem cells
Differentiation of ESC
Adult Stem Cells
Bone Marrow
Umbilical cord stem cells
Factors known to affect stem cells
Niche cells activates Stem cells
Regenerative Medicine : Indian Scenario
Stem cell therapies - a special case of therapy and research Arete-Zoe, LLC
I. Potential
II. Classification
III. Clinical research
IV. Patient demand
V. Regulatory and legal framework
- USA
- Europe
VI. Professional societies
https://www.aretezoe.com/stem-cells
Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, significant advancements have been made to regenerate in vitro culture or tissue platforms. Relatively simple flat or tubular organs are already in (pre)clinical trials .
There are two emerging technologies for solid organ fabrication.
One is decellularization of cadaveric organs followed by repopulation with terminally differentiated or progenitor cells.
The other is 3D bioprinting to deposit cell-laden bio-inks to attain complex tissue architecture.
Embryonic Stem Cells (ESCs)
– Derived from the blastocyst of a 5 day-old embryo
– Are pluripotent, i.e., they can differentiate into almost any cell type in the body (primary-like cells)
– Can renew themselves indefinitely
Adult Stem Cells (e.g. MSCs, NSCs, ADSCs)
– Isolated from adult tissues, organs or blood, cord blood, etc.
– Are multipotent – i.e., can give rise to a number of related cell types
– Can renew themselves a number of times but not indefinitely
Induced Pluripotent Stem Cells (iPS Cells)
Somatic cells can be reprogrammed to form pluripotent stem cells called induced pluripotential stem cells (iPS cell).
2. AllCells is a leading provider of hematology-based
Products & Services to the world’s Life Science research
community
• >800 healthy & diseased human primary cell products that
enable advancement of scientific research
• Superior Supply-Chain and Efficient Work-Flow: Tissue
Collection Clinic, lab facilities, plus network of diseased tissue
providers
• Established 1998, headquartered in Emeryville, CA
• Global Reach: direct USA sales force + WW distribution via
STEMCELL Technologies (ROW) and VERITAS (Japan)
• Small and Minority Owned Business certification
About AllCells, LLCAbout AllCells, LLC
3. AllCells primary cell Products & Services are used in areas of
drug discovery & screening, stem cell research, regenerative
medicine, cell therapy, cell-based assays, cell biology research,
and other life science applications
Markets & ApplicationsMarkets & Applications
4. AllCells provides biologically relevant products that enable its
customers to advance early stage drug discovery & preclinical
development
Pharmaceutical Value ChainPharmaceutical Value Chain
6. LeukoLabLeukoLab
• Wholly owned IRB-certified human tissue collection clinic
(Emeryville, CA)
• largest volume bone marrow aspirates (up to 100 ml)
• whole blood collections
• r-GCSF mobilized and non-mobilized leukopheresis
• large repository human donors
• Staffed with RNs, Physicians, Phlebotomists
• Recruit human donors directly according to customer
criteria - active donor pool of >1,000 healthy volunteers
• Procedures comply with federal and California State Dept.
of Health Regulations
8. Hematopoietic Stem cells
AllCells provides Hematopoietic Stem Cells isolated from various
Human tissue:
• Bone Marrow
• Normal Peripheral Blood
• Mobilized Peripheral Blood
• Cord Blood
• Fetal Liver
• CD34+ and CD133+ cells from all tissue types
• Available fresh or frozen
• Certificate of Analysis and FACScan Analysis Report
Products: Stem/ProgenitorProducts: Stem/Progenitor
10. Bone Marrow
• Unprocessed Whole Bone Marrow
• Mononuclear Cells
• Stem/Progenitor Cells (CD34+ or CD133+)
• Marrow Stromal Cells (similar to
Mesenchymal Stem Cells)
• Endothelial Cells (CD105+)
• Erythroid Cells (CD71+)
• Myeloid Cells (CD33+)
• Granulocytes (Neutrophils, Basophils, and
Eosinophils)
ProductsProducts
11. ProductsProducts
Normal Peripheral Blood
• Leuko Pak (contains average 1.6X1010
MNCs)
• Processed Mononuclear Cells
• Stem/Progenitor Cells (CD34+ or CD133+)
• T Cells (Pan T, CD4+, and CD8+)
• B Cells (CD19+)
• Monocytes (CD14+)
• NK Cells (CD56+)
• Granulocytes (Neutrophils, Basophils, Eosinophils)
• Dendritic Cells (BDCA4+ Lymphoid Dendritic and
Monocyte derived Immature Dendritic)
• Plasma, platelets, pure RBCs
12. ProductsProducts
G-CSF Mobilized Peripheral Blood
• Leuko Paks 1-Day and 2-Day collections
• Processed Mononuclear Cells
• Stem/Progenitor Cells (CD34+ or CD133+)
• Early Erythroid Progenitor Cells (CD36+)
• T Cells (Pan T, CD4+, and CD8+)
• B Cells (CD19+)
• Monocytes (CD14+)
• NK Cells (CD56+)
• Dendritic Cells (BDCA4+ Lymphoid Dendritic and Monocyte
derived Immature Dendritic)
13. ProductsProducts
Cord Blood
• Processed Mononuclear Cells
• Stem/Progenitor Cells (CD34+ or CD133+)
• Early Erythroid Progenitor Cells (CD36+)
• T Cells (Pan T, CD4+, CD8+, Naive T Cells (CD4+/CD45RA+)
• B Cells (CD19+)
• Monocytes (CD14+)
• NK Cells (CD56+)
• Endothelial Cells (HUVEC)
• Granulocytes (Neutrophils, Basophils, Eosinophils)
• Plasma
14. Other ProductsOther Products
• Fetal Liver Cells
• Stem/Progenitor Cells (CD34+ or CD133+)
• Early Erythroid Progenitor Cells (CD36+)
• RNA/cDNA (available for all cells types provided from AllCells)
• Non-Human Primate Cells (Bone Marrow and Peripheral Blood)
• Processed Mononuclear Cells
• Granulocytes
• Plasma
• Bone Marrow Stem/Progenitor Cells (CD34+)
• Rat & Mouse Cells
• Rat Pancreatic islets and other hematopoietic cells from Rat and Mouse
• Canine Endothelial Cells (CVEC)
16. • ALL/AML
– Newly diagnosed
– Relapsed/Refractory
– Bone Marrow and Peripheral Blood
– Purified cells
• CLL/CML
– Newly diagnosed
– Relapsed/Refractory
– Bone Marrow and Peripheral Blood
– Chronic phase/accelerated or Blast Crisis
(CML)
• Multiple Myeloma
– Newly diagnosed
– Relapsed/Refractory
• Non-Hodgkin’s Lymphoma
– Burkitt’s Lymphoma (BL)
– Diffuse Large B Cell Lymphoma
(DLBCL)
– Follicular Lymphoma (FLL)
– Mantle Cell Lymphoma (MCL)
– Waldenstrom’s Macroglobulinemia
(WM)
• Polycythemia Vera (PV)
AllCells has established Supply Agreements with an
extensive network of oncology clinical sites
Comprehensive clinical reports are available for each
sample and specific lot at www.allcells.com prior to
purchase.
Oncology / Diseased ProductsOncology / Diseased Products
17. • Large Scale Processing & Cell Isolation:
• healthy or diseased human tissue
• molecular products (RNA/DNA, etc.) & lysates
• Drug Discovery Assay Services
• colony formation assays e.g. CFU-GM, CFU-Mk
• in vitro proliferation/inhibition assays (EC50)
• mechanistic studies
• toxicology
• Flow Cytometry Services
• immunophenotyping, rare cell analysis, sorting
• Custom assays
• cell cycle analysis
• apoptosis, phospho protein analysis, CD34+ determination under
ISHAGE guidelines
Custom ServicesCustom Services
18. Industry Leader: Since 1998 AllCells has provided hematology-based
products & services to the global Life Science industry
Market Applications: Drug discovery / toxicity, cell-based screening
assays, stem cell research, cell therapy, regenerative medicine, Dx /
biomarker discovery, gene expression
AllCells Competitive Advantage: Exceptional supply chain control -
donor recruitment (profiles of interest), G-CSF mobilization, healthy &
diseased tissue / cells, wholly owned IRB-certified clinic, fresh or frozen
products, guaranteed cell viability, clinical reports, hematology
expertise
Custom Services: Tissue sourcing, cell isolation, molecular products,
cell-based assays, drug screening/preclinical development
Sales: Direct Sales USA + International Distributors
Bus. Dev: Interested in collaborations / strategic partnerships
SummarySummary
19. Ernie Desmarais
Regional Account Manager
Northeast Region
edesmarais@allcells.com
Mobile: (617)997-2120
Office: (510)521-2600
Your Reliable
Source of Human
Primary Cells
Thank You !
Editor's Notes
We’re located about 20 min east of San Francisco just across the Bay Bridge
Jay is a Hematologist by training and has published…
- LeukoLab: Leukapheresis -mobilized (G-CSF) & non-mobilized, bone marrow aspirate, whole blood collection
Through the process of leukapheresis, blood is drawn from one arm with the help of a catheter that is placed in one of the veins. The blood is then removed from the arm and placed into a centrifuge. The centrifuge spins the blood and separates it into various components according to the materials’ weight and density. Consequently, the blood can be separated into red blood cells, white blood cells, and platelets. Typically, the white blood cells are removed and the rest of the cells and the blood plasma are returned to the body through another catheter or a needle in the opposite arm
- Gene expression includes protein expression & characterization
Target ID/Discovery Look for proteins or mRNA expressed (or not expressed) in a diseased state, identify new drugable targets, receptor binding, time-on-target, validate & optimize
Preclinical Development: Understand protein pathways & interactions, mechanism, ADME, safety, efficacy, dose ranging.
Lead Discovery: Evaluate lead compounds that can potentially fix the problem (primary & secondary screening)
Pre-Clinical: in-vitro & animal tests for toxicity & efficacy of therapy
Clinical Ph 1: small group (10’s) of healthy human volunteers to check safety & toxicity
Clinical Ph 2: Patient population (100’s) to determine efficacy, dosage & safety
Clinical Ph 3: larger patient population (1000’s) to determine efficacy, dosage, safety, side effects, and interactions
Competitive advantage
Competitive advantage
One area of focus is the
LeukoLab: Leukapheresis -mobilized (G-CSF) & non-mobilized, bone marrow aspirate, whole blood collection
Through the process of leukapheresis, blood is drawn from one arm with the help of a catheter that is placed in one of the veins. The blood is then removed from the arm and placed into a centrifuge. The centrifuge spins the blood and separates it into various components according to the materials’ weight and density. Consequently, the blood can be separated into red blood cells, white blood cells, and platelets. Typically, the white blood cells are removed and the rest of the cells and the blood plasma are returned to the body through another catheter or a needle in the opposite arm
LeukoLab: Leukapheresis -mobilized (G-CSF) & non-mobilized, bone marrow aspirate, whole blood collection
Through the process of leukapheresis, blood is drawn from one arm with the help of a catheter that is placed in one of the veins. The blood is then removed from the arm and placed into a centrifuge. The centrifuge spins the blood and separates it into various components according to the materials’ weight and density. Consequently, the blood can be separated into red blood cells, white blood cells, and platelets. Typically, the white blood cells are removed and the rest of the cells and the blood plasma are returned to the body through another catheter or a needle in the opposite arm
Naive T cells are able to respond to novel pathogens that the immune system has not yet encountered. Having adequate numbers of naive T cells is essential for the immune system to continuously respond to unfamiliar pathogens.
A naive T cell is considered mature, but is distinguished from activated T cells or memory T cells, as it is thought not to have yet encountered cognate antigen in the periphery. Naive T cells are able to respond to novel pathogens that the immune system has not yet encountered. Recognition by a naive T cell clone of its cognate antigen results in the initiation of an acquired immune response. In the ensuing response, the T cell acquires an activated phenotype (CD25+, CD44+, CD62Llow, CD69+), and may further differentiate into a memory T cell.
Naive T cells are able to respond to novel pathogens that the immune system has not yet encountered. Having adequate numbers of naive T cells is essential for the immune system to continuously respond to unfamiliar pathogens.
A naive T cell is considered mature, but is distinguished from activated T cells or memory T cells, as it is thought not to have yet encountered cognate antigen in the periphery. Naive T cells are able to respond to novel pathogens that the immune system has not yet encountered. Recognition by a naive T cell clone of its cognate antigen results in the initiation of an acquired immune response. In the ensuing response, the T cell acquires an activated phenotype (CD25+, CD44+, CD62Llow, CD69+), and may further differentiate into a memory T cell.
Competitive advantage
IRB approved program for collecting various oncology related samples from a variety of health institutions. Current access to over 2,500 patient samples through our developed sourcing network.
Three largest oncology groups in Bay Area collecting for AllCells’ program
Expanding collection sites on East Coast with new tissue samples expected May 2010
Ability to screen samples for higher blast counts depending on your research needs
Ability to provide samples based on donors’ demographic information (age, sex, weight, smoker, HLA type, etc.)
Multiple Myeloma:
We can provide either fresh whole tissue (30cc of Peripheral Blood or 25cc of Bone Marrow) or fresh isolated MNCs in concentrations of 10 million and 100 million cells. Easily able to supply 2-3 samples per week needed for your project
There are many subtypes of Non-Hodgkin lymphoma (NHL), including:
Burkitt lymphoma (or "Burkitt's tumor", or "Malignant lymphoma, Burkitt's type") is a cancer of the lymphatic system (in particular, B lymphocytes). It is named after Denis Parsons Burkitt, a surgeon who first described the disease in 1956 while working in equatorial Africa.[1][2]
Diffuse large B-cell lymphoma (DLBL, DLBCL, or DLCL) is a type of aggressive lymphoma. It accounts for approximately 40% of lymphomas among adults.[1] It is typically diagnosed between the ages of 25 and 40 years. It is twice as common in women as in men.
Follicular lymphoma is the most common of the indolent non-Hodgkin's lymphomas, and the second most common form of non-Hodgkin's lymphomas overall. It is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts), which has at least a partially follicular pattern. It is positive for CD10,[1] and usually negative for CD5
Mantle cell lymphoma (MCL) is one of the rarest of the non-Hodgkin's lymphomas (NHLs), comprising about 6% of NHL cases. MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to a t(11:14)[2] chromosomal translocation in the DNA.
Polycythemia vera is a blood disorder in which the bone marrow makes too many red blood cells. Polycythemia vera may also result in the overproduction of white blood cells and platelets. Most of the health concerns associated with polycythemia vera are caused by a blood-thickening effect that results from an overproduction of red blood cells.
Waldenström's macroglobulinemia (WM, also known as lymphoplasmacytic lymphoma) is cancer involving a subtype of white blood cells called lymphocytes. The main attributing antibody is IgM. It is a type of lymphoproliferative disease, and shares clinical characteristics with the indolent non-Hodgkin lymphomas.