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Ovaries
Reproductive tract
Other targets
Steroids
Feedback
Hypothalamus
GnRH(gonadotrophin
releasing
hormone)
Pituitary
LH
FSH
+ (“gonadotrophins”)
Menstruation is an
external indicator
of ovarian events
controlled by the
hypothalamic-
pituitary axis
Roles of the ovary
1. Gametes (ova)
2. Hormones
MENSTRUATION
(oestradiol,
progesterone).
0 4 8 12 16 20 24 28
Timing events in the menstrual cycle.
2. LH surge
Day 1
Menstruation
Day 1
LH
OVULATION
Days before Days after
Follicular phase Luteal phase
0 4 8 12 16 20 24 28
LH
Day 1
Menstruation
OVULATION
Animated ovarian events
Progesterone
(and oestradiol)
Oestradiol
1. Follicular
growth
Key events in the ovarian cycle
3. Luteal function
2. Ovulation
4. Luteal
regression
Hypothalamus
Pituitary
Ovaries
GnRH
Oestradiol (E2)
+
_
Oestradiol
INHIBIN
Small follicles:
very dependent
on FSH
Large follicles: less
dependent on FSH
FSH
Decreased
FSH
+ +
Growth factors
Oestradiol
Insufficient
FSH
Dominant
follicle
Increasing
negative
feedback
0 4 8 12 16 20 24 28
Insufficient FSH to
keep smaller follicles
going – they become
atretic.
Oestradiol
FSH
FSH
secretion
suppressed
Dominant follicle(s)
can survive
0 4 8 12 16 20 24 28
OVULATION
Oestradiol
Progesterone
What maintains
the CL?
Why does the
CL degenerate
at the end of the
cycle?
Follicular phase:
Oestradiol domination
Luteal phase:
Progesterone domination

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Akos Murber - Female endocrine functions - summary

  • 1. Ovaries Reproductive tract Other targets Steroids Feedback Hypothalamus GnRH(gonadotrophin releasing hormone) Pituitary LH FSH + (“gonadotrophins”) Menstruation is an external indicator of ovarian events controlled by the hypothalamic- pituitary axis Roles of the ovary 1. Gametes (ova) 2. Hormones MENSTRUATION (oestradiol, progesterone).
  • 2. 0 4 8 12 16 20 24 28 Timing events in the menstrual cycle. 2. LH surge Day 1 Menstruation Day 1 LH OVULATION Days before Days after Follicular phase Luteal phase
  • 3. 0 4 8 12 16 20 24 28 LH Day 1 Menstruation OVULATION Animated ovarian events Progesterone (and oestradiol) Oestradiol 1. Follicular growth Key events in the ovarian cycle 3. Luteal function 2. Ovulation 4. Luteal regression
  • 4. Hypothalamus Pituitary Ovaries GnRH Oestradiol (E2) + _ Oestradiol INHIBIN Small follicles: very dependent on FSH Large follicles: less dependent on FSH FSH Decreased FSH + + Growth factors Oestradiol Insufficient FSH Dominant follicle Increasing negative feedback
  • 5. 0 4 8 12 16 20 24 28 Insufficient FSH to keep smaller follicles going – they become atretic. Oestradiol FSH FSH secretion suppressed Dominant follicle(s) can survive
  • 6. 0 4 8 12 16 20 24 28 OVULATION Oestradiol Progesterone What maintains the CL? Why does the CL degenerate at the end of the cycle? Follicular phase: Oestradiol domination Luteal phase: Progesterone domination