Ancestral Health Symposium, LA, August 2011Food and Western DiseaseStaffan Lindeberg MD PhDCenter for Primary Health Care ResearchLund University, Sweden
Western diseases:Cardiovascular diseasesdiabetes obesityhypertensiondementiacancersosteoporosisricketsiron deficiencyautoimmune diseasesgastroesophageal refluxirritable bowel syndromeand many othersLindeberg S. Food and Western Disease. Wiley-Blackwell 2010
The basis of nutritional advice
The basis of nutritional adviceStoriesS. GrahamA. LaneJ.H. KelloggD. BurkittBattle CreekM. Bircher-Benner
The basis of nutritional adviceStoriesA. Brillat-SavarinC. BernardW. BantingR. Atkins
The basis of nutritional adviceStories
MoneyThe basis of nutritional adviceStories
Money
Science
Epidemiology
Molecular biology
Clinical trialsPlacebo bread, real meatReal bread, placebo meat
The basis of nutritional adviceStories
Money
Science
Epidemiology
Molecular biology
Clinical trials
Evolutionary medicineThe basis of nutritional adviceStories
Money
Science
Epidemiology
Molecular biology
Clinical trials
Evolutionary medicineThe Trobriand Islands, Papua New Guinea
The Trobriand Islands, Papua New Guinea
The Trobriand Islands, Papua New GuineaKitavatropical island, 4 x 7 km
2,300 inhabitants (in 1990); 6% 60-96 years
diet: cultivated tubers (yam, sweet potato, taro, tapioka), fruit, fish, nuts and leafy vegetables — no western food
regular physical activity: ~1.7 x BMR13Estimated amount of foods consumed by Kitavan adults in Nov-Dec 1990Daily intake	Total	Protein	Fat	CHO	Energy(medians)	(g)	(g)	(g)	(g)	(kJ)Tubers	1200	25	2	300	5600Fruit	400	3	<1	50	920Coconut	110	4	43	7	1865Fish	85Pork	<1	-	-	-	-Other meat	<2	-	-	-	-Other	200	5	<1	14	360Western food	<1	0	<1	<1	20Total	2 000	54	50	370	9200Lindeberg S et al. AJCN 1997;66:845
The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
consistent with earlier observations (Schiefenhövel, Jüptner)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
consistent with earlier observations (Schiefenhövel, Jüptner)
consistent with studies in Melanesia(Breinl -15, Clements -36, Devine -46, Backhouse -58, Whyte -58, Barnes -61, Campbell and Arthur -64, Dewdney -65, Kariks -67, Vines -70, Aiken -74, Hornabrook -74, Mathews -74, Page -74, Somers -74, Sinnett -77, Korner -80, Palmer -82, Ree -82)
consistent with studies in Africa(Donnison -29, Vint -37, Muwazi -44, Davies -48, Thomas -60, Trowell -60, Reef -62, Seftel -63, Tejada -68, Dodu -72, Edginton -72, Okuwobi -72, Shaper -72, Walker -75, Truswell -76, Isaacson -77, Trowell -81)
consistent with studies in South America (Groom -71, Connor -78, Baruzzi -81)
consistent with studies in the Arctic (Price -36, Kromann -80, Schaefer -81, Dyerberg -89)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)
consistent with earlier observations (Schiefenhövel, Jüptner)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)
consistent with earlier observations (Schiefenhövel, Jüptner)
consistent with studies in East Africa (Trowell -81, Muwazi -44)Table. Incidence of stroke as proportion of acute neurologic disease in Kampala, Uganda.
The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)
consistent with earlier observations (Schiefenhövel, Jüptner)
consistent with studies in East Africa (Trowell -81, Muwazi -44)
consistent with studies in Papua New Guinea (Breinl -15, Clements -36, Backhouse -58, Campbell -64, Dewdney -65, Stanhope -69, Vines -70, Sinnett -73, Hornabrook -74, Hornabrook -75, Nagurney -75, Sinnett, PF -77, Palmer -82, Ree -82)Fig. Stroke incidence per 1000 person-years in the 1990s among selected westernized populations.Feigin VI et al. Lancet Neurol 2003;2:43
The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)
diabetes type 2 (Lindeberg S et al. Metabolism 1999;48:1216)Fig. Fasting serum glucosein Kitava and Sweden.
The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)
diabetes type 2 (Lindeberg S et al. Metabolism 1999;48:1216)
overweight (Lindeberg S et al. J Intern Med 1994;236:331)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)
diabetes type 2 (Lindeberg S et al. Metabolism 1999;48:1216)
overweight (Lindeberg S et al. J Intern Med 1994;236:331)
hypertension (Lindeberg S et al. J Intern Med 1994;236:331)Table. Blood pressure at age 40-60 years among hunter-gatherers, in Kitava and in Sweden (mm Hg, mean ± standard deviation)(modified from Lindeberg S et al. J Intern Med 1994;236:331).
The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
stroke (Lindeberg S et al. J Intern Med 1993;233:269)
diabetes type 2 (Lindeberg S et al. Metabolism 1999;48:1216)
overweight (Lindeberg S et al. J Intern Med 1994;236:331)

AHS Slides_Staffan Lindeberg

  • 1.
    Ancestral Health Symposium,LA, August 2011Food and Western DiseaseStaffan Lindeberg MD PhDCenter for Primary Health Care ResearchLund University, Sweden
  • 2.
    Western diseases:Cardiovascular diseasesdiabetesobesityhypertensiondementiacancersosteoporosisricketsiron deficiencyautoimmune diseasesgastroesophageal refluxirritable bowel syndromeand many othersLindeberg S. Food and Western Disease. Wiley-Blackwell 2010
  • 3.
    The basis ofnutritional advice
  • 4.
    The basis ofnutritional adviceStoriesS. GrahamA. LaneJ.H. KelloggD. BurkittBattle CreekM. Bircher-Benner
  • 5.
    The basis ofnutritional adviceStoriesA. Brillat-SavarinC. BernardW. BantingR. Atkins
  • 6.
    The basis ofnutritional adviceStories
  • 7.
    MoneyThe basis ofnutritional adviceStories
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
    Clinical trialsPlacebo bread,real meatReal bread, placebo meat
  • 13.
    The basis ofnutritional adviceStories
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
    Evolutionary medicineThe basisof nutritional adviceStories
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
    Evolutionary medicineThe TrobriandIslands, Papua New Guinea
  • 26.
    The Trobriand Islands,Papua New Guinea
  • 27.
    The Trobriand Islands,Papua New GuineaKitavatropical island, 4 x 7 km
  • 28.
    2,300 inhabitants (in1990); 6% 60-96 years
  • 29.
    diet: cultivated tubers(yam, sweet potato, taro, tapioka), fruit, fish, nuts and leafy vegetables — no western food
  • 30.
    regular physical activity:~1.7 x BMR13Estimated amount of foods consumed by Kitavan adults in Nov-Dec 1990Daily intake Total Protein Fat CHO Energy(medians) (g) (g) (g) (g) (kJ)Tubers 1200 25 2 300 5600Fruit 400 3 <1 50 920Coconut 110 4 43 7 1865Fish 85Pork <1 - - - -Other meat <2 - - - -Other 200 5 <1 14 360Western food <1 0 <1 <1 20Total 2 000 54 50 370 9200Lindeberg S et al. AJCN 1997;66:845
  • 31.
    The Trobriand Islands,Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 32.
    consistent with earlierobservations (Schiefenhövel, Jüptner)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 33.
    consistent with earlierobservations (Schiefenhövel, Jüptner)
  • 34.
    consistent with studiesin Melanesia(Breinl -15, Clements -36, Devine -46, Backhouse -58, Whyte -58, Barnes -61, Campbell and Arthur -64, Dewdney -65, Kariks -67, Vines -70, Aiken -74, Hornabrook -74, Mathews -74, Page -74, Somers -74, Sinnett -77, Korner -80, Palmer -82, Ree -82)
  • 35.
    consistent with studiesin Africa(Donnison -29, Vint -37, Muwazi -44, Davies -48, Thomas -60, Trowell -60, Reef -62, Seftel -63, Tejada -68, Dodu -72, Edginton -72, Okuwobi -72, Shaper -72, Walker -75, Truswell -76, Isaacson -77, Trowell -81)
  • 36.
    consistent with studiesin South America (Groom -71, Connor -78, Baruzzi -81)
  • 37.
    consistent with studiesin the Arctic (Price -36, Kromann -80, Schaefer -81, Dyerberg -89)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 38.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 39.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)
  • 40.
    consistent with earlierobservations (Schiefenhövel, Jüptner)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 41.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)
  • 42.
    consistent with earlierobservations (Schiefenhövel, Jüptner)
  • 43.
    consistent with studiesin East Africa (Trowell -81, Muwazi -44)Table. Incidence of stroke as proportion of acute neurologic disease in Kampala, Uganda.
  • 44.
    The Trobriand Islands,Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 45.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)
  • 46.
    consistent with earlierobservations (Schiefenhövel, Jüptner)
  • 47.
    consistent with studiesin East Africa (Trowell -81, Muwazi -44)
  • 48.
    consistent with studiesin Papua New Guinea (Breinl -15, Clements -36, Backhouse -58, Campbell -64, Dewdney -65, Stanhope -69, Vines -70, Sinnett -73, Hornabrook -74, Hornabrook -75, Nagurney -75, Sinnett, PF -77, Palmer -82, Ree -82)Fig. Stroke incidence per 1000 person-years in the 1990s among selected westernized populations.Feigin VI et al. Lancet Neurol 2003;2:43
  • 49.
    The Trobriand Islands,Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 50.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)
  • 51.
    diabetes type 2(Lindeberg S et al. Metabolism 1999;48:1216)Fig. Fasting serum glucosein Kitava and Sweden.
  • 52.
    The Trobriand Islands,Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 53.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)
  • 54.
    diabetes type 2(Lindeberg S et al. Metabolism 1999;48:1216)
  • 55.
    overweight (Lindeberg Set al. J Intern Med 1994;236:331)The Trobriand Islands, Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 56.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)
  • 57.
    diabetes type 2(Lindeberg S et al. Metabolism 1999;48:1216)
  • 58.
    overweight (Lindeberg Set al. J Intern Med 1994;236:331)
  • 59.
    hypertension (Lindeberg Set al. J Intern Med 1994;236:331)Table. Blood pressure at age 40-60 years among hunter-gatherers, in Kitava and in Sweden (mm Hg, mean ± standard deviation)(modified from Lindeberg S et al. J Intern Med 1994;236:331).
  • 60.
    The Trobriand Islands,Papua New GuineaStriking absence of Western diseasemyocardial infarction (Lindeberg S et al. J Intern Med 1993;233:269)
  • 61.
    stroke (Lindeberg Set al. J Intern Med 1993;233:269)
  • 62.
    diabetes type 2(Lindeberg S et al. Metabolism 1999;48:1216)
  • 63.
    overweight (Lindeberg Set al. J Intern Med 1994;236:331)