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Our Science
Aging Signs
And Symptoms
Aging Sources
TRADITIONAL
APPROACH
TO ANTI-AGING
SCIENCE
NU SKIN APPROACH TO
ANTI-AGING SCIENCE
Treat signs
and symptoms
Identify and
address the
sources of aging
NU SKIN’S
APPROACH
TO ANTI-AGING
SCIENCE
GENE
EXPRESSION
GENE
EXPRESSION
GENE
EXPRESSION
GENE
EXPRESSION
GENE
EXPRESSION
INTERNAL AGING AGGRESSORS
Genetics
Stress
Toxins
Debris
Cellular metabolism
Damage accumulation
Toxins
Stress
Anxiety
Pollutants
Sun
Smoke
EXTERNAL AGING AGGRESSORS
GENE
EXPRESSION
POSITIVE
GENE EXPRESSION
FROM YOUTH PRODUCT
Backed by more than 30 years of anti-aging gene
expression and nutrition science research, our
proprietary anti-aging scientific approach is unlike any
other in the world.
We continue to work with LifeGen
Technologies as we develop our ageLOC
nutritional products. Acquiring LifeGen gave
us exclusive ownership of the largest anti-
aging gene expression database of its kind.
This proprietary knowledge has led to a
deeper understanding of gene expression
and the way specific ingredients target and
modulate gene expression.
V
ageLOC Youth promotes your
youth span—the years you can enjoy
life being more active, energetic, and
healthy.*
OUR MOST ADVANCED
ANTI-AGING SUPPLEMENT EVER
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
What makes this our most advanced
anti-aging formula?
• Modulates aging defense
mechanisms resulting in systemic
youth preservation benefits
• Developed from proprietary gene
expression insights into healthy aging
• Proprietary blend of natural
ingredients extremely difficult
to obtain through diet alone
Aging Defense Mechanisms (ADMs)
DNA
Protection/
Repair
Stress
Response
Antioxidant
Defense
Inflammatory
Balance
Metabolism
Regulation
Tissue
Renewal
GENE
EXPRESSION
Systemic Health Benefits
 Cellular Health
• Reinforces the body’s protection and repair mechanisms at the
cellular level
• Helps balance healthy cellular response. Disruption of cellular
response can spark a cascade of other aging effects
• Positively modulates systemic cytokine responses
• Supports cellular DNA damage protection/repair
• Provides cellular antioxidant protection
 Brain Health
• Supports healthy brain structure and function
• Promotes youthful cognition and memory
• Promotes sense of wellbeing and healthy mood
 Heart Health
• Sustains overall cardiovascular health
• Promotes blood vessel integrity/elasticity, essential for healthy
blood circulation
• Supports normal blood glucose control
• Supports healthy blood pressure regulation
 Metabolic Health
• Supports healthy lipid metabolism
• Supports normal glucose metabolism
 Skin Health
• Promotes optimal skin barrier function and protection
• Maintains optimal skin health
 Bone Health
• Boosts bone health and supports bone structure and integrity
 Joint Health
• Supports healthy joints and promotes healthy joint fluidity
 Eye Health
• Provides ingredients important for healthy eye composition and
protection
• Promotes eye health and supports healthy vision
 Physical Performance
• Enables optimal physical performance
 Immune Health
• Promotes healthy immune function and response
• Supports a healthy immune system
Cellular Health
• Reinforces the body’s protection and repair
mechanisms at the cellular level
• Helps balance healthy cellular response. Disruption of
cellular response can spark a cascade of other aging
effects
• Positively modulates systemic cytokine responses
• Supports cellular DNA damage protection/repair
• Provides cellular antioxidant protection
Cellular Health
• Reinforces the body’s protection and repair
mechanisms at the cellular level
• Helps balance healthy cellular response. Disruption of
cellular response can spark a cascade of other aging
effects
• Positively modulates systemic cytokine responses
• Supports cellular DNA damage protection/repair
• Provides cellular antioxidant protection
 Brain Health
• Supports healthy brain structure and function
• Promotes youthful cognition and memory
• Promotes sense of wellbeing and healthy mood
 Brain Health
• Supports healthy brain structure and function
• Promotes youthful cognition and memory
• Promotes sense of wellbeing and healthy mood
 Heart Health
• Sustains overall cardiovascular health
• Promotes blood vessel integrity/elasticity, essential for
healthy blood circulation
• Supports normal blood glucose control
• Supports healthy blood pressure regulation
 Heart Health
• Sustains overall cardiovascular health
• Promotes blood vessel integrity/elasticity, essential for
healthy blood circulation
• Supports normal blood glucose control
• Supports healthy blood pressure regulation
 Metabolic Health
• Supports healthy lipid metabolism
• Supports normal glucose metabolism
 Metabolic Health
• Supports healthy lipid metabolism
• Supports normal glucose metabolism
 Skin Health
• Promotes optimal skin barrier function and protection
• Maintains optimal skin health
 Skin Health
• Promotes optimal skin barrier function and protection
• Maintains optimal skin health
 Bone Health
• Boosts bone health and supports bone structure and
integrity
 Bone Health
• Boosts bone health and supports bone structure and
integrity
 Joint Health
• Supports healthy joints and promotes healthy joint
fluidity
 Joint Health
• Supports healthy joints and promotes healthy joint
fluidity
 Eye Health
• Provides ingredients important for healthy eye
composition and protection
• Promotes eye health and supports healthy vision
 Eye Health
• Provides ingredients important for healthy eye
composition and protection
• Promotes eye health and supports healthy vision
 Physical Performance
• Enables optimal physical performance
 Physical Performance
• Enables optimal physical performance
 Immune Health
• Promotes healthy immune function and response
• Supports a healthy immune system
 Immune Health
• Promotes healthy immune function and response
• Supports a healthy immune system
Tissue Renewal
Stress Response
Inflammatory Balance
Metabolism Regulation
DNA Protection and
Repair
Antioxidant
Defense/Protection
ageLOC
Ingredients
BRAIN HEALTH
ageLOC Youth Targets
Multiple Aging Defense Mechanisms
BRAIN HEALTH
Cognitive Function and Neuroprotection
ageLOC Youth Targets
Multiple ADMs
• Supports healthy brain structure and function.
• Promotes youthful cognition and memory.
• Promotes sense of wellbeing and healthy mood.
EFFECTIVE AGING DEFENSE MECHANISMS*
Regulate body’s innate potential to stay YOUTHFUL
Require HEALTHY GENE EXPRESSION
to operate optimally
Yield SYSTEMIC anti-aging benefits to support
many structures and functions in the body.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
INGREDIENT BLEND
INGREDIENTLIBRARY
PROPRIETARYBLEND
Unique Ingredient Blend
Using our proprietary gene
expression research and the most
robust anti-aging scientific literature,
we selected ingredients based on
their unique health benefits and their
ability to positively impact gene
expression related to our aging
defense mechanisms.*
*These statements have not been
evaluated by the Food and Drug
Administration.
This product is not intended to
diagnose, treat, cure, or prevent any
disease.
Global Ingredient Blend
Many of these ingredients have
a long history of anti-aging
benefits in the cultures all over
the world that consume the
individual ingredient.
FRANCE
MEDITERRANEAN
OKINAWA JAPAN
JAPAN
SCANDINAVIA
PERU
ALASKA
Among natives, this diet is
known for promoting low rates
of cardiovascular disease.
This ancient diet is known for
nutrient dense “super foods.”
This diet is known for promoting
incredible longevity and low
rates of cardiovascular disease.
This diet is known for low rates
of cardiovascular disease. This diet is known
for promoting
impressive longevity.
This diet is known for low rates
of cardiovascular disease.
This diet is known for low
rates of cardiovascular
disease and osteoporosis.
Citrus
bioflavanoids:
naringin and hesperetin
plus essential citrus oil
containing d-Limonene
Dietary and Lifestyle Habits
ageLOC Youth delivers a potent
blend of anti-aging nutrients and
phytochemicals that are difficult
to obtain from diet alone.
ageLOC Youth provides consistent
levels of these powerful ingredients
twice per day.
Consistent, Precise Doses
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Systemic Youth
Preservation Benefits
Enabled By Aging
Defense Mechanisms
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
The unique ingredient blend in
ageLOC Youth provides systemic
anti-aging benefits for everyone,
regardless of your dietary intake
or supplement regimen.*
Systemic Anti-Aging
Benefits
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
ageLOC Youth - The Science

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ageLOC Youth - The Science

  • 2. Aging Signs And Symptoms Aging Sources TRADITIONAL APPROACH TO ANTI-AGING SCIENCE NU SKIN APPROACH TO ANTI-AGING SCIENCE Treat signs and symptoms Identify and address the sources of aging NU SKIN’S APPROACH TO ANTI-AGING SCIENCE
  • 4. GENE EXPRESSION GENE EXPRESSION INTERNAL AGING AGGRESSORS Genetics Stress Toxins Debris Cellular metabolism Damage accumulation Toxins Stress Anxiety Pollutants Sun Smoke EXTERNAL AGING AGGRESSORS
  • 6. Backed by more than 30 years of anti-aging gene expression and nutrition science research, our proprietary anti-aging scientific approach is unlike any other in the world.
  • 7. We continue to work with LifeGen Technologies as we develop our ageLOC nutritional products. Acquiring LifeGen gave us exclusive ownership of the largest anti- aging gene expression database of its kind. This proprietary knowledge has led to a deeper understanding of gene expression and the way specific ingredients target and modulate gene expression.
  • 8. V ageLOC Youth promotes your youth span—the years you can enjoy life being more active, energetic, and healthy.* OUR MOST ADVANCED ANTI-AGING SUPPLEMENT EVER *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • 9. What makes this our most advanced anti-aging formula? • Modulates aging defense mechanisms resulting in systemic youth preservation benefits • Developed from proprietary gene expression insights into healthy aging • Proprietary blend of natural ingredients extremely difficult to obtain through diet alone
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  • 16. Systemic Health Benefits  Cellular Health • Reinforces the body’s protection and repair mechanisms at the cellular level • Helps balance healthy cellular response. Disruption of cellular response can spark a cascade of other aging effects • Positively modulates systemic cytokine responses • Supports cellular DNA damage protection/repair • Provides cellular antioxidant protection  Brain Health • Supports healthy brain structure and function • Promotes youthful cognition and memory • Promotes sense of wellbeing and healthy mood  Heart Health • Sustains overall cardiovascular health • Promotes blood vessel integrity/elasticity, essential for healthy blood circulation • Supports normal blood glucose control • Supports healthy blood pressure regulation  Metabolic Health • Supports healthy lipid metabolism • Supports normal glucose metabolism  Skin Health • Promotes optimal skin barrier function and protection • Maintains optimal skin health  Bone Health • Boosts bone health and supports bone structure and integrity  Joint Health • Supports healthy joints and promotes healthy joint fluidity  Eye Health • Provides ingredients important for healthy eye composition and protection • Promotes eye health and supports healthy vision  Physical Performance • Enables optimal physical performance  Immune Health • Promotes healthy immune function and response • Supports a healthy immune system Cellular Health • Reinforces the body’s protection and repair mechanisms at the cellular level • Helps balance healthy cellular response. Disruption of cellular response can spark a cascade of other aging effects • Positively modulates systemic cytokine responses • Supports cellular DNA damage protection/repair • Provides cellular antioxidant protection Cellular Health • Reinforces the body’s protection and repair mechanisms at the cellular level • Helps balance healthy cellular response. Disruption of cellular response can spark a cascade of other aging effects • Positively modulates systemic cytokine responses • Supports cellular DNA damage protection/repair • Provides cellular antioxidant protection  Brain Health • Supports healthy brain structure and function • Promotes youthful cognition and memory • Promotes sense of wellbeing and healthy mood  Brain Health • Supports healthy brain structure and function • Promotes youthful cognition and memory • Promotes sense of wellbeing and healthy mood  Heart Health • Sustains overall cardiovascular health • Promotes blood vessel integrity/elasticity, essential for healthy blood circulation • Supports normal blood glucose control • Supports healthy blood pressure regulation  Heart Health • Sustains overall cardiovascular health • Promotes blood vessel integrity/elasticity, essential for healthy blood circulation • Supports normal blood glucose control • Supports healthy blood pressure regulation  Metabolic Health • Supports healthy lipid metabolism • Supports normal glucose metabolism  Metabolic Health • Supports healthy lipid metabolism • Supports normal glucose metabolism  Skin Health • Promotes optimal skin barrier function and protection • Maintains optimal skin health  Skin Health • Promotes optimal skin barrier function and protection • Maintains optimal skin health  Bone Health • Boosts bone health and supports bone structure and integrity  Bone Health • Boosts bone health and supports bone structure and integrity  Joint Health • Supports healthy joints and promotes healthy joint fluidity  Joint Health • Supports healthy joints and promotes healthy joint fluidity  Eye Health • Provides ingredients important for healthy eye composition and protection • Promotes eye health and supports healthy vision  Eye Health • Provides ingredients important for healthy eye composition and protection • Promotes eye health and supports healthy vision  Physical Performance • Enables optimal physical performance  Physical Performance • Enables optimal physical performance  Immune Health • Promotes healthy immune function and response • Supports a healthy immune system  Immune Health • Promotes healthy immune function and response • Supports a healthy immune system
  • 17. Tissue Renewal Stress Response Inflammatory Balance Metabolism Regulation DNA Protection and Repair Antioxidant Defense/Protection ageLOC Ingredients BRAIN HEALTH ageLOC Youth Targets Multiple Aging Defense Mechanisms
  • 18. BRAIN HEALTH Cognitive Function and Neuroprotection ageLOC Youth Targets Multiple ADMs • Supports healthy brain structure and function. • Promotes youthful cognition and memory. • Promotes sense of wellbeing and healthy mood.
  • 19. EFFECTIVE AGING DEFENSE MECHANISMS* Regulate body’s innate potential to stay YOUTHFUL Require HEALTHY GENE EXPRESSION to operate optimally Yield SYSTEMIC anti-aging benefits to support many structures and functions in the body. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • 22. Unique Ingredient Blend Using our proprietary gene expression research and the most robust anti-aging scientific literature, we selected ingredients based on their unique health benefits and their ability to positively impact gene expression related to our aging defense mechanisms.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • 23. Global Ingredient Blend Many of these ingredients have a long history of anti-aging benefits in the cultures all over the world that consume the individual ingredient. FRANCE MEDITERRANEAN OKINAWA JAPAN JAPAN SCANDINAVIA PERU ALASKA Among natives, this diet is known for promoting low rates of cardiovascular disease. This ancient diet is known for nutrient dense “super foods.” This diet is known for promoting incredible longevity and low rates of cardiovascular disease. This diet is known for low rates of cardiovascular disease. This diet is known for promoting impressive longevity. This diet is known for low rates of cardiovascular disease. This diet is known for low rates of cardiovascular disease and osteoporosis.
  • 24. Citrus bioflavanoids: naringin and hesperetin plus essential citrus oil containing d-Limonene Dietary and Lifestyle Habits
  • 25. ageLOC Youth delivers a potent blend of anti-aging nutrients and phytochemicals that are difficult to obtain from diet alone. ageLOC Youth provides consistent levels of these powerful ingredients twice per day. Consistent, Precise Doses *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • 26. Systemic Youth Preservation Benefits Enabled By Aging Defense Mechanisms *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  • 27. The unique ingredient blend in ageLOC Youth provides systemic anti-aging benefits for everyone, regardless of your dietary intake or supplement regimen.* Systemic Anti-Aging Benefits *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Editor's Notes

  1. Nu Skin’s ageLOC approach is to target the sources of the problem. Rather than just trying to mask the signs and symptoms, which is a traditional approach used by nutritional supplement and skin care companies, we specifically target the sources of aging.
  2. Through this ability to target the sources of aging, we identify changes in gene expression that accelerate the aging process. Aging defense mechanisms exist naturally in all of our cells to help resist aggressors that accelerate aging. The expression of our genes communicates with our aging defense mechanisms to tell them how to behave to protect the body and keep it functioning youthfully.
  3. However, from the moment we’re born, we’re exposed to external and internal aging aggressors. Aging aggressors are a broad class of factors including environmental factors like pollutants, toxins, sun, smoke, stress, and anxiety as well as internal factors like cellular metabolism, stress, debris, and damage accumulation. Although we are all born with aging defense mechanisms, over time they decline in function and performance due to changes in gene expression. We may begin to feel the effects of age.
  4. By maintaining the youthful activity of our aging defense mechanisms, we can help our bodies continue to feel and act young throughout our lives. Gene expression modulates aging defense mechanisms, which in turn elicit broad spectrum, systemic anti-aging benefits. Aging defense mechanisms are not genes or youth gene clusters; they are mechanisms that gene expression controls. Gene expression changes with age, leading to the loss of efficiency of aging defense mechanisms with age. ageLOC Youth targets the gene expression that controls aging defense mechanisms, reminding them to perform youthfully. Some of the ways that we experience these youthful effects is through systemic health benefits such as DNA protection and repair, optimal physical performance, metabolic health, and healthy cognition.
  5. Using our proprietary science, we have developed our most advanced anti-aging supplement to date. ageLOC Youth is a foundational product designed for all adults interested in wellness and youth preservation benefits.
  6. Our bodies have an amazing array of systems designed to maintain health and the benefits of youth. As mentioned before, we call these aging defense mechanisms. Currently, we are focusing on systemic mechanisms in six categories: Antioxidant Defense and Protection Systemic Detoxification and Stress Response DNA Protection and Repair Tissue Renewal Metabolism Regulation Regulation of Inflammatory Balance
  7. These aging defense mechanisms operate throughout the body and interact with one another, working synergistically to oppose aging aggressors.
  8. Over time, the function of all six aging defense mechanisms diminishes and declines due to changes in gene expression, accelerating the aging process.
  9. Through Nu Skin’s proprietary science we have the ability to identify ingredients that can positively modulate gene expression and restore our aging defense mechanisms to youthful activity.
  10. Youthful gene expression is optimal gene expression and that is what is necessary to regulate the healthy and efficient function of ADMs. We set out to identify ingredients that would positively modulate gene expression that regulates our ADMs. Here are the ADMs targeted by our anti-aging formula. All of these ADMs are defense mechanisms that we already have in our bodies and these particular ADMs work throughout our bodies. [Examples of categories of ADMs, the speaker would choose 1 or 2 of the following ADM categories to highlight/give more detail on how ADMs preserve youth] 1) The blend targets both exogenous and endogenous antioxidant defense and protection mechanisms. It provides dietary (exogenous) antioxidants like the carotenoids lutein, lycopene, and astaxanthin, but our bodies also have the ability to synthesize our own antioxidants (e.g. glutathione) and antioxidant enzymes (like catalase and glutathione peroxidase. The blend delivers ingredients that stimulate the production of these endogenous antioxidants. Therefore, the blend promotes antioxidant status from within and without, maximally supporting our antioxidant protection and defense mechanisms. 2) Similarly, the blend delivers ingredients that promote the activity of our intrinsic Systemic Detoxification and Stress Response Mechanisms, supporting our cells’ abilities to neutralize and excrete cellular toxins and protect against damage from cellular stress and contaminants. 3) The blend includes ingredients that promote the protection and repair of our DNA. 4) The blend supports the Mechanisms Regulating Inflammatory Balance, as we observed in the ADM video, a healthy inflammatory response is critical to preserve youth. 5) The blend targets Tissue Renewal Mechanisms. For example, rather than providing the building blocks for healthy bone e.g. calcium and magnesium, the blend promotes bone remodeling, it targets the mechanisms responsible for the removal of old, weaker bone cells for new, strong, healthy bone structure. 6) The blend targets Mechanisms Regulating Metabolism. For example, the blend positively influences both glucose and lipid metabolism, both of which are critical for youth preservation. This network of aging defense mechanisms works synergistically to defend against negative effects of aging, eliciting systemic youth preservation benefits.
  11. Systemic youth preservation benefits contribute to broad spectrum systemic health benefits.
  12. ADMs operate in all cells and interact with one another. Here is an example of several ADMs operating in the brain to maintain cognitive performance and neuroprotection. These are ADMs related to brain health and cognition.
  13. In this example, when we say brain health, these are some of the benefits that the product produces in the brain.
  14. These are the requirements for effective ADMs. With ageLOC Youth, we set out to identify ingredients that contribute to the effective function of ADMs.
  15. We used our proprietary gene expression screening tool to filter through a library of potential ingredients—filtering down to those that demonstrate a positive influence on gene expression and had the most robust anti-aging scientific substantiation to develop our most advanced anti-aging supplement. We then developed these ingredients into an optimal blend—a mixture that is the most beneficial for youth preservation benefits.
  16. We carefully selected ingredients based on their unique health benefits and their ability to positively impact gene expression using our proprietary anti-aging scientific approach. The result is a powerful blend of ingredients that strengthen and support our aging defense mechanisms. Our scientific approach with ageLOC Youth is different from multivitamins and mineral supplements that are focused primarily on filling nutritional gaps. ageLOC Youth provides targeted nutrients that are not common even in healthy diets.
  17. After selecting these ingredients based on scientific literature and gene expression research, we noticed that many of these ingredients are found in diets from all over the world—many of which are well known for the extraordinary health benefits in the specific cultures where these ingredients are consumed. These ingredients come from various regions all over the world, which is one of the reasons why this unique ingredient blend is not readily available even from a healthy diet.
  18. Another reason this ingredient blend is difficult to obtain from your diet is due to dietary habits and lifestyle. For example, in most places around the world, people typically discard the peels or rinds of citrus fruit. But these are great sources of naringin, hesperetin, and d-limonene, which is why in some places, such as the Mediterranean, people eat them. Eating the citrus peel may turn out to be one of the secrets to the health benefits of the Mediterranean diet, but this is not a habit that most people around the world are likely to adapt. ageLOC Youth delivers these ingredients in standardized amounts and in consistent doses. Other examples: anchovies, purple corn juice
  19. Obtaining the consistent, precise doses of ingredients for optimal benefits is also very difficult through diet. ageLOC Youth delivers a potent blend of anti-aging nutrients and phytochemicals that are difficult to obtain from diet alone. Some powerful ingredients such as resveratrol, coenzyme Q10, alpha lipoic acid, and carnosic acid are found at such low levels in foods that it would be nearly impossible to get enough—or even a consistent amount—from your diet each day. For example, astaxanthin is a carotenoid responsible for the pink color in marine sources such as shrimp, salmon, and seaweed. You could consume the same amount of astaxanthin found in ageLOC Youth by eating a full serving of salmon, but would you want to eat salmon every single day? Probably not. ageLOC Youth provides consistent levels of these powerful ingredients twice per day.
  20. ageLOC Youth delivers all-encompassing anti-aging protection. It promotes a wide range of functions from your heart to your brain—your bones to your metabolism.
  21. Everyone will benefit from this product. The benefits it provides are foundational and broad spectrum. This is the first product that everyone should reach for, regardless of diet, age, or lifestyle.