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Adenoma Hipofisis
• most are benign adenomas arising from the anterior pituitary
(adenohypophysis)
• presentation (p. 740): most common: symptoms from excess hormonal
secretion (includes: hyperprolactinemia, Cushing’s syndrome,
acromegaly…), mass effect (most commonly: bitemporal hemianopsia from
compression of optic chiasm, hypopituitarism from mass effect), H/A,
incidental finding, or infrequently with pituitary apoplexy (p. 741)
• work-up for a newly diagnosed intrasellar lesion: see ▶ Table 44.1
• prolactinoma is the only type for which medical therapy (DA agonists) may
be the primary treatment in certain cases (p. 759). For other tumor types,
options primarily consist of surgery (transsphenoidal or transcranial), or
XRT
• post-op concerns include: diabetes insipidus, adrenal insufficiency, CSF leak
• anterior pituitary gland is perfused by its portal venous system, which passes
down the hypophyseal stalk. This unusual vascular supply likely contributes to
frequency of pituitary apoplexy.
• Sindroma perburukan klinis yang mendadak
• syndrome caused by the rapid enlargement of a pituitary adenoma because of
hemorrhage or infarction
• usually evolving in hours, and include headache, vomiting, visual disturbance,
ophthalmoplegia, and altered consciousness
• changes in intracranial pressure associated with head injuries, repetitive
coughing, and procedures such as lumbar puncture, spinal anesthesia,
myelography, and angiography, or after radiation, which may damage blood
vessel integrity and impair blood supply
• A well-described theory is that with rapid growth, the tumor outstrips its blood
supply, resulting in ischemic necrosis and then hemorrhage
• intrinsic vasculopathy yang disebabkan oleh ischemic sehingga terjadi infarction
and haemorrhage
• supply darah berasal dari superior dan inferior hypophysial artery
• MOdalitas MRI
• CT scan
• Lateral Cranial X Ray
• The two pillars of management of pituitary apoplexy have been transsphenoidal
decompression and immediate institution of high-dose corticosteroid
replacement therapy
• Classically, pituitary tumors are divided into functional (or secreting), and non-
functional (AKA
• endocrine-inactive, which are either nonsecretory or else secrete products such
as gonadotropin
• that do not cause endocrinologic symptoms).
• 48% prolactin, 10% GH, 6% ACTH, 1% TSH
• Prolactin can cause amenorrhea-galactorrhea
• hypothalamic involvement may produce
• a) hypotension
• b) thermal dysautoregulation
• c) cardiac dysrhythmias
• d) respiratory pattern disturbances
• e) diabetes insipidus
• f) altered mental status: lethargy, stupor, or coma
• Goals of surgery:
• 1. to decompress the following structures if under pressure:
optic apparatus, pituitary gland, cavernous sinus, third
ventricle (relieving hydrocephalus)
• 2. obtain tissue for pathology
• 3. complete removal of tumor is usually not necessary
• 4. for hydrocephalus: ventricular drainage is generally
required
•Pasien dengan riwayat lapangan pandangan
menyempit 2 tahun
•Gangguan haid sejak 1 tahun lalu
•Apajah craniofaringioma dapat meningkatkan
prolaktin?
• 3 bulan lalu nyeri kepala dan padangan kabur
• gangguan
• baru saat itu dia berobat ke dokter mata
• disertai dengan gambaran ct scan, lesi mengisi sella
suprasella, balloning sella, batas tegas, gambaran fluid
gradation di lesi
• Apakah ini suatu apopleksi? dengan perdarahan kronis
• Apakah gambaran fluid gradatian suatu central nekrosis

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Adenoma Hipofisis pada Penyakit tumor otak

  • 2. • most are benign adenomas arising from the anterior pituitary (adenohypophysis) • presentation (p. 740): most common: symptoms from excess hormonal secretion (includes: hyperprolactinemia, Cushing’s syndrome, acromegaly…), mass effect (most commonly: bitemporal hemianopsia from compression of optic chiasm, hypopituitarism from mass effect), H/A, incidental finding, or infrequently with pituitary apoplexy (p. 741) • work-up for a newly diagnosed intrasellar lesion: see ▶ Table 44.1 • prolactinoma is the only type for which medical therapy (DA agonists) may be the primary treatment in certain cases (p. 759). For other tumor types, options primarily consist of surgery (transsphenoidal or transcranial), or XRT • post-op concerns include: diabetes insipidus, adrenal insufficiency, CSF leak
  • 3. • anterior pituitary gland is perfused by its portal venous system, which passes down the hypophyseal stalk. This unusual vascular supply likely contributes to frequency of pituitary apoplexy. • Sindroma perburukan klinis yang mendadak • syndrome caused by the rapid enlargement of a pituitary adenoma because of hemorrhage or infarction • usually evolving in hours, and include headache, vomiting, visual disturbance, ophthalmoplegia, and altered consciousness • changes in intracranial pressure associated with head injuries, repetitive coughing, and procedures such as lumbar puncture, spinal anesthesia, myelography, and angiography, or after radiation, which may damage blood vessel integrity and impair blood supply
  • 4. • A well-described theory is that with rapid growth, the tumor outstrips its blood supply, resulting in ischemic necrosis and then hemorrhage • intrinsic vasculopathy yang disebabkan oleh ischemic sehingga terjadi infarction and haemorrhage • supply darah berasal dari superior dan inferior hypophysial artery • MOdalitas MRI • CT scan • Lateral Cranial X Ray • The two pillars of management of pituitary apoplexy have been transsphenoidal decompression and immediate institution of high-dose corticosteroid replacement therapy
  • 5. • Classically, pituitary tumors are divided into functional (or secreting), and non- functional (AKA • endocrine-inactive, which are either nonsecretory or else secrete products such as gonadotropin • that do not cause endocrinologic symptoms). • 48% prolactin, 10% GH, 6% ACTH, 1% TSH • Prolactin can cause amenorrhea-galactorrhea • hypothalamic involvement may produce • a) hypotension • b) thermal dysautoregulation • c) cardiac dysrhythmias • d) respiratory pattern disturbances • e) diabetes insipidus • f) altered mental status: lethargy, stupor, or coma
  • 6. • Goals of surgery: • 1. to decompress the following structures if under pressure: optic apparatus, pituitary gland, cavernous sinus, third ventricle (relieving hydrocephalus) • 2. obtain tissue for pathology • 3. complete removal of tumor is usually not necessary • 4. for hydrocephalus: ventricular drainage is generally required
  • 7. •Pasien dengan riwayat lapangan pandangan menyempit 2 tahun •Gangguan haid sejak 1 tahun lalu •Apajah craniofaringioma dapat meningkatkan prolaktin?
  • 8. • 3 bulan lalu nyeri kepala dan padangan kabur • gangguan • baru saat itu dia berobat ke dokter mata • disertai dengan gambaran ct scan, lesi mengisi sella suprasella, balloning sella, batas tegas, gambaran fluid gradation di lesi • Apakah ini suatu apopleksi? dengan perdarahan kronis • Apakah gambaran fluid gradatian suatu central nekrosis