The document discusses acute renal failure (ARF), defining it as a sudden reduction in kidney function that results in waste accumulating in the blood. It classifies ARF by urine volume and lists the main causes as pre-renal, post-renal, and renal. Pre-renal causes include volume depletion and problems with blood flow. Post-renal causes involve urine outflow issues. Renal causes include tubular necrosis, interstitial nephritis, and glomerular disease. The document provides details on evaluating and managing ARF, including through fluid management, treating electrolyte abnormalities, and considering renal replacement therapy.

1. East Africa University
Faculty of Medicine
semester:11

3. DEFINITIONS
 Acute renal failure is a sudden reduction in
kidney function that results in nitrogenous
wastes accumulating in the blood.
 ARF is an abrupt decline in glomerular and
tubular function, resulting in the failure of the
kidneys to excrete nitrogenous waste products
and to maintain fluid and electrolyte
homeostasis.

4.  Acute renal failure (ARF) refers to a sudden
and usually reversible loss of renal function,
which develops over a period of days or weeks
and is usually accompanied by a reduction in
urine volume.

5. ACUTE RENAL FAILURE
CLASSIFICATION BY URINE
VOLUME
OLIGURIC: <400 CC/ 24 Hrs.
NON-OLIGURIC: >500 CC/24 Hrs.
ANURIC : <50 CC/24 Hrs. (some
references <100 cc/24 hrs.)

6. ETIOLOGY
 There are many possible causes and it is frequently
multifactorial. The clinical picture is often dominated by
the underlying condition (e.g. septic shock, trauma). If
the cause cannot be rapidly corrected and renal
function restored, temporary renal replacement therapy
may be required.
The causes can be:
I. PRE-RENAL 55-60%
II. POST RENAL <5%
III. RENAL 35-40%

8. Prerenal causes
 Most common cause of ARF
 Problems affecting the flow of blood before it reaches
the kidneys
1. Intravascular volume depletion (dehydration)
– Hemorrhage
– Vomiting, diarrhea
– “Third spacing”
– Diuretics

9. 2. Disruption of blood flow to the kidneys .
 Major surgery with blood loss, severe injury or burns, or
infection in the bloodstream.
 Blockage or narrowing of a blood vessel carrying blood to
the kidneys.
 Heart failure or heart attacks causing low blood flow.
 Liver failure causing changes in hormones that affect blood
flow and pressure to the kidney.

10. MECHANISMIS OF PRE RENAL
ARF

11. Post renal
 Problems affecting the movement of urine out
of the kidneys.
a) Kidney stone: usually only on one side.
b) Cancer of the urinary tract organs or structures
near the urinary tract that may obstruct the
outflow of urine.
c) Medications.

12. d) Bladder stone.
e) Benign prostate hyperplasia (the most
common cause in men).
f) Blood clot.
g)Bladder cancer.
Must be bilateral to result in ARF
– Unless : single kidney or prior chronic renal failure

13.  Suspect obstruction in anuria
 Etiology may be age dependent
– Young = congenital abnormality
– Older male = prostatic enlargement
 ARF most often associated with lesions in:
– Bladder, prostate or urethra

15. Intrinsic (renal) ARF
 Renal Problems with the kidney itself
that prevent proper filtration of blood
or production of urine, those include:
1. Tubular (ATN)
2. Interstitial (AIN)
3. Glomerular (Glomerulonephritis)
4. Vascular

16. Renal damage

17.  Vascular disease
– Vasculitis (SLE, polyarteritis etc.)
– Scleroderma
– Thromboembolic disease
– Malignant hypertension

18.  Glomerular disease
– Acute glomerulonephritis
Post infectious GN
Crescentic GN
– ANCA positive diseases
Goodpasture’s dis.
– Anti- glomerular basement antibody

19. ACUTE INTERSTITIAL NEPHRITIS
DRUG INDUCED
 Penicillins
 Sulfonamides
 Cephalosporin
 Rifampin ( 2nd time)
 Quinolones
 NSAID (fenoprofen)
 Allopurinol
 Phenytoin
 Thiazides
 Furosemide
 Cimetidine

20.  Fever
 Rash
 Eosinophilia
 Pyuria
 Eosinophiluria
 WBC Casts
Acute Interstitial Nephritis
Clinical picture

21.  Acute tubular necrosis
– Ischemic injury
– Toxic injury
 Endogenous toxins
– Hemoglobinuria
– Myoblobinuria (rhabdomyolysis)
– Endotoxemia

22.  Acute tubular necrosis
– Exogenous toxins
 Aminoglycosides
 Radiographic contrast
 Heavy metal compounds
 Ethylene glycol
 Methanol
 Carbon tetrachloride
 Cisplatin

23. ACUTE TUBULAR NECROSIS

24. Contrast-Induced ARF
Prevalence
Less than 1% in patients with normal renal
function
 Increases significantly with renal insufficiency

25. Risk Factors of contrast-induced ARF
 Renal insufficiency
 Diabetes mellitus
 Multiple myeloma
 High osmolar (ionic) contrast media
 Contrast medium volume

26. Clinical Characteristics
 Onset - 24 to 48 hrs. after exposure
 Duration - 5 to 7 days
 Non-oliguric (majority)
 Dialysis - rarely needed
 Urinary sediment - variable
 Low fractional excretion of Na

27. Prophylactic Strategies
 Use I.V. contrast only when necessary
 Hydration
 Minimize contrast volume
 Low-osmolar (nonionic) contrast media
 N-acetylcysteine, fenoldopam

28. RISK FACTORS
 Advanced age
 Blockages in the blood vessels in your arms or
legs
 Diabetes
 High blood pressure
 Heart failure
 Kidney diseases
 Liver disease

29. Common clinical features of ARF
 Azotemia “Is a medical condition characterized by abnormally high levels of
nitrogen-containing compounds (such as urea, creatinine, various body waste compounds,
and other nitrogen-rich compounds) in the blood.”
 Hypervolemia
 Electrolytes abnormalities:
 Increase K+ & phosphate
 Na+ & calcium
 Metabolic acidosis
 Hypertension
 Oliguria - anuria

30.  Weight loss.
 Nocturnal urination.
 pale urine.
 Less frequent urination, or in smaller amounts than usual, with
dark coloured urine
 Bone damage.
 Non-union in broken bones.
 Muscle cramps (caused by low levels of calcium which can cause
hypocalcaemia).:
 Abnormal heart rhythms.
 Muscle paralysis.

31. PHASES OF ARF
 Initiating phase
 Oliguric phase
 Diuretic phase
 Recovery phase

35. DIAGNOSTIC APPROACH TO ARF
 HISTORY
 PHYSICAL EXAMINATION
 ASSMENT OF URINE VOLUME
 URINE ANALYSIS
 BLOOD CHEMISTRY
 BLOOD AND URINE INDICES
 RADIOLOGIC STUDIES
 Biopsy

37. Urine Volume
 Anuria (< 100 ml/24h)
 – Acute bilateral arterial or venous occlusion
 – Bilateral cortical necrosis
 – Acute necrotizing glomerulonephritis
 – Obstruction (complete)
 – ATN (very rare)
 Oliguria (100-500 ml/24h)
 – Pre-renal azotemia
 – ATN
 Non-Oliguria (> 500 ml/24h)
 – ATN
 – Obstruction (partial)

38. Distinguishing tubulo-interstitial disease
from Pre-Renal ARF
 Most difficult classification of ARF
  Urine sediment helpful
(i) Bland
 Pre-renal azotemia
 Urinary outlet obstruction
(ii) RBC casts or dysmorphic RBCs
 Acute glomerulonephritis
 Small vessel vasculitis
(iii) WBC Cells and WBC Casts
 Acute interstitial nephritis
 Acute pyelonephritis
(iv) RTE cells, RTE cell casts, pigmented granular (“muddy brown”)
casts
 Acute tubular necrosis

39.  Urine chemistries is helpful
1) ATN = tubular necrosis; tubular function is
impaired, thus high urine Na
 (Reabsorption of water and sodium impaired in tubulo-
interstitial disease and ATN)
2) Pre-renal = intact tubular function, thus urine Na is
low
 (Reabsorption of water and sodium intact in pre-renal
failure).

40. Red Blood Cell Cast
 Two examples of red
blood cell casts, typical
of glomerular
bleeding.

41. Red Blood Cells
 Monomorphic
(nondysmorphic)RBC
suggest non-glomerular
source of bleeding – i.e.,
bleeding from the
calyces, pelvis, ureter(s),
bladder, prostate or
urethra.
 Dysmorphic red blood
cells suggest glomerular
injury.
Dysmorphic

42. Prevention of ARF
 Recognize patients at risk (postoperative
states, cardiac surgery, septic shock)
 Prevent progression from prerenal to renal
 Preserve renal perfusion
– isovolemia, cardiac output, normal blood pressure
 Avoid nephrotoxins (aminoglycosides,
NSAIDS, amphotericin)

43. Treatment of ARF
 Based on type/etiology of AKI (acute kidney injury) i.e.,
pre-renal, post-renal, or intrinsic renal initially
 – Pre-renal – volume, improve renal perfusion
 – Post-renal – relieve obstruction
 – Intrinsic – glomerular, tubular, interstitial, vascular
 Depends on type
 Follow clinically; attention to volume status, avoid
additional insults; treat complications of ARF

44. GENERAL PROTOCOL FOR
MANAGEMENT
 Treat the underlying disease
 Strictly monitor intake and output (weight,
urine output, insensible losses, IVF)
 Monitor serum electrolytes
 Adjust medication dosages according to GFR
 Avoid highly nephrotoxic drugs
 Attempt to convert oliguric to non-oliguric renal
failure (furosemide x 3)

45. Fluid therapy
 If patient is fluid overloaded
 • fluid restriction (insensible losses)
 • attempt furosemide 1-2 mg/kg
 • Renal replacement therapy
 If patient is dehydrated:
 • restore intravascular volume first
 • then treat as euvolemic (below)
 If patient is euvolemic:
 • restrict to insensible losses (30-35 ml/100kcal/24 hours) +
other losses (urine, chest tubes, etc)

46. Sodium
 most patients have dilutional hyponatremia
which should be treated with fluid restriction
 severe hyponatremia (Na< 125 mEq/L) or
hypernatremia (Na> 150 mEq/L): dialysis or
hemofiltration

47. Potassium
 Oliguric renal failure is often complicated by hyperkalemia,
increasing the risk in cardiac arrhythmias
 Treatment of hyperkalemia:
– sodium bicarbonate (1-2 mEq/kg)
– insulin + hypertonic dextrose: 1 unit of insulin/4 g glucose
– sodium polystyrene (Kayexalate): 1 gm/kg . Can be repeated
qh.
 (Hypernatremia and hypertension are potential
complications)
 – dialysis

48. Nutrition
 Provide adequate caloric intake
• limit protein intake to control increases in BUN
• minimize potassium and phosphorus intake
“Foods and fluid containing potassium or phosphorous (banana,
coffee) are restricted.”
• limit fluid intake
 If adequate caloric intake can not be
achieved due to fluid limitations, some form
of dialysis should be considered

49. Treatment of ARF

50. Hyperkalemia
 A plasma K+
concentration > 6 mmol/l.
 Must be treated immediately, to prevent the
development of life-threatening cardiac arrhythmias.
 Never occurs in the absence of renal excretory
problem
 Pseudohyperkalemia
– Leukocytosis
– Thrombocytosis
– Prolonged Application of Tourniquet

51. Hyperkalemia
 Significance of urine output
 Role of increased catabolism or tissue
breakdown
 Factors affecting shift of Potassium out of cells
 Etiololgy of the renal failure

52. Treatment of Hyperkalemia
 Urgency
 Role of the EKG in making the decision
 Clinical setting in which it occurs
– Acute renal failure
– Chronic renal failure

54. Table 5-3. Treatment of hyperkalemia
Medication Mechanism of action Dosage Peak effect
Calcium Antagonism of 10-30 ml of 10% solution IV -5 min
gluconate membrane over 2 min
Insulin and Increased K+
entry Insulin, 10 U IV bolus 30-60 min
Glucose into the cells followed by 0.5 mU/kg of
body weight per minute in
50 ml of 20% glucose
Sodium Increased K+
entry 44-50 mEq IV over 5 min; 30-60 min
bicarbonate into the cells can be repeated within 30
min
Albuterol Increased K+
entry
into the cells 20 mg in the nebulized form 30-60 min
Kayexalate Removal of the 20 g of resin with 100 ml of 2-4 hr
excess K+
20% sorbitol; can be
repeated every 4-6 hr
Hemodialysis Removal of the Dialysis bath K+
concentration 30-60 min
excess K+
variable

55. Indications for Dialysis
 A – acidosis
 E – electrolyte disturb., usually hyperkalemia
 I – intoxications (lithium, ethylene glycol, etc)
 O – overload (volume overload)
 U – uremia (symptoms, signs)

56. COMPLICATIONS
 ARF can affect the entire body
 Infection
 Hyperkalaemia, Hyperphosphataemia,
hyponatraemia
 water overload
 Pericarditis
 Pulmonary oedema.
 Reduced level of consciousness.
 Immune deficiency.

57. ARF -- Summary
 Dx AKI by falling GFR [rising BUN and
creatinine]
 Classify into pre-renal, renal, or postrenal by
history, PE, BUN:creat ratio, urine analysis
 Sometimes also need urine chemistries [urine
Na, FxExNa and/or FxExurea] to distinguish
pre-renal from ATN.

58. ARF – Summary (cont…)
 Sometimes need renal ultrasound to verify
obstruction [post-renal ARF]
 Rarely need other studies, esp to dx type of
intrinsic ARF [e.g., kidney biopsy: GN vs
interstitial nephritis vs ATN].

59. ARF – Summary (cont…)
 Distinguishing the types of intrinsic ARF
usually depends on history, PE, urine analysis
 – Vascular – large or small vessels
 – Tubular = ATN
 – Interstitial = AIN
 – Glomerular = acute GN