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Leslie T. Cooper, Jr., MDLeslie T. Cooper, Jr., MD
Chair, Cardiovascular DepartmentChair, Cardiovascular Department
Mayo Clinic in FloridaMayo Clinic in Florida
Myocarditis in the
Emergency Department
May 23rd, 2015
DISCLOSURE
Relevant Financial
Relationship(s)
None
Off Label Usage
None
32 year old man presents to your
ED with recent onset
chest pressure and dyspnea
•• He reports a flu-like illness 1 week priorHe reports a flu-like illness 1 week prior
•• Exam: HR 108 regular. BP 105/70.Exam: HR 108 regular. BP 105/70.
•• + Pericardial rub, + basilar rales+ Pericardial rub, + basilar rales
•• JVP 9 cm. No peripheral edema.JVP 9 cm. No peripheral edema.
•• Troponin T 12Troponin T 12
First Electrocardiogram
CP1291921-1
II
IIII
IIIIII
aVRaVR
aVLaVL
aVFaVF
V1V1
V2V2
V3V3
V4V4
V5V5
V6V6
Which of the following is least likely
to improve his left ventricular
function over the next 6 months?
•• LisinoprilLisinopril
•• CarvedilolCarvedilol
•• Prednisone and AzathioprinePrednisone and Azathioprine
And…..
avoid competitive sports for at least 3-6 months
Immunosuppression for Chronic iDCM
Inflammatory, Infiltrative, Infectious
Cardiomyopthies
•• MyocarditisMyocarditis
Post-viral/idiopathic, giant cell,Post-viral/idiopathic, giant cell,
rheumatologic or hypersensitivity-rheumatologic or hypersensitivity-
relatedrelated
•• Sarcoidosis-Sarcoidosis- 50%50% isolated to the heartisolated to the heart
•• HIV, Chagas’ and Lyme DiseasesHIV, Chagas’ and Lyme Diseases
•• AmyloidosisAmyloidosis
Cumulative Incidence Rates of Death, Heart
Transplantation and Left Ventricular Recovery
in Children with Myocarditis
Time to occurrence of event (years)
Eventprobability
No event
Echocardiographic normalization
Death
Transplant
Foerster et al: Circ Heart Fail, 2010
28 yo woman with same symptoms
And the following EKG
CP1304423-1
According to current ESC
and AHA scientific statements,
which of the following is a Class I
indication for EMB in acute DCM?
•• Failure to improve with GDMT after 2Failure to improve with GDMT after 2
weeksweeks
•• Sustained or symptomatic VTSustained or symptomatic VT
•• Mobitz type 2 or higher heart blockMobitz type 2 or higher heart block
•• All of the aboveAll of the above
Giant Cell Myocarditis
21%
Cardiac Sarcoidosis
18 yo man with pericardidic chest pain,
Troponin 10, normal LVEF and MRI:
According to a recent randomzed clinical
trial which of the following are useful to
control his chest pain?
•• Colchicine, dosed by weightColchicine, dosed by weight
•• Prednisone 20 mg/dayPrednisone 20 mg/day
•• HydrocodoneHydrocodone
•• None of the aboveNone of the above
Imazio, M. et al. Circ 2013
No Deaths
Will and Charlie
Mayo
Questions?
Cooper.leslie@mayo.edu
NewNew onset heart failure ofonset heart failure of 22
weeks to 3 monthsweeks to 3 months durationduration
associated with a dilated leftassociated with a dilated left
ventricle…andventricle…and
Class I, LOE B
Cooper, LT, et al Circulation 2007
•Ventricular arrhythmias, or
•High degree heart block, or
•Failure to respond to usual care within
1 to 2 weeks
Giant Cell versus Lymphocytic Myocarditis
Transplant-Free Survival
CP977755-6
Survival (yr)Survival (yr)
ProportionsurvivingProportionsurviving
LM groupLM group
GCM groupGCM group
Cooper, LT, NEJM 1997
25% of 72 patients 18-
55 with initially
unexplained AV block
had GCM or cardiac
sarcoidosis on
endomyocardial
biopsy
Circ. Arrhy and EP 2011:4(3). 303 -9
21% changed
management
Bennett, et al. Circ Heart Fail 2013
Immunohistology Predicts Outcome in
Patients with Acute Myocarditis
Freedomfromcardiac
deathandHTx
Months after biopsy
Kindermann et al: Circ 118:639, 2008 CP1324648-2
Positive
Negative
P<0.001
Immunohistology
Results
Histopathological Results
According to DALLAS Criteria
1.0
0.8
0.6
0.4
0.2
0.0
Months after biopsy
DALLAS negative
DALLAS positive
P=0.192
TIMIC Study
•• RCT- Biopsy guided therapy in chronicRCT- Biopsy guided therapy in chronic
DCM, n=DCM, n=8585; Screened; Screened 512512
•• AZA and prednisone-mean LVEFAZA and prednisone-mean LVEF
increased fromincreased from 26% to 46%26% to 46% at 6 monthsat 6 months
•• Immunosuppression may improve LVEFImmunosuppression may improve LVEF
in select patients with non-viral,in select patients with non-viral,
inflammatory DCM thatinflammatory DCM that fails to respondfails to respond
to usual careto usual care
Frustaci, A, et al. Eur Heart J 2009
Anti-CD3
Anti-CD68HLA-class II antigen
H and E
Select Histological Definitions of Myocarditis
From Staudt et al: Circ 2001

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Acute Heart Failure Myocarditis.

  • 1. Leslie T. Cooper, Jr., MDLeslie T. Cooper, Jr., MD Chair, Cardiovascular DepartmentChair, Cardiovascular Department Mayo Clinic in FloridaMayo Clinic in Florida Myocarditis in the Emergency Department May 23rd, 2015
  • 3. 32 year old man presents to your ED with recent onset chest pressure and dyspnea •• He reports a flu-like illness 1 week priorHe reports a flu-like illness 1 week prior •• Exam: HR 108 regular. BP 105/70.Exam: HR 108 regular. BP 105/70. •• + Pericardial rub, + basilar rales+ Pericardial rub, + basilar rales •• JVP 9 cm. No peripheral edema.JVP 9 cm. No peripheral edema. •• Troponin T 12Troponin T 12
  • 5.
  • 6. Which of the following is least likely to improve his left ventricular function over the next 6 months? •• LisinoprilLisinopril •• CarvedilolCarvedilol •• Prednisone and AzathioprinePrednisone and Azathioprine
  • 7. And….. avoid competitive sports for at least 3-6 months
  • 9. Inflammatory, Infiltrative, Infectious Cardiomyopthies •• MyocarditisMyocarditis Post-viral/idiopathic, giant cell,Post-viral/idiopathic, giant cell, rheumatologic or hypersensitivity-rheumatologic or hypersensitivity- relatedrelated •• Sarcoidosis-Sarcoidosis- 50%50% isolated to the heartisolated to the heart •• HIV, Chagas’ and Lyme DiseasesHIV, Chagas’ and Lyme Diseases •• AmyloidosisAmyloidosis
  • 10. Cumulative Incidence Rates of Death, Heart Transplantation and Left Ventricular Recovery in Children with Myocarditis Time to occurrence of event (years) Eventprobability No event Echocardiographic normalization Death Transplant Foerster et al: Circ Heart Fail, 2010
  • 11. 28 yo woman with same symptoms And the following EKG
  • 13. According to current ESC and AHA scientific statements, which of the following is a Class I indication for EMB in acute DCM? •• Failure to improve with GDMT after 2Failure to improve with GDMT after 2 weeksweeks •• Sustained or symptomatic VTSustained or symptomatic VT •• Mobitz type 2 or higher heart blockMobitz type 2 or higher heart block •• All of the aboveAll of the above
  • 15.
  • 16.
  • 17. 21%
  • 19. 18 yo man with pericardidic chest pain, Troponin 10, normal LVEF and MRI:
  • 20. According to a recent randomzed clinical trial which of the following are useful to control his chest pain? •• Colchicine, dosed by weightColchicine, dosed by weight •• Prednisone 20 mg/dayPrednisone 20 mg/day •• HydrocodoneHydrocodone •• None of the aboveNone of the above
  • 21. Imazio, M. et al. Circ 2013 No Deaths
  • 23. NewNew onset heart failure ofonset heart failure of 22 weeks to 3 monthsweeks to 3 months durationduration associated with a dilated leftassociated with a dilated left ventricle…andventricle…and Class I, LOE B Cooper, LT, et al Circulation 2007 •Ventricular arrhythmias, or •High degree heart block, or •Failure to respond to usual care within 1 to 2 weeks
  • 24. Giant Cell versus Lymphocytic Myocarditis Transplant-Free Survival CP977755-6 Survival (yr)Survival (yr) ProportionsurvivingProportionsurviving LM groupLM group GCM groupGCM group Cooper, LT, NEJM 1997
  • 25. 25% of 72 patients 18- 55 with initially unexplained AV block had GCM or cardiac sarcoidosis on endomyocardial biopsy Circ. Arrhy and EP 2011:4(3). 303 -9
  • 26. 21% changed management Bennett, et al. Circ Heart Fail 2013
  • 27. Immunohistology Predicts Outcome in Patients with Acute Myocarditis Freedomfromcardiac deathandHTx Months after biopsy Kindermann et al: Circ 118:639, 2008 CP1324648-2 Positive Negative P<0.001 Immunohistology Results Histopathological Results According to DALLAS Criteria 1.0 0.8 0.6 0.4 0.2 0.0 Months after biopsy DALLAS negative DALLAS positive P=0.192
  • 28. TIMIC Study •• RCT- Biopsy guided therapy in chronicRCT- Biopsy guided therapy in chronic DCM, n=DCM, n=8585; Screened; Screened 512512 •• AZA and prednisone-mean LVEFAZA and prednisone-mean LVEF increased fromincreased from 26% to 46%26% to 46% at 6 monthsat 6 months •• Immunosuppression may improve LVEFImmunosuppression may improve LVEF in select patients with non-viral,in select patients with non-viral, inflammatory DCM thatinflammatory DCM that fails to respondfails to respond to usual careto usual care Frustaci, A, et al. Eur Heart J 2009
  • 29. Anti-CD3 Anti-CD68HLA-class II antigen H and E Select Histological Definitions of Myocarditis From Staudt et al: Circ 2001