The goal of this webinar is to help healthcare professionals address the specific challenges of end-of-life care when determining a terminal prognosis, so they can provide the optimum care for the patient and family during the final stages of life.
Three hour slide deck for basics of palliative care including what is palliative care, symptom management (pain, dyspnea, nausea, constipation), goals-of-care, family meetings, comfort care, and issues around artificial nutrition.
Out-patient Primary and Specialty Palliative CareMike Aref
Presentation on primary and specialty palliative care, covering what is palliative care, basics of primary palliative care including pain and symptom management, and referral criteria for out-patient specialty palliative care.
This webinar provides expert guidance and clear answers to common myths about hospice care. Learn about the history and philosophy of hospice care, common hospice prognoses, who pays for hospice, and the difference between hospice and palliative care. Explore the four levels of care and the role of the interdisciplinary hospice team to provide medical, psychosocial and spiritual solutions that support quality of life at the end of life for patients and families. Learn how advance directives can ensure patients are referred to hospice care early in the disease process to enjoy its full benefits.
Our goal is to cover the wide areas of overlap and similarities between the two disciplines, and to also make the differences between the two clearer for you.
Dr. Elizabeth Paulk gives an excellent review of palliative care topics including end of life discussions, hospice, pain management, and family counseling.
•Don’t make firm predictions
•Do what predictions you do for yourself
•Don’t communicate unless asked
•Don’t be specific
•Don’t be extreme
•Be compassionate and optimistic
Three hour slide deck for basics of palliative care including what is palliative care, symptom management (pain, dyspnea, nausea, constipation), goals-of-care, family meetings, comfort care, and issues around artificial nutrition.
Out-patient Primary and Specialty Palliative CareMike Aref
Presentation on primary and specialty palliative care, covering what is palliative care, basics of primary palliative care including pain and symptom management, and referral criteria for out-patient specialty palliative care.
This webinar provides expert guidance and clear answers to common myths about hospice care. Learn about the history and philosophy of hospice care, common hospice prognoses, who pays for hospice, and the difference between hospice and palliative care. Explore the four levels of care and the role of the interdisciplinary hospice team to provide medical, psychosocial and spiritual solutions that support quality of life at the end of life for patients and families. Learn how advance directives can ensure patients are referred to hospice care early in the disease process to enjoy its full benefits.
Our goal is to cover the wide areas of overlap and similarities between the two disciplines, and to also make the differences between the two clearer for you.
Dr. Elizabeth Paulk gives an excellent review of palliative care topics including end of life discussions, hospice, pain management, and family counseling.
•Don’t make firm predictions
•Do what predictions you do for yourself
•Don’t communicate unless asked
•Don’t be specific
•Don’t be extreme
•Be compassionate and optimistic
Ethics at the End of Life and Introduction to Hospice and Palliative Care for Medical Students. Exploration of feeding tubes, code status, when to stop chemo. Discusses cases and the ethical principles and values that are the basis for disagreement in care and what to do when there is a conflict in ethical principles themselves. Also provides an introduction to decisions of last resort including physician aid in dying, palliative sedation and voluntary refusal of nutrition and hydration.
Basics of palliative care including symptom management: pain, dyspnea, nausea and constipation; family meetings, goals-of-care, end-of-life care, and artificial nutrition.
Palliative care is an approach to care which improves the quality of life of patients and their families facing the problem associated with life-threatening illness.
Palliative care is about providing well-being and the highest quality of life to patients with serious, progressive, chronic life-limiting illness, including during the dying process.
Through palliative care, we change the role of a patient into a whole human being.
Through palliative care, we transform the stages leading to death into times filled with life
Discover the concept of cumulative impact PTSD, how prevention is vital to helping first responders deal with the stresses they experience on a daily basis and how to identify early warning signs of burnout and ptsd
Determining Prognosis in Cancer and Non-cancer DiagnosisVITAS Healthcare
This helps physicians, nurses, case managers and social workers understand the trajectories of dying from cancer and non-cancer diagnoses, including heart, lung, kidney and liver disease, stroke, HIV/AIDS, dementia and neurodegenerative diseases. Aided by a better grasp of the decline-related domains involved in poor prognosis, disease progression and disease end stages, attendees will be better positioned to identify patients and residents who are appropriate for hospice care.
Ethics at the End of Life and Introduction to Hospice and Palliative Care for Medical Students. Exploration of feeding tubes, code status, when to stop chemo. Discusses cases and the ethical principles and values that are the basis for disagreement in care and what to do when there is a conflict in ethical principles themselves. Also provides an introduction to decisions of last resort including physician aid in dying, palliative sedation and voluntary refusal of nutrition and hydration.
Basics of palliative care including symptom management: pain, dyspnea, nausea and constipation; family meetings, goals-of-care, end-of-life care, and artificial nutrition.
Palliative care is an approach to care which improves the quality of life of patients and their families facing the problem associated with life-threatening illness.
Palliative care is about providing well-being and the highest quality of life to patients with serious, progressive, chronic life-limiting illness, including during the dying process.
Through palliative care, we change the role of a patient into a whole human being.
Through palliative care, we transform the stages leading to death into times filled with life
Discover the concept of cumulative impact PTSD, how prevention is vital to helping first responders deal with the stresses they experience on a daily basis and how to identify early warning signs of burnout and ptsd
Determining Prognosis in Cancer and Non-cancer DiagnosisVITAS Healthcare
This helps physicians, nurses, case managers and social workers understand the trajectories of dying from cancer and non-cancer diagnoses, including heart, lung, kidney and liver disease, stroke, HIV/AIDS, dementia and neurodegenerative diseases. Aided by a better grasp of the decline-related domains involved in poor prognosis, disease progression and disease end stages, attendees will be better positioned to identify patients and residents who are appropriate for hospice care.
Webinar Series on COVID-19 vaccine: Jointly organized by Malaysian Society of Infection Control and Infectious Diseases (MyICID) & Institute for Clinical Research (ICR), NIH
Speaker: Dr. Richard Lim Boon Leong is a Consultant Palliative Medicine Physician and Head of Palliative Care Unit, Selayang Hospital, Ministry of Health Malaysia.
Hospice care and palliative care: Is there a difference between the two, and if so, what?
Many people still think that palliative care means hospice care. But today, hospice is only a small part of palliative care.
The goal of palliative care is to prevent or treat the symptoms and side effects of a disease; and it should be part of the picture from the first day a serious illness is diagnosed.
Dr. Jim Meadows, Director of Hospice and Palliative Care at Tennessee Oncology, will discuss this important topic. How does a family and a health care team best work together to guide a patient through a terminal illness? How does everyone continue to support quality, patient-centered, end-of-life care?
I didn't know this option of Palliative care existed prior to my mother's passing earlier this year of colorectal cancer. However, I do now know about it and want to share it with all of you
Palliative care beyond cancer. Julia Addington-Hall. I Technical Conference about the Strategy in Palliative Care in The Nacional Health System of Spain. (Madrid, Ministry of Health and Consumer Affairs, 2008)
Goals of care should be patient-centered objectives that can be achieved by medical treatment. Too often in our healthcare system goals of care result in two extremes: (1) patients are led to believe that the goals of care only incorporates their hopes, regardless of the clinical situation, with this being the only possible clinical outcome, or (2) that goals of care are synonyms for a conversation about changing code status to “do not attempt resuscitation” and/or referral to hospice. In reality, goals of care should include both what the patient, their family, and providers hope for while simultaneously planning for the worst. Goals of care most encompass and evolve with the patient’s disease and not simply brought into and only focus on end of life.
This is the updated slideshow for the 2011 NFMBR presentation of Geriatrics. We apologize sincerely for the error in the manual, you can both view the slideshow online or download it to your computer and view with PowerPoint.
The goal of this webinar was to help hospice and healthcare professionals understand the ethics and application of artificial nutrition and hydration (ANH) for patients near the end of life.
When Decision-Making Is Imperative: Advance Care Planning for Busy Practice S...VITAS Healthcare
Complex, chronically ill patients present an opportunity to discuss and implement hospice and palliative care. Many elderly patients who present to the ED and other busy practice settings are hospice-eligible because of functional decline and multi-morbidity. Key tools can quickly facilitate goals-of-care (GOC) conversations, advance care planning, and hospice referrals amid time constraints and high-acuity challenges.
Assessment and Management of Disruptive Behaviors in Persons With DementiaVITAS Healthcare
This webinar helps physicians conduct a systematic evaluation for behavioral changes
in persons with dementia. It offers approaches for developing a comprehensive care plan for
disruptive behaviors. These methods incorporate caregiver education and non-pharmacologic
interventions followed by pharmacologic management.
Pain Management in the Context of an Opioid Epidemic: Considerations and Tool...VITAS Healthcare
This presentation details how to conduct a comprehensive pain assessment, considerations when prescribing analgesics, and when opioids may be appropriate.
Understanding Pain Management and Daily Practice ManagementVITAS Healthcare
Supported by evidence-based data, this webinar helped physicians and healthcare professionals gain greater understanding of the multifaceted applications of pain management in the context of palliative hospice care.
The goal of this webinar was to educate healthcare professionals about advance directives and advance care planning,
including the types and purposes of legal documents that govern patients’ decisions and
preferences.
The goal of this webinar was to help healthcare professionals improve care coordination for patients with advanced illness and to reduce hospital readmissions and length of stay (LOS).
The goal of this webinar was to educate physicians and healthcare professionals about hospice eligibility and the benefits of hospice for patients with advanced cardiac disease (ACD).
The goal of this webinar was to educate healthcare professionals about the differences between palliative and curative care while exploring the history and philosophy of the hospice movement.
The goal of this webinar was to equip healthcare professionals with an understanding of military veterans’ unique medical, emotional, and spiritual needs as they near the end of life.
The goal of this webinar was to equip healthcare professionals with an understanding of military veterans’ unique medical, emotional, and spiritual needs as they near the end of life.
Advanced Lung Disease: Prognostication and Role of HospiceVITAS Healthcare
The goal of this webinar was to educate physicians and healthcare professionals about the medical management of advanced lung disease (ALD), the value of advance care planning (ACP) and the benefits of hospice for end-of-life patients.
The clinical case study of a patient with advanced COPD who has multiple comorbid conditions and develops sepsis provideD the backdrop for two potential clinical pathways—sepsis and post-sepsis syndrome.
Understanding Pain Management and Daily Practice ManagementVITAS Healthcare
Supported by evidence-based data, this webinar helped physicians and healthcare professionals gain greater understanding of the multifaceted applications of pain management in the context of palliative hospice care.
The goal of this webinar was to help hospice and healthcare professionals understand the ethics and application of artificial nutrition and hydration (ANH) for patients near the end of life.
Key tools can quickly facilitate goals-of-care (GOC) conversations, advance care planning, and hospice referrals amid the ED’s time constraints and high-acuity challenges.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. Goal
To educate healthcare professionals about the
challenges of end-of-life care specifically when
determining a terminal prognosis, so that they
can assist, support and provide the optimum
care for the patient and family during the
final stages of life
3. Objectives
• Understand the challenges for patients, families and
healthcare providers in accessing hospice care
• Understand the Theoretical Trajectories of Dying
• Describe the General Guidelines for Clinical
Progression of Disease
• Describe the basic criteria for determining prognosis in
patients with various cancers
• Detail the clinical criteria for a number of end stage
(ES) non-cancer diseases
4. Reflections about Prognosis
• Cornerstone to clinical decision-making
– Elicit goals through shared decision-making
– Plan of care
• Multiple domains
– Remaining life expectancy
– Functional status, social status
• Inherent uncertainty
• Physicians are bad at it
– No clinical training
– In general overestimate everything
– Takes time and no reimbursement
Glare et al. Journal of Palliative Medicine 2008;11(1): 84-103
5. Science of Prognosis
• “Accurate” estimates of prognosis for a
population with a specific disease
• Increased “noise” as we attempt to estimate
the prognosis for an individual
• Further challenges with comorbidity
Stockler et al. Br. J Cancer, 2006;94(2):208-212
6. Medicare Hospice Benefit
Terminal Illness: “A medical prognosis (of a)
life expectancy of six months or less as
determined by two physicians, if the illness
runs its normal course”
7. Medicare Hospice Benefit
Benefits Protection and Improvement Act
(BIPA) 2000
Certification of terminal illness of an individual
who elects hospice “shall be based on the
physician’s or medical director’s clinical
judgment regarding the normal course of the
individual’s illness”
8. Lifetime Odds
Heart Disease 1:5
Stroke 1:23
Breast Cancer 1:8
Prostate Cancer 1:6
Lung Cancer Male/Female 1:13/1:16
Dementia 1:3
Death 1:1
9. Predicted versus
observed survival in
468 terminally ill
hospice patients.
Diagonal line
represents perfect
prediction. Patients
above diagonal are
those in whom
survival was
overestimated;
patients below line
are those in whom
survival was
underestimated.
Christakis NA, Lamont EB: Extent and determination of error in physicians’ prognoses
in terminally ill patients: Prospective cohort study. British Med J 320:269, 2000.
Predicting Prognosis
10. Copyright restrictions may apply.
Lunney J, Lynn J, Foley DJ, et al. Patterns of Functional
Decline at the End of Life. JAMA 289:2387-2392, 2003.
Theoretical Trajectories of Dying
11. General Domains to Consider
• Clinical judgment
• Nutrition
• Physical function
• Cognition
• Health care utilization
• Symptoms
• Disease-specific decline
13. Nutritional Status
Unintentional weight loss
• > 10% of normal body weight
• Declining Body Mass Index (BMI)
– < 22 kg/m2
• Anthropomorphic measures
– Triceps skin fold thickness
– Mid-arm muscle area (MMA)
• Low serum albumin levels
– Limited utility
Wright JB, Kinzbrunner BM: Predicting Prognosis: How to decide when end-
of life care is needed. Chapter 1 in Kinzbrunner BM, Policzer JS (eds): End-
of-Life Care: A Practical Guide. New York: McGraw Hill, 2011, p. 3.
14. Weight Loss and Prognosis
Long-Term Care
•153 residents, 24 lost 5%
weight in one month
•5.1 times more likely to
die in one year
Outpatient
•Prospective evaluation
of 91 patients with
weight loss
•35% no identifiable
cause
•25% died over the
ensuing year
(Cass, 1995) (Morton, et al, 1981)
15. Physical Function
• Palliative Performance Scale (PPS)
– scale of 0% (dead) to 100% (normal)
– PPS score of 50 indicates significant disease
• Activity of daily living (3/6 dependency)
– Bathing
– Dressing
– Continence
– Transferring
– Ambulation
– Feeding
• Falls
16. Palliative Performance
Scale (PPS)
PPS rating Ambulation Self-Care Intake LOC Activity Evidence of
disease
100 Full Full Normal Full Normal No evidence of
disease
90 Full Full Normal Full Normal Some evidence
of disease
80 Full Full Normal or
reduced
Full Normal with
effort
Some evidence
of disease
70 Reduced Full Normal or
reduced
Full Unable to do
normal work
Some evidence
of disease
60 Reduced Occasional
Assistance
Normal or
reduced
Full or
confusion
Unable to do
hobby or
housework
Significant
disease
50 Mainly Sit/Lie Considerable
Assistance
Normal or
reduced
Full or
confusion
Unable to do
any work
Extensive
disease
40 Mainly in Bed Complete
Assistance
Normal or
reduced
Full, drowsy,
or confusion
Unable to do
any work
Extensive
disease
30 Bed Confined Total Care Reduced Full, drowsy,
or confusion
Unable to do
any work
Extensive
disease
20 Bed Confined TotalCare Minimal sips Full, drowsy,
or confusion
Unable to do
any work
Extensive
disease
10 Bed Confined Total Care Mouth care
only
Drowsy or
coma
Unable to do
any work
Extensive
disease
0 Death
Anderson F, Downing GM, Hill J, et al: Palliative Performance
Scale (PPS): A new tool. J Palliative Care 12 (1):5, 1996.
17. Survival by PPS at Acute
Care Hospital
(Olajide, et al, 2007)
18. Activity of Daily Living
Difficulty and Death
(Steinman, et al, 2012)
ADL
Difficulty
Proportion
Population
Median
Survival
None 72.1% 10.6 yrs
Mild 16.1% 6.5 yrs
Moderate 7.0% 5.1 yrs
Severe 4.3% 3.8 yrs
Complete 0.5% 1.6 yrs
19. 25% of those who fell died within one year
Falls and One-Year Mortality
(Wild, et al, 1981)
20. Cognitive Decline
• Orientation to person, place and time
• State of consciousness/awake or asleep
in 24 hours
• Ability to communicate and follow
commands
• Recognize environment
21. Utilization of Health Care
• Clinic visits
– Primary care
– Subspecialty
• Emergency department
• Hospitalization
25. Cancer and Prognosis
• MDs are very good at predicting cure at five years
– Correlation 0.92
• MD’s optimistic bias in regard to estimating patient
prognosis for incurable disease
– In general, over-optimistic by a factor of three
• Physician predicted six weeks; patient lived
two weeks
– Survival predictions become more accurate
closer to date of death
– Overall clinical prediction significantly correlated
with actual survival
Christakis et al. BMJ 2000;320:467-473
Mackillop et al. J Clin Epidemiol 1997;50:21-29
26. Cancer Hospice
Appropriateness
• Performance status is key determinant
– Activity and energy
– Lose about 70% in last three months of life
• How much time do you spend sitting in a chair or
lying down?
– >50% then prognosis less than three months
• Patients with solid tumor and not receiving
chemotherapy prognosis less than six months
27. Cancer Prognosis:
Helpful Numbers
Cancer Syndrome Estimated Survival
Malignant Hypercalcemia 8 weeks (except newly diagnosed
breast or MM)
Malignant Pericardial Effusion 8 weeks
Carcinomatous Meningitis 8-12 weeks
Multiple brain mets 1-2 months no XRT, 3-6 months with
XRT
Malignant Ascites Less than 6 months
Malignant pleural effusion Less than 6 months
Malignant bowel obstruction Less than 6 months
Fast Fact 13
29. End-stage Cardiac Disease
• Dyspnea and/or fatigue at rest or with minimal exertion
(NYHA Class IV)
– Ejection Fraction not a predictor of appropiateness
• Symptoms despite optimal medical therapy with
vasodilators and diuretics, or
• Inability to tolerate optimal medical therapy due to
hypotension and/or renal insufficiency
• Not a surgical candidate
• Inotropic support not LVAD or transplant candidate
Wright JB, Kinzbrunner BM: Predicting Prognosis: How to decide when end-
of life care is needed. Chapter 1 in Kinzbrunner BM, Policzer JS (eds): End-
of-Life Care: A Practical Guide. New York: McGraw Hill, 2011, p. 17.
30. Study Description Patient
Characteristics
Enrollment
Period
1-year
mortality
Median
Survival
REMATCH RCT LVAD VS
OMM
NYHA III plus
inotrope or NYHA
IV
1998-2001 75% 5 months
COSI Prospective
study
outpatients on
inotropes
Stage D
outpatients on
chronic inotropes
1993-2002 94% 3.4 months
COMPANION RCT of CRT vs
OMM
NYHA III or IV
with EF<35%
2000-2002 25% Not available
Mortality Optimal Medical
Management Arms of Trials
32. Predicting Mortality in
Heart Failure
Lee DS, Austin PC, Rouleau JL et al. Predicting mortality among
patients hospitalized for heart failure. Derivation and validation of
a clinical model. J Am Med Assoc 290: 2581, 2003.
33. Predicting Mortality in
Heart Failure
Lee DS, Austin PC, Rouleau JL et al. Predicting mortality among
patients hospitalized for heart failure. Derivation and validation of a
clinical model. J Am Med Assoc 290: 2581, 2003.
34. End-Stage Pulmonary Disease
Disabling dyspnea as demonstrated by:
• Dyspnea at rest or with minimal exertion
• Dyspnea poorly responsive to bronchodilators
– FEV-1 < 30% predicted, post-bronchodilator
Progressive pulmonary disease as
manifested by:
• Multiple hospitalizations, ER visits or doctor’s
office visits
• Cor pulmonale
Wright JB, Kinzbrunner BM: Predicting Prognosis: How to decide when end-
of life care is needed. Chapter 1 in Kinzbrunner BM, Policzer JS (eds): End-
of-Life Care: A Practical Guide. New York: McGraw Hill, 2011, p. 16.
35. End-Stage Pulmonary
Disease (Cont.)
Other indicators of a poor prognosis
• Body weight
– < 90% ideal body weight or
– > 10% weight loss
• Resting tachycardia > 100/min
• Abnormal ABGs or O2 saturation
– pO2 < 55 mm Hg
– O2 saturation < 88%
– pCO2 > 50 mm Hg
• Continuous oxygen therapy
36. BODE Index for COPD
Celli BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction,
dyspnea, and exercise capacity index in chronic obstructive pulmonary
disease. N Engl J Med 350:1005, 2004.
37. BODE Index for COPD (Cont.)
Celli BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction,
dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N
Engl J Med 350:1005, 2004.
Quart 1: 0-2
Quart 2: 3-4
Quart 3: 5-6
Quart 4: 7-10
38. Dementias
• Progressive functional decline
• Dependence in 3/6 activities of daily living
(bathing, dressing, feeding, continence,
ambulation and feeding)
• Disease-related complication within last
six months
Wright JB, Kinzbrunner BM: Predicting Prognosis: How to decide when end-
of life care is needed. Chapter 1 in Kinzbrunner BM, Policzer JS (eds): End-
of-Life Care: A Practical Guide. New York: McGraw Hill, 2011, p. 19.
39. Dementias and Other End Stage
Neurodegenerative Disorders
Patient experienced complication in the last six months:
• Pneumonia
• Pyelonephritis or upper urinary tract infection
• Septicemia
• Two or more pressure ulcers: Stage III or IV
• Febrile episodes
• Altered nutritional status (weight loss 10% six months)
• Eating difficulty including feeding tube decision
• Hip fracture with or without repair
Wright JB, Kinzbrunner BM: Predicting Prognosis: How to decide when end-of
life care is needed. Chapter 1 in Kinzbrunner BM, Policzer JS (eds): End-of-
Life Care: A Practical Guide. New York: McGraw Hill, 2011, p. 19.
40. Natural History of Dementia
6-month mortality 38.6%
6-month mortality 44.5%
6-month mortality 46.7%
• Median survival was 478 days,
24.7% within 6 months
• 54.8% died, 93.8% in NH
Mitchell, et al. NEJM 2009
41. End-Stage
Cerebrovascular Disease
Acute End-Stage CVA
Patient has one or more of the following at least
three days after an acute stroke:
• Coma
• Persistent vegetative state
• Severe obtundation with myoclonus
• Postanoxic encephalopathy
Wright JB, Kinzbrunner BM: Predicting Prognosis: How to decide when end-
of life care is needed. Chapter 1 in Kinzbrunner BM, Policzer JS (eds): End-
of-Life Care: A Practical Guide. New York: McGraw Hill, 2011, p. 22.
42. One and Two Must Be Present
1.INR>1.5 or serum albumin <2.5gm/dl
2.Evidence end-stage liver disease
•Ascites refractory to treatment
•SBP
•HRS
•Encephalopathy
•Recurrent variceal bleeding
End-Stage Liver Disease
43. Other supportive features
•Progressive malnutrition
•Muscle wasting with decreased
strength/endurance
•Ongoing ETOH use
•HCC
End-Stage Liver Disease (Cont.)
44. AIDS and HIV Disease
• RNA viral load
– > 100,000 persistently
– < 100,000
• Refusing anti-retrovirals
• Declining functional status
• HIV related opportunistic illnesses
• Other factors
– Chronic persistent diarrhea – Age > 50
– Substance abuse – Symptomatic CHF
– Decision to forgo therapies
Wright JB, Kinzbrunner BM: Predicting Prognosis: How to decide when end-
of life care is needed. Chapter 1 in Kinzbrunner BM, Policzer JS (eds): End-
of-Life Care: A Practical Guide. New York: McGraw Hill, 2011, p. 24.
50. Kurella Tamura, N Engl J Med, 2009
Change in Functional Status
After Initiation of Dialysis
51. Malnutrition or Not
Otherwise Specified
*A low albumin level due to nephrotic syndrome is excluded from the diagnosis of malnutrition
“WHY is the patient appropriate for hospice now?”
52. Determining Prognosis
• Clinical judgment
• Nutrition
• Physical function
• Cognition
• Health Care utilization
• Symptoms
• Disease specific decline
Weight loss represents a key determinant of a poor prognosis which is readily obtainable for no significant additional cost. Two studies that demonstrate this point are highlighted on the slide. The first study looked at long-term care residents who did and did not have a weight loss of at least 5% in the preceding month. Those residents who lost 5% weight in 1 month were 5 times more likely to die compared to those who did not lose that much weight over the ensuing year. The second study examined weight loss (5% of body weight in last 6 months) among community-dwelling outpatients in Palo Alto California. Importantly, 35% of the sample had no identifiable cause of weight loss even after extensive evaluation. Among patients with weight loss, 25% had died over the ensuing year.
This is one of many studies that demonstrates the relationship of PPS with mortality. The lower the PPS the higher the mortality. The graph displayed demonstrates survival among a cohort of 277 patients evaluated on the Pain and symptom consult service at UNC. Importantly, a PPS of 50 is associated with a 50% survival around 180 days whereas a PPS of 10% has a 50% survival of days. Similar findings between PPS score and mortality have been found in hospice populations.
Again, ADL impairment is highly correlated with mortality and the greater the number of ADL impairments the greater the mortality. This is displayed in the slide were you can see the relationship between ADL difficulty and survival by cox-proportional hazzard modeling. In this study of nationally representative community-dwelling older adults those with no ADL impairment lived on average 10.6 years compared to those with complete ADL impairment who lived an average of 1.6 years after taking into account age, gender, ethnicity, and comorbid conditions. A little later we will examine the relationship between ADL loss surrounding a hospitalization and subsequent mortality to further emphasize this point.
ADL=0 no difficulty- eat, toilet, bathe, and walk without difficulty
ADL=1 Mild difficulty-
ADL=2 moderate difficulty
ADL 3=severe difficulty
ADL IV complete difficulty
Older adults commonly fall and recurrent falls put older adults at an increased risk of dying. The relationship between fallers and non-fallers is displayed on the slide derived from community swelling older adults in Alabama. A cohort of 125 community dwelling older adult fallers were matched to other community dwelling older adults and differences in survival were compared. As you can see from the graph, fallers were significantly more likely to die compared to non-fallers with 25% of those who fell dying over the next year. The cause of death is also listed and it is important to recognize that many of the conditions may not readily be attributable to a fall which re-enforces the point that falls often serve as a proxy of underlying disease severity.
Another important contributor to functional decline is cognition. Cognitive decline commonly occurs with the progression of chronic illness such as CHF, COPD, and cancer independent of whether or not an underlying dementia is present. Cognitive status can quickly be assessed by ascertaining orientation, wakefulness, ability to communication and interaction with the environment. A more comprehensive assessment of cognitive status is the Folstein mini-mental status exam which was developed as a measure of overall global cognitive function. Cognitive performance ranges from 30 to 0 with higher scores indicating better cognitive function. Overall performance can be used to categorize cognitive functioning into intact, mild impairment, moderate impairment, and severe impairment. We are going to go over the MMSE since some programs routinely use the measure and it is commonly scored incorrectly.
Health care utilization is also a powerful predictor of subsequent mortality among older adults. Increased health care utilization is commonly used to help demonstrate a patient’s prognosis is 6 months or less with hospitalization being the most commonly studied. The slide indicates the health care utilization of out patient KP over the past 6 months. On the next slide we will look at the relationship between ADL decline during a hospitalization and subsequent mortality.
The slide displays the results of a study that examined the relationship between recovery of ADL loss during a hospitalization and subsequent ongoing decline or death. For example, at 6 months, the group of patients that had no ADL decline surrounding an index hospitalization found 11% had died, 15% had developed functional decline, and 74% had maintained functional abilities. On the other hand, patients who experienced functional decline in ADL’s during the hospitalization found almost 33% had died, 34% had additional ADL decline, and only 36% maintained the level of ADL at hospital discharge. Of note, 41.3% of patients hospitalized and had functional decline were dead 1 year later.
The last indicator of functional status we are going to discuss today is symptoms. Many studies from different disease states demonstrate the relationship between uncontrolled symptoms and subsequent mortality. For example, in patients with CHF shortness of breath or fatigue with minimal exertion (NYHA class III) or at rest (NHYA class IV) with optimal medical management support a prognosis of 6 months or less and hospice appropriateness. As a result, a patient’s assessment should incorporate how physical and psychological symptoms are associated with or impacting the patient’s decline. For example, nausea has lead to reduced oral intake and contributed to the 10% weight loss.
One of the most common symptoms that present in hospice appropriate patients is delirium. Delirium is an acute state of confusion with poor attention that fluctuates over the course of the day and may or may not be associated with hallucinations. Delirium is a predictor of poor prognosis as demonstrated on the following slide.
The slide displays the findings of an observational cohort study in Canada in which hospitalized patients with (243) and without (118) delirium were followed after hospital discharge. Patients with delirium at the time of hospital discharge had a 12 month mortality rate of 41.6% compared to 14.4% among patients discharged without delirium. The study demonstrates the significantly increased risk of mortality when delirium is present.
Longer MD knew patient the less likely able to predict prognosis
20% of predictions accurate (defined as within 33% of survival)
May lead to late referral to hospice- more beneficial when earlier
May lead patients to elect for futile care
Exception not receiving chemo and good functional status is prostate and breast
Information about prognosis for patients with very advanced heart failure in an era of more sophisticated heart-failure therapies is available from several recent studies. The Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) study was a randomized controlled trial of destination LVAD versus optimal medical management (OMM) for patients with inotrope-dependent Class III or Class IV heart failure. Sixty-one patients were enrolled in the OMM arm of the study. Their mortality was 50% at 6 months, 75% at 12 months, and almost 100% at 2 years. The Continuous Outpatient Support with Inotropes (COSI) study followed 36 patients on home inotropic support. Mortality for these patients was 60% at 6 months and 94% at 1 year. Multiple randomized controlled trials comparing CRT with OMM have been published.324,328 In the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) study, 308 patients with Class III or IV heart failure and EF lower than 35% were enrolled in the OMM arm. Twenty-five percent of these patients died during the 12-month study period.320
Clinical sample of patients recruited from an inpatient hospital stay and followed over several years. 35-50% CHF admits secondary to diastolic dysfunction. No difference in survival from those with diastolic and systolic dysfunction. In diastolic dysfunction functional status a big predictor of survival. Simial rates of hospitalization as well
Another study I always like to highlight to further demonstrate this point is displayed on the slide. Over an 18 month study period, 323 residents that lived in the NH and had a cognitive performance score of 5 or 6 (a score of 5 is approximately an MMSE of 5.1) and a global deterioration score of at least 7 (inability to recognize family, incontinent, functionally dependent, unable to ambulate). 54.8% died in 18 mo; 24.7 % died in the 1st 6 mo. Median survival was 478 days. The figure has the cumulative incidence of each event, mortality rates at 6 months after the incident is at the side. In other words, during the 18month study period, 41.1% had pneumonia, 52.6% had a febrile episode, and 85.8% had an eating problem. The 6 month mortality rates after each event is listed above (46.7, 44.5, and 38.6% respectively). The mortality rates were substantially higher in the group that developed these complications compared to those who did not have a complication.
Importantly guidelines state other factors may indicate a prognosis of 6 months or less and should be taken into account when considering a patient appropriate for hospice services
Figure 2. Change in Functional Status after Initiation of Dialysis. Data were missing for 549 nursing home residents at 3 months, 696 residents at 6 months, 823 residents at 9 months, and 787 residents at 12 months from the full analytic cohort of 3702 residents.