Bone infections
OSTEOMYELITIS
(Acute, subacute and chronic)
Etiology
Pathophysiology
Presentation
Diagnosis
Management and complications
Osteomyelitis has long been one of the most difficult and challenging problems confronted by orthopaedic surgeons.
Currently, morbidity and mortality from osteomyelitis are relatively low because of modern treatment methods, including the use of antibiotics and aggressive surgical treatment.
I upload for my future reference.
Feel free to download if you need a fast reference or feel free to edit and improve if you need to do your presentations.
For undergraduate medical students.
Referred from Apley's.
Bone infections
OSTEOMYELITIS
(Acute, subacute and chronic)
Etiology
Pathophysiology
Presentation
Diagnosis
Management and complications
Osteomyelitis has long been one of the most difficult and challenging problems confronted by orthopaedic surgeons.
Currently, morbidity and mortality from osteomyelitis are relatively low because of modern treatment methods, including the use of antibiotics and aggressive surgical treatment.
I upload for my future reference.
Feel free to download if you need a fast reference or feel free to edit and improve if you need to do your presentations.
For undergraduate medical students.
Referred from Apley's.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Contact us if you are interested:
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Threema: PXHY5PDH
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Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
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of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
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The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. • Mainly disease of children
• Rarely happen in adult, usually when their resistance is lowered
• The incidence of acute haematogenous osteomyelitis in Western European
children is thought to have declined in recent years because improving social
conditions
• decrease surgical treatment related to earlier and more effective antibiotic
treatment
3. Etiology
• Staphylococcus aureus 70% of cases in both adults and children
• Gram positive cocci, group A beta-haemolytic (Streptococcus pyogenes) less often
– in chronic skin infection
• Group B streptococcus – especially in newborn babies
• 1 and 4 years age, gram negative Haemophilus influenzae fairly common
pathogen
• In recent years its Kingella kingae, mainly following upper respiratory infection in
young children.
• Other Gram-negative organisms (e.g. Escherichia coli, Pseudomonas aeruginosa,
Proteus mirabilis and the anaerobic Bacteroides fragilis) occasionally cause acute
bone infection.
• patients with sickle-cell disease are prone to infection by Salmonella typhi.
4. • In infants, in whom there are still anastomoses between metaphyseal and
epiphyseal blood vessels, infection can also reach the epiphysis
• In adults, haematogenous infection accounts for only about 20% of cases of
osteomyelitis. Staphylococcus aureus is the commonest organism but
Pseudomonas aeruginosa often appears in patients using intravenous drugs.
• Adults with diabetes and vascular disease, who are prone to soft-tissue infections
of the foot, may develop contiguous bone infection involving a variety of
organisms.
5. Pathogenesis
• The bloodstream is invaded from a minor skin abrasion (sharp object, an injection
point, a boil, a septic tooth or in the newborn from an infected umbilical cord.
• In adults, the source of infection may be a urethral catheter, an indwelling arterial
line or a contaminated needle and syringe.
• In children, the infection usually starts in the vascular metaphysis of a long bone,
most often in the proximal tibia or in the distal or proximal ends of the femur.
• The structure of the fine vessels in the hypertrophic zone of the physis may more
easily allow bacteria to pass through and adhere to type 1 collagen in that area
6. • Predilection for this site has traditionally been attributed to
the peculiar arrangement of the blood vessels in that area:
• The non-anastomosing terminal branches of the
nutrient artery twist back in hairpin loops before
entering the large network of sinusoidal veins;
• the relative vascular stasis ; and
• consequent lowered oxygen tension are believed to
favour bacterial colonization.
7. ACUTE OSTEOMYELITIS IN CHILDREN
The ‘classical’ picture is seen in children between 2 and 6 years.
• metaphysis acute inflammatory reaction with vascular congestion
• exudation of fluid and infiltration by polymorphonuclear leucocytes rapidly
• The intraosseous pressure rises causing intense pain, obstruction to blood flow
and intravascular thrombosis.
• Bone tissue is threatened impending ischaemia
• Second or third day, pus forms within the bone and forces its way along the
Volkmann canals to the surface where it produces a subperiosteal abscess
8. • Increase intraosseous pressure, vascular stasis, small-vessel thrombosis and
periosteal stripping increasingly compromise the blood supply
• By the end of a week there is usually microscopic evidence of bone death.
• Bacterial toxins and leucocytic enzymes also may play their part in the advancing
tissue destruction.
• With the gradual ingrowth of granulation tissue the boundary between living and
devitalized bone becomes defined.
• Pieces of dead bone may separate as sequestra varying in size from mere spicules
to large necrotic segments of the cortex in neglected cases.
9. • Another feature of advancing acute osteomyelitis is new bone formation.
• Initially, the area around the infected zone is porotic (probably due to
hyperaemia and osteoclastic activity) but if the pus is not released, either
spontaneously or by surgical decompression, new bone starts forming on
viable surfaces in the bone and from the deep layers of the stripped
periosteum.
• New bone thickens to form a casement (involucrum) enclosing the
sequestrum and infected tissue.
• If the infection persists, pus and tiny sequestrated spicules of bone may
discharge through perforations (cloacae) in the involucrum and track by
sinuses to the skin surface
10. ACUTE OSTEOMYELITIS IN INFANTS
• During the first year of life, is the frequency with which the metaphyseal infection
spreads to the epiphysis and from there into the adjacent joint. In the process, the
physeal anlage may be irreparably damaged, further growth at that site is severely
retarded and the joint will be permanently deformed.
• During the first 6–9 months of life, small metaphyseal vessels penetrate the
physeal cartilage and this may permit the infection to spread into the cartilaginous
epiphysis,
• Sometimes bizarre new bone formation along the diaphysis;
11. ACUTE OSTEOMYELITIS IN ADULTS
• Bone infection in the adult usually follows an open injury, an operation or spread
from a contiguous focus of infection (e.g. a neuropathic ulcer or an infected
diabetic foot) in over 70% of the cases.
• A vertebral infection may spread through the end plate and the intervertebral disc
into an adjacent vertebral body. If a long bone is infected, the abscess is likely to
spread within the medullary cavity, eroding the cortex and extending into the
surrounding soft tissues.
• If the bone end becomes involved, there is also a risk of the infection spreading
into an adjacent joint.
12. Clinical features
• IN CHILDREN
• a child over 4 years, presents with severe pain, malaise and a
fever, toxaemia
• refuses to use one limb or to allow it to be handled or even
touched
• recent history of infection looks ill and feverish
• the pulse rate is likely to be over 100 and the temperature is
raised.
• Local redness, swelling, warmth and oedema are later signs and
signify that pus has escaped from the interior of the bone
• Lymphadenopathy is common but non-specific.
13. • IN INFANTS
• In children under 1 year old, and especially in the newborn fails to thrive and
is drowsy but irritable.
• Metaphyseal tenderness and resistance to joint movement can signify either
osteomyelitis or septic arthritis;
• history of birth difficulties, umbilical artery catheterization or a site of
infection
14. • IN ADULTS
• A common site for haematogenous infection is the thoracolumbar spine
• mild fever and backache
• Local tenderness is not very marked
16. Diagnostic imaging
• PLAIN X-RAY
• the first week after the onset of symptoms, the plain radiograph shows no
abnormality
• By the second week there may be a faint extracortical outline due to periosteal
new bone formation; this is the classic X-ray sign of early pyogenic
osteomyelitis,
• ULTRASONOGRAPHY
• may detect a subperiosteal collection of fluid in the early stages of
osteomyelitis, but it cannot distinguish between a haematoma and pus.
17. • SPECT/CT
• Increasingly used in musculoskeletal infections.
• Excellent differentiation between soft-tissue and bone infections, assessment
of suspected infected sites with underlying structural bone alterations, and
clear definition of infective foci within complex anatomical locations.
18. • MAGNETIC RESONANCE IMAGING (MRI)
• helpful in cases of doubtful diagnosis, and particularly in suspected infection
of the axial skeleton
• the best method of demonstrating bone marrow inflammation.
• extremely sensitive, even in the early phase of bone infection
• assist in differentiating between soft-tissue infection and osteomyelitis.
19. CT
• The advantage of planar bone definition, including bone destruction and soft
tissue mass, such as an abscess, within or surrounding bone.
RADIONUCLIDE SCANNING
• This is a highly sensitive investigation, even in the very early stages, but it has
relatively low specificity and other inflammatory lesions can show similar
changes.
20. Laboratory investigations
• The most certain way to confirm the clinical diagnosis is o aspirate pus or fluid
from the metaphyseal subperiosteal abscess, the extraosseous soft tissues or an
adjacent joint.
• best done using a 16- or 18-gauge trocar needle
• Blood cultures should be obtained if fever above 38 °C is detected
• C-reactive protein (CRP) values are usually elevated within 12–24 hours
• the erythrocyte sedimentation rate (ESR) within 24–48 hours after the onset of
symptoms
• The white blood cell (WBC) count rises and the haemoglobin concentration may
be diminished
• Anti-staphylococcal antibody titres may be raised
21. Treatment
• Treatment started immediately without waiting for final confirmation of the
diagnosis.
• ANTIBIOTICS : intravenous administration of antibiotics is so vital that
treatment should not await the result.
• Staphylococcus aureus is the most common at all ages,
22. • Neonates and infants up to 6 months of age : Staphylococcus aureus, Group B
streptococcus and Gram-negative organisms.
• flucloxacillin plus a third-generation cephalosporin such as cefotaxime.
• Children 6 months to 6 years of age : Empirical treatment in this age group
should include cover against Haemophilus influenzae
• combination of intravenous flucloxacillin and cefotaxime or cefuroxime.
• Older children and previously fit adults : The vast majority in this group will
have a staphylococcal infection and can be started on intravenous flucloxacillin
and fusidic acid.
23. • Elderly and previously unfit patients : combination of flucloxacillin and a
second- or third-generation cephalosporin.
• Patients with sickle-cell disease : third-generation cephalosporin or a
fluoroquinolone such as ciprofloxacin.
• Heroin addicts and immunocompromised patients : best treated empirically with
a broad-spectrum antibiotic such as one of the third-generation cephalosporins or
a fluoroquinolone preparation, depending on the results of sensitivity tests.
• Patients considered to be at risk of methicillinresistant Staphylococcus aureus
(MRSA) infection : intravenous vancomycin (or other glucopeptide such as
teicoplanin) together with a third- generation cephalosporin.
25. • appropriate antimicrobial therapy (first empirical, then specific)
• surgical drainage if required
• splintage and rest of the affected part
• supportive treatment for pain and dehydration.