1. Acute appendicitis is caused by obstruction of the appendix, most commonly from lymphoid hyperplasia or fecaliths. It presents with migrating pain from the epigastric to right lower quadrant along with nausea, vomiting, and fever. 2. Diagnosis is based on history and physical exam findings like rebound tenderness. Differential diagnosis includes other abdominal and gynecological conditions. Complications include perforation and peritonitis if not treated surgically. 3. Appendectomy remains the standard treatment, though diagnosis can be challenging in atypical cases like retrocecal or pelvic appendicitis or in children and elderly patients where symptoms may be milder

1. ACUTE APPENDICITIS

2. Acute appendicitis is an inflammation of a vermiform appendix caused by purulent microflora . Approximately 7 percent of the population will have appendicitis in their lifetime with the peak incidence occurring between the ages of 10 and 30 years. Despite technologic advances, the diagnosis of appendicitis is still based primarily on the patient's history and the physical examination. The mortality rate in nonperforated appendicitis is less than 1 % , but it may be as high as 5 % or more in young and elderly patients, in whom diagnosis may often be delayed, thus making perforation more likely. Prompt diagnosis and surgical referral may reduce the risk of perforation and prevent complications.

3. Etiology and pathogenesis Obstruction of the narrow appendiceal lumen initiates the clinical illness of acute appendicitis. Obstruction has multiple causes, including lymphoid hyperplasia (related to viral illnesses, including upper respiratory infection, mononucleosis, gastroenteritis), fecaliths, parasites, foreign bodies, Crohn's disease, primary or metastatic cancer and carcinoid syndrome. Lymphoid hyperplasia is more common in children and young adults, accounting for the increased incidence of appendicitis in these age groups.

4. Classification (by V.I. Kolesnikov) 1. Appendiceal colic. 2. Simple superficial appendicitis. 3. Destructive appendicitis: а) phlegmonous ; б ) gangrenous; в ) perforated . 4. Complicated appendicitis: а) appendicular infiltrate ; б ) appendicular abscess; в) diffuse purulent peritonitis. 5. Other complications of acute appendicitis (pylephlebitis, sepsis, retroperitoneal phlegmon, local abscesses of abdominal cavity).

5. Symptoms of simple appendicitis 1. Pain localized in a right iliac area. In 70 % of patients the pain arises in a epigastric area – it is an epigastric phase of acute appendicitis. In 2-4 hours it migrates to the area of appendix (the Kocher’s sign). 2. Single nausea and vomiting. 3. Fever to 37.5-38 0 C. 4. Retention of stool or single diarrhea. 5. Muscular tension in a right iliac area. Rovsing's sign - pain in right lower quadrant during palpation of left lower quadrant Sitkovsky’s sign - increase of pain in a right iliac area when the patient lies on the left side Bartomier’s sign - the increase of pain intensity during the palpation of right iliac area when the patient lies on the left side. Dunphy's sign-increased pain with coughing

6. Symptoms of phlegmonous appendicitis 1. Expressed pain in a right iliac area. 2. Fever to 38-39 0 C. 3. Muscular rigidity in a right iliac area. 4. Peritoneal signs Blumberg’s sign. After gradual pressing by fingers of anterior abdominal wall quick taking off the hand causes the sharp increase of pain. Voskresenky’s sign. The increase of pain during quick sliding movements by the tips of fingers from epigastric to right iliac area. Rozdolskyy’s sign. Painfulness in a right iliac area during percussion.

7. Symptoms of gangrenous appendicitis 1. Expressed pain in a right iliac area. 2. Grave condition of the patient. 3. Signs of local peritonitis. 4. Signs of intoxication

8. Symptoms of retrocaecal appendicitis 1. Non-expressive abdominal clinic. 2. Expressed pain in a right lumbar area. 3. Pain and muscular rigidity in a right iliac area during palpation. Yaure-Rozanov sign - Painfullness during palpation of Petit triangle Gabay’s sign - Blumberg’s sign in Petit triangle Pasternatsky’s sign - tapping of lumbar region cause the pain Psoas sign-pain on extension of right thigh

9. Symptoms of retrocaecal retroperitoneal appendicitis 1. Clinic of retroperitoneal phlegmon. 2. The signs of retrocaecal appendicitis. 3. Flank tenderness in right lower quadrant .

10. Symptoms of pelvic appendicitis 1. Clinic of irritation of pelvic organs (dysuria, pulling rectal pain, tenesmi). 2. Absence of muscular tenderness. 3. Painfullness of anterior rectal wall and posterior vaginal vault.

11. Symptoms of left-side appendicitis All the appendicular signs locate on the left iliac region

12. Clinic of appendicitis in children In infants acute appendicitis occurs infrequently, but quite often has atypical character. It results from the peculiarities of anatomy of appendix, insufficient plastic properties of the peritoneum, short omentum and high reactivity of child’s organism. The inflammatory process in the appendix of children rapidly progresses in the first half of the day, resulting in destruction, even perforation. The children more frequently than an adult suffer from vomiting. General condition worsening quickly and the positive peritoneal symptoms have been shown already during the first hours of the disease. The temperature reaction is also considerably expressed. In blood revealed high leukocytosis. It is necessary to remember, that the examination of anxious children requires to use a chloralhydrate enema.

13. Clinic of appendicitis in elderly patiens This group of patients is hospitalized rather late, usually in 2-3 days after the beginning of the disease. Because of the increased threshold of pain sensitivity, the pain in such patients is slightly expressed, therefore they almost do not pay attention to the epigastric phase of appendicitis. Frequently nausea and vomiting is present, and the temperature reaction is expressed poorly. Tension of muscles of abdominal wall is absent or is insignificant due to old-age relaxation of muscles. But the symptoms of irritation of peritoneum keep the diagnostic value in this group of patients. Thus, the sclerosis of vessels of appendix results in initially-gangrenous forms of appendicitis in this group.

14. Clinic of appendicitis during pregnancy Enlarged uterus bends the appendix and disturbs its blood flow resulting in appendicitis. In the first half of pregnancy the clinic of appendicitis usually without peculiarities. In the second half of pregnancy, the enlarged uterus displaces the caecum together with the appendix upwards, and overdistension of abdominal wall does not create adequate tension. It is necessary also to remember, that pregnant women periodically can have a moderate pain in the abdomen and changes in the blood test. Nevertheless, psoas-sign and the Bartomier’s sign has a diagnostic value.

15. Complications 1. Appendicular infiltrate. 2. Appendicular abscess. 3. Diffuse peritonitis. 4. Pilephlebitis

16. Diagnostics 1. Anamnesis. 2. Objective examination. 3. General blood and urine analyses. 4. Vaginal examination for women. 5. Rectal examination for men.

17. Differential diagnostics Gastrointestinal Cholecystitis Crohn's disease Duodenal ulcer Gastroenteritis Intestinal obstruction Meckel's diverticulitis Mesenteric lymphadenitis Necrotizing enterocolitis Neoplasm (carcinoid, carcinoma, lymphoma) Gynecologic Ectopic pregnancy Endometriosis Ovarian torsion Pelvic inflammatory disease Ruptured ovarian cyst Tubo-ovarian abscess

18. Differential diagnostics Systemic Diabetic ketoacidosis Henoch-Schonlein purpura Pulmonary Pleuritis Pneumonia (basilar) Pulmonary infarction Genitourinary Kidney stone Pyelonephritis Wilms' tumor Other Parasitic infection Psoas abscess Rectus sheath hematoma

19. Differential diagnostics of acute appendicitis with perforative peptic ulcer Pain in the right iliac region Muscular tenderness in the right iliac region Single vomiting and diarrhea Sharp acute diffuse pain Ulcerative anamnesis Absence of hepatic dullness On X-ray of the abdomen air above the liver (air sickle) Rigidity of anterior abdominal wall

20. Differential diagnostics of acute appendicitis with intestinal obstruction Constant pain in the right iliac region Muscular tenderness in the right iliac region Single vomiting and diarrhea Periodic acute diffuse pain Constant vomiting and nausea without any relief Retention of stool and gases Abdominal distension On X-ray of the abdomen Kloiber's cups (air-fluid levels) Splashing sound, increased peristalsis

21. Differential diagnostics of acute appendicitis with acute cholecystitis Constant pain in the right iliac region Muscular tenderness in the right iliac region Single vomiting and diarrhea Acute pain in a right hypohondrium with irradiation to the scapula Muscular tenderness in a right hypohondrium Vomiting by bile and nausea without any relief Ortner's symptom, phrenic symptom, Murphy’s sign Increased serum bilirubin

22. Differential diagnostics of acute appendicitis with gynecologic disorders Constant pain in the right iliac region Muscular tenderness in the right iliac region Single vomiting and diarrhea Acute pain in a lower part of the abdomen Dependence on menstrual cycle Vaginal discharge Blood by punction of vaginal vault Bimanual vaginal investigation

23. Differential diagnostics of acute appendicitis with renal colic Constant pain in the right iliac region Muscular tenderness in the right iliac region Single vomiting and diarrhea Periodic acute pain in the lumbar region with irradiation to thigh Vomiting and nausea Pasternatsky’s sign Fresh erythrocytes in urine analysis

24. Steps of operation in appendicitis

25. Steps of operation in appendicitis

26. Steps of operation in appendicitis

27. Steps of operation in appendicitis

28. Steps of operation in retrocaecal appendicitis

29. Steps of operation in retrocaecal retroperitoneal appendicitis