This document discusses various forms of academic misconduct including fabrication of data, cherry picking results, and harking. It notes that misconduct leads to artificially strong positive results and positive publication bias. Examples of misconduct include plagiarism, double publication, and undeserved authorship. Trends show misconduct is increasing as evidenced by rising retraction rates and disappearing negative results. Those who engage in misconduct tend to be highly respected researchers who publish proficiently and quickly. Potential remedies include improved mentoring, blinded data assessment, and strong leadership.