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Classroom Slides:
Brain Chemistry
Teacher’s Guide
Nancy P. Moreno, PhD
Barbara Z. Tharp, MS
Tadzia GrandPré, PhD
Center for
Educational Outreach
Baylor College of Medicine
© Mathieu Letellier. CC-BY-NC-ND.
Cerebral
Hemispheres
(top view)
The Brain and Spinal Cord
Cerebrum Cerebral
Cortex
Corpus
Callosum
Spinal
Cord
Brain
Stem
Limbic
System
Cerebellum
Illustrations © Williams & Wilkins. All rights reserved.
Internal Brain Structure
This MRI of a
normal brain
reveals the
different regions
of the brain,
each of which
has specific
functions.
Such detailed
images allow physicians to visualize diseases,
effects of injuries and abnormalities in the brain.
Image © Mikhail Basov.
The Human Nervous System
The brain and
spinal cord
make up the
central nervous
system. All
other nerves in
the body form
the peripheral
nervous system.
Illustrations © Williams & Wilkins. All rights reserved.
Normal Brain Development
The MRI images above show normal brain
development (left to right) at ages 1 week,
3 months, 1 year, 2 years, and 10 years.
Images such as these serve as a baseline
for pediatricians when determining problems
within the brain.
MRI image courtesy of NIH from the MRI
Study of Normal Brain Development Project.
What Is a Neuron?
Microscopic image of
a neuron from the
hippocampus. Most
neurons receive
signals from many
other neurons. The
combined effects of
these signals
determine the
response of the
receiving neuron.
© Baylor College of MedicineRobert S. McNeil.
Purkinje Neurons
Purkinje cells are
large neurons with
branching, tree-like
dendrites. These
neurons form the sole
output pathway of the
cerebellar cortex, and
they serve as an
essential link in
regulating the body’s
muscle tone and
movement.
SEM courtesy of The Gene Expression Nervous
System Atlas (GENSAT) project, NINDS.
Pyramidal Neurons
Pyramidal cells
are found in the
cerebral cortex and
other parts of the
central nervous
system. Pyramidal
cells have a
pyramid-shaped
cell body and many
dendritic branches.
BrainMaps: An Interactive Multiresolution Brain Atlas. CC-BY-SA 3.0.
Typical Structure of Neurons
 A typical neuron has an enlarged cell
body which contains the nucleus.
Most neurons have branches, known
as dendrites. Each neuron typically
also has a longer tail-like fiber, or
extension, called an axon.
 Information typically is received on
the dendrites or cell body, and is
transmitted in one directions down the
axon and passed to next neuron.
 Neurons vary greatly in size and
shape. Although neurons generally
have only a single axon, they can
have hundreds of dendrites.
Illustration © Williams & Wilkins. All rights reserved.
Neuron Firing
This microscopic
image shows
a motor neuron’s
nerve endings
on top of muscle
fibers. When a
neuron fires, a
neurotransmitter
is released into
the space
between the
motor neuron (synaptic cleft) and that of the muscle fiber; it
diffuses across the space and triggers the series of events that
leads to contraction of the muscle.
Image courtesy of Thomas Caceci, PhD, Virginia-
Maryland Regional College of Veterinary Medicine.
Neuron Circuits
 When a neuron “fires,” it
sends an impulse to one
or more other neurons.
 Some neurons are
coupled directly, so that
an electrical signal
traveling down one
neuron passes directly to the next one.
 Other neurons use chemical messengers, known
as neurotransmitters, to send signals to other
neurons.
SEM courtesy of Paul De Koninck, PhD, Laval University.
Build a Circuit
 Wrap the exposed end of one wire from the light bulb
around one pole on the battery. Tape it in place with a
piece of electrical tape.
 Attach the end of the other wire to the
second battery pole and tape it in place.
 Test the connection by briefly touching
the exposed ends of the two loose
wires together. (The bulb should
burn brightly.)
 Wrap the exposed ends of the loose wires with the
aluminum foil, as shown above.
Neurotransmitters Contain Chemicals
A scanning electron
microscope image
of a nerve ending
(large, round object).
It has been broken
open to reveal
vesicles containing
chemicals (orange
and blue) used to
pass messages in
the nervous system.
Image courtesy of Tina Carvalho, MS, University of Hawai’i.
Neurons Have Specialized Receptors
Microscopic image of a single neuron stained to
reveal receptor sites for a specific chemical.
Image © Baylor College of MedicineRobert S. McNeil.
Chemical Communication
In most cases,
communication across
the synapse occurs
chemically instead of
electrically. Chemical
messengers, called
neurotransmitters, can
either promote or
inhibit the firing of
receiving neurons.
Illustration © Baylor College of MedicineM.S. Young.
Crossing the Synaptic Gap
This microscopic image
has been modified to
reveal the synaptic cleft
between the axon of a
nerve cell in the
hippocampus (part of the
limbic system needed for
memory) and a receiving
neuron. Vesicles (small,
circular pink objects)
release neurotransmitters
into the synaptic cleft.
Transmitting
Neuron
Receiving
Neuron
Synaptic
Gap
TEM image © Dennis Kunkel Microscopy, Inc.
A Balance of Hormones
Special neurons in the hypothalamus region, like the three shown
above, release hormones associated with high calorie intake and
lower energy levels. Other neurons in the hypothalamus release
hormones that act in direct opposition, thereby providing clues as
to how the brain controls our food intake and sleep patterns.
SEM courtesy of Anthony van den Pol, PhD, Yale School of Medicine.
Seeing Addiction in the Brain
Drug addiction compromises the brain circuits involved in
processing reward and punishment, and in exerting
control over one’s actions.
This set of MRI
scans shows what
happens in the brain
when drugs are abused.
On the left is a scan of a
normal brain. Notice the bright areas of activity. The scan
on the right is of a person who is abusing cocaine. The
large dark areas show the loss of neuronal activity. This
loss can be reversed if an abuser stops taking the drug.
MRI image courtesy of NIDA.
Food for the Brain
Reading Food Labels
 Serving sizes often are smaller than the
portions we actually eat.
 Look for low levels of saturated, hydrogenated
and trans fats.
 Cholesterol is found in foods of animal origin.
 Look for foods that have more carbohydrates
as fiber and fewer as sugar. Only foods from
plants provide fiber.
 Protein is important for muscles and growth. It
is found in animal and plant foods.
 Vitamins and minerals are essential for health.
Calcium is important for bones and teeth.
 The amount of calories needed by each
person depends on many factors, including
exercise.

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A0FFBFA9-A1A6-AF45-999FD8E2B9C17BA0.pptx

  • 1. Classroom Slides: Brain Chemistry Teacher’s Guide Nancy P. Moreno, PhD Barbara Z. Tharp, MS Tadzia GrandPré, PhD Center for Educational Outreach Baylor College of Medicine © Mathieu Letellier. CC-BY-NC-ND.
  • 2. Cerebral Hemispheres (top view) The Brain and Spinal Cord Cerebrum Cerebral Cortex Corpus Callosum Spinal Cord Brain Stem Limbic System Cerebellum Illustrations © Williams & Wilkins. All rights reserved.
  • 3. Internal Brain Structure This MRI of a normal brain reveals the different regions of the brain, each of which has specific functions. Such detailed images allow physicians to visualize diseases, effects of injuries and abnormalities in the brain. Image © Mikhail Basov.
  • 4. The Human Nervous System The brain and spinal cord make up the central nervous system. All other nerves in the body form the peripheral nervous system. Illustrations © Williams & Wilkins. All rights reserved.
  • 5. Normal Brain Development The MRI images above show normal brain development (left to right) at ages 1 week, 3 months, 1 year, 2 years, and 10 years. Images such as these serve as a baseline for pediatricians when determining problems within the brain. MRI image courtesy of NIH from the MRI Study of Normal Brain Development Project.
  • 6. What Is a Neuron? Microscopic image of a neuron from the hippocampus. Most neurons receive signals from many other neurons. The combined effects of these signals determine the response of the receiving neuron. © Baylor College of MedicineRobert S. McNeil.
  • 7. Purkinje Neurons Purkinje cells are large neurons with branching, tree-like dendrites. These neurons form the sole output pathway of the cerebellar cortex, and they serve as an essential link in regulating the body’s muscle tone and movement. SEM courtesy of The Gene Expression Nervous System Atlas (GENSAT) project, NINDS.
  • 8. Pyramidal Neurons Pyramidal cells are found in the cerebral cortex and other parts of the central nervous system. Pyramidal cells have a pyramid-shaped cell body and many dendritic branches. BrainMaps: An Interactive Multiresolution Brain Atlas. CC-BY-SA 3.0.
  • 9. Typical Structure of Neurons  A typical neuron has an enlarged cell body which contains the nucleus. Most neurons have branches, known as dendrites. Each neuron typically also has a longer tail-like fiber, or extension, called an axon.  Information typically is received on the dendrites or cell body, and is transmitted in one directions down the axon and passed to next neuron.  Neurons vary greatly in size and shape. Although neurons generally have only a single axon, they can have hundreds of dendrites. Illustration © Williams & Wilkins. All rights reserved.
  • 10. Neuron Firing This microscopic image shows a motor neuron’s nerve endings on top of muscle fibers. When a neuron fires, a neurotransmitter is released into the space between the motor neuron (synaptic cleft) and that of the muscle fiber; it diffuses across the space and triggers the series of events that leads to contraction of the muscle. Image courtesy of Thomas Caceci, PhD, Virginia- Maryland Regional College of Veterinary Medicine.
  • 11. Neuron Circuits  When a neuron “fires,” it sends an impulse to one or more other neurons.  Some neurons are coupled directly, so that an electrical signal traveling down one neuron passes directly to the next one.  Other neurons use chemical messengers, known as neurotransmitters, to send signals to other neurons. SEM courtesy of Paul De Koninck, PhD, Laval University.
  • 12. Build a Circuit  Wrap the exposed end of one wire from the light bulb around one pole on the battery. Tape it in place with a piece of electrical tape.  Attach the end of the other wire to the second battery pole and tape it in place.  Test the connection by briefly touching the exposed ends of the two loose wires together. (The bulb should burn brightly.)  Wrap the exposed ends of the loose wires with the aluminum foil, as shown above.
  • 13. Neurotransmitters Contain Chemicals A scanning electron microscope image of a nerve ending (large, round object). It has been broken open to reveal vesicles containing chemicals (orange and blue) used to pass messages in the nervous system. Image courtesy of Tina Carvalho, MS, University of Hawai’i.
  • 14. Neurons Have Specialized Receptors Microscopic image of a single neuron stained to reveal receptor sites for a specific chemical. Image © Baylor College of MedicineRobert S. McNeil.
  • 15. Chemical Communication In most cases, communication across the synapse occurs chemically instead of electrically. Chemical messengers, called neurotransmitters, can either promote or inhibit the firing of receiving neurons. Illustration © Baylor College of MedicineM.S. Young.
  • 16. Crossing the Synaptic Gap This microscopic image has been modified to reveal the synaptic cleft between the axon of a nerve cell in the hippocampus (part of the limbic system needed for memory) and a receiving neuron. Vesicles (small, circular pink objects) release neurotransmitters into the synaptic cleft. Transmitting Neuron Receiving Neuron Synaptic Gap TEM image © Dennis Kunkel Microscopy, Inc.
  • 17. A Balance of Hormones Special neurons in the hypothalamus region, like the three shown above, release hormones associated with high calorie intake and lower energy levels. Other neurons in the hypothalamus release hormones that act in direct opposition, thereby providing clues as to how the brain controls our food intake and sleep patterns. SEM courtesy of Anthony van den Pol, PhD, Yale School of Medicine.
  • 18. Seeing Addiction in the Brain Drug addiction compromises the brain circuits involved in processing reward and punishment, and in exerting control over one’s actions. This set of MRI scans shows what happens in the brain when drugs are abused. On the left is a scan of a normal brain. Notice the bright areas of activity. The scan on the right is of a person who is abusing cocaine. The large dark areas show the loss of neuronal activity. This loss can be reversed if an abuser stops taking the drug. MRI image courtesy of NIDA.
  • 19. Food for the Brain
  • 20. Reading Food Labels  Serving sizes often are smaller than the portions we actually eat.  Look for low levels of saturated, hydrogenated and trans fats.  Cholesterol is found in foods of animal origin.  Look for foods that have more carbohydrates as fiber and fewer as sugar. Only foods from plants provide fiber.  Protein is important for muscles and growth. It is found in animal and plant foods.  Vitamins and minerals are essential for health. Calcium is important for bones and teeth.  The amount of calories needed by each person depends on many factors, including exercise.