IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Evaluation of Breast Cancer in Reference to Skin ChangesQUESTJOURNAL
Introduction:- Breast cancer is the most commonly occurring female cancer in the world which is more than double that of the second ranked cancer i.e. cervical cancer. Breast cancer accounts for 23% of all cancer deaths. It is the most frequent cancer death in developing countries of the world. Mammary skin changed in breast carcinoma is categorized as advance stage in breast cancer classification. In the present study we evaluated the correlation of macroscopic, microscopic and no skin changes with axillary lymph node using histologic factor dermal lymphatic involvement. Materials and methods: prospective study was conducted on 42 breast cancer admitted patients of different age groups. Based on degree of skin involvement patients were placed into four groups, i.e. clinical stageT1 toT4. All groups were compared on the basis of percentage of patients involvement according to T1, T2, T3 and T4 stage, tumor size, histopathological dermis and epidermis involvement, dermal lymphatic invasion, tumor size and tumor subtype. Results: Majority of the patients with skin (dermis and epidermis) infiltration by the tumor (94.4%) were of T4 stage (along with dermal lymphatic invasion). Majority of the patients with only dermal lymphatic involvement (87.5%) without dermis and epidermis infiltration were of T2 stage. Conclusion: In our study, most of the patients of stage T2 and T3 with dermal lymphatic invasion had involved node when studied by routine histologic technique even though they were not clinically palpable. The identification of characteristics of the primary tumor like dermal lymphatic invasion that are associated with nodal metastases should encourage the surgeon to perform a more extensive axillary lymph node dissection and the pathologist to use methods of examining the nodes that increase the likelihood of finding metastatic disease. From this we can conclude that patients in early stage breast cancer may also have metastatic axillary lymph nodes. Dermal lymphatic invasion may be regarded as the precursor of nodal involvement, and all patients with nodal involvement can be assumed to have lymphatic invasion in the primary tumors. However the converse may not be true, not all patients with lymphatic invasion have nodal involvement.
Dr. Stephanie Blank and Dr. Melissa Frey update us on the latest developments in ovarian cancer research and treatment from the annual conference of the Society of Gynecologic Oncology. Dr. Blank is a gynecologic oncologist at Perlmutter Cancer Center at NYU Langone Medical Center and an associate professor at NYU School of Medicine. Dr. Frey is a Gynecological Oncology Fellow at NYU Langone Medical Center.
Impact of Multidisciplinary Discussion on Treatment Outcome For Gynecologic C...Emad Shash
Tumor conferences are multidisciplinary meetings at which the
management of cancer patients is discussed. They have been
an integral part of oncology services and are regarded
as an essential component of quality control and continuing
medical education. There are data to suggest that the tumor conference enhances patient care. Many studies of effectiveness have been conducted. Reported benefits include improved patient management and treatment. In this presentation, I'll try to assess the role of the multidisciplinary tumor conference in patient management in gynecologic oncology services.
Evaluation of Breast Cancer in Reference to Skin ChangesQUESTJOURNAL
Introduction:- Breast cancer is the most commonly occurring female cancer in the world which is more than double that of the second ranked cancer i.e. cervical cancer. Breast cancer accounts for 23% of all cancer deaths. It is the most frequent cancer death in developing countries of the world. Mammary skin changed in breast carcinoma is categorized as advance stage in breast cancer classification. In the present study we evaluated the correlation of macroscopic, microscopic and no skin changes with axillary lymph node using histologic factor dermal lymphatic involvement. Materials and methods: prospective study was conducted on 42 breast cancer admitted patients of different age groups. Based on degree of skin involvement patients were placed into four groups, i.e. clinical stageT1 toT4. All groups were compared on the basis of percentage of patients involvement according to T1, T2, T3 and T4 stage, tumor size, histopathological dermis and epidermis involvement, dermal lymphatic invasion, tumor size and tumor subtype. Results: Majority of the patients with skin (dermis and epidermis) infiltration by the tumor (94.4%) were of T4 stage (along with dermal lymphatic invasion). Majority of the patients with only dermal lymphatic involvement (87.5%) without dermis and epidermis infiltration were of T2 stage. Conclusion: In our study, most of the patients of stage T2 and T3 with dermal lymphatic invasion had involved node when studied by routine histologic technique even though they were not clinically palpable. The identification of characteristics of the primary tumor like dermal lymphatic invasion that are associated with nodal metastases should encourage the surgeon to perform a more extensive axillary lymph node dissection and the pathologist to use methods of examining the nodes that increase the likelihood of finding metastatic disease. From this we can conclude that patients in early stage breast cancer may also have metastatic axillary lymph nodes. Dermal lymphatic invasion may be regarded as the precursor of nodal involvement, and all patients with nodal involvement can be assumed to have lymphatic invasion in the primary tumors. However the converse may not be true, not all patients with lymphatic invasion have nodal involvement.
Dr. Stephanie Blank and Dr. Melissa Frey update us on the latest developments in ovarian cancer research and treatment from the annual conference of the Society of Gynecologic Oncology. Dr. Blank is a gynecologic oncologist at Perlmutter Cancer Center at NYU Langone Medical Center and an associate professor at NYU School of Medicine. Dr. Frey is a Gynecological Oncology Fellow at NYU Langone Medical Center.
Impact of Multidisciplinary Discussion on Treatment Outcome For Gynecologic C...Emad Shash
Tumor conferences are multidisciplinary meetings at which the
management of cancer patients is discussed. They have been
an integral part of oncology services and are regarded
as an essential component of quality control and continuing
medical education. There are data to suggest that the tumor conference enhances patient care. Many studies of effectiveness have been conducted. Reported benefits include improved patient management and treatment. In this presentation, I'll try to assess the role of the multidisciplinary tumor conference in patient management in gynecologic oncology services.
A protocol for the management of breast cancer developed by the multidisciplinary oncology team at University of Nigeria Teaching Hospital, fully adapted to our environment
Dr. Maurie Markman, President of Science and Medicine at Cancer Treatment Centers of America, shares his expertise on the latest developments in immunotherapy for ovarian cancer.
Twenty five year follow up for breast cancer incidence 12-feb2014Miguel Pizzanelli
Twenty five year follow-up for breast cancer incidence
and mortality of the Canadian National Breast
Screening Study: randomised screening trial
OPEN ACCESS
Anthony B Miller professor emeritus, Claus Wall data manager, Cornelia J Baines professor
emerita, Ping Sun statistician , Teresa To senior scientist , Steven A Narod professor Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada; 2Women’s College Research Institute, Women’s College Hospital, Toronto, Ontario M5G 1N8, Canada; 3Child Health Evaluative Services, The Hospital for Sick Children, Toronto, Ontario, Canada
Survival Analysis of Determinants of Breast Cancer Patients at Hossana Queen ...Premier Publishers
Breast cancer is one of the most severe diseases in the world and become the public’s ever day’s agenda in both developed and developing countries. The primary goal of this study was to identify the determinants of survival time of breast cancer patients at Hossana hospital, south Ethiopia. Kaplan-Meier estimation method and a new two-parameter probability distribution called hypertabastic are introduced to model the survival time of the data. A simulation study was carried out to evaluate the performance of the hypertabastic distribution in comparison with popular distribution with the help of R and SAS statistical software Packages. One-fourth (25%) of the total patients survived for only 2 days. 31(35.2%) were censored, and 55(62.5%) were died. Hypertabastic survival model was found to be best fitting to the breast cancer data and age, level of education, family history, breast problem before, High fat diet, child late age, early menarche, late menopause were significant risk factors for the death of breast cancer patients. Awareness has to be given for the society on causes of breast cancer and screening test and early detection policies for most risky groups has to be established.
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post...Enrique Moreno Gonzalez
Post-surgery therapies are given to early-stage breast cancer patients due to the possibility of residual micrometastasis, and optimized by clincopathological parameters such as tumor stage, and hormone receptor/lymph node status. However, current efficacy of post-surgery therapies is unsatisfactory, and may be varied according to unidentified patient genetic factors. Increases of breast cancer occurrence and recurrence have been associated with dyslipidemia, which can attribute to other known risk factors of breast cancer including obesity, diabetes and metabolic syndrome. Thus we reasoned that dyslipidemia-associated nucleotide polymorphisms (SNPs) on the APOA1/C3/A5 gene cluster may predict breast cancer risk and tumor progression.
Original StudyType of Breast Cancer Diagnosis, Screening,a.docxvannagoforth
Original Study
Type of Breast Cancer Diagnosis, Screening,
and Survival
Carla Cedolini,1 Serena Bertozzi,1 Ambrogio P. Londero,2 Sergio Bernardi,3,4
Luca Seriau,1 Serena Concina,1 Federico Cattin,1 Andrea Risaliti1
Abstract
Organized, invitational breast cancer screening in our population succeeded in detecting early-stage tumors,
which have been consequently treated more frequently with breast and axillary conservative surgery, com-
plementary breast irradiation, and eventual hormonal therapy. The diagnosis of invasive cancer with screening
in our population resulted in a survival gain at 5 years from the diagnosis.
Introduction: Breast cancer screening is known to reduce mortality. In the present study, we analyzed the prevalence
of breast cancers detected through screening, before and after introduction of an organized screening, and we
evaluated the overall survival of these patients in comparison with women with an extrascreening imaging-detected
breast cancer or those with palpable breast cancers. Materials and Methods: We collected data about all women
who underwent a breast operation for cancer in our department between 2001 and 2008, focusing on type of tumor
diagnosis, tumor characteristics, therapies administered, and patient outcome in terms of overall survival, and re-
currences. Data was analyzed by R (version 2.15.2), and P < .05 was considered significant. Results: Among the 2070
cases of invasive breast cancer we considered, 157 were detected by regional mammographic screening (group A),
843 by extrascreening breast imaging (group B: 507 by mammography and 336 by ultrasound), and 1070 by extra-
screening breast objective examination (group C). The 5-year overall survival in groups A, B, and C were, respectively,
99% (95% CI, 98%-100%), 98% (95% CI, 97%-99%), and 91% (95% CI, 90%-93%), with a significant difference
between the first 2 groups and the third (P < .05) and a trend between groups A and B (P ¼ .081). Conclusion: The
diagnosis of invasive breast cancer with screening in our population resulted in a survival gain at 5 years from the
diagnosis, but a longer follow-up is necessary to confirm this data.
Clinical Breast Cancer, Vol. 14, No. 4, 235-40 ª 2014 Elsevier Inc. All rights reserved.
Keywords: Breast cancer, Breast cancer screening, Invasive breast cancer, Mammographic screening, Overall survival
Introduction
Because of the detection of early-stage tumors, breast cancer
screening reduced breast cancer mortality in Europe by 25%-31%
in patients who were invited for screening and by 38%-48% in
those who were actually screened during the last decade of the
twentieth century and the first decade of the twenty-first.1 In our
region of Italy, an organized breast cancer screening was firstly intro-
duced in 2005, but despite the high compliance of invited women
1Clinic of Surgery
2Clinic of Obstetrics and Gynecology
University of Udine, Udine, Italy
3Department of Surgery, Ospedale Civile di Latisana, Udine, Italy
4 ...
A protocol for the management of breast cancer developed by the multidisciplinary oncology team at University of Nigeria Teaching Hospital, fully adapted to our environment
Dr. Maurie Markman, President of Science and Medicine at Cancer Treatment Centers of America, shares his expertise on the latest developments in immunotherapy for ovarian cancer.
Twenty five year follow up for breast cancer incidence 12-feb2014Miguel Pizzanelli
Twenty five year follow-up for breast cancer incidence
and mortality of the Canadian National Breast
Screening Study: randomised screening trial
OPEN ACCESS
Anthony B Miller professor emeritus, Claus Wall data manager, Cornelia J Baines professor
emerita, Ping Sun statistician , Teresa To senior scientist , Steven A Narod professor Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada; 2Women’s College Research Institute, Women’s College Hospital, Toronto, Ontario M5G 1N8, Canada; 3Child Health Evaluative Services, The Hospital for Sick Children, Toronto, Ontario, Canada
Survival Analysis of Determinants of Breast Cancer Patients at Hossana Queen ...Premier Publishers
Breast cancer is one of the most severe diseases in the world and become the public’s ever day’s agenda in both developed and developing countries. The primary goal of this study was to identify the determinants of survival time of breast cancer patients at Hossana hospital, south Ethiopia. Kaplan-Meier estimation method and a new two-parameter probability distribution called hypertabastic are introduced to model the survival time of the data. A simulation study was carried out to evaluate the performance of the hypertabastic distribution in comparison with popular distribution with the help of R and SAS statistical software Packages. One-fourth (25%) of the total patients survived for only 2 days. 31(35.2%) were censored, and 55(62.5%) were died. Hypertabastic survival model was found to be best fitting to the breast cancer data and age, level of education, family history, breast problem before, High fat diet, child late age, early menarche, late menopause were significant risk factors for the death of breast cancer patients. Awareness has to be given for the society on causes of breast cancer and screening test and early detection policies for most risky groups has to be established.
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post...Enrique Moreno Gonzalez
Post-surgery therapies are given to early-stage breast cancer patients due to the possibility of residual micrometastasis, and optimized by clincopathological parameters such as tumor stage, and hormone receptor/lymph node status. However, current efficacy of post-surgery therapies is unsatisfactory, and may be varied according to unidentified patient genetic factors. Increases of breast cancer occurrence and recurrence have been associated with dyslipidemia, which can attribute to other known risk factors of breast cancer including obesity, diabetes and metabolic syndrome. Thus we reasoned that dyslipidemia-associated nucleotide polymorphisms (SNPs) on the APOA1/C3/A5 gene cluster may predict breast cancer risk and tumor progression.
Original StudyType of Breast Cancer Diagnosis, Screening,a.docxvannagoforth
Original Study
Type of Breast Cancer Diagnosis, Screening,
and Survival
Carla Cedolini,1 Serena Bertozzi,1 Ambrogio P. Londero,2 Sergio Bernardi,3,4
Luca Seriau,1 Serena Concina,1 Federico Cattin,1 Andrea Risaliti1
Abstract
Organized, invitational breast cancer screening in our population succeeded in detecting early-stage tumors,
which have been consequently treated more frequently with breast and axillary conservative surgery, com-
plementary breast irradiation, and eventual hormonal therapy. The diagnosis of invasive cancer with screening
in our population resulted in a survival gain at 5 years from the diagnosis.
Introduction: Breast cancer screening is known to reduce mortality. In the present study, we analyzed the prevalence
of breast cancers detected through screening, before and after introduction of an organized screening, and we
evaluated the overall survival of these patients in comparison with women with an extrascreening imaging-detected
breast cancer or those with palpable breast cancers. Materials and Methods: We collected data about all women
who underwent a breast operation for cancer in our department between 2001 and 2008, focusing on type of tumor
diagnosis, tumor characteristics, therapies administered, and patient outcome in terms of overall survival, and re-
currences. Data was analyzed by R (version 2.15.2), and P < .05 was considered significant. Results: Among the 2070
cases of invasive breast cancer we considered, 157 were detected by regional mammographic screening (group A),
843 by extrascreening breast imaging (group B: 507 by mammography and 336 by ultrasound), and 1070 by extra-
screening breast objective examination (group C). The 5-year overall survival in groups A, B, and C were, respectively,
99% (95% CI, 98%-100%), 98% (95% CI, 97%-99%), and 91% (95% CI, 90%-93%), with a significant difference
between the first 2 groups and the third (P < .05) and a trend between groups A and B (P ¼ .081). Conclusion: The
diagnosis of invasive breast cancer with screening in our population resulted in a survival gain at 5 years from the
diagnosis, but a longer follow-up is necessary to confirm this data.
Clinical Breast Cancer, Vol. 14, No. 4, 235-40 ª 2014 Elsevier Inc. All rights reserved.
Keywords: Breast cancer, Breast cancer screening, Invasive breast cancer, Mammographic screening, Overall survival
Introduction
Because of the detection of early-stage tumors, breast cancer
screening reduced breast cancer mortality in Europe by 25%-31%
in patients who were invited for screening and by 38%-48% in
those who were actually screened during the last decade of the
twentieth century and the first decade of the twenty-first.1 In our
region of Italy, an organized breast cancer screening was firstly intro-
duced in 2005, but despite the high compliance of invited women
1Clinic of Surgery
2Clinic of Obstetrics and Gynecology
University of Udine, Udine, Italy
3Department of Surgery, Ospedale Civile di Latisana, Udine, Italy
4 ...
A retrospective study on ovarian cancer with a median follow-up of 36 months ...AI Publications
Ovarian cancer is relatively common but serious and has a poor prognosis. The aim of this study is to highlight the epidemiological, diagnostic, therapeutic and evolutionary aspects of this malignant pathology managed at the Bejaia university hospital center. This is a retrospective and descriptive study over a period of 3 years (2019 - 2022) carried out on 20 patients who developed ovarian cancer. The average age of the patients was 50 years old, 53.23% of whom were over 45 years old. The CA-125 blood test was positive in 18 out of 20 patients. The tumors were discovered on ultrasound in 87.10% of cases and at laparotomy in 12.90%. Total hysterectomy with bilateral adnexectomy was the most performed procedure (64.52%). The early postoperative course was simple. 15 patients underwent second look surgery (16.13%) for locoregional recurrences. Epithelial tumors were the most frequent histological type (93.55%), including 79% in the advanced stage ( IIIc -IV) and 21% in the early stage (Ia- Ib ). Adjuvant chemotherapy was administered in 80% of patients. With a median follow-up of 36 months, 2 patients were lost to follow-up. The evolution was favorable in 27.42% and in 25.81% deaths occurred late postoperatively. Ovarian cancer is not common but serious given the advanced stages and the high rate of late postoperative deaths which were largely observed in patients deprived of adequate neoadjuvant or adjuvant chemotherapy.
Radiation-Induced Angiosarcoma of the Breast: Retrospective Analysis at a Reg...semualkaira
Radiation-induced angiosarcoma (RIA) of the breast is an uncommon but morbid complication after radiotherapy for breast cancer. This retrospective study analysed the treatment and outcome of breast RIA patients at Cambridge University Hospital (CUH), a regional treatment centre in the East of England.
Radiation-Induced Angiosarcoma of the Breast: Retrospective Analysis at a Reg...semualkaira
Radiation-induced angiosarcoma (RIA) of the breast is an uncommon but morbid complication after radiotherapy for breast cancer. This retrospective study analysed the treatment and outcome of breast RIA patients at Cambridge University Hospital (CUH), a regional treatment centre in the East of England.
Knowledge Discovery from Breast Cancer Databaseiosrjce
In this paper, we study various factors leading to breast cancer and also a few symptoms that act as
biomarkers for the occurrence of breast cancer in women. Totally 18 factors are taken for study. Statistical
techniques are used to analyze the influence of various factors towards the disease and test for significance of
factors is also done. Besides association rule mining is attempted to generate possible factors that may lead to
breast cancer. An attempt to classify the given dataset using information gain techniques and CHAID
techniques was done. Clustering was also done to predict the occurrence of breast cancer. The results show
that there is more possibility of developing breast cancer among married working women who have breast fed less than 2.5 years in total.
breast cancer
cancer
epidemiology
community medicine
awareness of breast cancer
سرطان الثدي
وبائيات سرطان الثدي
epidemiology of breast cancer
prevention of breast cancer
risk factors of breast cancer
epidemiology of breast cancer in iraq
sign and symptoms of breast cancer
location of breast cancer
Study on Histopathological Correlation with ER, PR, and HER 2 Neu Receptor Status in Breast Carcinoma and its Prognostic Importance
Mahendra Singh, Jagdish Kumar*, Anita Omhare, Vandana Mishra, Chayanika Kala
http://dx.doi.org/10.21276/SSR-IIJLS.2019.5.1.3
An Examination of Effectuation Dimension as Financing Practice of Small and M...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Does Goods and Services Tax (GST) Leads to Indian Economic Development?iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Childhood Factors that influence success in later lifeiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Emotional Intelligence and Work Performance Relationship: A Study on Sales Pe...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Customer’s Acceptance of Internet Banking in Dubaiiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study of Employee Satisfaction relating to Job Security & Working Hours amo...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Consumer Perspectives on Brand Preference: A Choice Based Model Approachiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Student`S Approach towards Social Network Sitesiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Broadcast Management in Nigeria: The systems approach as an imperativeiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study on Retailer’s Perception on Soya Products with Special Reference to T...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study Factors Influence on Organisation Citizenship Behaviour in Corporate ...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Consumers’ Behaviour on Sony Xperia: A Case Study on Bangladeshiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Design of a Balanced Scorecard on Nonprofit Organizations (Study on Yayasan P...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Public Sector Reforms and Outsourcing Services in Nigeria: An Empirical Evalu...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Media Innovations and its Impact on Brand awareness & Considerationiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Customer experience in supermarkets and hypermarkets – A comparative studyiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Social Media and Small Businesses: A Combinational Strategic Approach under t...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Secretarial Performance and the Gender Question (A Study of Selected Tertiary...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Implementation of Quality Management principles at Zimbabwe Open University (...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Organizational Conflicts Management In Selected Organizaions In Lagos State, ...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
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This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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A prospective study of breast lump andclinicopathologicalanalysis in relation to malignancy: A review of 100 cases
1. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 11 Ver. VIII (Nov. 2015), PP 127-132
www.iosrjournals.org
DOI: 10.9790/0853-14118127132 www.iosrjournals.org 127 | Page
A prospective study of breast lump andclinicopathologicalanalysis
in relation to malignancy: A review of 100 cases
Shameer Deen1
, Siddharth J. Singh1
, Rajkamal Kanojiya2
, Saroj Chabra3
,
S.C. Dutt4
1.
Post Graduate Resident, Dept. of General Surgery; 2.
Assistant Professor, Dept. of General Surgery; 3.
Associate
Professor, Dept. of General Surgery; 4.
Professor, Dept. of General Surgery Mahatma Gandhi Medical College
and Hospital Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, India
Abstract: Worldwide, breast cancer is the most frequently diagnosed life-threatening cancer in women and the
leading cause of cancer death among women. In India, it is the most prevalent cancer in females after cancer of
the cervix. The exact cause is uncertain, but is influenced and predisposed by various epidemiologic factors. The
average size of the tumor with which the patient presents to the clinician has decreased, due to various health
and screening programs but despite improvements in surgery, chemotherapy and radiotherapy but during the
past few decades the mortality rate has remained rather constant.
Objective: To evaluate the various types of breast lump, percentage of benign versus malignant lump, stages of
malignancy at time of presentation and understand the ecological, environmental and other patterns for breast
lump in the local population.
Patients and Duration: The prospective study was conducted by the Dept. of General Surgery, Mahatma
Gandhi Medical College and Hospital, Jaipur. We reviewed 100 patients who were admitted to the surgical
department suspected of having carcinoma breast from August 2014 to August 2015
Method: A total of 100 patients with a palpable breast lump of various sizes and characteristics were included
in the study. Patients were initially classified as per history, general and local examination and those who were
suspected of having malignancy on clinical grounds were further investigated by FNAC, Core Biopsy and/or
frozen section biopsy.Mean age of inclusion was 10 to 80 years
Results: 100 patients having breast lump were included in the present study. All cases underwent surgery for
resection of the lump. Out of 100 cases, 74 cases were benign and 26 were malignant with 24 positive for
estrogen and progesterone receptors. Incidence was highest in 20-29 year age group (30%), Lesions were most
commonly noted in the upper outer quadrant of the breast (45.94%), premenopausal women accounted for
65.95% (62) cases, 92% of cases did not present with any skin changes while 3% presented with ulceration,
Axillary nodal involvement was noted in 17% cases. Oral contraceptive use was noted in 17 patients. Surgical
management was considered the treatment of choice. 70% cases were managed by lumpectomy whereas
modified radical mastectomy was done in 22%. Post operatively complications developed in 19 patients, 7
patients developed wound infections, and 6 developed wound dehiscence and haemorrhage.Hormonal therapy
was administered to all 24 patients who were estrogen and progesterone receptor positive and local
radiotherapy was given to all 26 patients with malignant histopathology.
Conclusion: In this era of modern medicine, with increased awareness and early diagnosis, the incidence of
malignant breast disease has remarkably reduced. In our study, benign breast disease was the most commonly
identified disease. Understanding importance of diagnosis and triple assessment and planning for effective
management either surgical or conservative is the key to management. Malignant conditions must be
dynamically managed and robustly followed in terms of chemotherapy, radiotherapy and possibility of
recurrence.
Keywords: Breast Lump, Carcinoma, Fibroadenoma, FNAC.
I. Introduction:
Worldwide, breast cancer is the most frequently diagnosed life-threatening cancer in women. In less-
developed countries, it is the leading cause of cancer death in women. The general approach to evaluation of
breast cancer has become formalized as triple assessment: clinical examination, imaging (usually
mammography, ultrasonography, or both), and histopathological assessment. Increased public awareness and
improved screening have led to earlier diagnosis, at stages amenable to complete surgical resection and curative
therapies. Improvements in therapy and screening have led to improved survival rates for women diagnosed
with breast cancer.
Surgery and radiation therapy, along with adjuvant hormone or chemotherapy when indicated, are now
considered primary treatment for breast cancer. For many patients with low-risk early-stage breast cancer,
surgery with local radiation is curative. Adjuvant breast cancer therapies are designed to treat micrometastatic
2. A prospective study of breast lump andclinicopathologicalanalysis in relation to malignancy...
DOI: 10.9790/0853-14118127132 www.iosrjournals.org 128 | Page
disease or breast cancer cells that have escaped the breast and regional lymph nodes but do not yet have an
established identifiable metastasis.
Over the past 3 decades, extensive and advocate-driven breast cancer research has led to extraordinary
progress in the understanding of the disease. This has resulted in the development of more targeted and less
toxic treatments.
With early detection and significant advances in treatment, death rates from breast cancer have been
decreasing over the past 25 years in North America and parts of Europe. In many African and Asian countries
(eg, Uganda, South Korea, and India), however, breast cancer death rates are rising.[1]In India, the overall
incidence of breast cancer is less as compared to the US. But if you see the actual number of cases, India is not
far behind. In the year 2012, there were about 2,32,000 breast cancer cases reported in the US, whereas in India,
1,45,000 new cases were diagnosed. This implies that, though, because of India's population, the percentage of
total women affected seems less, the breast cancer burden in India has almost reached about 2/3rds of that of the
US and is steadily rising.For the year 2015-2016, there will be an estimated 1,55,000 new cases of breast cancer
and about 76000 women in India are expected to die of the disease. The gap only seems to be widening, which
means, we need to work aggressively on early detection.
Two of the most important prognostic factors in breast cancer detection are tumor size and axillary
lymph node status, the size of the tumor directly correlating with the probability of nodal metastasis i.e. patients
with large breast masses or higher clinical stage are more likely to have positive nodes. Node positive patients
experience relapses into distant organs. It is also noted that clinically palpable axillary lymph nodes may often
turn out to be negative for metastasiswhereas non palpable nodes may be positive for metastasis. Thus the
histopathological evaluation of axillary lymph node status is an important prognostic discriminator rather than
clinical assessment alone.
The study to follow tries to draw a relationship between tumor size, benign versus malignant,
metastasis and whether conservative breast therapy is possible.
II. Patients and Methods:
The study encompasses 100 cases presenting to the surgical outdoor or admitted in the surgical wards
from August 2014 to August 2015 of Mahatma Gandhi Medical College and Hospital, Jaipur.
Patients presented to the outpatient clinic with the clinical features suggestive of lump breast
underwent a detailed history taking procedure, general and local examination. Patients were then subjected to
routine blood investigations, Mammogram, Ultrasonography, FNAC and/or Core biopsy. After diagnosis,
definitive surgery was done followed by adjuvant treatment (chemotherapy, radiotherapy, hormone therapy or a
combination of these) based on histopathological report.
Fine needle aspiration cytology was done as an outdoor procedure using a 20cc syringe, 20/22 gauge
needles, clean glass slides and 95% alcohol for fixation.
Core Biopsy was done using a no. 12 size core biopsy needle and was placed in formalin and sent for
histopathological analysis.
Intraoperative frozen sections were done and histological reports acquired to assess the primary tumor
and lymph node metastases.
The patients were advised to come to follow-up after chemotherapy and/or radiotherapy as per the following
schedule:
1. Every 3 months for the 1st three years
2. Every 6 months for the next 2 years
3. Annually after 5 years
III. Results:
The present study was prospective and carried out in 100 patients having lump breast. All cases
underwent surgery for resection of the lump. Out of 100 cases, 74 cases were benign and 26 were malignant.
Distribution with respect to nature of lesion and age was determined. The details mentioned in the table below.
Table1: Age related distribution
Age Group Total Cases Benign Malignant
10-19 yrs
10
(10%)
10
(10%)
-
20-29 yrs
30
(30%)
30 (40.54%) 6 (23.07%)
30-39 yrs
18
(18%)
12
(16.21%)
06 (23.07%)
40-49 yrs
28
(28%)
20
(27.02%)
08
(30.76%)
3. A prospective study of breast lump andclinicopathologicalanalysis in relation to malignancy...
DOI: 10.9790/0853-14118127132 www.iosrjournals.org 129 | Page
50-59 yrs
08
(08%)
02
(2.70%)
06
(23.07)
60-69 yrs
06
(06%)
06
(06%)
70 and above - - -
Incidence was highest in 20-29 year age group (30%). Next in order of frequency was in 40-49 year
group with 28 cases (28%). Maximum number of benign cases was noted in 20-29 year age group, 30 cases
(30.54%), followed by 40-49 year age group with 20 cases (27.02%). Maximum number of malignancy was 8
cases (30.76%) in the 40-49 years age group with equal distribution of 6 cases in the age groups of 30-39, 50-59
and 60-69 respectively. All cases in the age group of 60-70 were malignantpositive for estrogen and
progesterone receptors.Data from SEER (Surveillance, Epidemiology and End Results) suggests that the
incidence of invasive breast cancer for women younger than 50 years is 44.0 per 100,000 as compared with 345
per 100,000 for women aged 50 years or older2, However in our region incidence of breast lump was highest in
the age group of 20-29 years.
Table 2: Sex distribution
Age Group Total Cases Male Female
10-19 yrs
10
(10%)
02 (33.33%) 08
(8.51%)
20-29 yrs
30
(30%)
02 (33.33%) 28
(29.78%)
30-39 yrs
18
(18%)
-
18
(19.14%)
40-49 yrs
28
(28%)
-
28
(29.78%)
50-59 yrs
08
(08%)
02 (33.33%) 08
(8.51%)
60-69 yrs
06
(06%)
04
(6.38%)
70 and above - - -
Total 100 06 94
4 male patients in the study were suffering from gynaecomastia and two patients suffered from duct
adenocarcinoma.
Table3: Distribution of cases according to side
Type of
Lesion
No. of
Cases
Side of lesion
Left Right Bilateral
Benign 74 26
(35.14%)
42
(56.76%)
06
(8.1%)
Malignant 26 14
(53.84%)
12
(46.15%)
-
Total 100 40
(40%)
54
(54%)
06
(06%)
Table 4: Distribution according to Quadrant
Quadrant Total Cases
Type of Lesion
Benign Malignant
UOQ
46
(46%)
34
(45.94%)
12
(46.12%)
LOQ
08
(08%)
06
(8.10%)
02
(7.69%)
LIQ
20
(20%)
16
(21.62%)
04
(15.38%)
UIQ
08
(08%)
06
(8.10%)
02
(7.69%)
Central
12
(12%)
08
(10.81%)
04
(15.38%)
Diffuse
06
(06%)
04
(5.40%)
02
(7.69%)
Total 100 74 26
UOQ: Upper outer quadrant, LOQ: Lower outer quadrant, LIQ: Lower inner quadrant, UIQ: Upper
inner quadrant.
Lesions were most commonly noted in the upper outer quadrant of the breast (45.94%) followed by
lower inner quadrant (21.62%), central retroareolar region (10.81%), upper inner and outer quadrant (8.1%)
4. A prospective study of breast lump andclinicopathologicalanalysis in relation to malignancy...
DOI: 10.9790/0853-14118127132 www.iosrjournals.org 130 | Page
each. There were 6 cases where breast were involved diffusely, diagnosed as gynaecomastia, giant
fibroadenoma and carcinoma respectively.
In terms of menstrual status, premenopausal women accounted for 65.95% (62)cases and 34.04% (32)
were postmenopausal. Family history was noted in only 1 patient. In relation to parity 69 women were parous
and 27 were nulliparous.
Late age at first pregnancy, nulliparity, early onset of menses, and late age of menopause have all been
consistently associated with an increased risk of breast cancer3,4,5,6,7.
Malignant cases presented with various clinical aspects as briefed below.
Table 5:Clinical Presentation
Clinical Presentation
No. of
Cases
Percentage
Lump Axilla 4 15.38%
Breast Pain 14 53.84%
Ulcer Breast 3 11.53%
Nipple Ulcer 1 3.84%
Nipple Retraction 2 7.69%
Nipple Discharge 2 7.69%
Total 26 100%
92% of cases did not present with any skin changes while 3% presented with ulceration.
Table6: Skin Changes
Clinical Presentation
No. of
Cases
Percentage
Ulcer 3 3%
Tethering 1 1%
PeauD’orange 2 2%
Eczema 0 -
Oedema 1 1%
Dimpling 1 1%
No skin changes 92 92%
Total 100
Clinically palpable breast lumps were classified as per size. 5 patients presented with a lump of size
less than 2 cm. 52 patients presented with a lump of size 2-5cms and 43 patients has a lump of size more than
5cms.
Lymph Node involvement was a critical aspect of the study and involvement was analysed, majority of
patients has nolymphadenopathy. Axillary nodal involvement was noted in 17% cases.
Table 7: Lymph Node Involvement
Lymphadenopathy
No. of
Cases
Percentage
Axillary 17 17%
Supraclavicular 5 5%
Cervical 3 3%
Internal Mammary 1 1%
No Lymphadenopathy 74 74%
Total 100 100%
In all cases pertaining to a malignancy, histopathological conformation was sought. Percentage
distribution of different type of lesion on cytology is briefed below.
Table8: Histopathological correlation of various clinical cases studied
Cytodiagnosis Total number of cases
Benign Lesions 72 (72%)
Fibroadenoma 34 (34%)
Fibrocystic disease / Benign
Cyctic Lesion
10 (10%)
Benign breast disease 18 (18%)
Inflammatory lesion 04 (4%)
Gynaecomastia 04 (4%)
Lactating adenoma -
Duct estasia -
5. A prospective study of breast lump andclinicopathologicalanalysis in relation to malignancy...
DOI: 10.9790/0853-14118127132 www.iosrjournals.org 131 | Page
Giant Fibroadenoma / Benign
Phyllodes
02 (2%)
Malignant 22 (22%)
Intraductal carcinoma 22 (22%)
Lobular carcinoma -
Suspicious Malignancy 02 (2%)
Unsatisfactory / Inconclusive 04 (4%)
Total 100
Oral contraceptive use was noted in 17 patients.Positive diagnostic mammogram was seen in 44
patients.One of the most widely studied factors in breast cancer aetiology is the use of exogenous hormones in
the form of oral contraceptives (OCs) and hormone replacement therapy (HRT)8,9.
Surgical management was considered the treatment of choice, 70% cases were managed by
lumpectomy whereas modified radical mastectomy was done in 22%.
Table 8: Surgical procedure performed
Procedure
No. of
Cases
Percentage
Microdochectomy 4 4%
Lumpectomy 70 70%
Simple Mastectomy 4 4%
Modified Radical
Mastectomy
22 22%
Total 100 100%
Post operatively complications developed in 19 patients, 7 patients developed wound infections, and 6
developed wound dehiscence and haemorrhage each.
Post-operative histopathological diagnosis was sought for correlation with cytology analysis. Out of the
72 cases being reported benign, histopathological and cytological correlation was achieved in 70 cases while
remaining 2 cases were proved malignant by histopathological analysis, which was later identified as ductal
carcinoma in situ. There was no false positive in malignant cases
Table 9: Histopathological results
Cytodiagnosis
No. of
Cases
Histopathological Diagnosis
Benign Malignant
Benign 72 70 02
Malignant 20 00 22
Suspicious of
Malignancy
02 - 02
Unatisfactory 06 04 -
Total 100 74 26
TP: True Positive, TN: False Positive, FP: False Positive, FN: False Negative
IV. Discussion:
The study reveals that benign breast disease presents in myriads of ways ranging from simple mastitis
to well defined lumps in the breast.
Breast lumps are one of the most common presentations in women, although a lot of research on
etiopathogenesis, diagnosis, prevention and management is being pursued, after the development of FNAC and
core biopsy the diagnosis has changed drastically thus the diagnosis is easy, quick, reliable and well in the
comfort of the patient.
From our present study, we noted that the highest number of cases was noted in the 20-29 year age
group, which were mostly benign whereas maximum malignant cases were identified in the 40-49 year age
group. Majority of the patients were not taking oral contraceptives and were parous in the premenopausal age
group. Family history of malignant breast disease was seen only in one patient and majority of patients had lump
in the right breast. Lesions were more common in the upper outer quadrant. Patients generally presented with
pain in the breast followed by development of lump in axilla and did not have any skin changes and size in lump
was less than 5cms. Axillary lymphadenopathy was noted in 17 patients. Fibroadenoma was the most commonly
diagnosed and histologically proved condition, followed by intraductal carcinoma. FNAC has 91.7% sensitivity
and 100% specificity. Majority of cases were managed by lumpectomy, malignant lesions were managed by
MRM with no major post-operative complications.
Benign breast diseases are the most confused areas of surgical disease and even in the modern era of
enormous and elaborate studies there is no definite conclusionin regard to the aetiology and its relation to the
development of subsequent breast carcinoma.Hussain et al.,10 and Khemka et al.,11 studied 50 patients and they
6. A prospective study of breast lump andclinicopathologicalanalysis in relation to malignancy...
DOI: 10.9790/0853-14118127132 www.iosrjournals.org 132 | Page
also found that the maximum number of patients were in the age group of 31-40 years. Khemka et
al.11 observed that benign lesions of breast were more commonly seen in younger age groups with maximum
number of patients found in the age group 30-34 years. Ganiat et al.,12 reported maximum number of patients
with malignant lesions in the fourth to seventh decade of life.
V. Conclusion:
In this era of modern medicine, with increased awareness and early diagnosis, the incidence of
malignant breast disease has remarkably reduced. In our study, benign breast disease was the most commonly
identified disease. Understanding importance of diagnosis and triple assessment and planning for effective
management either surgical or conservative is the key to management. Malignant conditions must be
dynamically managed and robustly followed in terms of chemotherapy, radiotherapy and possibility of
recurrence.
References:
[1]. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar.
65(2):87-108.
[2]. Surveillance Epidemiology and End Results (SEER). SEER Stat Fact Sheets: Breast. Available at http://seer.cancer.gov
/statfacts/html/breast.html#incidence-mortality. Accessed: September12, 2015.
[3]. Kelsey JL, Bernstein L. Epidemiology and prevention of breast cancer. Annu Rev Public Health. 1996. 17:47-67. [Medline].
[4]. Colditz GA, Rosner B. Cumulative risk of breast cancer to age 70 years according to risk factor status: data from the Nurses' Health
Study. Am J Epidemiol. 2000 Nov 15. 152(10):950-64. [Medline].
[5]. Deligeoroglou E, Michailidis E, Creatsas G. Oral contraceptives and reproductive system cancer. Ann N Y Acad Sci. 2003 Nov.
997:199-208. [Medline].
[6]. Colditz GA, Rosner BA, Chen WY, Holmes MD, Hankinson SE. Risk factors for breast cancer according to estrogen and
progesterone receptor status. J Natl Cancer Inst. 2004 Feb 4. 96(3):218-28. [Medline].
[7]. Pike MC, Pearce CL, Peters R, Cozen W, Wan P, Wu AH. Hormonal factors and the risk of invasive ovarian cancer: a population-
based case-control study. FertilSteril. 2004 Jul. 82(1):186-95.
[8]. Marchbanks PA, McDonald JA, Wilson HG, Folger SG, Mandel MG, Daling JR, et al. Oral contraceptives and the risk of breast
cancer. N Engl J Med. 2002 Jun 27. 346(26):2025-32. [Medline].
[9]. Garbe E, Levesque L, Suissa S. Variability of breast cancer risk in observational studies of hormone replacement therapy: a meta-
regression analysis. Maturitas. 2004 Mar 15. 47(3):175-83
[10]. Hussain MT. Comparison of fine needle aspiration cytology with excision biopsy of breast lump. J Coll Physicians Surg Pak
2005;15:211-4
[11]. Khemkha A, Chakrabarti N, Shah S, Patel V. Palpable breast lumps: Fine needle aspiration cytology versus histopathology: A
correlation of diagnostic accuracy. Internet J Surg 2009;18:
[12]. Ganiat O, Omoniyi-Esan G, Osasan S, Titiloye N, Olasode B. Cytopathological review of breast lesions in Ile-Ife Nigeria. The
Internet J. of Third World Med.2008;8:10-25