SlideShare a Scribd company logo
Jing Fang
Department of Dermatology
Affiliated Hospital of Nantong University
Definition
It is an inflammatory reaction of the skin ,
caused by direct contact with certain external
substances.
Irritant contact dermatitis (ICD)
--- primary irritation
Allergic contact dermatitis(ACD)
--- hypersensitivity reaction
•9
Etiology and Pathogenesis
Irritant contact dermatitis
•strong irritants •weak irritants
•12
•Examples of common skin irritants and their sources
Irritant Examples of Common Sources
Acids Organic acids(eg,chromic,formic,hydrochloric,hydrofluoric)
Alcohols Antiseptics,waterless and cleansers
Alkalis Organic alkalis(eg,calcium oxide and potassium)
Body fluids Urine, feses,saliva
Concrete Wet cement
Detergents Hand soap,shampoo,dish detergents
Fiberglass Insulation
Food Friut acids,meat enzymes,proteins,vinegar
Metal salts Metal working,pulp,steel and paper manufacturing
Physical agents Temperature extremes,friction,humidity
Plastic resins Unpolymerized monomers in plastic industries
Solvents Turpentine,gasoline,kerosene,benzene
•10
Clinical Manifestation
• erythema,swelling,blister,scale
• erosion , exudation
• pruritus,pain,burning
•13
Diagnosis
• History
• Clinical Manifestation
• Laboratory Findings
Allergic Contact Dermatitis is an
inflammatory response of the skin to
allergenic substances.
These external agents can affect the skin by
direct contact, or by airborne contamination.
plant
cosmetic
drugs
pesticide
metals (nickel)
industrial materials and products
ACD arises as a result of two essential
stages – a sensitization phase which
primes and sensitizes the immune
system for an allergic response, and
an elicitation phase in which this
response is triggered.
Contact allergens are essentially soluble haptens
(low in molecular weight) and, as such, have the
physico-chemical properties that allow them to
cross the stratum corneum of the skin.
The conjugate
formed is
recognized as
a foreign body
by the
Langerhans
cells (LC) in
the epidermis,
then internalize
the protein As the LC are transported to the lymph nodes, they become
differentiated and transform into dentric cells (DC), which act
to present the allergenic epitope to T lymphocytes. As a result,
these T cells divide and differentiate.
When the skin is again exposed to the antigen, the memory t-cells
in the skin recognize the antigen and produce cytokines (chemical
signals), which cause more T-cells to migrate from blood vessels.
This starts a complex immune cascade leading to skin inflammation,
itching, and the typical rash of contact dermatitis.
Type IV delayed hypersensitivity reaction involving
a cell-mediated allergic response.
Allergic contact dermatitis is characterized by spongiosis
and a superficial lymphohistiocytic infiltrate
,
• Plastic slippers
• incubation period
• widespread
• recurrent
• skin patch test positive
•20
Body site Common Sources
All locations Topical preparations, Personal care products
Face
Cosmetics, Personal care products, Hair products, Cell phones
eyeglasses,headsets
Eyelids Cosmetics, Eye drops, Jewelry
Hands Gloves, Hand soap, Tools
Neck,shoulders Jewelry,Hair products
Feet Shoes
Under clothing only
Clothing dye, Clothing finishes
In depth questioning is the
first step.
Distribution of the skin
lesions often gives a clue to
the nature of the allergen.
Acute
Subacute
Chronic
History
Clinical features
Laboratory examination
Patch test
It is intended to produce a local allergic reaction on a small area of the
patient's back, where the diluted chemicals were planted. The chemicals
in the patch test kit include metals (e.g., nickel), rubber, leather, lanolin,
fragrance, Cosmetics, hair dyes, medicine, and other additives.
Application of the patch tests will take about half an hour. Tiny quantities
of materials (allergens) in individual square plastic or round aluminium
chambers are applied to the upper back. kept in place with special
hypoallergenic adhesive tape. They must stay in place undisturbed for at
least 48 hours.
48 hours later, the patches are removed. Use the marker to identify the
test sites, and a preliminary reading is done after 10 min.
Usually 24–48 hours later (72–96 hours after application), in some cases,
a reading at 7 days may be requested, especially if a special metal series is
tested.
The readings are scored according
to the reaction seen.
Interpretation of patch tests
Clinical findings Grading
Negative Normal skin 0
Irritant reaction
miliaria (sweat rash), follicular
pustules, and burn-like reactions
IR
Equivocal / uncertain Minimal erythema 1+
Weak positive
slightly elevated pink or red plaques,
usually with mild vesiculation
2+
Strong positive papulovesicles 3+
Extreme reaction
spreading redness, severe itching, and
blistersor ulcers
4+
0 1+ 2+ 3+ 4+
• Avoidance of the irritants and allergen
• Antihistamine drugs
• Corticosteroid
• Repair of the normal barrier
9 Eczematous Dermatitis--CD.pptx awesome

More Related Content

Similar to 9 Eczematous Dermatitis--CD.pptx awesome

ECZEMA.ppt
ECZEMA.pptECZEMA.ppt
ECZEMA.ppt
DrSachinPandey2
 
7 Dermatitis.pptx
7 Dermatitis.pptx7 Dermatitis.pptx
7 Dermatitis.pptx
EstibelMengist
 
CASE PRESENTATION derma2 pptx.pptx
CASE PRESENTATION derma2 pptx.pptxCASE PRESENTATION derma2 pptx.pptx
CASE PRESENTATION derma2 pptx.pptx
NaveenaPatel1
 
Eczema/ Dermatitis
Eczema/ DermatitisEczema/ Dermatitis
Eczema/ Dermatitis
Satish Rathod
 
Seminar hand eczema
Seminar  hand eczemaSeminar  hand eczema
Seminar hand eczema
Dr Daulatram Dhaked
 
Dermatology
DermatologyDermatology
Dermatology
sunayna sharma
 
specific allergens
specific allergensspecific allergens
specific allergens
dr maria saeed
 
Contact dermatitis
Contact dermatitisContact dermatitis
Allergic and irritant contact dermatitis
Allergic and irritant contact dermatitis Allergic and irritant contact dermatitis
Allergic and irritant contact dermatitis
Dr Daulatram Dhaked
 
Household substance toxic to pets
Household substance toxic to petsHousehold substance toxic to pets
Household substance toxic to petssuniu
 
18Occupational Skin diseases and management, Dr. Dincy peter
18Occupational Skin diseases and management, Dr. Dincy peter18Occupational Skin diseases and management, Dr. Dincy peter
18Occupational Skin diseases and management, Dr. Dincy peter
ohscmcvellore
 
minor skin ailments.pptx
minor skin ailments.pptxminor skin ailments.pptx
minor skin ailments.pptx
Monika Puri
 
Irritant contact dermatitis by dr maria saeed
Irritant contact dermatitis by dr maria saeedIrritant contact dermatitis by dr maria saeed
Irritant contact dermatitis by dr maria saeed
dr maria saeed
 
Hydrofluoric Acid #2
Hydrofluoric Acid #2Hydrofluoric Acid #2
Hydrofluoric Acid #2Delphine Goh
 
Haz Chem Handling 27.12.15
Haz Chem Handling 27.12.15Haz Chem Handling 27.12.15
Haz Chem Handling 27.12.15Suman Sarkar
 
Notifiable Diseases.pptx
Notifiable Diseases.pptxNotifiable Diseases.pptx
Notifiable Diseases.pptx
AdarshChourasiya2
 
ECZEMA. .
ECZEMA.                                 .ECZEMA.                                 .
ECZEMA. .
AFFIFA HUSSAIN
 
Integumentary System for midwife.pptx
Integumentary System for midwife.pptxIntegumentary System for midwife.pptx
Integumentary System for midwife.pptx
Wubshet Estifanos
 

Similar to 9 Eczematous Dermatitis--CD.pptx awesome (20)

ECZEMA.ppt
ECZEMA.pptECZEMA.ppt
ECZEMA.ppt
 
7 Dermatitis.pptx
7 Dermatitis.pptx7 Dermatitis.pptx
7 Dermatitis.pptx
 
CASE PRESENTATION derma2 pptx.pptx
CASE PRESENTATION derma2 pptx.pptxCASE PRESENTATION derma2 pptx.pptx
CASE PRESENTATION derma2 pptx.pptx
 
Eczema/ Dermatitis
Eczema/ DermatitisEczema/ Dermatitis
Eczema/ Dermatitis
 
Seminar hand eczema
Seminar  hand eczemaSeminar  hand eczema
Seminar hand eczema
 
Eczema Rangeen
Eczema RangeenEczema Rangeen
Eczema Rangeen
 
Dermatology
DermatologyDermatology
Dermatology
 
specific allergens
specific allergensspecific allergens
specific allergens
 
Contact dermatitis
Contact dermatitisContact dermatitis
Contact dermatitis
 
Allergic and irritant contact dermatitis
Allergic and irritant contact dermatitis Allergic and irritant contact dermatitis
Allergic and irritant contact dermatitis
 
Household substance toxic to pets
Household substance toxic to petsHousehold substance toxic to pets
Household substance toxic to pets
 
Plaq_Dipho_EN_2014_HD
Plaq_Dipho_EN_2014_HDPlaq_Dipho_EN_2014_HD
Plaq_Dipho_EN_2014_HD
 
18Occupational Skin diseases and management, Dr. Dincy peter
18Occupational Skin diseases and management, Dr. Dincy peter18Occupational Skin diseases and management, Dr. Dincy peter
18Occupational Skin diseases and management, Dr. Dincy peter
 
minor skin ailments.pptx
minor skin ailments.pptxminor skin ailments.pptx
minor skin ailments.pptx
 
Irritant contact dermatitis by dr maria saeed
Irritant contact dermatitis by dr maria saeedIrritant contact dermatitis by dr maria saeed
Irritant contact dermatitis by dr maria saeed
 
Hydrofluoric Acid #2
Hydrofluoric Acid #2Hydrofluoric Acid #2
Hydrofluoric Acid #2
 
Haz Chem Handling 27.12.15
Haz Chem Handling 27.12.15Haz Chem Handling 27.12.15
Haz Chem Handling 27.12.15
 
Notifiable Diseases.pptx
Notifiable Diseases.pptxNotifiable Diseases.pptx
Notifiable Diseases.pptx
 
ECZEMA. .
ECZEMA.                                 .ECZEMA.                                 .
ECZEMA. .
 
Integumentary System for midwife.pptx
Integumentary System for midwife.pptxIntegumentary System for midwife.pptx
Integumentary System for midwife.pptx
 

Recently uploaded

The Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official PublicationThe Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official Publication
Delapenabediema
 
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
EugeneSaldivar
 
Lapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdfLapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdf
Jean Carlos Nunes Paixão
 
Digital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and ResearchDigital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and Research
Vikramjit Singh
 
Synthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptxSynthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptx
Pavel ( NSTU)
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
Atul Kumar Singh
 
Palestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptxPalestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptx
RaedMohamed3
 
special B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdfspecial B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdf
Special education needs
 
How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17
Celine George
 
Overview on Edible Vaccine: Pros & Cons with Mechanism
Overview on Edible Vaccine: Pros & Cons with MechanismOverview on Edible Vaccine: Pros & Cons with Mechanism
Overview on Edible Vaccine: Pros & Cons with Mechanism
DeeptiGupta154
 
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXXPhrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
MIRIAMSALINAS13
 
Introduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp NetworkIntroduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp Network
TechSoup
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
Vivekanand Anglo Vedic Academy
 
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
Levi Shapiro
 
The Accursed House by Émile Gaboriau.pptx
The Accursed House by Émile Gaboriau.pptxThe Accursed House by Émile Gaboriau.pptx
The Accursed House by Émile Gaboriau.pptx
DhatriParmar
 
Embracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic ImperativeEmbracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic Imperative
Peter Windle
 
Chapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptxChapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptx
Mohd Adib Abd Muin, Senior Lecturer at Universiti Utara Malaysia
 
"Protectable subject matters, Protection in biotechnology, Protection of othe...
"Protectable subject matters, Protection in biotechnology, Protection of othe..."Protectable subject matters, Protection in biotechnology, Protection of othe...
"Protectable subject matters, Protection in biotechnology, Protection of othe...
SACHIN R KONDAGURI
 
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdf
Welcome to TechSoup   New Member Orientation and Q&A (May 2024).pdfWelcome to TechSoup   New Member Orientation and Q&A (May 2024).pdf
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdf
TechSoup
 
Model Attribute Check Company Auto Property
Model Attribute  Check Company Auto PropertyModel Attribute  Check Company Auto Property
Model Attribute Check Company Auto Property
Celine George
 

Recently uploaded (20)

The Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official PublicationThe Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official Publication
 
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
 
Lapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdfLapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdf
 
Digital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and ResearchDigital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and Research
 
Synthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptxSynthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptx
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
 
Palestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptxPalestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptx
 
special B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdfspecial B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdf
 
How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17
 
Overview on Edible Vaccine: Pros & Cons with Mechanism
Overview on Edible Vaccine: Pros & Cons with MechanismOverview on Edible Vaccine: Pros & Cons with Mechanism
Overview on Edible Vaccine: Pros & Cons with Mechanism
 
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXXPhrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
 
Introduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp NetworkIntroduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp Network
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
 
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
 
The Accursed House by Émile Gaboriau.pptx
The Accursed House by Émile Gaboriau.pptxThe Accursed House by Émile Gaboriau.pptx
The Accursed House by Émile Gaboriau.pptx
 
Embracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic ImperativeEmbracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic Imperative
 
Chapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptxChapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptx
 
"Protectable subject matters, Protection in biotechnology, Protection of othe...
"Protectable subject matters, Protection in biotechnology, Protection of othe..."Protectable subject matters, Protection in biotechnology, Protection of othe...
"Protectable subject matters, Protection in biotechnology, Protection of othe...
 
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdf
Welcome to TechSoup   New Member Orientation and Q&A (May 2024).pdfWelcome to TechSoup   New Member Orientation and Q&A (May 2024).pdf
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdf
 
Model Attribute Check Company Auto Property
Model Attribute  Check Company Auto PropertyModel Attribute  Check Company Auto Property
Model Attribute Check Company Auto Property
 

9 Eczematous Dermatitis--CD.pptx awesome

  • 1. Jing Fang Department of Dermatology Affiliated Hospital of Nantong University
  • 2. Definition It is an inflammatory reaction of the skin , caused by direct contact with certain external substances.
  • 3. Irritant contact dermatitis (ICD) --- primary irritation Allergic contact dermatitis(ACD) --- hypersensitivity reaction
  • 4.
  • 5. •9 Etiology and Pathogenesis Irritant contact dermatitis •strong irritants •weak irritants
  • 6. •12 •Examples of common skin irritants and their sources Irritant Examples of Common Sources Acids Organic acids(eg,chromic,formic,hydrochloric,hydrofluoric) Alcohols Antiseptics,waterless and cleansers Alkalis Organic alkalis(eg,calcium oxide and potassium) Body fluids Urine, feses,saliva Concrete Wet cement Detergents Hand soap,shampoo,dish detergents Fiberglass Insulation Food Friut acids,meat enzymes,proteins,vinegar Metal salts Metal working,pulp,steel and paper manufacturing Physical agents Temperature extremes,friction,humidity Plastic resins Unpolymerized monomers in plastic industries Solvents Turpentine,gasoline,kerosene,benzene
  • 7. •10 Clinical Manifestation • erythema,swelling,blister,scale • erosion , exudation • pruritus,pain,burning
  • 8. •13 Diagnosis • History • Clinical Manifestation • Laboratory Findings
  • 9.
  • 10. Allergic Contact Dermatitis is an inflammatory response of the skin to allergenic substances. These external agents can affect the skin by direct contact, or by airborne contamination.
  • 12. ACD arises as a result of two essential stages – a sensitization phase which primes and sensitizes the immune system for an allergic response, and an elicitation phase in which this response is triggered.
  • 13. Contact allergens are essentially soluble haptens (low in molecular weight) and, as such, have the physico-chemical properties that allow them to cross the stratum corneum of the skin. The conjugate formed is recognized as a foreign body by the Langerhans cells (LC) in the epidermis, then internalize the protein As the LC are transported to the lymph nodes, they become differentiated and transform into dentric cells (DC), which act to present the allergenic epitope to T lymphocytes. As a result, these T cells divide and differentiate. When the skin is again exposed to the antigen, the memory t-cells in the skin recognize the antigen and produce cytokines (chemical signals), which cause more T-cells to migrate from blood vessels. This starts a complex immune cascade leading to skin inflammation, itching, and the typical rash of contact dermatitis. Type IV delayed hypersensitivity reaction involving a cell-mediated allergic response.
  • 14. Allergic contact dermatitis is characterized by spongiosis and a superficial lymphohistiocytic infiltrate
  • 15.
  • 16. ,
  • 17.
  • 18.
  • 19.
  • 21. • incubation period • widespread • recurrent • skin patch test positive
  • 22. •20 Body site Common Sources All locations Topical preparations, Personal care products Face Cosmetics, Personal care products, Hair products, Cell phones eyeglasses,headsets Eyelids Cosmetics, Eye drops, Jewelry Hands Gloves, Hand soap, Tools Neck,shoulders Jewelry,Hair products Feet Shoes Under clothing only Clothing dye, Clothing finishes
  • 23. In depth questioning is the first step. Distribution of the skin lesions often gives a clue to the nature of the allergen.
  • 26. Patch test It is intended to produce a local allergic reaction on a small area of the patient's back, where the diluted chemicals were planted. The chemicals in the patch test kit include metals (e.g., nickel), rubber, leather, lanolin, fragrance, Cosmetics, hair dyes, medicine, and other additives.
  • 27. Application of the patch tests will take about half an hour. Tiny quantities of materials (allergens) in individual square plastic or round aluminium chambers are applied to the upper back. kept in place with special hypoallergenic adhesive tape. They must stay in place undisturbed for at least 48 hours.
  • 28. 48 hours later, the patches are removed. Use the marker to identify the test sites, and a preliminary reading is done after 10 min. Usually 24–48 hours later (72–96 hours after application), in some cases, a reading at 7 days may be requested, especially if a special metal series is tested.
  • 29. The readings are scored according to the reaction seen. Interpretation of patch tests Clinical findings Grading Negative Normal skin 0 Irritant reaction miliaria (sweat rash), follicular pustules, and burn-like reactions IR Equivocal / uncertain Minimal erythema 1+ Weak positive slightly elevated pink or red plaques, usually with mild vesiculation 2+ Strong positive papulovesicles 3+ Extreme reaction spreading redness, severe itching, and blistersor ulcers 4+
  • 30. 0 1+ 2+ 3+ 4+
  • 31. • Avoidance of the irritants and allergen • Antihistamine drugs • Corticosteroid • Repair of the normal barrier