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Moulin de Verville
95760 Valmondois
Tel. 00 33 (0)1 30 34 76 76
Fax. 00 33 (0)1 30 34 76 70
References
They are trusting us
www.prevor.com
• The aggressive chemicals
burn
CORROSIVE
Concentrated acids and bases Solvents, oils…
Specific danger if combined
with toxic risk
(example - Hydrofluoric acid)
SIGNIFICANT REACTIONS WEAK REACTIONS
IRRITANT
IRREVERSIBLE EFFECTS REVERSIBLE EFFECTS
• The mechanism of a chemical
burn
THE EXCHANGE
• The action of soda NaOH:
Healthy cells as
seen under
a microscope
Addition of soda
0.5N (2%)
Cells are completely
destroyed
Two categories of chemicals can
provoke a burn by a direct contact:
corrosives and irritants.
The seriousness of the chemical burn depends
on the number of cells destroyed and will be
more significant in the case of corrosives. In
some cases, the aggressive product can also
have toxic or harmful effects, the
consequences of which should not
be neglected.
A
chemical
b u r n i s
caused by the
capability of cor-
rosives and irritants to
create an exchange (ion,
proton, electron…) with the tissues of
the skin or the eye. The degree of the burn will
depend on the number of molecules destroyed and on the type
of modification (reversible or irreversible)
The chemical
©Création:LaurentMarchet-14/10/14
* **
* Picture source: ACTO, Prof. Norbert Schrage, Aachen.
AIR LIQUIDE - AKZO NOBEL - AOSTE - AP-HP - ARCELORMITTAL - ARJOWIGGINS
ARKEMA - ASTRAZENECA - BAYER - BONDUELLE - BRENNTAG - CARGILL - CEA
CEPHALON - CLARIANT - COCA COLA - CRISTAL UNION - DANONE - DASSAULT
DCNS - DOW - ECOLAB - EDF - ERAMET - FAREVA - GDF SUEZ - HOLCIM
HUNTSMAN - IBERDROLA - IMERYS - INTERNATIONAL PAPER - IPSEN - IRSN
ITALCEMENTI - LACTALIS - L'OREAL - NESTLE - PREZIOSO - QUARON - RIO TINTO
ROQUETTE - ROULLIER - SAFRAN - SAINT GOBAIN - SAIPOL - SANOFI - SERVIER
SIAAP - SIGMA ALDRICH - SNCF - SOLVAY - SUDZUCKER - TEREOS - TERRENA
THALES - TOTAL - VALEO - VALLOUREC ET MANNESMAN - VEOLIA - VINCI - YARA
YVES ROCHER…
To be effective regardless of the
type of accident and to avoid the
risk of error for the victim, it is necessary
to be able to stop these 6 aggressive reactions.• Basic •
• There are 6 types of aggressive chemical
reactions
To stop the evolution of the burn
• Factors influencing the penetration
• The length of exposure time
The principles
of emergency
washing
H+
OH-• Acid •
• Chelating •
• Oxidising •
TRANSFER
TRANSFER
A POLYVALENT PRODUCT IS ESSENTIAL
• The temperature
A PRODUCT ABLE TO STOP THE AGGRESSIVE
CHEMICAL IS ESSENTIAL
E-
E-
ACETONE
ETHANOL
• Reducing •
•Solvent•
• The type of product and
its concentration
To stop the aggressive reactions
Ca++
Chemical product
CONTACT
PENETRATION REACTION
BURN
A chemical burn is initiated by the contact between the aggressive product and the skin or the eye.
Following this contact, a part of the aggressive chemical will penetrate into the tissue and cause
destruction of the cells.
To effectively decontaminate the splash, it will be necessary, not only to decontaminate the product on
the surface, but also to control its penetration inside the tissue.
A N T I C I P A T E A N D S A V E
Toxicology Laboratory  Chemical Risk Management
In accordance with the Standard EN 15154 CE 0459
Find
solutions
Understand
chemical
products
WE HELP YOU TO FACE
CHEMICAL HAZARDS
MASTER
DIAGNOSE
ANALYZE
RISKS
DEEPEN
BURNS
TOXICITY
Advise
ACCOMPANY
UNIVERSITY TEACHING
TRAIN
REGULATION
HELP TO EVALUATE
SHARE
STANDARDISATION
TRANSFER
KNOWLEDGE
A N T I C I P A T E A N D S A V E
Toxicology Laboratory  Chemical Risk Management
People saving People
ENVIRONMENT
MANAGEMENT
ASSISTANCE
SAFETY
PROTECT
DECONTAMINATION
NEUTRALIZER/
ABSORBER
HEALTH
ANTICIPATE
SAVE
MAKE THE
COLLECTION EASIER
SIEW
LPM LMPE
- It is a liquid which enables it to obtain the same effect as water on the surface of the skin or eye.
- DIPHOTERINE® solution is an amphoteric chelating agent, which enables it to stop the aggressiveness of
the chemicals in a polyvalent way (for HF and its derivatives, use the HEXAFLUORINE® solution).
- DIPHOTERINE® solution mechanism can be illustrated as follows:
How to use
A sterile washing solution
Dispensers for the skin, in the form of micronised sprays (optimising the surface of contact)
DIPHOTERINE® solution?
To be used immediately after the accident
Dispensers for the eyes, equipped with an ergonomic eyecup, which assists the opening of the eye for a more
effective washing
• The principles of washing with DIPHOTERINE®
solution
ACIDBASE ACIDBASE ACIDBASE
- DIPHOTERINE® solution, unlike water, will stop the penetration of the chemical.
MICRO
DAP
DAP
 To decontaminate an entire body
 To decontaminate
a hand
Typical equipment for locations where
there are large quantities of chemicals :
- Production areas	
- Warehousing areas
- Off-loading and decanting areas
An ideal complement for a Wall
Mounted Eyewash, where the quantities
of chemicals are limited:
Laboratories
Ideal personal equipment for
small splashes:
Workshops
Maintenance personnel
 To decontaminate
a face or an arm
 To decontaminate an eye
 Personal equipment to
decontaminate an eye:
To carry on oneself or to put in the work
area:
- Laboratories
- Warehousing areas
Portable eyewash: when the equipment
must be mobile: first aid kits, emergency
vehicles, infirmaries
In areas where fixed equipments
are appropriate:
- Laboratories
- Production areas
- Warehouse areas
- Decanting areas Ideal for the maintenance
personnel
Imperatively worn
by individual
 Kit for chemical splashes
Protocol for the first aid intervention with
DIPHOTERINE®
solution in the event of a chemical splash
Go away from
the danger1/ Get undressed
2/ Wash as quickly as possible,
respecting the instructions for use
of DIPHOTERINE® solution
3/ Alert
4/ Seek medical
advice5/
…to DIPHOTERINE®
solution
DIPHOTERINE® solution will attract the
chemical in contact with the tissues.
The acid site of DIPHOTERINE® solution
will fix bases to make them harmless.
The basic site of DIPHOTERINE® solution
will fix acids to make them harmless.
Healthy cells as seen
under a microscope.
Beginning of the washing with
DIPHOTERINE® solution: the cells contract
slightly.
End of the washing:
the cells are preserved.
MINI
DAP
RESULTS
EXPERIENCE FEEDBACK:
Results on the skin in emergency
Independent retrospective study conducted by Dr Donaghue, chief medical
officer of Alcoa Australia (alumina refineries). It covers 180 cases studied
from May 1st 2005 to April 30th 2008, specifically on the skin.
• Assessment before washing with DIPHOTERINE® solution: grade IV burn on the Roper-Hall
scale, which usually requires a corneal graft to achieve healing.
• After a washing with 1 litre of DIPHOTERINE® solution within one hour after the splash
and 6 months of appropriate care, the victim regained a visual acuity of 14/20 without
requiring a corneal graft, a first in the history of medicine.
 Ammonia ocular burn, washed with DIPHOTERINE® solution after 1 hour
Sources : Gérard M, Merle H, Chiambaretta F, Rigal Rigal D, Schrage N. An amphoteric rince used in the emergency treatment of a serious
ocular burn. Burns 2002;7:670–3.
DIPHOTERINE® solution retains an interest in delayed washing for
a better healing
Criteria used:
1 : Time elapsed between the chemical splash and clinical evaluation.
2 : Time elapsed between the chemical splash and application of
DIPHOTERINE® solution.
3 : Percentage of skin surface affected by the chemical.
Severity scale
and associated signs
1 (no sign) 52,9% (73 cases) 21,4% (9 cases)
2 (erythema) 39,1% (54 cases) 54,8% (23 cases)
3 (blisters) 7,2% (10 cases) 19,0% (8 cases)
4 (more serious) 0,7% (1 case) 4,8% (2 cases)
TOTAL 100% (138 cases) 100% (42 cases)
FIRST AID EMERGENCY SOLUTION
Firstwashingwitha
DIPHOTERINE® DAP First washing with water
Washing must begin within the first
minute following the splash
ALL THESE PACKAGES MEET THE NEW EUROPEAN STANDARD EN 15154 PARTS 3 AND 4
Washing must begin within the first minute following the splash
Washing must begin within the first
10 seconds following the splash
• The principles of washing with water
- a washing of the surface to remove quickly the aggressive product
- the dilution of the chemical to reduce its aggressiveness
- a universal product avoids the risks of error at the time of the accident
First-aid treatment:
From water…
• What are its limitations?
- the concentrated products which penetrate very quickly
- the intervention time of 10 seconds which is not always achievable
- the washing comfort : risk of hypothermia under a water shower
difficulty to open the eye
Healthy cells as seen under
a microscope.
*
The beginning of washing:
water penetrates inside the
cells and makes them
expand.
*
The end of washing : cells are
destroyed because water causes
them to burst.
*
Ex vivo test on the eye
EXPERIENCE FEEDBACKS:
Result on the eye with
a delayed washing
Efficacy of the active washing with DIPHOTERINE®
solution:
Ex Vivo EVEIT Model - OCT
Sources : Burgher, Mathieu, Fosse, Rihawi, Gérard, Merle, Schrage, Ocular chemical burn : Experimental proof of the influence of key
parameters on the diffusion and the decontamination. 114th
Congress of the SFO Paris May 2008.
Rabbit corneas, 16 minutes after an
application of 500 µL 1M NaOH for 20 s.
a) without any washing
b) with DIPHOTERINE® solution
washing
Corrosive penetration is stopped.
The structural changes in the stroma are
negligible. The endothelium is completely
preserved.
a)
b)
The ideal product in case of a chemical splash must:
Retain the advantages of water:
- Fast washing of the surface
- Single protocol
DIPHOTERINE® solution is recognized as a reference solution by the SFO, French Society of Ophtalmology and the DOG, Deutsche Ophtalmologische Gesellschaft
Bring improvements to compensate
for the limitations of water:
- Guarantee a total efficacy whatever
the product
- Increase the intervention time
- Improve washing comfort to increase
the effectiveness
Supplied with
the holster
*photo : ACTO, Pr. Norbert Schrage, Aix la Chapelle
Wall mounted station
extreme cold
Wall mounted station
extreme cold

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Plaq_Dipho_EN_2014_HD

  • 1. Moulin de Verville 95760 Valmondois Tel. 00 33 (0)1 30 34 76 76 Fax. 00 33 (0)1 30 34 76 70 References They are trusting us www.prevor.com • The aggressive chemicals burn CORROSIVE Concentrated acids and bases Solvents, oils… Specific danger if combined with toxic risk (example - Hydrofluoric acid) SIGNIFICANT REACTIONS WEAK REACTIONS IRRITANT IRREVERSIBLE EFFECTS REVERSIBLE EFFECTS • The mechanism of a chemical burn THE EXCHANGE • The action of soda NaOH: Healthy cells as seen under a microscope Addition of soda 0.5N (2%) Cells are completely destroyed Two categories of chemicals can provoke a burn by a direct contact: corrosives and irritants. The seriousness of the chemical burn depends on the number of cells destroyed and will be more significant in the case of corrosives. In some cases, the aggressive product can also have toxic or harmful effects, the consequences of which should not be neglected. A chemical b u r n i s caused by the capability of cor- rosives and irritants to create an exchange (ion, proton, electron…) with the tissues of the skin or the eye. The degree of the burn will depend on the number of molecules destroyed and on the type of modification (reversible or irreversible) The chemical ©Création:LaurentMarchet-14/10/14 * ** * Picture source: ACTO, Prof. Norbert Schrage, Aachen. AIR LIQUIDE - AKZO NOBEL - AOSTE - AP-HP - ARCELORMITTAL - ARJOWIGGINS ARKEMA - ASTRAZENECA - BAYER - BONDUELLE - BRENNTAG - CARGILL - CEA CEPHALON - CLARIANT - COCA COLA - CRISTAL UNION - DANONE - DASSAULT DCNS - DOW - ECOLAB - EDF - ERAMET - FAREVA - GDF SUEZ - HOLCIM HUNTSMAN - IBERDROLA - IMERYS - INTERNATIONAL PAPER - IPSEN - IRSN ITALCEMENTI - LACTALIS - L'OREAL - NESTLE - PREZIOSO - QUARON - RIO TINTO ROQUETTE - ROULLIER - SAFRAN - SAINT GOBAIN - SAIPOL - SANOFI - SERVIER SIAAP - SIGMA ALDRICH - SNCF - SOLVAY - SUDZUCKER - TEREOS - TERRENA THALES - TOTAL - VALEO - VALLOUREC ET MANNESMAN - VEOLIA - VINCI - YARA YVES ROCHER… To be effective regardless of the type of accident and to avoid the risk of error for the victim, it is necessary to be able to stop these 6 aggressive reactions.• Basic • • There are 6 types of aggressive chemical reactions To stop the evolution of the burn • Factors influencing the penetration • The length of exposure time The principles of emergency washing H+ OH-• Acid • • Chelating • • Oxidising • TRANSFER TRANSFER A POLYVALENT PRODUCT IS ESSENTIAL • The temperature A PRODUCT ABLE TO STOP THE AGGRESSIVE CHEMICAL IS ESSENTIAL E- E- ACETONE ETHANOL • Reducing • •Solvent• • The type of product and its concentration To stop the aggressive reactions Ca++ Chemical product CONTACT PENETRATION REACTION BURN A chemical burn is initiated by the contact between the aggressive product and the skin or the eye. Following this contact, a part of the aggressive chemical will penetrate into the tissue and cause destruction of the cells. To effectively decontaminate the splash, it will be necessary, not only to decontaminate the product on the surface, but also to control its penetration inside the tissue. A N T I C I P A T E A N D S A V E Toxicology Laboratory Chemical Risk Management In accordance with the Standard EN 15154 CE 0459 Find solutions Understand chemical products WE HELP YOU TO FACE CHEMICAL HAZARDS MASTER DIAGNOSE ANALYZE RISKS DEEPEN BURNS TOXICITY Advise ACCOMPANY UNIVERSITY TEACHING TRAIN REGULATION HELP TO EVALUATE SHARE STANDARDISATION TRANSFER KNOWLEDGE A N T I C I P A T E A N D S A V E Toxicology Laboratory Chemical Risk Management People saving People ENVIRONMENT MANAGEMENT ASSISTANCE SAFETY PROTECT DECONTAMINATION NEUTRALIZER/ ABSORBER HEALTH ANTICIPATE SAVE MAKE THE COLLECTION EASIER
  • 2. SIEW LPM LMPE - It is a liquid which enables it to obtain the same effect as water on the surface of the skin or eye. - DIPHOTERINE® solution is an amphoteric chelating agent, which enables it to stop the aggressiveness of the chemicals in a polyvalent way (for HF and its derivatives, use the HEXAFLUORINE® solution). - DIPHOTERINE® solution mechanism can be illustrated as follows: How to use A sterile washing solution Dispensers for the skin, in the form of micronised sprays (optimising the surface of contact) DIPHOTERINE® solution? To be used immediately after the accident Dispensers for the eyes, equipped with an ergonomic eyecup, which assists the opening of the eye for a more effective washing • The principles of washing with DIPHOTERINE® solution ACIDBASE ACIDBASE ACIDBASE - DIPHOTERINE® solution, unlike water, will stop the penetration of the chemical. MICRO DAP DAP To decontaminate an entire body To decontaminate a hand Typical equipment for locations where there are large quantities of chemicals : - Production areas - Warehousing areas - Off-loading and decanting areas An ideal complement for a Wall Mounted Eyewash, where the quantities of chemicals are limited: Laboratories Ideal personal equipment for small splashes: Workshops Maintenance personnel To decontaminate a face or an arm To decontaminate an eye Personal equipment to decontaminate an eye: To carry on oneself or to put in the work area: - Laboratories - Warehousing areas Portable eyewash: when the equipment must be mobile: first aid kits, emergency vehicles, infirmaries In areas where fixed equipments are appropriate: - Laboratories - Production areas - Warehouse areas - Decanting areas Ideal for the maintenance personnel Imperatively worn by individual Kit for chemical splashes Protocol for the first aid intervention with DIPHOTERINE® solution in the event of a chemical splash Go away from the danger1/ Get undressed 2/ Wash as quickly as possible, respecting the instructions for use of DIPHOTERINE® solution 3/ Alert 4/ Seek medical advice5/ …to DIPHOTERINE® solution DIPHOTERINE® solution will attract the chemical in contact with the tissues. The acid site of DIPHOTERINE® solution will fix bases to make them harmless. The basic site of DIPHOTERINE® solution will fix acids to make them harmless. Healthy cells as seen under a microscope. Beginning of the washing with DIPHOTERINE® solution: the cells contract slightly. End of the washing: the cells are preserved. MINI DAP RESULTS EXPERIENCE FEEDBACK: Results on the skin in emergency Independent retrospective study conducted by Dr Donaghue, chief medical officer of Alcoa Australia (alumina refineries). It covers 180 cases studied from May 1st 2005 to April 30th 2008, specifically on the skin. • Assessment before washing with DIPHOTERINE® solution: grade IV burn on the Roper-Hall scale, which usually requires a corneal graft to achieve healing. • After a washing with 1 litre of DIPHOTERINE® solution within one hour after the splash and 6 months of appropriate care, the victim regained a visual acuity of 14/20 without requiring a corneal graft, a first in the history of medicine. Ammonia ocular burn, washed with DIPHOTERINE® solution after 1 hour Sources : Gérard M, Merle H, Chiambaretta F, Rigal Rigal D, Schrage N. An amphoteric rince used in the emergency treatment of a serious ocular burn. Burns 2002;7:670–3. DIPHOTERINE® solution retains an interest in delayed washing for a better healing Criteria used: 1 : Time elapsed between the chemical splash and clinical evaluation. 2 : Time elapsed between the chemical splash and application of DIPHOTERINE® solution. 3 : Percentage of skin surface affected by the chemical. Severity scale and associated signs 1 (no sign) 52,9% (73 cases) 21,4% (9 cases) 2 (erythema) 39,1% (54 cases) 54,8% (23 cases) 3 (blisters) 7,2% (10 cases) 19,0% (8 cases) 4 (more serious) 0,7% (1 case) 4,8% (2 cases) TOTAL 100% (138 cases) 100% (42 cases) FIRST AID EMERGENCY SOLUTION Firstwashingwitha DIPHOTERINE® DAP First washing with water Washing must begin within the first minute following the splash ALL THESE PACKAGES MEET THE NEW EUROPEAN STANDARD EN 15154 PARTS 3 AND 4 Washing must begin within the first minute following the splash Washing must begin within the first 10 seconds following the splash • The principles of washing with water - a washing of the surface to remove quickly the aggressive product - the dilution of the chemical to reduce its aggressiveness - a universal product avoids the risks of error at the time of the accident First-aid treatment: From water… • What are its limitations? - the concentrated products which penetrate very quickly - the intervention time of 10 seconds which is not always achievable - the washing comfort : risk of hypothermia under a water shower difficulty to open the eye Healthy cells as seen under a microscope. * The beginning of washing: water penetrates inside the cells and makes them expand. * The end of washing : cells are destroyed because water causes them to burst. * Ex vivo test on the eye EXPERIENCE FEEDBACKS: Result on the eye with a delayed washing Efficacy of the active washing with DIPHOTERINE® solution: Ex Vivo EVEIT Model - OCT Sources : Burgher, Mathieu, Fosse, Rihawi, Gérard, Merle, Schrage, Ocular chemical burn : Experimental proof of the influence of key parameters on the diffusion and the decontamination. 114th Congress of the SFO Paris May 2008. Rabbit corneas, 16 minutes after an application of 500 µL 1M NaOH for 20 s. a) without any washing b) with DIPHOTERINE® solution washing Corrosive penetration is stopped. The structural changes in the stroma are negligible. The endothelium is completely preserved. a) b) The ideal product in case of a chemical splash must: Retain the advantages of water: - Fast washing of the surface - Single protocol DIPHOTERINE® solution is recognized as a reference solution by the SFO, French Society of Ophtalmology and the DOG, Deutsche Ophtalmologische Gesellschaft Bring improvements to compensate for the limitations of water: - Guarantee a total efficacy whatever the product - Increase the intervention time - Improve washing comfort to increase the effectiveness Supplied with the holster *photo : ACTO, Pr. Norbert Schrage, Aix la Chapelle Wall mounted station extreme cold Wall mounted station extreme cold