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(Foundation Block 4)
Homeostasis I
By Ahmad Ahmeda
aahmeda@ksu.edu.sa
0536313454
1
Learning Objectives
• Define the components of a homeostatic system.
• Be able to recognize each of the components in
representative systems.
• Define negative feedback.
• Explain how homeostatic mechanisms regulated by
negative feedback detect and respond to
environmental changes.
• Define positive feedback.
• Describe the actions of a positive feedback loop.
2
Homeostasis
• Homeostasis is the ability to maintain a
relatively stable internal environment in
an ever-changing outside world.
• Is the tendency toward internal balance
• Chemical, thermal, and neural factors
interact to maintain homeostasis.
3
Concept of Homeostasis
• The internal environment of the body (ECF)
is in a dynamic state of equilibrium
• All different body systems operate in
harmony to provide homeostasis
• Extreme dysfunction leads to death;
moderate dysfunction leads to sickness.
4
Components of Homeostatic Systems
• The body maintains homeostasis by using
homeostatic control systems
– Three components associated with each system:
• receptor
• control center
• effector
Receptor
– The structure that detects changes in a variable,
the stimulus
• e.g., a change in temperature
– Consists of sensory nerves
5
Components of Homeostatic Systems
Control center
– The structure that interprets input from the
receptor
– Initiates changes through the effector
– A portion of the nervous system or an endocrine
organ
Effector
– The structure that brings about change to alter the
stimulus
– Most body structures
• e.g., muscles or glands
6
Maintenance of Homeostasis
• Nervous system
– Controls and coordinates bodily activities that
require rapid responses
– Detects and initiates reactions to changes in
external environment
– e.g., regulation of blood pressure upon rising
• Endocrine system
– Secreting glands of endocrine regulate activities
that require duration rather than speed
– e.g., parathyroid hormone regulating calcium
levels
7
Factors Homeostatically Regulated
• Concentration of nutrient molecules
• Concentration of water, salt, and other electrolytes
• Concentration of waste products
• Concentration of O2 = 100mmHg and CO2 = 40
mmHg
• pH = 7.35
• Blood volume 4-6 L and pressure 120/80
• Temperature = 37o C
8
• Response of a homeostatic system occurs through
a feedback loop:
– stimulus
– detection of stimulus by a receptor
– information relayed to the control center
– integration of the input by control center and
initiation of change through effectors
– return of homeostasis by the actions of effectors
9
Stimulus:
Produces
change
in variable
1
2
3
Change
detected
by receptor
Input:
Information
sent along
afferent
pathway to
5 Response of
effector feeds
back to influence
magnitude of
stimulus and
returns
variable to
homeostasis
Variable (in homeostasis)
Receptor (sensor)
Control
center 4 Output:
Information sent
along efferent
pathway to
Effector
Homeostatic
Control
Mechanisms
10
The Control of Room Temperature
11
Homeostatic Control Systems
• Feedback - refers to responses
made after change has been
detected
– Types of feedback systems
• Negative
• Positive
12
Feedback Loops: Types
• Negative feedback loop
– original stimulus reversed
– most feedback systems in the body are
negative
– used for conditions that need frequent
adjustment
• Positive feedback loop
– original stimulus intensified
– seen during normal childbirth
13
Homeostatic Systems Regulated by
Negative Feedback
• Negative feedback
– A type of homeostatic control system that maintains
the variable within a normal range
– Resulting action in the opposite direction of stimulus
– Controls most processes in the body
– Variable maintained within a normal level, its set point
• fluctuates around the set point
– If stimulus increases, homeostatic control system
activated to cause a decrease in the stimulus
– If stimulus decreases, homeostatic control system
activated to cause an increase in the stimulus
14
Temperature regulation
– Body temperature drops
– Sensory receptors detect this and signal the hypothalamus
(component of the brain)
– Hypothalamus alerts nerve impulses in blood vessels in the
skin to decrease the inside opening of the vessels
– This decreases amount of amount of blood circulating to the
surface of the body
– Less heat is released through skin
– Nerve impulses are sent to skeletal muscles, causing
shivering
– Nerve impulses are sent to smooth muscles of hair follicles,
causing “goosebumps”
Homeostatic Systems Regulated by
Negative Feedback
15
Temperature regulation (continued)
– Body temperature rises
– Sensory receptors detect this and signal the
hypothalamus
– Hypothalamus alerts nerve impulses in blood
vessels in the skin to increase the inside opening
of the vessels
– This increases the amount of blood circulating to
the body surface
– More heat is released through skin
17
Homeostatic Systems Regulated by
Negative Feedback
• Other examples of homeostatic regulation:
– withdrawal reflex in response to injury
– regulating heart rate and blood pressure during
exercise
– changing breathing rate in response to increased
carbon dioxide
– parathyroid hormone release in response to
decreased calcium
– release of insulin by the pancreas in response to
increased blood glucose
19
Homeostatic Systems Regulated by
Negative Feedback
Homeostatic Systems Regulated by
Positive Feedback
• Positive feedback during breastfeeding
– Sensory detectors detect baby suckling
– Message is transmitted to the hypothalamus
– Hypothalamus signals posterior pituitary to release the
hormone oxytocin
– Oxytocin stimulates the mammary gland to eject breast
milk
– Cycle repeats as long as the baby suckles
• Other examples of positive feedback:
– blood clotting cascade
– uterine contractions of labor
20
Positive Feedback during Childbirth
• Stretch receptors in walls of uterus send signals to
the brain
• Brain induces release of hormone (oxytocin) into
bloodstream
• Uterine smooth muscle contracts more forcefully
• More stretch, more hormone, more contraction etc.
• Cycle ends with birth of the baby & decrease in
stretch
22
Homeostasis of
Blood Pressure
• Baroreceptors in walls of
blood vessels detect an
increase in BP
• Brain receives input and
signals from blood vessels
and heart
• Blood vessels dilate, HR
decreases
• BP decreases
23
24

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4-Foundation Block Lecture 4 (Homeostasis I).ppt

  • 1. (Foundation Block 4) Homeostasis I By Ahmad Ahmeda aahmeda@ksu.edu.sa 0536313454 1
  • 2. Learning Objectives • Define the components of a homeostatic system. • Be able to recognize each of the components in representative systems. • Define negative feedback. • Explain how homeostatic mechanisms regulated by negative feedback detect and respond to environmental changes. • Define positive feedback. • Describe the actions of a positive feedback loop. 2
  • 3. Homeostasis • Homeostasis is the ability to maintain a relatively stable internal environment in an ever-changing outside world. • Is the tendency toward internal balance • Chemical, thermal, and neural factors interact to maintain homeostasis. 3
  • 4. Concept of Homeostasis • The internal environment of the body (ECF) is in a dynamic state of equilibrium • All different body systems operate in harmony to provide homeostasis • Extreme dysfunction leads to death; moderate dysfunction leads to sickness. 4
  • 5. Components of Homeostatic Systems • The body maintains homeostasis by using homeostatic control systems – Three components associated with each system: • receptor • control center • effector Receptor – The structure that detects changes in a variable, the stimulus • e.g., a change in temperature – Consists of sensory nerves 5
  • 6. Components of Homeostatic Systems Control center – The structure that interprets input from the receptor – Initiates changes through the effector – A portion of the nervous system or an endocrine organ Effector – The structure that brings about change to alter the stimulus – Most body structures • e.g., muscles or glands 6
  • 7. Maintenance of Homeostasis • Nervous system – Controls and coordinates bodily activities that require rapid responses – Detects and initiates reactions to changes in external environment – e.g., regulation of blood pressure upon rising • Endocrine system – Secreting glands of endocrine regulate activities that require duration rather than speed – e.g., parathyroid hormone regulating calcium levels 7
  • 8. Factors Homeostatically Regulated • Concentration of nutrient molecules • Concentration of water, salt, and other electrolytes • Concentration of waste products • Concentration of O2 = 100mmHg and CO2 = 40 mmHg • pH = 7.35 • Blood volume 4-6 L and pressure 120/80 • Temperature = 37o C 8
  • 9. • Response of a homeostatic system occurs through a feedback loop: – stimulus – detection of stimulus by a receptor – information relayed to the control center – integration of the input by control center and initiation of change through effectors – return of homeostasis by the actions of effectors 9
  • 10. Stimulus: Produces change in variable 1 2 3 Change detected by receptor Input: Information sent along afferent pathway to 5 Response of effector feeds back to influence magnitude of stimulus and returns variable to homeostasis Variable (in homeostasis) Receptor (sensor) Control center 4 Output: Information sent along efferent pathway to Effector Homeostatic Control Mechanisms 10
  • 11. The Control of Room Temperature 11
  • 12. Homeostatic Control Systems • Feedback - refers to responses made after change has been detected – Types of feedback systems • Negative • Positive 12
  • 13. Feedback Loops: Types • Negative feedback loop – original stimulus reversed – most feedback systems in the body are negative – used for conditions that need frequent adjustment • Positive feedback loop – original stimulus intensified – seen during normal childbirth 13
  • 14. Homeostatic Systems Regulated by Negative Feedback • Negative feedback – A type of homeostatic control system that maintains the variable within a normal range – Resulting action in the opposite direction of stimulus – Controls most processes in the body – Variable maintained within a normal level, its set point • fluctuates around the set point – If stimulus increases, homeostatic control system activated to cause a decrease in the stimulus – If stimulus decreases, homeostatic control system activated to cause an increase in the stimulus 14
  • 15. Temperature regulation – Body temperature drops – Sensory receptors detect this and signal the hypothalamus (component of the brain) – Hypothalamus alerts nerve impulses in blood vessels in the skin to decrease the inside opening of the vessels – This decreases amount of amount of blood circulating to the surface of the body – Less heat is released through skin – Nerve impulses are sent to skeletal muscles, causing shivering – Nerve impulses are sent to smooth muscles of hair follicles, causing “goosebumps” Homeostatic Systems Regulated by Negative Feedback 15
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  • 17. Temperature regulation (continued) – Body temperature rises – Sensory receptors detect this and signal the hypothalamus – Hypothalamus alerts nerve impulses in blood vessels in the skin to increase the inside opening of the vessels – This increases the amount of blood circulating to the body surface – More heat is released through skin 17 Homeostatic Systems Regulated by Negative Feedback
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  • 19. • Other examples of homeostatic regulation: – withdrawal reflex in response to injury – regulating heart rate and blood pressure during exercise – changing breathing rate in response to increased carbon dioxide – parathyroid hormone release in response to decreased calcium – release of insulin by the pancreas in response to increased blood glucose 19 Homeostatic Systems Regulated by Negative Feedback
  • 20. Homeostatic Systems Regulated by Positive Feedback • Positive feedback during breastfeeding – Sensory detectors detect baby suckling – Message is transmitted to the hypothalamus – Hypothalamus signals posterior pituitary to release the hormone oxytocin – Oxytocin stimulates the mammary gland to eject breast milk – Cycle repeats as long as the baby suckles • Other examples of positive feedback: – blood clotting cascade – uterine contractions of labor 20
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  • 22. Positive Feedback during Childbirth • Stretch receptors in walls of uterus send signals to the brain • Brain induces release of hormone (oxytocin) into bloodstream • Uterine smooth muscle contracts more forcefully • More stretch, more hormone, more contraction etc. • Cycle ends with birth of the baby & decrease in stretch 22
  • 23. Homeostasis of Blood Pressure • Baroreceptors in walls of blood vessels detect an increase in BP • Brain receives input and signals from blood vessels and heart • Blood vessels dilate, HR decreases • BP decreases 23
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