4-Dialkylaminopyridines were soon found to have general applicability for catalysis of a wide variety of reactions. 4-dimethylaminopyridine’s (DMAP) wide applicability has been frequently reviewed since the first review appeared in 1978. [3] The accelerating pace of reported applications for DMAP and the availability of DMAP in commercial quantities, at modest prices, have continued to stimulate great interest in its use as a catalyst in the fields of organic, polymer, analytical and biochemist

1. Description
4-Dialkylaminopyridines were soon found to have general applicability for catalysis of a wide
variety of reactions. 4-dimethylaminopyridine’s (DMAP) wide applicability has been frequently
reviewed since the first review appeared in 1978. [3] The accelerating pace of reported
applications for DMAP and the availability of DMAP in commercial quantities, at modest prices,
have continued to stimulate great interest in its use as a catalyst in the fields of organic, polymer,
analytical and biochemist
http://www.echemi.com/
Basic Attributes
CAS No：1122-58-3
Molecular Formula ：C7H10N2
Molecular Mass ：122.16800
Exact Mass ：122.08400
PSA ：16.13000
InChIKeys ：VHYFNPMBLIVWCW-UHFFFAOYSA-N
H-bond Acceptor ：2
H-bond Donor ：0
SP3 ：0.29
RBN ：1
Characteristics
Density ：1.012 g/cm3
Melting Point ：108-113ºC
Bolling Point ：162ºC (50 mmHg)
Flash Point ：110ºC
Refractive Index ：n20/D 1.431

2. Solubility ：76 g/L (25 ºC)
Storage Condition ：Store in dark
Vapor Pressure ：0.431mmHg at 25°C
Stability ：Stable. Incompatible with acids, oxidizing agents.
Safety Information
Packing Group ：II
Hazard Class ：8
HS Code ：2933399090
UN No. ：UN 1760/2811
WGK_Germany ：3
Risk Code ：R24/25; R34
Safety Instructions ：S26-S28-S36/37/39-S45
RTECS No. ：US8400000
Dangerous Mark ：T

3. P Code ： Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P305 + P351 +
P338-P361 + P364
Hazard Statements ：H301-H310-H315-H319-H335
Toxicity ：LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg
Product Usage
1. A highly efficient catalyst for acylation reactions.
2. 4-Dimethylaminopyridine is a versatile hypernucleophilic acylation catalyst, it is used to
improve the yield, reduce the reaction time, improving relaxation process conditions. Widely
used in perfumes, dyes, pigments, pesticides, pharmaceuticals and polymer compounds and
other fields. Also used as a catalyst for the synthesis of polyurethane, a curing agent and a
blowing catalyst.
3. DMAP is a useful highly basic nucleophilic catalyst for a variety of reactions such as
esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation, the
Steglich rearrangement.
4. A highly fluorescent adenosine analogue, which in a dimethoxytrityl, phosphoramidite
protected form, can be site-specifically inserted into oligonucleotides through a
3?5?phosphodiester linkage using an automated DNA synthesizer
Material and Products
Material ：Methanol Reagent, LITHIUMDIMETHYLAMIDE, 4-DIMETHYLAMINOPYRIDINEN-OXIDE,
3-Nitroaniline, N-(4-Pyridyl)pyridiniumchloridehydrochloride, Dimethylamine, guanidine,
4-Chloropyridiniumchloride, 1,2,4-Triazine, Dimethylamine hydrochloride, 2,4-Pentanedione,
4-chloropyridine, 4-Cyanopyridine, PHENYLSILANE, 4-Aminopyridine, N,N-Dimethylformamide,
4-Phenoxypyridine, 4-MethoxypyridineN-oxide, 4-Methoxypyridine,
2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE
Products ： Phthalic Anhydride, Paclitaxel, Formaldehyde, Piperidine, PHENYLSILANE,
N,N'-DICYCLOHEXYLUREA, 2,6-PYRIDINEDICARBOXAMIDE, Pyridinehydrochloride, Benzylether,
(S)-N-Boc-1-Naphthylalanine, 4,6-Dichloropyrimidine, 2-Amino-5-bromo-4,6-dimethylpyrimidine,
4-DIMETHYLAMINOPYRIDINEN-OXIDE, 2-Acetamido-5-nitropyridine, N-Phenylhydroxylamine,
Isoquinoline, 5-ACETOXYMETHYL-2-FURANCARBOXYLIC ACID, 2-Bromo-4-dimethylaminopyridine,
N,N-Dimethylpiperidin-4-amine, N-Methyl-4-pyridinamine