Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.

1. Chemical Naproxen Description
Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell
assay.
Chemical Naproxen Basic Attributes
CAS No：22204-53-1
Molecular Formula ：C14H14O3
Molecular Mass ：230.26
Exact Mass ：230.094299
PSA ：46.5 A^2
LogP ：3.3
EINECS ：244-838-7
InChIKeys ：CMWTZPSULFXXJA-VIFPVBQESA-N
H-bond Acceptor ：3
H-bond Donor ：1
SP3 ：0.21
RBN ：3

2. Chemical Naproxen Characteristics
Density ：1.2±0.1 g/cm3
Melting Point ：152-154 °C(lit.)
Bolling Point ：403.8°C at 760 mmHg
Flash Point ：9℃
Refractive Index ：1.609
Solubility ：Insoluble in water.
Storage Condition ：-20°C Freezer
Vapor Pressure ：1.89X10-6 mm Hg at 25 deg C (est)
BRN ：3591067
Specific Rotation ：D +66° (in chloroform)
Chemical Naproxen Safety Information
Packing Group ：III
Hazard Class ：6.1(b)
HS Code ：2918990090
UN No. ：UN 2811 6.1/PG 3
WGK_Germany ：3
Risk Code ：22-39/23/24/25-23/24/25-11-36/37/38
Safety Instructions ：36/37-45-16-7-26
RTECS No. ：UF5275000
Dangerous Mark ：Xn,T,F
Storage ： The warehouse is ventilated, low temperature and dry; stored and transported
separately from food materials

3. P Code ：P301 + P310
Hazard Statements ：H301
Flammability ：Flammable; burning produces toxic and spicy irritating smoke
Toxicity ：Oral-Rat LD50 248 mg/kg; Oral-Mouse LD50: 360 mg/kg
Toxicity Class ：highly
Chemical Naproxen Production Methods
Using 2-naphthol through methylation and acetylation to obtain 6-methoxy-2-naphthyl ethyl
ketone, then condensed with chloroacetate, and then subjected to isomerization, hydrolysis,
oxidation, neutralization, resolution and other reactions be made of.