Echemi Chemical D(-)-4-Hydroxyphenylglycine Description off-white powder Echemi Chemical D(-)-4-Hydroxyphenylglycine Basic Attributes CAS No：22818-40-2 Molecular Formula ：C8H9NO3 Molecular Mass ：167.16196 Exact Mass ：167.058243 PSA ：83.6 A^2 LogP ：-2.1 EINECS ：245-247-7 InChIKeys ：LJCWONGJFPCTTL-SSDOTTSWSA-N H-bond Acceptor ：4 H-bond Donor ：3 SP3 ：0.13 RBN ：2

1. CAS No:22818-40-2
Formula:C8H9NO3
China Export:From 2018.11 to 2019.11, total export volume of D(-)-4-Hydroxyphenylglycine from
China was 476,558,086KG while total export value was $672,910,582. The biggest proportion of
exporting volume in the last 12 months was 10.11% in 2018.11.
Echemi Chemical D(-)-4-Hydroxyphenylglycine Description
off-white powder
Echemi Chemical D(-)-4-Hydroxyphenylglycine Basic Attributes
CAS No：22818-40-2
Molecular Formula ：C8H9NO3
Molecular Mass ：167.16196
Exact Mass ：167.058243
PSA ：83.6 A^2
LogP ：-2.1
EINECS ：245-247-7
InChIKeys ：LJCWONGJFPCTTL-SSDOTTSWSA-N
H-bond Acceptor ：4
H-bond Donor ：3
SP3 ：0.13
RBN ：2
Echemi Chemical D(-)-4-Hydroxyphenylglycine Characteristics
Density ：1.4±0.1 g/cm3
Melting Point ：240 °C (dec.)(lit.)
Bolling Point ：365.8°C at 760 mmHg
Flash Point ：175.0±25.1 °C
Refractive Index ：1.633

2. Solubility ：H2O: 5 g/L (20 ºC)
Echemi Chemical D(-)-4-Hydroxyphenylglycine Safety Information
HS Code ：2922509090
UN No. ：NONH for all modes of transport
WGK_Germany ：3
Risk Code ：R36/37/38
Safety Instructions ：S26-S36-S24/25
Dangerous Mark ：Xi:Irritant
P Code ： P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321,
P332+P313, P337+P313, P362, P403+P233, P405, P501
Echemi Chemical D(-)-4-Hydroxyphenylglycine Product Usage
4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β
-lactam antibiotics.
Echemi Chemical D(-)-4-Hydroxyphenylglycine Production Methods
Compound I-1 (31.0 mmol) was dissolved in 200 mL of a 1: 1 mixture of tetrahydrofuran and
water, and Fmoc-Cl (32.5 mmol) and sodium bicarbonate (33.0 mmol) in 50 mL of
tetrahydrofuran were added dropwise over 25 minutes. ). The mixed solution was stirred for 8
hours, then diluted with water and extracted with ether. The aqueous phase was acidified to pH =

3. 3 and extracted with ethyl acetate. The combined organic layers were washed with saturated
brine, dried over anhydrous sodium sulfate, filtered, and the organic solvent was removed by
rotary evaporation under reduced pressure. The obtained crude product was recrystallized from
ethyl acetate: petroleum ether (5: 1) to obtain a white solid, which is Compound I-2 (yield: 95%,
Thionyl chloride (1.5mL, 33.0mmol) was added dropwise to a suspension of
(R)-4-hydroxyphenylglycine 15 (5.00g, 29.91mmol) in dry methanol (25mL) while stirring at 15°C
under nitrogen. The reaction mixture was allowed to warm to room temperature and stirred
overnight.