(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].

1. CAS No:2216-51-5
Formula:C10H20O
Synonyms:Menthol; L-Menthol; menthol crystal
China Export:From 2018.11 to 2019.11, total export volume of L-Menthol from China was
6,905,272KG while total export value was $201,304,664. The biggest proportion of exporting
volume in the last 12 months was 11.43% in 2019.03.
Echemi Chemical Products L-Menthol Description
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor
potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase
[Ca2+]i[1]. Antitumor activity[1].
Echemi Chemical Products L-Menthol Basic Attributes
CAS No：2216-51-5
Molecular Formula ：C10H20O
Molecular Mass ：156.26500
Exact Mass ：156.15100
PSA ：20.23000
LogP ：3
EINECS ：218-690-9
InChIKeys ：NOOLISFMXDJSKH-KXUCPTDWSA-N
H-bond Acceptor ：1
H-bond Donor ：1
SP3 ：1.00
RBN ：1
Echemi Chemical Products L-Menthol Characteristics
Density ：0.89
Melting Point ：41-43ºC
Bolling Point ：212ºC

2. Flash Point ：93ºC
Refractive Index ：1.46
Solubility ：H2O: 0.49 mg/mL at 25 °C
Storage Condition ：-20ºC
Vapor Pressure ：0.8 mm Hg ( 20 °C)
Vapor Density ：5.4 (NTP, 1992) (Relative to Air)
Stability ：Stable.
Echemi Chemical Products L-Menthol Safety Information
HS Code ：29061100
UN No. ：NONH for all modes of transport
WGK_Germany ：2
Risk Code ：R36/37/38; R41
Safety Instructions ：S26-S37/39
RTECS No. ：OT0700000
Dangerous Mark ：Xi

3. P Code ：P261-P280-P305 + P351 + P338
Hazard Statements ：H315-H318-H335
Toxicity ：LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg
Echemi Chemical Products L-Menthol Product Usage
Both menthol and racemic menthol can be used as flavoring agents for toothpaste, perfume,
beverages and candies. It is used as a stimulant in medicine, acting on the skin or mucous
membranes, and has the effect of cooling and relieving itching; orally, it can be used as an
anti-wind medicine for headache and inflammation of the nose, throat, and throat. Its esters are
used in perfumes and medicines. In the world, my country and Brazil are the main natural mint
producers, and the annual output of mint oil both reaches 2000-3000t. The main component of
peppermint oil. Because of its unique mint flavor and cooling effect, it is widely used in candy,
cosmetics and toothpaste.
Echemi Chemical Products L-Menthol Material and Products
Material ：
Acetic acid, Thymol, VINYL ACETATE MONOMER, Triethylamine, L-MENTHYLACRYLATE, Ethanol,
Water, (+)-PULEGONE, Citronellal, Piperidine, Sodium ethoxide, Aluminiumtri-sec-butoxide,
3,3-DIMETHYL-2-BUTANOL, Aluminumbromide, ISOPULEGOL, Benzaldehyde, L-MENTHONE,
L-MENTHYLAMINE, (R)-6-(isopropyl)-3-methylcyclohex-2-en-1-one, Diethylether
Products ：
Triphenyl Phosphate, ISOPROPYLCYCLOPENTANE, menglytate, 2-PHENYLPROPIONALDEHYDE,
p-Cymene, (3R,4S)-1-Benzoyl-3-(1-methoxy-1-methylethoxy)-4-phenyl-2-azetidinone,
p-Mentha-2-ene, P-MENTHANE-3,8-DIOL, Cinnamylalcohol, 3-Methyladipicacid,
(+)-TRANS-P-MENTH-2-ENE, Menthylacetate, p-ToluenethiosulfonicacidS-p-tolylester,
Monomethyl succinate, alpha-Terpinene, (+)-NEOMENTHOL, DIHYDROTERPINEOL, Formic Acid,
(1R,2S,5R)-(-)-MENTHYL(S)-P-TOLUENESULFINATE, ISOMENTHONE