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THERMOREGULATION.
 During the flow of metabolic processes there is a
release of energy in the form of heat. This heat creates
the human body temperature .All organisms divide on 2
groups: poikilothermic (cold-blooded) and homeothermic
(warm-blooded). Organisms are named cold-blooded
when their body temperature depends on the
temperature of external environment. Organisms
capable of maintaining their body temperatures within
very narrow limits are called homeothermic.
 Not all parts of the body have the same temperature.
Rectal temperature is used as an estimate of internal
temperature. It is about 37,7°C. Oral temperature
averages about 0,5°C less than rectal. The body
temperature in axillary area is 36,6°Ñ. There is a
characteristic circadian fluctuation of about one degree,
temperature being lowest during the night and highest
during the day. An added variation in women is a higher
temperature during the last half of the menstrual cycle.
The body temperature of 42-43°Ñ causes death by
protein denaturation. The body temperature of 26°Ñ
causes death by stop of the heart.
Thermoregulation.
THERMOREGULATION
Regulation of body temperature consists of:
 Heat production
 Heat loss
MECHANISMS OF HEAT PRODUCTION
 Muscle tone. Muscles are not contracted, but
muscular tone and metabolism increase.
MECHANISMS OF HEAT PRODUCTION
 Shivering. It is involuntary process. At shivering all
energy is directed on increase of heat production
MECHANISMS OF HEAT PRODUCTION
 Voluntary activity of muscles. It is a conscious
increase of contraction of muscles (foot stamping
and hand clapping).
MECHANISMS OF HEAT PRODUCTION
 The major mechanism of heat production in
children is oxidation of fat. It is located in cheeks.
MECHANISMS OF HEAT LOSS
 Radiation.
 Convection.
 Conduction.
 Evaporation
 Radiation – is based on the principle that hot
object emits electromagnetic waves (infrared
rays) and by doing so the energy is lost from the
object and the temperature decreases. The
direction of radiation is always from hot object to
cold object. Example: when human is in cold room
the body that has higher temperature emits infrared
waves towards the surrounding environment and in
some time human is getting cold (and the opposite
can be). If a human sits naked at normal room
temperature, radiation will account for around 60 %
of the total heat loss!
 Conduction – this is a process of transfer of
energy (temperature) from one object to another via
direct contact between them (!). Example: when
human touches cold object in some time that object
becomes warmer and the opposite can be. The
process of conduction significantly increases when
being in water.
 Convection – is a process of exchange of energy
(temperature) based on the fact that warm air is lighter
than cold air. The convection occurs only in air medium
and it becomes more significant when there is a
movement of air (!). As an example the heater (used in
the room for increase of temperature) warms the air
around it by conduction, this air becomes lighter and
rises to the top of the room, at the same time the cold air
that always concentrates in the bottom of the room
replaces the warm air around the heater and new cycle
begins  overall temperature of the room increases.
This form of heat loss becomes especially noticeable
when there is a cool breeze blowing, as the air close to
the body surface is being replaced by cold air more
rapidly (the wind chill effect). Together, conduction and
convection to the air account for between 15 and 20 %
of heat loss to the environment. Light clothing reduces
loss by this route to about half that from a naked body!
 Evaporation – is a process that is based on the
fact that during the transformation of water from the
liquid to gaseous state the energy is lost (cooling
effect of evaporation).

Evaporation is a necessary cooling mechanism
at very high air temperatures. As long as skin
temperature is greater than the temperature of
the surroundings, heat can be lost by radiation
and conduction. But when the temperature of
the surroundings becomes greater than that of
the skin, instead of losing heat, the body gains
heat by both radiation and conduction. Under
these conditions, the only way for the body to
lose heat is by evaporation.
The more is concentration of water in the air (humidity) the
more difficult is process of evaporation (when air humidity is
100 % there is no evaporation!).
THERMOREGULATION
 Conduction, convection and radiation provide heat
loss, when the temperature of external environment
is lower than temperature of body. When the
temperature of external environment is higher than
temperature of body heat loss is provided by
evaporation.
 Consequently, normal body temperature is balance
between the processes of heat production and heat
loss.
THERMOREGULATION
 Gomeothermic organisms have the
system of thermoregulation which
maintains normal body temperature at
permanent level. The changes of body
temperature are detected by
thermoreceptors. There are 2 types of
thermoreceptors: peripheral and central.
Peripheral thermoreceptors are located
in the skin and divided into warm and
cold (cold receptors prevail). Central
thermoreceptors is located in
hypothalamus and also divided into
warm and cold (mainly warm receptors).
THERMOREGULATION
 The major centre of thermoregulation is located in
hypothalamus (predominantly in anterior hypothalamic-
preoptic area).
 There are 2 types of thermoreceptors:
 central – located in thermoregulatory centre of
hypothalamus.
 peripheral: a) cold; b) warmth  located everywhere
except hypothalamus.
 The critical level at which the thermoregulatory
mechanisms of the body try to maintain core
temperature is known as the set-point of the system.
This set-point is under the control of the hypothalamus
which behaves as a kind of thermostat maintaining a
balance between heat loss and heat production. The
set-point is normally close to 37°C; above this
temperature, mechanisms promoting heat loss come
into operation, while below it heat-conserving and heat-
generating mechanisms are initiated.
 Insensible water loss – is a process of passive
evaporation from the skin, mucosa and lungs,
because their surface is moist. We lose 600-700 ml
of water per day via this way.

 Sweating – is an active process of secreting fluid
(sweat) by the specialized sweating glands
(exocrine glands). This sweat undergoes
evaporation and human lose energy (heat). By
evaporation of 1 ml of sweat we lose 0.58 kcal of
energy.
 The sweating glands are mostly located in the skin
of back and chest. In cold conditions human
releases less than 500 ml of sweat per day, in hot
conditions the quantity can be increased up to 6
litres and more.
 The composition of sweat: 1) water (99 %); 2)
electrolytes (especially Sodium and Chlorides).
 Mechanism of secretion of sweat: when the
temperature of environment increases the impulses
via sympathetic nervous system (in this case there
is a release of acetylcholine) go to sweating glands
 glands actively begin to produce fluid: in the
sweating gland itself the fluid is called the primary
sweat (its composition is very similar to blood
plasma with the exception that it doesn’t contain
proteins and glucose). Then when this primary
sweat flows via the gland duct to the surface of the
skin its composition changes due to the
reabsorption of some of the constituents of this
fluid.
 The final composition (the secondary sweat)
depends upon the rate at which it is being
produced. At low sweat rates much of the sodium
and chloride in the primary sweat is reabsorbed and
the sweat is very dilute. However, at higher sweat
rates there is less time for reabsorption as the
sweat flows along the duct, and consequently more
sodium and chloride is lost from the body.
Appreciable amounts of urea, lactic acid, and
potassium ions are also present in sweat.
 One of the major roles in thermoregulation belongs
to the blood supply to skin: 1) when there is
vasoconstriction (narrowing of lumen of blood
vessel) the less blood flows to skin and the less
warmth is lost (this occurs in cold conditions); 2)
when there is vasodilation (increase of lumen of
blood vessel) the more blood flows to skin and thus
the more heat is lost from the body (this occurs in
hot conditions).
THERMOREGULATION.
 The method for measurement of body temperature is called
thermometry and the device is thermometer.
 In most countries the unit for measurement of temperature is
degree of Celsius (°C). The older one scale (used now in
USA and some other countries) is degree of Fahrenheit (°F).
THERMOREGULATION.
 Formula of conversion of °C to °F is the following: [°F]
= [°C] × 9 ⁄ 5 + 32 (So 36.6 °C is equal to 97.88 °F).
 Different regions of the body have different temperatures
at rest. We distinguish:
 Core body temperature – the temperature of internal
organs (brain, muscles + organs of thoracic and
abdominal cavities). This temperature is kept at almost
constant level by the system of thermoregulation.
 Shell body temperature – the temperature of skin. It
depends from the temperature of surrounding
environment. In different places on skin it is different, for
example skin temperature of trunk and head is at range
33-34 °C, skin temperature of limbs (especially of distal
parts) is around 28 °C.
PLACES OF BODY TEMPERATURE
MEASUREMENT:
 oral cavity – normal range is
36.7 to 37.0 °C.
 axilla (underarm pit) – normal
temperature is 36.6 °C.
 rectum – normal range is 37.0
to 37.5 °C (especially used in
newborns and babies).
THERMOREGULATION.
 At optimal temperature conditions all human vital
functions run properly.
 Normothermia – state when core body temperature
is within the normal range.
 Hyperthermia – state when core body temperature
rises more than 37.5 °C.
 Hypothermia – state when core body temperature
falls below 35.0 °C.
 Fever (pyrexia) – pathological state when core body
temperature rises due to the increase of regulatory
“set-point” in hypothalamus (the centre of
thermoregulation in humans).
30-Thermoregulation (Iryna ma'am).pptx

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30-Thermoregulation (Iryna ma'am).pptx

  • 2.  During the flow of metabolic processes there is a release of energy in the form of heat. This heat creates the human body temperature .All organisms divide on 2 groups: poikilothermic (cold-blooded) and homeothermic (warm-blooded). Organisms are named cold-blooded when their body temperature depends on the temperature of external environment. Organisms capable of maintaining their body temperatures within very narrow limits are called homeothermic.
  • 3.  Not all parts of the body have the same temperature. Rectal temperature is used as an estimate of internal temperature. It is about 37,7°C. Oral temperature averages about 0,5°C less than rectal. The body temperature in axillary area is 36,6°Ñ. There is a characteristic circadian fluctuation of about one degree, temperature being lowest during the night and highest during the day. An added variation in women is a higher temperature during the last half of the menstrual cycle. The body temperature of 42-43°Ñ causes death by protein denaturation. The body temperature of 26°Ñ causes death by stop of the heart. Thermoregulation.
  • 4.
  • 5. THERMOREGULATION Regulation of body temperature consists of:  Heat production  Heat loss
  • 6. MECHANISMS OF HEAT PRODUCTION  Muscle tone. Muscles are not contracted, but muscular tone and metabolism increase.
  • 7. MECHANISMS OF HEAT PRODUCTION  Shivering. It is involuntary process. At shivering all energy is directed on increase of heat production
  • 8. MECHANISMS OF HEAT PRODUCTION  Voluntary activity of muscles. It is a conscious increase of contraction of muscles (foot stamping and hand clapping).
  • 9. MECHANISMS OF HEAT PRODUCTION  The major mechanism of heat production in children is oxidation of fat. It is located in cheeks.
  • 10. MECHANISMS OF HEAT LOSS  Radiation.  Convection.  Conduction.  Evaporation
  • 11.  Radiation – is based on the principle that hot object emits electromagnetic waves (infrared rays) and by doing so the energy is lost from the object and the temperature decreases. The direction of radiation is always from hot object to cold object. Example: when human is in cold room the body that has higher temperature emits infrared waves towards the surrounding environment and in some time human is getting cold (and the opposite can be). If a human sits naked at normal room temperature, radiation will account for around 60 % of the total heat loss!
  • 12.  Conduction – this is a process of transfer of energy (temperature) from one object to another via direct contact between them (!). Example: when human touches cold object in some time that object becomes warmer and the opposite can be. The process of conduction significantly increases when being in water.
  • 13.  Convection – is a process of exchange of energy (temperature) based on the fact that warm air is lighter than cold air. The convection occurs only in air medium and it becomes more significant when there is a movement of air (!). As an example the heater (used in the room for increase of temperature) warms the air around it by conduction, this air becomes lighter and rises to the top of the room, at the same time the cold air that always concentrates in the bottom of the room replaces the warm air around the heater and new cycle begins  overall temperature of the room increases. This form of heat loss becomes especially noticeable when there is a cool breeze blowing, as the air close to the body surface is being replaced by cold air more rapidly (the wind chill effect). Together, conduction and convection to the air account for between 15 and 20 % of heat loss to the environment. Light clothing reduces loss by this route to about half that from a naked body!
  • 14.  Evaporation – is a process that is based on the fact that during the transformation of water from the liquid to gaseous state the energy is lost (cooling effect of evaporation).  Evaporation is a necessary cooling mechanism at very high air temperatures. As long as skin temperature is greater than the temperature of the surroundings, heat can be lost by radiation and conduction. But when the temperature of the surroundings becomes greater than that of the skin, instead of losing heat, the body gains heat by both radiation and conduction. Under these conditions, the only way for the body to lose heat is by evaporation. The more is concentration of water in the air (humidity) the more difficult is process of evaporation (when air humidity is 100 % there is no evaporation!).
  • 15. THERMOREGULATION  Conduction, convection and radiation provide heat loss, when the temperature of external environment is lower than temperature of body. When the temperature of external environment is higher than temperature of body heat loss is provided by evaporation.  Consequently, normal body temperature is balance between the processes of heat production and heat loss.
  • 16.
  • 17. THERMOREGULATION  Gomeothermic organisms have the system of thermoregulation which maintains normal body temperature at permanent level. The changes of body temperature are detected by thermoreceptors. There are 2 types of thermoreceptors: peripheral and central. Peripheral thermoreceptors are located in the skin and divided into warm and cold (cold receptors prevail). Central thermoreceptors is located in hypothalamus and also divided into warm and cold (mainly warm receptors).
  • 19.  The major centre of thermoregulation is located in hypothalamus (predominantly in anterior hypothalamic- preoptic area).  There are 2 types of thermoreceptors:  central – located in thermoregulatory centre of hypothalamus.  peripheral: a) cold; b) warmth  located everywhere except hypothalamus.  The critical level at which the thermoregulatory mechanisms of the body try to maintain core temperature is known as the set-point of the system. This set-point is under the control of the hypothalamus which behaves as a kind of thermostat maintaining a balance between heat loss and heat production. The set-point is normally close to 37°C; above this temperature, mechanisms promoting heat loss come into operation, while below it heat-conserving and heat- generating mechanisms are initiated.
  • 20.  Insensible water loss – is a process of passive evaporation from the skin, mucosa and lungs, because their surface is moist. We lose 600-700 ml of water per day via this way.   Sweating – is an active process of secreting fluid (sweat) by the specialized sweating glands (exocrine glands). This sweat undergoes evaporation and human lose energy (heat). By evaporation of 1 ml of sweat we lose 0.58 kcal of energy.  The sweating glands are mostly located in the skin of back and chest. In cold conditions human releases less than 500 ml of sweat per day, in hot conditions the quantity can be increased up to 6 litres and more.
  • 21.  The composition of sweat: 1) water (99 %); 2) electrolytes (especially Sodium and Chlorides).  Mechanism of secretion of sweat: when the temperature of environment increases the impulses via sympathetic nervous system (in this case there is a release of acetylcholine) go to sweating glands  glands actively begin to produce fluid: in the sweating gland itself the fluid is called the primary sweat (its composition is very similar to blood plasma with the exception that it doesn’t contain proteins and glucose). Then when this primary sweat flows via the gland duct to the surface of the skin its composition changes due to the reabsorption of some of the constituents of this fluid.
  • 22.  The final composition (the secondary sweat) depends upon the rate at which it is being produced. At low sweat rates much of the sodium and chloride in the primary sweat is reabsorbed and the sweat is very dilute. However, at higher sweat rates there is less time for reabsorption as the sweat flows along the duct, and consequently more sodium and chloride is lost from the body. Appreciable amounts of urea, lactic acid, and potassium ions are also present in sweat.
  • 23.  One of the major roles in thermoregulation belongs to the blood supply to skin: 1) when there is vasoconstriction (narrowing of lumen of blood vessel) the less blood flows to skin and the less warmth is lost (this occurs in cold conditions); 2) when there is vasodilation (increase of lumen of blood vessel) the more blood flows to skin and thus the more heat is lost from the body (this occurs in hot conditions).
  • 24. THERMOREGULATION.  The method for measurement of body temperature is called thermometry and the device is thermometer.  In most countries the unit for measurement of temperature is degree of Celsius (°C). The older one scale (used now in USA and some other countries) is degree of Fahrenheit (°F).
  • 25. THERMOREGULATION.  Formula of conversion of °C to °F is the following: [°F] = [°C] × 9 ⁄ 5 + 32 (So 36.6 °C is equal to 97.88 °F).  Different regions of the body have different temperatures at rest. We distinguish:  Core body temperature – the temperature of internal organs (brain, muscles + organs of thoracic and abdominal cavities). This temperature is kept at almost constant level by the system of thermoregulation.  Shell body temperature – the temperature of skin. It depends from the temperature of surrounding environment. In different places on skin it is different, for example skin temperature of trunk and head is at range 33-34 °C, skin temperature of limbs (especially of distal parts) is around 28 °C.
  • 26. PLACES OF BODY TEMPERATURE MEASUREMENT:  oral cavity – normal range is 36.7 to 37.0 °C.  axilla (underarm pit) – normal temperature is 36.6 °C.  rectum – normal range is 37.0 to 37.5 °C (especially used in newborns and babies).
  • 27.
  • 28. THERMOREGULATION.  At optimal temperature conditions all human vital functions run properly.  Normothermia – state when core body temperature is within the normal range.  Hyperthermia – state when core body temperature rises more than 37.5 °C.  Hypothermia – state when core body temperature falls below 35.0 °C.  Fever (pyrexia) – pathological state when core body temperature rises due to the increase of regulatory “set-point” in hypothalamus (the centre of thermoregulation in humans).