This paper discusses how science, technology, and innovation (STI) can be used to improve quality of life and sustainable development in developing countries. It argues that access to appropriate technologies promotes improvements in living conditions. The ability of local firms to access technological know-how is important for economic growth. Examples discussed include using computers to enhance production, transportation, energy, commerce, education and health. The paper concludes that developing countries cannot suppress change and must find ways for technology to be applied to address pressing needs.