Toxicology is the study of the adverse effects of chemicals on living organisms. It is a multidisciplinary field that draws from areas like chemistry, pharmacology, biochemistry, physiology, biology, genetics, epidemiology, law, and economics. Toxicology examines both acute and chronic effects of toxicants. Acute effects occur from short term, high dose exposure while chronic effects result from long term, repeated exposure to lower doses. Toxicology seeks to understand how chemicals enter organisms, are distributed and metabolized, and how they impact various body systems, as well as their effects on populations, ecosystems, and the environment.
Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms that arise following exposure to toxic substances.
Introduction to toxicology gases and metalsNITISH SHAH
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Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms that arise following exposure to toxic substances.
Introduction to toxicology gases and metalsNITISH SHAH
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
introduction toxicology, general information on some basic toxins used in day to day life and also unknown toxins we are always in contact with but little do we know about them
Toxicology
Terms related to toxicology
Mechanism of Toxicity
Classification of toxins
General Toxicity Management Techniques
Specific Toxicity Management Techniques
Legal Guidelines
1. Toxicology, Scope of Pharmacology in Cosmetic Tech .pptxJagruti Marathe
Cosmetology is the study and application of beauty treatment. Branches of specialty include hairstyling, skin care, cosmetics, manicures/pedicures, non-permanent hair removal such as waxing and sugaring, and permanent hair removal processes such as electrology and intense pulsed light.
INTRODUCTION
Toxicology is the science of the poisons. It also studies the nature, effects, detection, assessment and treatment of their effects on biological material.
Toxicology is a multidisciplinary science. The ultimate objective of the combined research is to determine how an organism is affected by exposure to an agent.
This includes an understanding of:
How the agent moves and interact with living cells and tissues of the organism;
What parts of the organism are affected by its presence and health outcomes of this exposure.
Evaluation of the toxicity of substances whose biological effects may not have been well characterized.
The influence of chemical toxicity is mainly
determined by the dosage, duration of exposure,
route of exposure, species, age, sex, and environment.
The goal of toxicology is to contribute to the
general knowledge and harmful actions of
chemical substances.
2. to study their mechanisms of action,
3. and to estimate their possible risks to humans
HISTORY
Dioscorides, a Greek physician in the court of the Roman emperor Nero, made the first attempt to classify plants according to their toxic and therapeutic effect. Poisonous plants and animals were recognized and their extracts used for hunting or in warfare.
In 1500 BC people used hemlock, opium, arrow poisons, and certain metals to poison enemies or for state executions.
Theophrastus Phillipus Auroleus Bombastus von Hohenheim (1493–1541) (also referred to as Paracelsus, a Roman physician from the first century) is considered "the father" of toxicology.
He stated that "All things are poisonous and nothing is without poison; only the dose makes a thing not poisonous.“
Mathieu Orfila (1813) is considered the modern father of toxicology.
In 1850, Jean Stas became the first person to successfully isolate plant poisons from human tissue.
Hippolyte Visart de Bocarmé used nicotine to kill his brother-in-law. He extracted nicotine from tobacco leaves.
The 20th and 21st Centuries have marked by great advancements in the level of understanding of toxicology. DNA and various biochemicals that maintain body functions have been discovered. Our level of knowledge of toxic effects on organs and cells has expanded to the molecular level.
Ecotoxicology is the study of the effects of toxic chemicals on biological organisms, especially at the population, community, ecosystem, and biosphere levels.
introduction toxicology, general information on some basic toxins used in day to day life and also unknown toxins we are always in contact with but little do we know about them
Toxicology
Terms related to toxicology
Mechanism of Toxicity
Classification of toxins
General Toxicity Management Techniques
Specific Toxicity Management Techniques
Legal Guidelines
1. Toxicology, Scope of Pharmacology in Cosmetic Tech .pptxJagruti Marathe
Cosmetology is the study and application of beauty treatment. Branches of specialty include hairstyling, skin care, cosmetics, manicures/pedicures, non-permanent hair removal such as waxing and sugaring, and permanent hair removal processes such as electrology and intense pulsed light.
INTRODUCTION
Toxicology is the science of the poisons. It also studies the nature, effects, detection, assessment and treatment of their effects on biological material.
Toxicology is a multidisciplinary science. The ultimate objective of the combined research is to determine how an organism is affected by exposure to an agent.
This includes an understanding of:
How the agent moves and interact with living cells and tissues of the organism;
What parts of the organism are affected by its presence and health outcomes of this exposure.
Evaluation of the toxicity of substances whose biological effects may not have been well characterized.
The influence of chemical toxicity is mainly
determined by the dosage, duration of exposure,
route of exposure, species, age, sex, and environment.
The goal of toxicology is to contribute to the
general knowledge and harmful actions of
chemical substances.
2. to study their mechanisms of action,
3. and to estimate their possible risks to humans
HISTORY
Dioscorides, a Greek physician in the court of the Roman emperor Nero, made the first attempt to classify plants according to their toxic and therapeutic effect. Poisonous plants and animals were recognized and their extracts used for hunting or in warfare.
In 1500 BC people used hemlock, opium, arrow poisons, and certain metals to poison enemies or for state executions.
Theophrastus Phillipus Auroleus Bombastus von Hohenheim (1493–1541) (also referred to as Paracelsus, a Roman physician from the first century) is considered "the father" of toxicology.
He stated that "All things are poisonous and nothing is without poison; only the dose makes a thing not poisonous.“
Mathieu Orfila (1813) is considered the modern father of toxicology.
In 1850, Jean Stas became the first person to successfully isolate plant poisons from human tissue.
Hippolyte Visart de Bocarmé used nicotine to kill his brother-in-law. He extracted nicotine from tobacco leaves.
The 20th and 21st Centuries have marked by great advancements in the level of understanding of toxicology. DNA and various biochemicals that maintain body functions have been discovered. Our level of knowledge of toxic effects on organs and cells has expanded to the molecular level.
Ecotoxicology is the study of the effects of toxic chemicals on biological organisms, especially at the population, community, ecosystem, and biosphere levels.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
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Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
2. INTRODUCTION TO TOXICOLOGY - Outline
• What is Toxicology
• Scope
• Basic divisions of toxicology
• Goals
• Concepts - Types of Toxicants
3. Toxicology Formerly The Science of Poisons
Now
The science that deals with the adverse effects of chemicals on living organisms
and assesses the probability of their occurrence
Toxicology term derived from
Toxicon – arrow (poison)
logos – study
Scientifically speaking, toxicology is the quantitative and qualitative study of the
adverse or toxic effects of chemicals and other anthropogenic materials or
xenobiotic on organisms.
Toxicology is the youngest science of poisons
4. Definition of toxicology
• The study of the adverse effects of a toxicant on living organisms.
Adverse effects may be
• any change from an organism’s normal state
• dependent upon the concentration of active compound at the target site for a
sufficient time.
• Toxicant
• any agent capable of producing a deleterious response in a biological system
• Living organism
• a „sac of water” with target sites, storage depots and enzymes
5. Toxicology is both
Science , like medicine and
An art, like practise
• It is one of the several multi disciplinary fields of environmental sciences where many
disciplines are common with other fields
• It is concern with the study of concentrations, transport, distribution , transformation
and the ultimate fate of toxins and chemicals in the environment.
• It is essential to understand the chemical reactions (eg. Hydrolysis, oxidation,
photolysis), physical (eg. Molecular structure, solubility, volatility and sorption) and
biological (eg. Biotransformation, accumulation, biomagnification) factors that affect
environmental concentration of chemicals in order to assess how toxic agents act in
environment and how environment act and try to neutralize these agents and impact
on living beings.
• Environmental toxicology: The study of the effects of pollutants on organisms,
populations, ecosystems, and the biosphere.
SCOPE OF TOXICOLOGY
6. Environmental toxicology is a multidisciplinary science involving many widely
diverse areas of study such as
• chemistry, the characterization of toxins;
• pharmacology, the mode of entry and distribution of toxins in the body;
• biochemistry, the metabolism and interaction of toxins with cell components;
• physiology, the effect of toxins on body organs;
• .biology, the effect of toxins on the environment;
• .genetics, the effect toxins can have on the reproductive system and on future generations by
altering genetic codes;
• epidemiology, the effect on the population as a whole of chronic exposure to small quantities of
suspected agents;
• law, regulation of the use or release into the environment of toxic substances; and
• economics, evaluation of the environmental cost vs. benefit ofeconomic development and the
determination of trade-offs among economy, health, and the environment.
7. BASIC DIVISIONS OF TOXICOLOGY
On the basis of toxic effects of the chemical,
toxicity is subdivided into
• Acute effects – related to short term exposure of few hours, days
or weeks to a chemical . They are much severe in nature
• Chronic effects – ingestion of smaller quantities over a
prolonged period of time leading to toxic concentrations or long term
exposures
8. DEFINITIONS
• TOXIC SUBSTANCE- is the one which demonstrate the potential to induce cancer,
body injury or long term disease
• TOXIN – can be of plant, microbial or animal origin or a synthetic substance
• TOXICITY – is a relative term commonly used to compare one chemical’s potential
with another.
• Toxicity of a substance is capacity to cause injury to a living organism
• Toxicity is thus, a relative term which is a function of the concentration of the
chemical and duration of exposure
• TOXICITY TESTS - are performed to evaluate the adverse effects of a chemical o
living organism under standardised conditions .
• TOXICANT - is an agent that can produce an adverse response in the biological
system, seriously damaging its structure and function or even, death.
9. ENTRY OF TOXICANTS
• NON- POINT SOURCES – such as agricultural runoff,
contaminated ground water, urban discharges etc.
• POINT SOURCES- such as effluent discharge from
manufacturing plants, hazardous waste disposal sites,
municipal waste treatment plants etc.
10. TOXINS
• Naturally occurring toxicants originate from animal, plant or mineral
sources
• Animal toxins- such as venoms
• Plant toxins – such as opium, atropine, reserpine, quinine, picrotoxin etc.
• Crude plant extracts used in veterinary medicine
• Large number of antibiotics come from microorganisms as mycotoxins
• Many heavy metals such as lead, cadmium, zinc, mercury etc.
• Radioactive substances as hazards
• All Pollutants
11. • Toxins – biological compounds (Ricin, botulism)
• Carcinogens - may induce cancer or increase its incidence and can
affect any cells or tissues (benzene, vinyl chloride, benzo(a)pyrene )
• Mutagen - may induce hereditary genetic defects or increase their
incidence and effect on the germ cells (gonads). (radiation,
nitrosoamines)
• Teratogens - may induce non-hereditary congenital malformations or
increase their incidence and effect on the growing fetus (rubella,
thalidomide, PCBs, Dioxins)
• Endocrine disruptor – hormone mimic (PBDE, BPA)
CHEMICALS: Major Types of Toxicity