The Computerized Symptom Capture Tool (C-SCAT) is a novel iPad application designed to explore symptoms and symptom clusters from the perspective of adolescents and young adults with cancer. The study tested the feasibility and acceptability of using C-SCAT with 72 adolescents and young adults receiving chemotherapy. Participants were able to complete C-SCAT within 25 minutes on average. The majority found it an acceptable way to report their symptoms and felt it increased their self-awareness. Most participants identified multiple symptoms and some described symptom clusters. The study demonstrates the potential for C-SCAT to generate rich data on individual symptom experiences to inform symptom management.