1. Mode-of-Action: What is it and what is it good for 2. MOA Examples: Thyroid hormone disruption, thyroid cancer and developmental neurotoxicity 3. Thyroid 101: Hormones, homeostasis and signaling 4. Sites-of-action for TDCs 5. Relevancy of animal data to humans 6. How can MOA help identify research needs 7. Developmental neurotoxicity of TDCs 8. Acute neurotoxicity of pyrethroids 9. How can thinking of MOA help with screening for toxicity