This document discusses controversies in the management of ankle fractures. It summarizes two studies on the treatment of syndesmotic ankle fractures and medial malleolar fractures. For syndesmotic fractures, the optimal diagnosis and treatment is unclear. While displaced injuries require surgery, evidence is sparse on whether stabilizing nondisplaced fractures improves outcomes. For medial malleolar fractures, a randomized study found no difference in outcomes between using single screw fixation versus double screw fixation, suggesting single screw fixation is sufficient.
ANKLE FRACTURES
Pott’s fracture
A Pott’s fracture is a type of ankle fracture that is characterized by a break in one or more bony prominences on the sides of the ankle known as the malleoli.
Also known as Broken Ankle, Ankle Fracture and malleolar fracture.
Pott’s fracture often occurs in combination with other injuries such as a sprained ankle or other fractures of the foot, ankle or lower leg.
Trauma Society of India is a pioneering initiative to promote knowledge in the fields of orthopedics and traumatology. The society has taken a giant leap in its endeavors by launching the first ever standard guidelines for orthopedic clinicians. These guidelines would go a long way in establishing treatment protocols and providing a roadmap to clinicians that guides them in the assessment, decision-making and management of complex fracture situations.
The guidelines will be published in a series of books titled Guidelines in Fracture Management, compiled by eminent Indian and international clinicians. They illustrate all possible treatment options and latest management techniques that can be used, with special emphasis on the health scenario in the Asia-Pacific region.
Guidelines in Fracture Management--Proximal Tibia discusses the classification, assessment of personality, and planning and treatment protocols for the much-debated proximal tibia fractures.
In this article, we present how to evaluate syndesmosis injury by a case discussion. We also review the current concepts of syndesmosis injury in ankle fracture especially intraoperative evaluation and how to set syndesmotic screw fixation.
In the elderly osteoporotic fractures although the principles are the same but some special considerations in management of the soft tissues and the bony injuries are considered.
ANKLE FRACTURES
Pott’s fracture
A Pott’s fracture is a type of ankle fracture that is characterized by a break in one or more bony prominences on the sides of the ankle known as the malleoli.
Also known as Broken Ankle, Ankle Fracture and malleolar fracture.
Pott’s fracture often occurs in combination with other injuries such as a sprained ankle or other fractures of the foot, ankle or lower leg.
Trauma Society of India is a pioneering initiative to promote knowledge in the fields of orthopedics and traumatology. The society has taken a giant leap in its endeavors by launching the first ever standard guidelines for orthopedic clinicians. These guidelines would go a long way in establishing treatment protocols and providing a roadmap to clinicians that guides them in the assessment, decision-making and management of complex fracture situations.
The guidelines will be published in a series of books titled Guidelines in Fracture Management, compiled by eminent Indian and international clinicians. They illustrate all possible treatment options and latest management techniques that can be used, with special emphasis on the health scenario in the Asia-Pacific region.
Guidelines in Fracture Management--Proximal Tibia discusses the classification, assessment of personality, and planning and treatment protocols for the much-debated proximal tibia fractures.
In this article, we present how to evaluate syndesmosis injury by a case discussion. We also review the current concepts of syndesmosis injury in ankle fracture especially intraoperative evaluation and how to set syndesmotic screw fixation.
In the elderly osteoporotic fractures although the principles are the same but some special considerations in management of the soft tissues and the bony injuries are considered.
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Clinical & surgical management of the mandibular condylar process fractures has generated a great deal of controversy in maxillofacial trauma and there are many various approaches to treat this injury. Before, many surgeons seem to favor closed treatment with maxillomandibular fixation (MMF), but recently open treatment of condylar fractures with rigid internal fixation (RIF) has become more common & acceptable. The objective of this presentation was to evaluate the factors that determine the choice of method for treatment of condylar fractures: open or closed, pointing out their indications, contra-indications, advantages and disadvantages.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
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Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
3. Syndesmotic Ankle Fractures:
State of the Art
J Orthop Trauma ,Volume 32, Number 1, January 2018
James D. Michelson, MD, Department of Orthopaedics and
Rehabilitation, University of Vermont College of Medicine
4. •The diagnosis and treatment of syndesmotic
ankle fractures is controversial
•This is the current understanding addressing
several clinical questions that arise in the
treatment of such injuries.
•Disagreements exist indicates that the
optimal diagnosis or treatment paradigmhas
not been discovered
6. Diagnosis of Syndesmotic Injury
• There was no evidence that fixation of a
nondisplaced, but unstable syndesmosis by “stress-
test,” resulted in improved outcomes
• It should be emphasized that this is not true for
displaced syndesmotic injuries, where
restoration of the mortise does improve the clinical
outcome.
7. • It is reasonable to surgically stabilize a nondisplaced unstable
syndesmosis, recognizing that it is not clear if this improves the
clinical outcome.
•All displaced syndesmotic injuries should
undergo surgical stabilization.
8. Assessment of Accuracy of the Reduction
Although every effort should be
made to accurately reduce the
syndesmosis, subtle rotary
malreduction may be difficult to
detect but may not affect the clinical
outcome.
9. Choice of Hardware
• The number of screws used and cortices engaged in
stabilization screws is at the surgeon’s discretion.
• Alternative fixation methods (bioabsorbable screws,
endobuttons, and direct ligament reconstruction) may
have the same clinical results, although the
supporting data for these are weak
13. Single-Screw Fixation Compared
With Double Screw
Fixation for Treatment of Medial
Malleolar Fractures:
A Prospective Randomized Trial
Richard Buckley, MD, FRCSC,
From the Section of Orthopedics, Department of Surgery, University of Calgary,
Calgary, AB, Canada
J Orthop Trauma Volume 32, Number 11, November 2018
14. • Traditional teaching is to use two 4.0-mm screws instead of
1 for medial malleolar fixation to ensure rotational control.
• However, the medial malleolus usually fails in tension or
compression, and it is questionable if significant torsional
forces exist, which might require 2 screws for stable
fixation
15. Classified according to the Herscovici
classification.
• type-A fractures are avulsions of the tip of the malleolus,
• type-B occur between the tip and the level of the plafond,
• type-C are located at the level of the plafond and
• type-D extends vertically above this level
16. •A large randomized study was necessary to
determine whether DS fixation had any
clinical advantage over SS fixation for medial
malleolar fractures
•Samples size was 127
17.
18. • The primary outcome, the SF-36, and the secondary
outcome, AHS, at baseline, 3, and 24 months did not show
a single point of statistical difference in any of the 8
categories between groups.
• This lack of difference points to SS fixation being an
equivalent fracture care method in terms of the 8 general
health categories of the SF-36
19. • The analysis of secondary objectives showed that there
was no difference in the OR time, days in hospital
postsurgery, or need for syndesmotic fixation between
groups.
• Importantly, the fracture classification or complexity did
not influence the overall trends in functional assessment or
secondary objectives.
20. • Perhaps the most notable and important finding from the study was
the patient crossover.
• Fourteen patients, almost 25% of those randomized to receive 2
screws, received only 1 screw
•A 2-year follow-up proved that clinical and
functional outcome was no different regardless
of the number of screws used
21. There are multiple strengths with this study. This
prospectively designed and powered study with a large
sample size (n = 140) provides results that are
applicable to a wide demographic. In addition, the
crossover between groups occurred only in 1
direction, from the DS to the SS group, strengthening
the notion that an SS can be as effective as 2
screws. This study will also be generalizable because it
was conducted by 4 experienced trauma
surgeons on a fracture that is common worldwide and
treated regularly every day
22. • In conclusion, SS fixation seems to be an efficacious
treatment for most medial malleolar fractures.
• After medial malleolar fixation with either 1 or 2
screws, no significant difference with specific or
general outcome scores, operating time, or
complications was found, indicating that single screw
and DS fixation provide equivalent medium-term
patient outcomes.