1. The document discusses fracture dislocations of the elbow, which are complex injuries that often require surgical intervention due to associated fractures.
2. Common fracture patterns include posterior dislocations with radial head or coronoid fractures. Surgical fixation may involve screws, plates, or replacement of fractured bone.
3. Soft tissue injuries like lateral collateral ligament avulsions must also be repaired to prevent recurrent instability.
4. Potential complications addressed include heterotopic ossification, recurrent instability, ulnar neuropathy, arthrofibrosis, and post-traumatic arthrosis. Careful restoration of bony and soft tissue anatomy can help reduce complications.
I delivered this talk to a group of hand and arm therapists. Find out more about hand and arm problems at http://www.noelhenley.com
Ozark Orthopaedic: Henley C Noel MD
3317 North Wimberly Drive, Fayetteville, AR 72703
(479) 521-2752
An Introduction, History, Diagnosis, Current Guidelines on Treatment of trochanteric fractures of femur. Presentation also contain an introduction of Dynamic Hip Screw and Surgical Techniques.
I delivered this talk to a group of hand and arm therapists. Find out more about hand and arm problems at http://www.noelhenley.com
Ozark Orthopaedic: Henley C Noel MD
3317 North Wimberly Drive, Fayetteville, AR 72703
(479) 521-2752
An Introduction, History, Diagnosis, Current Guidelines on Treatment of trochanteric fractures of femur. Presentation also contain an introduction of Dynamic Hip Screw and Surgical Techniques.
Complex Fractures and Instability of the Elbow joint: Advances in Mechanism and Pathophysiology, Injury paterns, Treatment principals and Results are discussed in this presentation.
Οι εξελίξεις στην χειρουργική των σύνθετων καταγμάτων του αγκώνα συζητούνται σε αυτή την παρουσίαση
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. •The elbow is a highly congruent
trochoginglymoid joint with a significant amount
of stability conferred from its bony structures.
•Functional range of motion at the elbow is
classically described as 50 degrees of pronation
and supination with a 100degree arc of flexion,
ranging from 30 to 130 degrees
3. •In general, complex dislocations are described as
anterior or posterior based on the translation of the
ulna with respect to the distal humerus.
•Posterior dislocations are typically the result of an
axial load applied through a supinated elbow with
valgus stress.
•Conversely, anterior dislocations occur in the setting
of a posterior force applied to the elbow in a flexed
position or hyperextension trauma.
4. •The Horii circle,
described by
O’Driscoll and
colleagues,outlines
the typical pattern
of soft tissue injury
for elbow
dislocations
proceeding from
lateral to medial
5. Ring and Jupiter noted 4 common patterns of
injury:
1. Posterior dislocation of the elbow with fracture of the radial head
2. Posterior dislocation with fracture of both the radial head and
coronoid, described by Hotchkiss as the “terrible triad”
3. Anterior transolecranon fracture dislocation
4. Proximal Monteggia posterior fracture dislocations
6. •Elbow dislocations with associated
periarticular fractures (ie, complex
dislocations); frequently necessitate surgical
intervention, and the indications are
predicated on the specific fracture pattern.
•For this reason, CT scan is often helpful in
preoperative planning
7. Posterior elbow
dislocation. (A) Lateral
and (B) AP views of a
posteriorly dislocated
elbow. Visualization
and assessment of
small periarticular
fractures is difficult on
plain film imaging;
however, CT images
clearly demonstrate
fractures of the (C)
coronoid and (D)
lateral epicondyle.
8. 1. Radial Head Fractures
•Always conserve the radial head as far as
possible in the setting of acute elbow dislocation
•Nonoperative treatment is reserved only for
cases where concentric reduction is achieved,
there are no blocks to motion, and fracture
fragments are small and nondisplaced
9. 2. Coronoid fractures
Surgical fixation is indicated for elbow dislocations
with fractures greater than 10% of coronoid
height as well as the well-known terrible triad
injury of simultaneous elbow dislocation with
coronoid and radial head fractures
10. 3.Olecranon fracture
The ulnar articular surface must be anatomically
restored and any associated injuries to the
coronoid, distal humerus, or radial head
addressed at the time of fixation
11. 4. Soft Tissue Injury
• O’Driscoll and colleagues described the disruption of soft tissue
structures from lateral to medial in elbow dislocations originating at
the lateral ulnar collateral ligament (LUCL) and, in cases of high
energy trauma, progressing to disruption of the medial ulnar
collateral ligament (MUCL).
• After bony anatomy is restored, attention should be turned to the
soft tissue structures for reconstruction. The annular ligament and
LUCL should be repaired, because rotatory instability ensues with any
deficit in the lateral collateral ligament (LCL) complex
12. 4. Soft Tissue Injury ……contd
• The medial collateral ligament (MCL), however, needs only to be
restored if the elbow remains unstable after all other fractures and
soft tissue structures have been addressed.
• An alternative option is to place a hinged external fixator in this
situation
18. Regardless of the interval chosen,
dissection should be carried out with
the elbow in pronation to reduce risk
of injury to the posterior
interosseous nerve (PIN)
19. •Medially, an anteromedial interval between the
pronator teres and brachialis may be used to
access the anterior capsule.
•The posteromedial (flexor carpi ulnaris [FCU]-
splitting) exposure necessitates anterior ulnar
nerve transposition and the FCU is divided
between the 2 heads of the muscle
20. The Hotchkiss over-the-top approach splits the flexor-pronator
mass and the pronator teres is released from the epicondyle to
provide access to the coronoid and medial elbow structures
22. For Coronoid
• Type I requires only suture fixation
• Suture fixation may also be used for type 2 fractures if adequate
screw fixation is not possible due to fracture size or bone quality or to
augment internal fixation
23. •The coronoid can frequently be approached through the
lateral approach, because the radial-sided structures are
commonly already interrupted.
•If suture fixation is chosen 2 drill holes are created along
the subcutaneous border of the ulna to serve as tunnels
for the suture, directed toward either side of the
coronoid footprint
•Typically the coronoid fragment is too small to
accommodate drill holes and, therefore, is most
commonly captured by passing a number-1 braided
suture through its anterior capsular attachment
25. •Types 2 and 3 fractures often require a medialsided
approach because they are commonly fixed with formal
open reduction and internal fixation.
•Smaller fractures can be fixed with a headless screw that
can be augmented with the addition of suture fixation.
•In this case, the fragment must be large enough to
accommodate the screw and the bone must be of
adequate quality.
•The screw should be placed in the posterior to anterior
direction to achieve greater fixation strength and to
reduce the risk of injury to anterior neurovascular
structure
26. •For larger fragments, anteromedial buttress
plating can be used with or without combined
headless compression screws.
•Occasionally, a surgeon is faced with multiple
coronoid fragments that may necessitate
separate medial and dorsal plates, which again
may be augmented with suture or screw
fixation.
27.
28. For radial head
• If a few large fragments exist and bone is healthy enough to achieve
secure fixation, headless compression screws may be used.
• The radial ead articular surface is anatomically restored and
maintained with pointed reduction forceps.
• Kirschner wires are placed and cannulated headless compression
screws are implanted over their respective pins.
• If standard screws are used, it is important to place these implants in
the nonarticulating safe zone of the radius to avoid any symptoms
with pronation or supination
30. •Fracture extension into the neck is treated
with a buttress plate, again placed in the
safe zone of the proximal radius to avoid
impingement
•It is important to restore anatomic
alignment and length to avoid future
instability
31.
32. •If the radial head is extensively comminuted or
osteopenic, internal fixation may not be ideal.
•In this situation, radial head replacement is
advisable and has demonstrated good results
•The most important aspects of replacement are
appropriate sizing and positioning of the
prosthesis.
•Importantly, the radial head must not be
overstuffed, which inevitably leads to increased
radiocapitellar contact pressures, elbow pain,
loss of range of motion, and component failure
33. For soft tissue injury
• Due to the critical role of the LCL as the primary lateral elbow
stabilizer, soft tissue repair is mandatory at the time of surgery
because failure to address this injury is a significant cause for
recurrent instability.
• Most commonly, the LCL and posterolateral capsule are avulsed as a
sleeve from the lateral condyle, leaving a characteristic bare spot
• Surgical repair with suture anchors or bone tunnels placed at the
origin of the LCL at the bare area on the epicondyle with the elbow in
supination