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Alfredo R. Galassi and Nicolaus Reifart
The Sicilian and the German (sicilian)
Update Euro CTO Registry
Euro CTO Club Membership
0
10
20
30
40
50
60
2006 2007 2008 2009 2010 2011 2012 2013
13
21
29
33
38
43
52
55
0
500
1000
1500
2000
2500
3000
2008 2009 2010 2011 2012 2013
1303
1724
2189
2634 2603 2660
Online Registry 2008-2013
0
20
40
60
80
100
2006 2007 2008 2009 2010 2011 2012 2013
75 77
80 82
85.3 85 85.3 87
Angiographic Success
%
0%
20%
40%
60%
80%
100%
2008 2009 2010 2011 2012 2013
90 88.5 89.5 86
77
71
10 11.5 10.5 14
23
29
Antegrade Retrograde± Antegrade
Antegrade /Retrograde
Procedures
0%
20%
40%
60%
80%
100%
2008 2009 2010 2011 2012 2013
50
31 28.6
20.5 18.8 14.6
50
69 71.4
79.5 81.2 85.4
Antegrade only Retrograde + Antegrade
Antegrade /Retrograde
Operators
N=48N=48N=44N=35N=29N=24
0
20
40
60
80
100
2008 2009 2010 2011 2012 2013
85.5 86.5 88.1 87.6 87.8 90.3
73.6
64.2
77.1 76.5 77.8
79.5
Antegrade Retrograde
Angiographic Success
%
J-CTO score
Morino et al. J Am Coll Cardiol 2011
70
80
90
100
2008 2009 2010 2011 2012 2013
1
2
3
0
Angiographicsuccess(%)
J-CTOscore(median)
J-CTO score / Success
1.6 1.7 1.6
2
2.3
2.4
80
82
86 85 85. 3
87
0%
20%
40%
60%
80%
100%
2008 2009 2010 2011 2012 2013
50
23
17
11 13
5
33
27
17
25 16
22
17
40
49
34
37
23
10
17
36 31
42
4 8 8
<50 50-100 100-200 200-500 >500
Operators Experience
N=48N=48N=44N=35N=29N=24
2008-2012 CTO
interventions
8647 patients
9643 lesions
Drop out for missing data
47 patients
54 lesions
Included
8600 patients
9589 lesions
Retrograde (16.5%)
1395 patients
1582 lesions
Antegrade (83.5%)
7205 patients
8007 lesions
Procedural success
(75%)
1060 patients
1191 lesions
Procedural failure
(25%)
335 patients
391 lesions
Clinical follow-up
24.7 ± 15 months
931 patients (66.7%)
Retrograde CTO revascularization in Europe
Clinical Follow-up
0
10
20
30
40
50
MACCE Death MI Stroke Revasc.
13.6
1.9
3.2
0.6
13
8.7
0.6 2.3
0.9
8.6
23.9
4.3 5.4
0
23.6
Overall Successful Unsuccessful
%
P<0.001
P=0.001 P=0.014 P=0.120
P<0.001
Gender (M)
COPD
Prior MI
Prior PCI
LVEF < 35%
J-CTO score
Failure p<0.001
p<0.001
p=0.005
p=0.018
p=0.221
p=0.074
p=0.001
Predictors of MACCE Occurrence
Symptoms
(Successful Procedures)
0%
20%
40%
60%
80%
100%
CCS pre CCS post NYHA pre NYHA post
27.1
83.5
53.2
78.4
44
15.1
36.7
18.328.9
1.4
9.2
2.3
0 0 0.9 0.9
Class I Class II Class III Class IV
P<0.001 P<0.001
Credibility check of the online
EuroCTO-registry 2008-14
• Logical checks on data ( predefined
value ranges)
• Logical consistency-tests with respect
to other data fields
• Automatic warnings when data are
missing
At random : „ your patient was
selected for monitoring“
Automatic export of registry
parameters
9
parameters to be
checked by reviewer
Step 1 CD will automatically be uploaded (Videoloader)
Operator
It automatically stores
all files to prepare
Step 2 select EuroCTO Club-owned page
Step 3 select the runs to be reviewed
Any run can be played at high resolution and be reviewed
4 Cineruns to be uploaded
1. CTO vessel with retrograde/antegrade
distal filling;
2. Wire passage
3. If applicable also for retrograde access
4. Final result showing residual lesion
and runoff.
1
2
3
4
5/ 6
7
8 9
Monitor:
• The monitor will evaluate the case in a
structured way that finally results in an
• a) agreement,
• b) agreement with slight differences or
• c) relevant disagreement (i.e. no CTO or
no TIMI 3 flow)
Test: Operator NR Monitor GW
Calculated accordance 84 %
Summary: ERCTO-Monitoring
• Randomly selects 10% of cases
• Non biased controll of data entry
• Will indentify: errors of data entry,
interpretation or coding and errors of
intention
• Will increase credibility and scientific
value ( at no costs except our efforts)

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14:05 Galassi - Update EuroCTO Registry

  • 1. Alfredo R. Galassi and Nicolaus Reifart The Sicilian and the German (sicilian) Update Euro CTO Registry
  • 2. Euro CTO Club Membership 0 10 20 30 40 50 60 2006 2007 2008 2009 2010 2011 2012 2013 13 21 29 33 38 43 52 55
  • 3. 0 500 1000 1500 2000 2500 3000 2008 2009 2010 2011 2012 2013 1303 1724 2189 2634 2603 2660 Online Registry 2008-2013
  • 4. 0 20 40 60 80 100 2006 2007 2008 2009 2010 2011 2012 2013 75 77 80 82 85.3 85 85.3 87 Angiographic Success %
  • 5. 0% 20% 40% 60% 80% 100% 2008 2009 2010 2011 2012 2013 90 88.5 89.5 86 77 71 10 11.5 10.5 14 23 29 Antegrade Retrograde± Antegrade Antegrade /Retrograde Procedures
  • 6. 0% 20% 40% 60% 80% 100% 2008 2009 2010 2011 2012 2013 50 31 28.6 20.5 18.8 14.6 50 69 71.4 79.5 81.2 85.4 Antegrade only Retrograde + Antegrade Antegrade /Retrograde Operators N=48N=48N=44N=35N=29N=24
  • 7. 0 20 40 60 80 100 2008 2009 2010 2011 2012 2013 85.5 86.5 88.1 87.6 87.8 90.3 73.6 64.2 77.1 76.5 77.8 79.5 Antegrade Retrograde Angiographic Success %
  • 8. J-CTO score Morino et al. J Am Coll Cardiol 2011
  • 9. 70 80 90 100 2008 2009 2010 2011 2012 2013 1 2 3 0 Angiographicsuccess(%) J-CTOscore(median) J-CTO score / Success 1.6 1.7 1.6 2 2.3 2.4 80 82 86 85 85. 3 87
  • 10. 0% 20% 40% 60% 80% 100% 2008 2009 2010 2011 2012 2013 50 23 17 11 13 5 33 27 17 25 16 22 17 40 49 34 37 23 10 17 36 31 42 4 8 8 <50 50-100 100-200 200-500 >500 Operators Experience N=48N=48N=44N=35N=29N=24
  • 11. 2008-2012 CTO interventions 8647 patients 9643 lesions Drop out for missing data 47 patients 54 lesions Included 8600 patients 9589 lesions Retrograde (16.5%) 1395 patients 1582 lesions Antegrade (83.5%) 7205 patients 8007 lesions Procedural success (75%) 1060 patients 1191 lesions Procedural failure (25%) 335 patients 391 lesions Clinical follow-up 24.7 ± 15 months 931 patients (66.7%) Retrograde CTO revascularization in Europe
  • 12. Clinical Follow-up 0 10 20 30 40 50 MACCE Death MI Stroke Revasc. 13.6 1.9 3.2 0.6 13 8.7 0.6 2.3 0.9 8.6 23.9 4.3 5.4 0 23.6 Overall Successful Unsuccessful % P<0.001 P=0.001 P=0.014 P=0.120 P<0.001
  • 13. Gender (M) COPD Prior MI Prior PCI LVEF < 35% J-CTO score Failure p<0.001 p<0.001 p=0.005 p=0.018 p=0.221 p=0.074 p=0.001 Predictors of MACCE Occurrence
  • 14. Symptoms (Successful Procedures) 0% 20% 40% 60% 80% 100% CCS pre CCS post NYHA pre NYHA post 27.1 83.5 53.2 78.4 44 15.1 36.7 18.328.9 1.4 9.2 2.3 0 0 0.9 0.9 Class I Class II Class III Class IV P<0.001 P<0.001
  • 15. Credibility check of the online EuroCTO-registry 2008-14 • Logical checks on data ( predefined value ranges) • Logical consistency-tests with respect to other data fields • Automatic warnings when data are missing
  • 16. At random : „ your patient was selected for monitoring“ Automatic export of registry parameters 9 parameters to be checked by reviewer
  • 17. Step 1 CD will automatically be uploaded (Videoloader) Operator It automatically stores all files to prepare
  • 18. Step 2 select EuroCTO Club-owned page
  • 19. Step 3 select the runs to be reviewed
  • 20. Any run can be played at high resolution and be reviewed
  • 21. 4 Cineruns to be uploaded 1. CTO vessel with retrograde/antegrade distal filling; 2. Wire passage 3. If applicable also for retrograde access 4. Final result showing residual lesion and runoff.
  • 23. 8 9
  • 24. Monitor: • The monitor will evaluate the case in a structured way that finally results in an • a) agreement, • b) agreement with slight differences or • c) relevant disagreement (i.e. no CTO or no TIMI 3 flow)
  • 25. Test: Operator NR Monitor GW
  • 27. Summary: ERCTO-Monitoring • Randomly selects 10% of cases • Non biased controll of data entry • Will indentify: errors of data entry, interpretation or coding and errors of intention • Will increase credibility and scientific value ( at no costs except our efforts)

Editor's Notes

  1. 0