Vaccination in adults - Slideset by Professor Paolo BonanniWAidid
The slideset by professor Paolo Bonanni on vaccination in adults makes an overview on influenza, streptococcus pneumoniae, diphtheria, tetanus, pertussis, Human Papilloma Virus (HPV), measles, mumps, rubella, varicella and tick borne encephalitis. Where we were and where we are.
Meningococcal vaccination needed in india july 2016Gaurav Gupta
Menactra Meningococcal Conjugate Vaccine in India, is it really needed?
July 2016 Sanofi Pasteur Talk for Pediatricians, Child Specialist Doctors related to Vaccination, Immunization etc.
Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patientsijtsrd
Patients in the active phase of treatment for cancer are a population at risk of coronavirus disease 19 COVID 19 with poor prognosis. While a majority of patients treated for cancer expressed their will to be vaccinated as early as December 2020 in a French survey, no data were available in terms of vaccine efficacy and tolerance, because they were excluded from initial registration trials. Several clinical facilities aimed to assess the safety and immunogenicity of the BNT162b2 Pfizer–BioNTech vaccine in patients with cancer. In patients with cancer, one dose of the BNT162b2 vaccine yields poor efficacy. Immunogenicity increased significantly in patients with solid cancer within 2 weeks of a vaccine boost at day 21 after the first dose. However, the anti SARS CoV 2 immune response was lower in patients with solid tumors who were vaccinated a second dose of BNT162b2 vaccine than in healthy individuals. These data support prioritization of patients with cancer for an early day 21 second dose of the BNT162b2 vaccine. Takuma Hayashi | Nobuo Yaegashi | Ikuo Konishi "Confirmation of Safety of COVID-19 mRNA Vaccination for Cancer Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42563.pdf Paper URL: https://www.ijtsrd.commedicine/other/42563/confirmation-of-safety-of-covid19-mrna-vaccination-for-cancer-patients/takuma-hayashi
Vaccination in adults - Slideset by Professor Paolo BonanniWAidid
The slideset by professor Paolo Bonanni on vaccination in adults makes an overview on influenza, streptococcus pneumoniae, diphtheria, tetanus, pertussis, Human Papilloma Virus (HPV), measles, mumps, rubella, varicella and tick borne encephalitis. Where we were and where we are.
Meningococcal vaccination needed in india july 2016Gaurav Gupta
Menactra Meningococcal Conjugate Vaccine in India, is it really needed?
July 2016 Sanofi Pasteur Talk for Pediatricians, Child Specialist Doctors related to Vaccination, Immunization etc.
Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patientsijtsrd
Patients in the active phase of treatment for cancer are a population at risk of coronavirus disease 19 COVID 19 with poor prognosis. While a majority of patients treated for cancer expressed their will to be vaccinated as early as December 2020 in a French survey, no data were available in terms of vaccine efficacy and tolerance, because they were excluded from initial registration trials. Several clinical facilities aimed to assess the safety and immunogenicity of the BNT162b2 Pfizer–BioNTech vaccine in patients with cancer. In patients with cancer, one dose of the BNT162b2 vaccine yields poor efficacy. Immunogenicity increased significantly in patients with solid cancer within 2 weeks of a vaccine boost at day 21 after the first dose. However, the anti SARS CoV 2 immune response was lower in patients with solid tumors who were vaccinated a second dose of BNT162b2 vaccine than in healthy individuals. These data support prioritization of patients with cancer for an early day 21 second dose of the BNT162b2 vaccine. Takuma Hayashi | Nobuo Yaegashi | Ikuo Konishi "Confirmation of Safety of COVID-19 mRNA Vaccination for Cancer Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42563.pdf Paper URL: https://www.ijtsrd.commedicine/other/42563/confirmation-of-safety-of-covid19-mrna-vaccination-for-cancer-patients/takuma-hayashi
Meningococcal vaccination needed in india may 2017 chd revisedGaurav Gupta
Menactra, Sanofi Pasteur, latest data from India regarding Meningococcal disease, with information regarding need for vaccination in Indian situation for Pediatricians.
Presented in Chandigarh in May 2017
Avi Morris est le pseudonyme d'un chercheur et universitaire israélien qui, depuis plusieurs semaines, nous apporte ses observations de la campagne vaccinale contre la Covid-19 via l’ « exemple » israélien.
Infectious diseases are the second most common cause of death in end-stage renal disease (ESRD) patients. Patients with ESRD are at high risk for several infections, due to exposure to blood products and frequent dialysis. The increased susceptibility to infections among these patients is indicative of a complex and varied state of immunodeficiency manifested by abnormal phagocytosis, T and B lymphocytes abnormalities and impaired response to T cell dependent pathogens such as hepatitis B and influenza viruses. These immunologic abnormalities are complicated by the use of immunosuppressive drugs used to treat and control underlying disease and exacerbated by nutritional deficiency and the dialysis procedure. Though many of these infections can be prevented by appropriate vaccination, the usual schedules of vaccination may be less effective.
The aim of this paper is to review the studies on the use of vaccines in ESRD patients
and summarize the vaccines required in this population.
Preparedness for and response to meningococcal outbreaks: preliminary results of a Canadian Immunization Research Network (CIRN) randomized controlled trial of two schedules of 4CMenB vaccine in adolescents and young adults.
https://www.meningitis.org/mrf-conference-2017
Global lung cancer vaccine market & pipeline insight 2015KuicK Research
“Global Lung Cancer Vaccine Market & Pipeline Insight 2015” Report Highlights:
Introduction to Lung Cancer Vaccine
Global Lung Cancer Vaccine Market Analysis
Global Lung Cancer Vaccine Pipeline by Company & Phase
Global Lung Cancer Vaccine Pipeline: 29 Vaccines
Majority Lung Cancer Vaccines in Phase-II: 8 Vaccines
Marketed Lung Cancer Vaccines: 3 ( BV NSCLC 001, Mycidac-C™ & Vaxira®)
Personalized Cancer Vaccines: Progress & Possibilities
Lung Cancer Vaccine Mechanism
Meningococcal vaccination needed in india may 2017 chd revisedGaurav Gupta
Menactra, Sanofi Pasteur, latest data from India regarding Meningococcal disease, with information regarding need for vaccination in Indian situation for Pediatricians.
Presented in Chandigarh in May 2017
Avi Morris est le pseudonyme d'un chercheur et universitaire israélien qui, depuis plusieurs semaines, nous apporte ses observations de la campagne vaccinale contre la Covid-19 via l’ « exemple » israélien.
Infectious diseases are the second most common cause of death in end-stage renal disease (ESRD) patients. Patients with ESRD are at high risk for several infections, due to exposure to blood products and frequent dialysis. The increased susceptibility to infections among these patients is indicative of a complex and varied state of immunodeficiency manifested by abnormal phagocytosis, T and B lymphocytes abnormalities and impaired response to T cell dependent pathogens such as hepatitis B and influenza viruses. These immunologic abnormalities are complicated by the use of immunosuppressive drugs used to treat and control underlying disease and exacerbated by nutritional deficiency and the dialysis procedure. Though many of these infections can be prevented by appropriate vaccination, the usual schedules of vaccination may be less effective.
The aim of this paper is to review the studies on the use of vaccines in ESRD patients
and summarize the vaccines required in this population.
Preparedness for and response to meningococcal outbreaks: preliminary results of a Canadian Immunization Research Network (CIRN) randomized controlled trial of two schedules of 4CMenB vaccine in adolescents and young adults.
https://www.meningitis.org/mrf-conference-2017
Global lung cancer vaccine market & pipeline insight 2015KuicK Research
“Global Lung Cancer Vaccine Market & Pipeline Insight 2015” Report Highlights:
Introduction to Lung Cancer Vaccine
Global Lung Cancer Vaccine Market Analysis
Global Lung Cancer Vaccine Pipeline by Company & Phase
Global Lung Cancer Vaccine Pipeline: 29 Vaccines
Majority Lung Cancer Vaccines in Phase-II: 8 Vaccines
Marketed Lung Cancer Vaccines: 3 ( BV NSCLC 001, Mycidac-C™ & Vaxira®)
Personalized Cancer Vaccines: Progress & Possibilities
Lung Cancer Vaccine Mechanism
PERTUSSIS PROTECTION - CURRENT SCHEDULES IN EUROPEWAidid
Slide set by Professor Susanna Esposito, president WAidid, presented at the 3rd ESCMID Conference on Vaccines, held in Lisbon (Portugal), 6- 8 March 2015. Learn more: http://goo.gl/8GUwwL
Knowledge and Practice of Immunization amongst the care-givers of 12-23 month...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Emerging concepts in pneumococcal disease prevention in India sept 2011Gaurav Gupta
Latest information about Pneumococcal disease and its prevention from Indian perspective - as of sept 2011.
Covers latest Pneumonet data, and review from other studies like IBIS, ANSORP etc.
A Serological Survey of Human Parainfluenza Viruses (HPIVs) among Children in...iosrjce
This study was done to carry out a survey of Human Parainfluenza Virus in children aged 1-12years
in Kaduna Metropolis, Nigeria using the Enzyme Linked Immunosorbent Assay Diagnostic kits. Of the 376
samples tested for IgG antibody of HPIV 1, 2 and 3, 288 were seropositive (76.6%). Risk and demographic
factors such as age of the children parental occupation, parental educational status, vitamin A deficiency,
frequency of eating, household size, duration of breastfeeding, environmental smoke, respiratory symptoms,
fever, sickle cell and underlying diseases were analysed. Age (χ2=17.408, p=0.001), parental occupation
(χ2=10.116, p=0.039), duration of breastfeeding (χ2=8.439, p=0.015), presence of respiratory symptoms
(χ2=5.116, p=0.024) were significantly associated with the infection. Observation from the study showed the
importance of Human Parainfluenza Virus as an agent of respiratory tract infection in children. As antiviral
drugs are not readily available, preventive measures should be adhered to in the control of the infection.
Dr. Theoklis Zaoutis - Antimicrobial Use and Stewardship in the Pediatric Out...John Blue
Antimicrobial Use and Stewardship in the Pediatric Outpatient Setting - Dr. Theoklis Zaoutis, Chief, Division of Infectious Diseases, Professor of Pediatrics and Epidemiology of the University of Pennsylvania, from the 2014 NIAA Symposium on Antibiotics Use and Resistance: Moving Forward Through Shared Stewardship, November 12-14, 2014, Atlanta, Georgia, USA.
More presentations at http://www.swinecast.com/2014-niaa-antibiotics-moving-forward-through-shared-stewardship
To Assess the Severity and Mortality among Covid 19 Patients after Having Vac...YogeshIJTSRD
The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
13 valent pneumococcal conjugate vaccine (pcv13) r mm5909
1. Morbidity and Mortality Weekly Report
Weekly / Vol. 59 / No. 9 March 12, 2010
Invasive Pneumococcal Disease in Young Children Before Licensure of
13-Valent Pneumococcal Conjugate Vaccine — United States, 2007
Invasive pneumococcal disease (IPD), caused by Streptococcus population of children aged <5 years for these 10 sites was 2.1
pneumoniae (pneumococcus), remains a leading cause of seri- million. A case of IPD was defined as isolation of S. pneumoniae
ous illness in children and adults worldwide (1). After routine from a normally sterile body site (primarily blood or cerebrospi-
infant immunization with a 7-valent pneumococcal conjugate nal fluid) in a resident of an ABCs area. Pneumococcal isolates
vaccine (PCV7) began in 2000, IPD among children aged <5 were serotyped at CDC and reference laboratories. Serotype
years in the United States decreased by 76%; however, IPD information was analyzed by vaccine serotype group (Table 1).
from non-PCV7 serotypes, particularly 19A, has increased (2). Age-, race- and vaccine serotype-specific rates of IPD were
In February 2010, the Advisory Committee on Immunization calculated using observed IPD cases in the 2007 ABCs data as
Practices (ACIP) issued recommendations for use of a newly the numerator and U.S. Census Bureau projections of the 2007
licensed 13-valent pneumococcal conjugate vaccine (PCV13) population of ABCs sites as the denominator. To estimate the
(3). PCV13 contains the seven serotypes in PCV7 (4, 6B, 9V, incidence and total number of IPD cases in the United States
14, 18C, 19F, and 23F) and six additional serotypes (1, 3, in 2007, rates were standardized to the entire U.S. population,
5, 6A, 7F, and 19A). To characterize the potentially vaccine- adjusting for small differences between age and race distribu-
preventable IPD burden among children aged <5 years in the tions of ABCs areas and the U.S. population.
United States, CDC and investigators analyzed 2007 data from Investigators reviewed medical records to identify children
Active Bacterial Core surveillance (ABCs). is report summa- aged 24–59 months with underlying medical conditions who
rizes the results of that analysis, which found that among 427 are recommended by ACIP to receive the 23-valent pneumo-
IPD cases with known serotype in children aged <5 years, 274 coccal polysaccharide vaccine (PPSV23) (1). Characteristics of
(64%) were caused by serotypes contained in PCV13. In 2007, these high-risk children and healthy children were compared
an estimated 4,600 cases of IPD occurred in children in this age by chi-square test; data from 2006 and 2007 were summed
group in the United States, including approximately 2,900 cases
caused by serotypes covered in PCV13 (versus 70 cases caused
by PCV7 serotypes). PCV13 use has the potential to further INSIDE
reduce IPD in the United States. Post-licensure monitoring
will help characterize the effectiveness of PCV13 in different 258 Licensure of a 13-Valent Pneumococcal Conjugate
Vaccine (PCV13) and Recommendations for Use
populations and track the potential changes in disease burden
Among Children — Advisory Committee on
caused by non-PCV13 serotypes. Immunization Practices (ACIP), 2010
ABCs* of the Emerging Infections Program (EIP) Network
is a collaboration between CDC and 10 selected sites. ABCs 262 Short-Term E ects of Health-Care Coverage
Legislation — Massachusetts, 2008
conducts population- and laboratory-based active surveillance.
During 2006 and 2007, IPD surveillance was conducted 268 Progress Toward Poliomyelitis Eradication —
in Connecticut, Minnesota, and New Mexico, and selected Afghanistan and Pakistan, 2009
counties in California, Colorado, Georgia, Maryland, New 273 Licensure of a Meningococcal Conjugate Vaccine
York, Oregon, and Tennessee. In 2007, the total catchment (Menveo) and Guidance for Use — Advisory
Committee on Immunization Practices (ACIP), 2010
* Available at http://www.cdc.gov/abcs/index.html.
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
www.cdc.gov/mmwr
2. MMWR Morbidity and Mortality Weekly Report
because of the small number of IPD cases with Among the 427 IPD cases with known serotype
underlying medical conditions among persons in in children aged <5 years, 274 (64%) were caused by
this age group. serotypes contained in PCV13. Of these 274 cases,
In 2007, a total of 493 children aged <5 years 260 (95%) were caused by three of the six additional
(<60 months) with IPD were identified in the ABCs serotypes (3, 7F, and 19A) that are not included in
population (Table 2), and information on the sero- PCV7; overall, 180 (42%) of the 427 were caused
type of the pneumococcal isolate was available for by serotype 19A. Within each 1-year age group, the
427 (87%) of those children. Among the 427, the proportions of all IPD cases caused by serotypes
group aged <12 months accounted for 36% of all covered by PCV13 were relatively similar, ranging
cases, and the 12–23 months group accounted for from 59% to 71%. e proportions of all IPD cases
29%. Overall rates were highest in children aged <12 caused by the 13 serotypes were comparable in black
months and 12–23 months (40.5 and 31.2 cases per children (61%), children of other races (62%), and
100,000 population, respectively); among children white children (67%).
aged 24–59 months, rates of all IPD decreased with Information on hospitalization and clinical out-
each additional year of age. Information on race was come was available for 99% of serotyped IPD cases.
available for 378 (89%) cases for which serotype Among 272 children with IPD caused by serotypes
information was available. Among children aged <5 covered by PCV13 for whom hospitalization status,
years, rates of overall IPD in black children (35.8 cases clinical presentation, and outcome were known, 168
per 100,000) and children of other races (30.7 cases (62%) were hospitalized, and four (2%) died; 101
per 100,000) were approximately twofold and 1.7- (37%) had bacteremia without confirmed source, 24
fold higher, respectively, than rates for white children (9%) had meningitis, and 115 (42%) had pneumonia
(18.4 per 100,000). with bacteremia.
e MMWR series of publications is published by the Office of Surveillance, Epidemiology, and Laboratory Services, Centers for Disease
Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333.
Suggested citation: Centers for Disease Control and Prevention. [Article title]. MMWR 2010;59:[inclusive page numbers].
Centers for Disease Control and Prevention
omas R. Frieden, MD, MPH, Director
Peter A. Briss, MD, MPH, Acting Associate Director for Science
James W. Stephens, PhD, Office of the Associate Director for Science
Stephen B. acker, MD, MSc, Deputy Director for Surveillance, Epidemiology, and Laboratory Services
MMWR Editorial and Production Sta
Frederic E. Shaw, MD, JD, Editor, MMWR Series
Christine G. Casey, MD, Deputy Editor, MMWR Series Martha F. Boyd, Lead Visual Information Specialist
Robert A. Gunn, MD, MPH, Associate Editor, MMWR Series Malbea A. LaPete, Stephen R. Spriggs, Terraye M. Starr,
Teresa F. Rutledge, Managing Editor, MMWR Series Visual Information Specialists
Douglas W. Weatherwax, Lead Technical Writer-Editor Kim L. Bright, Quang M. Doan, MBA, Phyllis H. King,
Information Technology Specialists
Donald G. Meadows, MA, Jude C. Rutledge, Writer-Editors
MMWR Editorial Board
William L. Roper, MD, MPH, Chapel Hill, NC, Chairman
Virginia A. Caine, MD, Indianapolis, IN Patricia Quinlisk, MD, MPH, Des Moines, IA
Jonathan E. Fielding, MD, MPH, MBA, Los Angeles, CA Patrick L. Remington, MD, MPH, Madison, WI
David W. Fleming, MD, Seattle, WA Barbara K. Rimer, DrPH, Chapel Hill, NC
William E. Halperin, MD, DrPH, MPH, Newark, NJ John V. Rullan, MD, MPH, San Juan, PR
King K. Holmes, MD, PhD, Seattle, WA William Schaffner, MD, Nashville, TN
Deborah Holtzman, PhD, Atlanta, GA Anne Schuchat, MD, Atlanta, GA
John K. Iglehart, Bethesda, MD Dixie E. Snider, MD, MPH, Atlanta, GA
Dennis G. Maki, MD, Madison, WI John W. Ward, MD, Atlanta, GA
Sue Mallonee, MPH, Oklahoma City, OK
254 MMWR / March 12, 2010 / Vol. 59 / No. 9
3. MMWR Morbidity and Mortality Weekly Report
TABLE 1. Serotypes included in the three pneumococcal During 2006–2007, a total of 301 IPD cases with
vaccine formulations* available in the United States, 2010 a known serotype occurred among children aged
Vaccine 24–59 months; 31 cases (10%) occurred in a child at
Pneumococcal
serotype PCV7 PCV13 PPSV23 high risk recommended for vaccination with PPSV23
4 X X X (1). Of these 31 cases, the 11 serotypes included in
6B X X X PPSV23 but not in PCV13 (Table 1) accounted
9V X X X
14 X X X
for four cases (13%), serotypes covered in PCV13
18C X X X accounted for 13 cases (42%), and the remaining 14
19F X X X cases (45%) were caused by serotypes not covered
23F X X X
1 X X
in either vaccine. PCV13 serotypes accounted for
3 X X a smaller proportion of cases among children with
5 X X underlying medical conditions than among healthy
6A X children aged 24–59 months (42% [13 of 31] versus
7F X X
19A X X 65% [175 of 270]; p = 0.01).
2 X
8 X
Reported by
9N X MM Farley, MD, Georgia Emerging Infections Program.
10A X S Petit, MPH, Connecticut Dept of Public Health, Emerging
11A X
Infections Program. LH Harrison, MD, RA Hollick, MS,
12F X
15B X
Johns Hopkins Bloomberg School of Public Health, Baltimore,
17F X Maryland. SM Zansky, PhD, New York State Dept of Health,
20 X Emerging Infections Program. K Gershman, MD, Colorado
22F X Dept of Public Health and Environment, W Schaffner, MD,
33F X B Barnes, T McMinn, Vanderbilt Univ School of Medicine,
* The 13-valent pneumococcal conjugate vaccine (PCV13) includes
Nashville, Tennessee. A omas, Oregon Public Health Div.
the seven serotypes in the 7-valent vaccine (PCV7) and six additional PD Kirley, MT, MPH, California Emerging Infections
serotypes. The 23-valent pneumococcal polysaccharide vaccine Program. J Baumbach, MD, New Mexico Dept of Health.
(PPSV23) includes 12 of the serotypes included in PCV13 (it does C Lexau, PhD, Minnesota Dept of Health. J Henry, MSPH,
not include serotype 6A) and 11 additional serotypes. B Beall, PhD, CG Whitney, MD, M Moore, MD, JP Nuorti,
MD, Respiratory Diseases Br, Div of Bacterial Diseases,
Based on the 2007 rate of IPD in children aged National Center for Immunization and Respiratory Diseases;
<5 years (22 cases per 100,000), an estimated 4,600 JB Rosen, MD, EIS Officer, CDC.
cases of IPD occurred in this age group in the United
States. Included among those cases were an estimated Editorial Note
70 cases caused by serotypes covered in PCV7 and Routine infant immunization with PCV7 since
2,900 cases caused by serotypes covered in PCV13. 2000 has decreased rates of IPD in young children
markedly, but IPD from non-PCV7 serotypes,
TABLE 2. Number of cases and incidence of invasive pneumococcal disease (IPD), by age and serotype group, among children aged <5 years —
Active Bacterial Core surveillance (ABCs), 10 U.S. sites, 2007*
All IPD† PCV13 serotypes§ Non-PCV13 serotypes Serotype 19A
Age (mos) No. (%) Incidence No. (%) Incidence No. (%) Incidence No. (%) Incidence
<12 155 (36) 40.5 104 (38) 27.2 51 (33) 13.3 60 (33) 16.2
12–23 124 (29) 31.2 73 (27) 18.4 51 (33) 12.8 57 (32) 14.7
24–35 71 (17) 17.4 43 (16) 10.5 28 (18) 6.9 32 (18) 8.3
36–47 48 (11) 12.4 34 (12) 8.8 14 (9) 3.6 20 (11) 5.2
48–59 29 (7) 7.8 20 (7) 5.4 9 (6) 2.4 11 (6) 3.1
All <60 427 (100) 22 274 (100) 14.1 153 (100) 7.9 180 (100) 9.4
* Cases per 100,000 population. A case of IPD was de ned as isolation of Streptococcus pneumoniae from a normally sterile body site (primarily blood or cerebrospi-
nal uid) in a resident of an ABCs surveillance area. Sites include Connecticut, Minnesota, and New Mexico, and selected counties in California, Colorado, Georgia,
Maryland, New York, Oregon, and Tennessee.
† Excludes cases missing serotypes (13%); a total of 493 IPD cases were identi ed among children aged <5 years.
§ The 13-valent pneumococcal conjugate vaccine (PCV13) includes serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F.
MMWR / March 12, 2010 / Vol. 59 / No. 9 255
4. MMWR Morbidity and Mortality Weekly Report
≥12 months who had received 3 previous doses of
What is already known on this topic?
PCV7 induced an antibody response comparable to
In February 2010, a new 13-valent pneumococcal the 3-dose infant PCV13 series, and the safety profile
conjugate vaccine (PCV13) was licensed by the Food
and Drug Administration and recommended by the
of this supplemental dose was comparable to that
Advisory Committee on Immunization Practices (ACIP) after a fourth dose of PCV13 (5). Although rates of
for prevention of invasive pneumococcal disease in IPD are relatively low in these older children, ACIP
children; PCV13 succeeds the 7-valent vaccine (PCV7) also considered the emergence of multidrug-resistant
used in the routine childhood immunization schedule serotype 19A strains causing meningitis and other
since 2000.
severe invasive infections (6,7) and the substantial
What is added by this report? burden of noninvasive pneumococcal disease as
In 2007, 64% of 427 invasive pneumococcal disease additional factors in making the recommendation.
(IPD) cases observed in the Active Bacterial Core Cost-effectiveness evaluations suggest that supple-
surveillance (ABCs) were caused by the serotypes cov-
ered by PCV13; 42% of cases were caused by serotype
mental PCV13 vaccination appears comparable in
19A alone. cost effectiveness to other accepted interventions
What are the implications for public health practice?
(CDC, unpublished data, 2009).
After PCV7 was introduced, rates of IPD caused
Achieving and maintaining a high coverage of PCV13
can further reduce IPD among children aged <5 years; by the seven serotypes covered in the vaccine also
postlicensure monitoring will help characterize the decreased substantially among unvaccinated children
e ectiveness of PCV13 and track the potential change and adults. is indirect (or herd) effect resulted from
in disease burden caused by non-PCV13 serotypes. reduced nasopharyngeal carriage of pneumococcus
in vaccinated children and reduced transmission
from children to unvaccinated children and adults
predominantly serotype 19A, has increased and (8). Immunization of children with PCV13 also is
partially offset these reductions (2,4). Overall, rates of anticipated to have herd effects among adults. For
IPD have remained stable at 22–25 cases per 100,000 example, as of 2007, serotype 19A had emerged as
since 2002 (2,4). Based on the findings in this report, the most common cause of IPD in all age groups after
the use of PCV13 in the routine immunization PCV7 introduction (CDC, unpublished data, 2009).
schedule has the potential to further reduce IPD Colonization and disease caused by serotype 19A have
caused by the six additional serotypes (1, 3, 5, 6A, a similar epidemiological pattern to those caused by
7F, or 19A) among children aged <5 years. PCV7 serotypes, and some degree of herd effects in
PPSV23 has been available for use in adults aged the population might be expected. In contrast, some
≥65 years and persons aged ≥2 years with certain of the other new serotypes in PCV13 might have dif-
underlying medical conditions since 1983 (1). In ferent epidemiologic characteristics (9). In particular,
this analysis, approximately 42% of IPD cases among serotypes 1 and 5 are rarely found in the nasopharynx,
children aged 24–59 months with underlying medi- so the potential herd effects of PCV13 vaccination on
cal conditions were caused by serotypes covered in disease caused by these serotypes is uncertain. In the
PCV13; an additional 13% of cases were caused by United States, however, serotypes 1 and 5 are relatively
serotypes not covered in PCV13 but included in uncommon causes of IPD.
PPSV23. e role for PPSV23 in high-risk children Although rates of pneumonia hospitalizations
might become clearer when more data are available on decreased after PCV7 introduction among children
disease burden and serotype distribution after routine aged <2 years (10), the potential effects of PCV13 on
use of PCV13. noninvasive disease, such as nonbacteremic pneumo-
Based on available safety, immunogenicity and nia and otitis media, are difficult to evaluate because of
disease burden data, ACIP also recommends that a lack of standard case definitions, sensitive and specific
single supplemental PCV13 dose be given to healthy diagnostic methods, and routine surveillance for these
children aged 14–59 months and to children with conditions. Information on these noninvasive pneu-
underlying medical conditions up to age 71 months mococcal diseases is not available in the ABCs dataset.
who already have completed a schedule of PCV7 (3). Because PCV13 was licensed on the basis of immu-
In one study, a single dose of PCV13 in children aged nogenicity studies rather than clinical efficacy trials,
post-licensure monitoring is important to characterize
256 MMWR / March 12, 2010 / Vol. 59 / No. 9
5. MMWR Morbidity and Mortality Weekly Report
the effectiveness of PCV13 in different populations 4. CDC. Invasive pneumococcal disease in children 5 years after
and to track the potential changes in disease burden conjugate vaccine introduction—eight states, 1998–2005.
MMWR 2008;57:144–8.
caused by non-PCV13 serotypes. 5. Kieninger DM, Kueper K, Steul K, et al. Safety and
immunologic non-inferiority of 13-valent pneumococcal
Acknowledgments conjugate vaccine compared to 7-valent pneumococcal
e findings in this report are based, in part, on con- conjugate vaccine given as a 4-dose series with routine vaccines
tributions by W Baughman, MSPH, P Malpiedi, MPH, in healthy infants and toddlers. In: Proceedings of the 48th
Annual Interscience Conference on Antimicrobial Agents
KE Arnold, MD, Georgia Emerging Infections Program; and Chemotherapy; October 25–28, 2008; Washington, DC.
M Cartter, MD, Z Fraser, Connecticut Dept of Public Arlington, VA: Infectious Diseases Society of America; 2008.
Health, Emerging Infections Program; G Smith, N Spina, 6. Pelton SI, Huot H, Finkelstein JA, et al. Emergence of
MPH, J Karr, MPH, S Solghan, MPH, G Nattanmai, New 19A as virulent and multidrug resistant pneumococcus in
York State Dept of Health, Emerging Infections Program; Massachusetts following universal immunization of infants
with pneumococcal conjugate vaccine. Pediatr Infect Dis J
MM Lewis, MPH, ER Zell, MStat, C Van Beneden, MD, 2007;26:468–72.
KA Toews, MPH, E Weston, MPH, and C Wright, ABCs 7. Kaplan SL, Barson WJ, Lin PL, et al. Serotype 19A is the most
Team, Respiratory Diseases Br, Div of Bacterial Diseases, common serotype causing invasive pneumococcal infections
National Center for Immunization and Respiratory in children. Pediatrics 2010;125:429–36.
Diseases, Atlanta, Georgia. 8. CDC. Direct and indirect effects of routine vaccination of
children with 7-valent pneumococcal conjugate vaccine on
References incidence of invasive pneumococcal disease—United States,
1998–2003. MMWR 2005;54:893–7.
1. CDC. Preventing pneumococcal disease among infants 9. Hausdorff WP, Feikin DR, Klugman KP. Epidemiological
and young children: recommendations of the Advisory differences among pneumococcal serotypes. Lancet Infect
Committee on Immunization Practices (ACIP). MMWR Dis 2005;2:83–93
2000;49(No. RR-9). 10. CDC. Pneumonia hospitalizations among young
2. Pilishvili T, Lexau C, Farley MM, et al. Sustained reductions children before and after introduction of pneumococcal
in invasive pneumococcal disease in the era of conjugate conjugate vaccine—United States, 1997–2006. MMWR
vaccine. J Infect Dis 2010;201:32–41. 2009;58:1–4.
3. CDC. Licensure of a 13-valent pneumococcal conjugate
vaccine (PCV13) and recommendations for use among
children—Advisory Committee on Immunization Practices
(ACIP), 2010. MMWR 2010;59:258–61.
MMWR / March 12, 2010 / Vol. 59 / No. 9 257
6. MMWR Morbidity and Mortality Weekly Report
Licensure of a 13-Valent Pneumococcal Conjugate Vaccine
(PCV13) and Recommendations for Use Among Children —
Advisory Committee on Immunization Practices (ACIP), 2010
On February 24, 2010, a 13-valent pneumococ- PCV13 is administered intramuscularly and is avail-
cal conjugate vaccine (PCV13 [Prevnar 13, Wyeth able in single-dose, prefilled syringes that do not
Pharmaceuticals Inc., a subsidiary of Pfizer Inc.]) contain latex (2).
was licensed by the Food and Drug Administration Immunogenicity profile. e immunogenicity
(FDA) for prevention of invasive pneumococcal dis- of PCV13 was evaluated in a randomized, double-
ease (IPD) caused by the 13 pneumococcal serotypes blind, active-controlled trial in which 663 U.S. infants
covered by the vaccine and for prevention of otitis received at least 1 dose of PCV13 or PCV7 (3). To
media caused by serotypes in the 7-valent pneumococ- compare PCV13 antibody responses with those for
cal conjugate vaccine formulation (PCV7 [Prevnar, PCV7, criteria for noninferior immunogenicity after
Wyeth]). PCV13 is approved for use among children 3 and 4 doses of PCV13 (pneumococcal immuno-
aged 6 weeks–71 months and succeeds PCV7, which globulin G [IgG] antibody concentrations measured
was licensed by FDA in 2000. e Pneumococcal by enzyme immunoassay) were defined for the seven
Vaccines Work Group of the Advisory Committee serotypes common to PCV7 and PCV13 (4, 6B, 9V,
on Immunization Practices (ACIP) reviewed avail- 14, 18C, 19F, and 23F) and for the six additional
able data on the immunogenicity, safety, and cost- serotypes in PCV13 (serotypes 1, 3, 5, 6A, 7F, and
effectiveness of PCV13, and on estimates of the 19A). Functional antibody responses were measured
vaccine-preventable pneumococcal disease burden. by opsonophagocytosis assay (OPA) in a subset of the
e working group then presented policy options for study population. Evaluation of these immunologic
consideration of the full ACIP. is report summarizes parameters indicated that PCV13 induced levels of
recommendations approved by ACIP on February antibodies that were comparable to those induced by
24, 2010, for 1) routine vaccination of all children PCV7 and shown to be protective against IPD (3).
aged 2–59 months with PCV13, 2) vaccination Among infants receiving the 3-dose primary series,
with PCV13 of children aged 60–71 months with responses to three PCV13 serotypes (the shared sero-
underlying medical conditions that increase their types 6B and 9V, and new serotype 3) did not meet the
risk for pneumococcal disease or complications, and prespecified, primary endpoint criterion (percentage
3) PCV13 vaccination of children who previously of subjects achieving an IgG seroresponse of ≥0.35 µg/
received 1 or more doses of PCV7 (1). CDC guid- mL 1 month after the third dose); however, detect-
ance for vaccination providers regarding transition able OPA antibodies to each of these three serotypes
from PCV7 to the PCV13 immunization program indicated the presence of functional antibodies (3).
also is included. e percentages of subjects with an OPA titer ≥1:8
were similar for the seven common serotypes among
Prevnar 13 Licensure PCV13 recipients (range: 90%–100%) and PCV7
Vaccine formulation. PCV13 contains polysac- recipients (range: 93%–100%); the proportion of
charides of the capsular antigens of Streptococcus PCV13 recipients with an OPA titer ≥1:8 was >90%
pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, for all of the 13 serotypes (3).
18C, 19A, 19F, and 23F, individually conjugated After the fourth dose, the IgG geometric mean
to a nontoxic diphtheria CRM197 (CRM, cross- concentrations (GMCs) were comparable for 12 of
reactive material) carrier protein. A 0.5-mL PCV13 the 13 serotypes; the noninferiority criterion was not
dose contains approximately 2 µg of polysaccharide met for serotype 3. However, measurable OPA titers
from each of 12 serotypes and approximately 4 µg were present for all serotypes after the fourth dose;
of polysaccharide from serotype 6B; the total con- the percentage of PCV13 recipients with an OPA titer
centration of CRM197 is approximately 34 µg. e ≥1:8 ranged from 97% to 100% for the 13 serotypes
vaccine contains 0.125 mg of aluminum as aluminum and was 98% for serotype 3 (3).
phosphate adjuvant and no thimerosal preservative.
258 MMWR / March 12, 2010 / Vol. 59 / No. 9
7. MMWR Morbidity and Mortality Weekly Report
A schedule of 3 doses of PCV7 followed by 1 dose No previous PCV7/PCV13 vaccination. e
of PCV13 resulted in somewhat lower IgG GMCs for ACIP recommendation for routine vaccination with
the six additional serotypes compared with a 4-dose PCV13 and the immunization schedules for infants
PCV13 series. However, the OPA responses after and toddlers through age 59 months who have not
the fourth dose were comparable for the two groups, received any previous PCV7 or PCV13 doses are the
and the clinical relevance of these lower antibody same as those previously published for PCV7 (4,5).
responses is not known. e single dose of PCV13 PCV13 is recommended as a 4-dose series at ages 2, 4,
among children aged ≥12 months who had received 6, and 12–15 months. Infants receiving their first dose
3 doses of PCV7 elicited IgG immune responses to at age ≤6 months should receive 3 doses of PCV13
the six additional serotypes that were comparable to at intervals of approximately 8 weeks (the minimum
those after a 3-dose infant PCV13 series (3). interval is 4 weeks). e fourth dose is recommended
Safety profile. e safety of PCV13 was assessed at age 12–15 months, and at least 8 weeks after the
in 13 clinical trials in which 4,729 healthy infants and third dose (Table 2).
toddlers were administered at least 1 dose of PCV13 Children aged 7–59 months who have not been
and 2,760 children received at least 1 dose of PCV7, vaccinated with PCV7 or PCV13 previously should
concomitantly with other routine pediatric vaccines. receive 1 to 3 doses of PCV13, depending on their
e most commonly reported (more than 20% of sub- age at the time when vaccination begins and whether
jects) solicited adverse reactions that occurred within underlying medical conditions are present (Table 2).
7 days after each dose of PCV13 were injection-site Children aged 24–71 months with chronic medical
reactions, fever, decreased appetite, irritability, and conditions that increase their risk for pneumococcal
increased or decreased sleep (2). e incidence and disease should receive 2 doses of PCV13. Interruption
severity of solicited local reactions at the injection of the vaccination schedule does not require reinsti-
site (pain/tenderness, erythema, and induration/ tution of the entire series or the addition of extra
swelling) and solicited systemic reactions (irritability, doses.
drowsiness/increased sleep, decreased appetite, fever, Incomplete PCV7/ PCV13 vaccination. Infants
and restless sleep/decreased sleep) were similar in the and children who have received 1 or more doses of
PCV13 and PCV7 groups. ese data suggest that the PCV7 should complete the immunization series with
safety profiles of PCV13 and PCV7 are comparable PCV13 (Table 3). Children aged 12–23 months who
(2); CDC will conduct postlicensure monitoring for have received 3 doses of PCV7 before age 12 months
adverse events, and the manufacturer will conduct a are recommended to receive 1 dose of PCV13, given
Phase IV study. at least 8 weeks after the last dose of PCV7. No addi-
Supportive data for safety outcomes were provided tional PCV13 doses are recommended for children
by a catch-up study among 354 children aged 7–71 aged 12–23 months who received 2 or 3 doses of
months who received at least 1 dose of PCV13. In PCV7 before age 12 months and at least 1 dose of
addition, an open label study was conducted among PCV13 at age ≥12 months.
284 healthy U.S. children aged 15–59 months who Similar to the previous ACIP recommendation for
had previously received 3 or 4 doses of PCV7 (2). use of PCV7 (6), 1 dose of PCV13 is recommended
Among these children, the frequency and severity of for all healthy children aged 24–59 months with any
solicited local reactions and systemic adverse reac- incomplete PCV schedule (PCV7 or PCV13). For
tions after 1 dose of PCV13 were comparable to children aged 24–71 months with underlying medical
those among children receiving their fourth dose of conditions who have received any incomplete sched-
PCV13 (2). ule of <3 doses of PCV (PCV7 or PCV13) before
age 24 months, 2 doses of PCV13 are recommended.
Indications and Guidance for Use For children with underlying medical conditions who
ACIP recommends PCV13 for all children aged have received 3 doses of PCV (PCV7 or PCV13) a
2–59 months. ACIP also recommends PCV13 for single dose of PCV13 is recommended through age
children aged 60–71 months with underlying medical 71 months. e minimum interval between doses is
conditions that increase their risk for pneumococcal 8 weeks.
disease or complications (Table 1).
MMWR / March 12, 2010 / Vol. 59 / No. 9 259
8. MMWR Morbidity and Mortality Weekly Report
TABLE 1. Underlying medical conditions that are indications for pneumococcal vaccination among children, by risk group —
Advisory Committee on Immunization Practices (ACIP), United States, 2010
Risk group Condition
Immunocompetent children Chronic heart disease*
Chronic lung disease†
Diabetes mellitus
Cerebrospinal uid leaks
Cochlear implant
Children with functional or Sickle cell disease and other hemoglobinopathies
anatomic asplenia Congenital or acquired asplenia, or splenic dysfunction
Children with HIV infection
immunocompromising conditions Chronic renal failure and nephrotic syndrome
Diseases associated with treatment with immunosuppressive drugs or radiation therapy, including
malignant neoplasms, leukemias, lymphomas, and Hodgkin disease; or solid organ transplantation
Congenital immunode ciency§
* Particularly cyanotic congenital heart disease and cardiac failure.
† Including asthma if treated with prolonged high-dose oral corticosteroids.
§ Includes B- (humoral) or T-lymphocyte de ciency; complement de ciencies, particularly C1, C2, C3, and C4 de ciency; and phagocytic
disorders (excluding chronic granulomatous disease).
TABLE 2. Recommended routine vaccination schedule for 13-valent pneumococcal conjugate vaccine (PCV13) among infants
and children who have not received previous doses of 7-valent vaccine (PCV7) or PCV13, by age at rst dose — Advisory
Committee on Immunization Practices (ACIP), United States, 2010
Age at rst dose (mos) Primary PCV13 series* PCV13 booster dose†
2–6 3 doses 1 dose at age 12–15 mos
7–11 2 doses 1 dose at age 12–15 mos
12–23 2 doses —
24–59 (Healthy children) 1 dose —
24–71 (Children with certain chronic diseases or 2 doses —
immunocompromising conditions§)
* Minimum interval between doses is 8 weeks except for children vaccinated at age <12 months for whom minimum interval between doses
is 4 weeks. Minimum age for administration of rst dose is 6 weeks.
† Given at least 8 weeks after the previous dose.
§ For complete list of conditions, see Table 1.
TABLE 3. Recommended transition schedule from 7-valent pneumococcal conjugate vaccine (PCV7) to 13-valent vaccine
(PCV13) vaccination among infants and children, according to number of previous PCV7 doses received — Advisory
Committee on Immunization Practices (ACIP), United States, 2010
Supplemental
Infant series Booster dose PCV13 dose
2 mos 4 mos 6 mos ≥12 mos* 14–59 mos†
PCV7 PCV13 PCV13 PCV13 —
PCV7 PCV7 PCV13 PCV13 —
PCV7 PCV7 PCV7 PCV13 —
PCV7 PCV7 PCV7 PCV7 PCV13
* No additional PCV13 doses are indicated for children age 12–23 months who have received 2 or 3 doses of PCV before age 12 months
and at least 1 dose of PCV13 at age ≥12 months.
† Forchildren with underlying medical conditions (see Table 1), a single supplemental PCV13 dose is recommended through age 71
months
260 MMWR / March 12, 2010 / Vol. 59 / No. 9
9. MMWR Morbidity and Mortality Weekly Report
Complete PCV7 vaccination. A single supple- According to the manufacturer, supplies of PCV13
mental dose of PCV13 is recommended for all chil- should be adequate to allow providers to vaccinate
dren aged 14–59 months who have received 4 doses children according to the routine immunization
of PCV7 or another age-appropriate, complete PCV7 schedule and provide a supplemental dose as rec-
schedule (Table 3). For children who have underlying ommended. For private vaccine supplies, providers
medical conditions, a single supplemental PCV13 should contact Pfizer’s customer service department
dose is recommended through age 71 months. is (telephone, 800-666-7248) with questions about
includes children who have previously received the purchasing quantities of PCV13 or returning PCV7
23-valent pneumococcal polysaccharide vaccine for credit. For public vaccine supplies, including
(PPSV23). PCV13 should be given at least 8 weeks Vaccines for Children Program vaccine, providers
after the last dose of PCV7 or PPSV23. should contact their state/local immunization pro-
In addition, a single dose of PCV13 may be gram to determine when PCV13 will become available
administered to children aged 6–18 years who are at for ordering in their jurisdiction and what to do with
increased risk for IPD because of sickle cell disease, unused supplies of PCV7.
human immunodeficiency virus (HIV) infection or e PCV13 Vaccine Information Statement is
other immunocompromising condition, cochlear available at http://www.cdc.gov/vaccines/pubs/vis/
implant, or cerebrospinal fluid leaks, regardless of default.htm. Details about the routine pneumococ-
whether they have previously received PCV7 or cal conjugate vaccination schedule are available at
PPSV23. Routine use of PCV13 is not recommended http://www.cdc.gov/vaccines/recs/schedules/default.
for healthy children aged ≥5 years. htm#child. Adverse events after receipt of any vac-
cine should be reported to the Vaccine Adverse Event
Precautions and Contraindications Reporting System at http://vaers.hhs.gov.
Before administering PCV13, vaccination provid- References
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warnings, and contraindications. Vaccination with pneumococcal conjugate vaccine (PCV13) among infants
PCV13 is contraindicated among persons known to and children. Available at http://www.cdc.gov/vaccines/recs/
have severe allergic reaction (e.g., anaphylaxis) to any provisional/downloads/pcv13-mar-2010-508.pdf. Accessed
March 9, 2010.
component of PCV13 or PCV7 or to any diphtheria 2. Food and Drug Administration. Vaccines: approved products.
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Available at http://www.fda.gov/BiologicsBloodVaccines/
Vaccines/ApprovedProducts/ucm201667.htm. Accessed
Transition from PCV7 to PCV13 March 5, 2010
When PCV13 is available in the vaccination 3. Food and Drug Administration. Prevnar 13: clinical review
provider’s office, unvaccinated children and children of new product license application. Rockville, MD: Food and
Drug Administration; 2010.
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the immunization series with PCV13. If the only young children: recommendations of the Advisory Committee
pneumococcal conjugate vaccine available in a pro- on Immunization Practices (ACIP). MMWR 2000;49(No.
RR-9).
vider’s office is PCV7, that vaccine should be provided 5. CDC. Recommended immunization schedule for persons
to children and infants who are due for vaccination; aged 0 through 18 years—United States, 2010. MMWR
these children should complete their series with 2010;58(51&52).
6. CDC. Updated recommendation from the Advisory
PCV13 at subsequent visits. Children for whom the Committee on Immunization Practices (ACIP) for use of
supplemental PCV13 dose is recommended should 7-valent pneumococcal conjugate vaccine (PCV7) in children
receive it at their next medical visit, at least 8 weeks aged 24–59 months who are not completely vaccinated.
after the last dose of PCV7. MMWR 2008;57:343–4.
MMWR / March 12, 2010 / Vol. 59 / No. 9 261