HUMAN MEDICAL SCHOOL




                       Group:10
Cancer is now recognized as a genetic
disorder arising from errors in cell
replication, arising from various factors, such
as environmental damage by the action of
chemical agents and radiation or even
lifestyle, leading to uncontrolled cell
reproduction. Here we see the latest Cancer
Research
The Journal of the American Medical
Association.



 Suggest that taking a daily
 multivitamin may reduce the risk
 of cancer of older men.
A randomized trial of 14,000 men after 50
years or more for an average of 11 years.



                        They found that those taking a daily
                        multivitamin supplement were 8
                        percent less likely to be diagnosed
                        with cancer than those taking a
                        placebo.
The building blocks of an emerging science that is
enabling cancer researchers to break new ground in the
way we treat disease.



                             nanotechnology, researchers
                             in the laboratory


                             seek to reduce side effects and
                             improve the effectiveness of
                             cancer drugs.


      Scientists giving greater control over the selection
      of treatments.
Ovarian Cancer Screenings Are Not Effective

           According to a study published last year in the
              journal of the American medical society

                                       of


             78.216 American women between the
             ages of 55 to 74 years



  half of them have been selected to
                                            while the other half not.
  continue a control that had a
  duration of 11 to 13 years
ultrasound exams
                                                    for elevated Levels of
                                      and           a substance called
 The screening
 consisted                     blood tests          CA-125



                                                    Which can be a sign
                                                    of ovarian cancer




                  There was no advantage        the death rate from ovarian
Result
                 to screening:                  cancer was the same in the
                                                two groups.
Genes Now They Can not Tell Secrets Doctors Utter



    Dr. Arul Chinnaiyan stared at a printout of gene sequences
    from a man with cancer, a subject in one of his studies




    There, Along with the man's cancer genes, was something
    unexpected - genes of the virus causes AIDS That ...
In laboratories around the world,




using genetic tools Researchers are ever more sophisticated
That to peer into the DNA of cells are increasingly finding
things They Were not looking for


                                 Including


   Information That Could make a big difference
   to an anonymous donor.
Studies have long Shown an Increased risk of
breast cancer in women Whose breasts are
considered "dense," or less fatty.
New research showing patients with breast
cancer That dense breasts Were no more likely
to die than other patients.




                The women with less dense breasts Were
                more likely to die of Their Breast Cancers




                                                         The study included more
                                                         than 9,000 women
The cancers are fueled by stem cells that
chemotherapy drugs do not kill


                                                    Strategies can be designed to kill


                        Everything has a weakness, with all modern
                      molecular techniques and modern approaches we
                                     have, we can kill




                                                specific cells within tumors are responsible
                                                          for its continued growth
molecular tricks allow scientists to make certain
              tumor cells brightly




     When these tagged cells are divided, all daughter
              cells were stained similarly




                                    This allowed the researchers to determine if any old cell
                                    into a tumor may continue to fuel growth or only a subset
                                    of cells is responsible.
Next, the scientists Treated the mice with a chemotherapy drug Rapidly dividing That
                                    Kills tumor cells.




                                                    When the tumors grew back, do as
                                                    glioblastomas



                                                           Generally, the scientists used other
                                                           chemical tricks to seeThat



the new cells were all descendants of the
green-glowing cells That Were not killed by
the drug.




The next step was to see what would happen if the
cancer stem cells Were wiped out
Were wiped out, to test That was possible Because of the way the mice Were
                            genetically constructed




                                                    Without the stem cells, the tumors
                                                   never grew as large and the animals
                                                   lived longer.




                                                          The scientists Concluded




   That They Had Destroyed the wellspring of the
   tumor cells renew




That When other cancer cells stop dividing
Within the mass.
Today, only kill cancer medications Generally Rapidly dividing cells



                                                   scientists do not yet know enough
                                                   about cancer stem cells to target
                                                   them



                                                 Biotech companies and academics are working on
                                                 the problem.




Overall, scientists are finding That grotesque
caricatures Cancers are of normal body tissues



 said John E.Dick, senior scientist at
 Toronto's Princess Margaret Cancer
 Center


             Whose work in the 1990s provided early evidence for stem cells in leukemia
Just as healthy tissues Contain a mix of cells - - ones That are dividing




                                                               , ones That have taken on distinct
                                                               identities, and Stem Cells That
                                                               Periodically replenish the tissue




   - so, too, do cancers.
   And just as usual tissue growth Involves a




complicated dance of chemical messages among
cells, so, too, might the growth of cancers.
That complexity makes the prospect of devising new
therapies seem daunting, Dick said




But, I added, it opens up a whole new menu of Strategies That scientists can try.
10   oncologic research

10 oncologic research

  • 1.
  • 3.
    Cancer is nowrecognized as a genetic disorder arising from errors in cell replication, arising from various factors, such as environmental damage by the action of chemical agents and radiation or even lifestyle, leading to uncontrolled cell reproduction. Here we see the latest Cancer Research
  • 4.
    The Journal ofthe American Medical Association. Suggest that taking a daily multivitamin may reduce the risk of cancer of older men.
  • 5.
    A randomized trialof 14,000 men after 50 years or more for an average of 11 years. They found that those taking a daily multivitamin supplement were 8 percent less likely to be diagnosed with cancer than those taking a placebo.
  • 6.
    The building blocksof an emerging science that is enabling cancer researchers to break new ground in the way we treat disease. nanotechnology, researchers in the laboratory seek to reduce side effects and improve the effectiveness of cancer drugs. Scientists giving greater control over the selection of treatments.
  • 7.
    Ovarian Cancer ScreeningsAre Not Effective According to a study published last year in the journal of the American medical society of 78.216 American women between the ages of 55 to 74 years half of them have been selected to while the other half not. continue a control that had a duration of 11 to 13 years
  • 8.
    ultrasound exams for elevated Levels of and a substance called The screening consisted blood tests CA-125 Which can be a sign of ovarian cancer There was no advantage the death rate from ovarian Result to screening: cancer was the same in the two groups.
  • 9.
    Genes Now TheyCan not Tell Secrets Doctors Utter Dr. Arul Chinnaiyan stared at a printout of gene sequences from a man with cancer, a subject in one of his studies There, Along with the man's cancer genes, was something unexpected - genes of the virus causes AIDS That ...
  • 10.
    In laboratories aroundthe world, using genetic tools Researchers are ever more sophisticated That to peer into the DNA of cells are increasingly finding things They Were not looking for Including Information That Could make a big difference to an anonymous donor.
  • 11.
    Studies have longShown an Increased risk of breast cancer in women Whose breasts are considered "dense," or less fatty.
  • 12.
    New research showingpatients with breast cancer That dense breasts Were no more likely to die than other patients. The women with less dense breasts Were more likely to die of Their Breast Cancers The study included more than 9,000 women
  • 14.
    The cancers arefueled by stem cells that chemotherapy drugs do not kill Strategies can be designed to kill Everything has a weakness, with all modern molecular techniques and modern approaches we have, we can kill specific cells within tumors are responsible for its continued growth
  • 15.
    molecular tricks allowscientists to make certain tumor cells brightly When these tagged cells are divided, all daughter cells were stained similarly This allowed the researchers to determine if any old cell into a tumor may continue to fuel growth or only a subset of cells is responsible.
  • 16.
    Next, the scientistsTreated the mice with a chemotherapy drug Rapidly dividing That Kills tumor cells. When the tumors grew back, do as glioblastomas Generally, the scientists used other chemical tricks to seeThat the new cells were all descendants of the green-glowing cells That Were not killed by the drug. The next step was to see what would happen if the cancer stem cells Were wiped out
  • 17.
    Were wiped out,to test That was possible Because of the way the mice Were genetically constructed Without the stem cells, the tumors never grew as large and the animals lived longer. The scientists Concluded That They Had Destroyed the wellspring of the tumor cells renew That When other cancer cells stop dividing Within the mass.
  • 18.
    Today, only killcancer medications Generally Rapidly dividing cells scientists do not yet know enough about cancer stem cells to target them Biotech companies and academics are working on the problem. Overall, scientists are finding That grotesque caricatures Cancers are of normal body tissues said John E.Dick, senior scientist at Toronto's Princess Margaret Cancer Center Whose work in the 1990s provided early evidence for stem cells in leukemia
  • 19.
    Just as healthytissues Contain a mix of cells - - ones That are dividing , ones That have taken on distinct identities, and Stem Cells That Periodically replenish the tissue - so, too, do cancers. And just as usual tissue growth Involves a complicated dance of chemical messages among cells, so, too, might the growth of cancers.
  • 20.
    That complexity makesthe prospect of devising new therapies seem daunting, Dick said But, I added, it opens up a whole new menu of Strategies That scientists can try.