Infectious diseases account for a significant portion of global mortality, particularly in developing countries. New pathogens are emerging and spreading rapidly, while multidrug-resistant pathogens are a growing problem. A multidisciplinary approach is needed to address infectious disease challenges. This document outlines the agenda for the 3rd International Research Meeting on microbiology and infectious diseases, highlighting France's major research institutions in this area and the scientific sessions to be covered.

1. 3rd International Research Meeting June 10th, 2011, Hôtel Marigny Introduction Pr Jean-François Delfraissy Institut de Microbiologie et Maladies Infectieuses (IMMI) Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) CHU Bicetre – Paris XI CEA CHRU CNRS CPU INRA INRIA INSERM INSTITUT PASTEUR IRD

2. Infectious diseases account for 26% of all deaths worldwide Leading cause of mortality in ressources limited countries Two-thirds of worldwide deaths in children <5 years old The Heavy Burden of Infectious Diseases % of deaths 18% 15% 31% 36% Pneumonia Diarrhoea Other infections Non infectious

3. « Emergence »: a global threat Newly apparent pathogens: HIV, Ebola, H5N1, H1N1… Rapidly increasing in incidence or geographic range : dengue, chikungunya, West Nile Multidrug Resistant Pathogens : NDM-1, E.Coli (EHEC) Importance of zoonosis Multidisciplinary approach Vectors Hosts Humans

4. A new vision of microbiology Discovery of new viruses, new bacteria The commensal microbiota : from homeostasis to disease New technologies : deep sequencing, omics… Molecular basis of host defense Host genetic control Biomarkers, Point of care, Pharmacogenomics

5. Medical and Scientific challenges Transmission of infection (mechanisms, nosocomial…) Emerging diseases ; zoonosis, human ecology, biodiversity Resistance : Tuberculosis, Bacteria, MDR… Infectious agents and non infectious diseases : cancer, cardiovascular, obesity, allergy, inflammation,… Vaccination : new vaccines, immunity, SHS… The big 3 : HIV, Tuberculosis, Malaria

6. IMMI: French Biomedical research Centers Institut Pasteur Paris Pitié Salpétrière Mondor/Bicêtre/Orsay/CEA/Saclay Bichat/St Louis Cochin/Cordeliers BIOPOLE Lyon-Grenoble IRT Lyon/Pasteur Institut Pasteur Lille Bordeaux Strasbourg INFECTIOPOLE Sud Marseille-Montpellier-Nice IHU

7. Microbiology and Infectious Diseases Key points: France 2011 Major Institutions : Institut Pasteur, Inserm, CNRS, IRD Others : ANRS, CEA, CIRAD, INRA, INVS, Universities 12% of French research forces : 300 teams, 2000 Scientists & Technical staff 18% of French biomedical publications : 5000 publications per year Translationnal and clinical research: 35 clinical units involved, including HIV and hepatits Network of vaccine research centers Large research network in ressources limited countries

8. Scientific Program (1) 8.55 -11.30 Session 1 : UNDERSTANDING INFECTIOUS DISEASES: NEW MECHANISMS & PARADIGMS Session 2 : NEW TARGETS AND TOOLS IN INFECTIOLOGY 11.30 Transfer to Elysée Palace 12.15 The President Sarkozy Lecture 12.45 – 13.45 Buffet-Lunch

9. Scientific Program (2) 14.00 – 14.30 Session 3 : NORTH-SOUTH PARTNERSHIPS: POWERFUL RESEARCH TOOLS 14.30 – 17.00 R&D Dating Session : Twenty one companies will meet successively with 4 scientific teams representatives This very short meeting allows to define whether a future in depth meeting should be scheduled in case of confirmed common interests 17.15 Conclusion remarks: Pierre TEILLAC – Chairman of ARIIS 17.45 Allocution by the Minister Mr Eric BESSON