07 rencontres biomédicale LIR Bart Staels
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This document discusses diabetes and cardiovascular disease risk factors and complications. It summarizes that obesity predisposes individuals to both diabetes and cardiovascular disease. It then outlines various circadian and molecular pathways involved in metabolic regulation and the potential role of nuclear receptors and transcription factors like Rev-erbα and RORα. Finally, it describes several European research consortia studying diabetes and cardiovascular disease, as well as the creation of the European Genomics Institute of Diabetes, which aims to conduct basic, clinical, and translational research towards developing new diabetes treatments through collaborations between academia and the pharmaceutical industry.
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2. What is the full complement of proteins and metabolites secreted by different kinds of adipocytes?
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The relationship between_health_and_growth
This paper revisits the relationship between health and growth in light of modern endogenous growth theory. We propose an unified framework that encompasses the growth effects of both, the accumulation and the level of health. Based on cross-country regressions where we instrument for both variables, we find that a higher initial level and a higher rate of improvement in life expectancy, both have a significantly positive impact on per capita GDP growth.
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In its role of think tank and within the framework of the “Assises du Médicament”, the LIR considered useful to make realize by the researchers of the ESSEC an international study on the policies of management of conflicts of interests.
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- 3. Obesity predisposes to diabetes and cardiovascular disease
- 4. Nutrition Exercise Signal transduction pathways Transcription factors Genes Insulin resistance Inflammation Hyper- tension Lipid disorders
- 5. Clock Sleep-wake cycles Body temperature Activation of intestinal system Endocrine systems Liver metabolism Renal activity Cardiovascular system (blood pressure, heart beat, …) Example 1: Circadian dysregulation and Metabolic disorders
- 6. Clock outputs Physiological response / metabolic adaptation Metabolic signals Molecular pathways? (ex.Rev-erb and ROR ) Chronopharmacology
- 8. Normal state NR interactome A Cistrome A Regulon A Example 2: Molecular analysis of gene regulation in cardiometabolic diseases Pathological state Epigenetic events NR interactome B Regulon B Cistrome B
- 9. Lean PPAR interactome A Cistrome A Regulon A GO functional classification: 1) Extracellular signalling 2) Carboxylic acid metabolism 3) Oxido-reduction 4) Development 5) Subcellular transport Role of the proteasome in the response visceral WAT responsiveness to PPAR Lefebvre et al. J.Clin.Invest. 2009 Hypoxia UCHL1, Proteasome Obese PPAR interactome B Regulon B Cistrome B GO functional classification: 1) Monocarboxylic acid and lipid metabolism 2) Mitochondrion 3) Metabolic processes 4) Glucose and pyruvate metabolism 5) Citrate cycle
- 12. European Genomics Institute of Diabetes : a model of industrie – academia partnership, towards tomorrow’s treatments Basic Research Clinical Research Translational Research Valorisation Platform Pharmaceutical industrie
Editor's Notes
- HD: i have replaced the title by the project title
- HD: format changes to fit the screen; 05/11/2008: change title (add ‘hypothesis’)
- HD: front change so that the ‘nuclear receptor’ fit into the circles + 05/11/2008: I have added the nature med reference