This document provides a summary of Joseph F. Dellaria Jr.'s career profile and experience. It outlines his competencies in areas such as creating and leading teams, expediting innovation discovery, patent strategy development, innovative synthesis of new compounds, and understanding of bioavailability issues. It then details his professional experience including founding his own consulting firm and previous roles at 3M Pharmaceuticals and Abbott Labs where he led research teams, published papers, was granted patents, and more. The document closes with his education history and list of 64 granted patents.
16.02.09 10 msu strategic business decision making_student handout after the ...Joseph Dellaria
Presentation on Strategic Planning, how the information status influences what you do with an idea, the Idea Formula provides a unique approach to qualifying the value of an idea, proving whether an idea can work is a binary (yes or no) process, four types of ideas,
Encouraging Transparency in Lab Safety via Teachable Moments and Positive Fee...Melinda Box
Transparency is an essential part of developing and maintaining an ethical culture and a safety culture. We found two practices that significantly contributed to both - capitalizing on teachable moments and the active provision of detailed positive feedback. When we applied these to instances of evaluating performance, we found that they facilitated communication and supported the inquiry necessary to develop and sustain openness. While enforcement, an alternative approach, may evoke rapid compliance, it may also tend to reduce discussion. By contrast, we found that consideration of the vulnerability of those in non-compliance tended to ease the exchange and support the robust relations needed to create and maintain safe conditions. Appreciation for the state of intense interest and hunger for information characteristic of these teachable moments led to providing specific guidance that recipients were ready to use immediately. In addition, reinforcement of existing desirable practice via specific positive comments gave recipients the guidance necessary to build on their current foundation of skills, knowledge, and strengths. This presentation brings together research in neurological science, principles of management and evaluation, and cases of our observation to illustrate how performance evaluations can be leveraged to achieve an ethically responsive culture.
The document summarizes the launch of Draths Corporation by scientists Dr. John Frost and Dr. Karen Draths. It details their backgrounds and pioneering green technology research. It describes how they secured an initial $1 million investment from an angel investor in 2005 to launch Draths Corporation and commercialize their renewable energy technology. It outlines some of their early successes, including winning government grants, additional investment rounds, patent issuances, and partnerships with major companies.
Babatunde Ojo has over 25 years of experience in organic and medicinal chemistry. He holds a Ph.D. in Medicinal Chemistry and has published 20 peer-reviewed articles and holds 3 patents. Currently he is the Director of a non-profit organization where he develops abstinence education programs. Previously he was an Associate Professor of Chemistry for 10 years where he mentored students and developed a new Ph.D program in Biotechnology. He has received awards for his role in motivating and guiding minority students in STEM fields.
Renna Stevens-Wolfe is a PhD candidate in neuroscience expected to graduate in December 2010. She received her BA in neuroscience from Smith College in 2003, graduating magna cum laude with highest honors. Her research focuses on cellular and circuit mechanisms of cortical plasticity. She has extensive experience in neurophysiology techniques, data analysis, teaching, outreach, and publishing. She has presented her research at multiple scientific conferences and has several peer-reviewed publications.
This document is a resume for Pamela A. Haile. It summarizes her education, professional experience, awards, publications, and membership. She has a PhD in Chemistry from UNC-Chapel Hill and is currently a Senior Scientific Investigator at GlaxoSmithKline in the Immuno-Inflammation Therapeutic Area. She has over 15 years of experience in medicinal chemistry and has received several awards and recognitions from GSK for her work.
This document provides guidance on conducting research for a project. It discusses choosing a topic that interests the reader and meets assignment requirements. It also covers finding and evaluating information from various sources, as well as thinking through the purpose, audience, and context of the research. The document emphasizes that research involves answering questions and sharing results with others. It stresses clarifying the assignment, managing time, and outlining the research process.
1) Animals are used in scientific research for various purposes like studying basic life processes, educational processes, experimental work on animal breeding and nutrition, diagnostic testing, and developing commercial products.
2) The welfare of research animals can be affected by some experiments that involve surgery or inducing painful conditions, as well as inadequate housing and husbandry. Researchers must seek to replace animal models, reduce animal usage to a minimum, and refine experiments to minimize pain and distress.
3) Standards for computer ethics and research ethics aim to prevent harm, ensure informed consent and privacy, and avoid conflicts of interest and other problems like plagiarism, fabrication, and exploitation of vulnerable groups. Upholding ethical guidelines is important for responsible conduct of
16.02.09 10 msu strategic business decision making_student handout after the ...Joseph Dellaria
Presentation on Strategic Planning, how the information status influences what you do with an idea, the Idea Formula provides a unique approach to qualifying the value of an idea, proving whether an idea can work is a binary (yes or no) process, four types of ideas,
Encouraging Transparency in Lab Safety via Teachable Moments and Positive Fee...Melinda Box
Transparency is an essential part of developing and maintaining an ethical culture and a safety culture. We found two practices that significantly contributed to both - capitalizing on teachable moments and the active provision of detailed positive feedback. When we applied these to instances of evaluating performance, we found that they facilitated communication and supported the inquiry necessary to develop and sustain openness. While enforcement, an alternative approach, may evoke rapid compliance, it may also tend to reduce discussion. By contrast, we found that consideration of the vulnerability of those in non-compliance tended to ease the exchange and support the robust relations needed to create and maintain safe conditions. Appreciation for the state of intense interest and hunger for information characteristic of these teachable moments led to providing specific guidance that recipients were ready to use immediately. In addition, reinforcement of existing desirable practice via specific positive comments gave recipients the guidance necessary to build on their current foundation of skills, knowledge, and strengths. This presentation brings together research in neurological science, principles of management and evaluation, and cases of our observation to illustrate how performance evaluations can be leveraged to achieve an ethically responsive culture.
The document summarizes the launch of Draths Corporation by scientists Dr. John Frost and Dr. Karen Draths. It details their backgrounds and pioneering green technology research. It describes how they secured an initial $1 million investment from an angel investor in 2005 to launch Draths Corporation and commercialize their renewable energy technology. It outlines some of their early successes, including winning government grants, additional investment rounds, patent issuances, and partnerships with major companies.
Babatunde Ojo has over 25 years of experience in organic and medicinal chemistry. He holds a Ph.D. in Medicinal Chemistry and has published 20 peer-reviewed articles and holds 3 patents. Currently he is the Director of a non-profit organization where he develops abstinence education programs. Previously he was an Associate Professor of Chemistry for 10 years where he mentored students and developed a new Ph.D program in Biotechnology. He has received awards for his role in motivating and guiding minority students in STEM fields.
Renna Stevens-Wolfe is a PhD candidate in neuroscience expected to graduate in December 2010. She received her BA in neuroscience from Smith College in 2003, graduating magna cum laude with highest honors. Her research focuses on cellular and circuit mechanisms of cortical plasticity. She has extensive experience in neurophysiology techniques, data analysis, teaching, outreach, and publishing. She has presented her research at multiple scientific conferences and has several peer-reviewed publications.
This document is a resume for Pamela A. Haile. It summarizes her education, professional experience, awards, publications, and membership. She has a PhD in Chemistry from UNC-Chapel Hill and is currently a Senior Scientific Investigator at GlaxoSmithKline in the Immuno-Inflammation Therapeutic Area. She has over 15 years of experience in medicinal chemistry and has received several awards and recognitions from GSK for her work.
This document provides guidance on conducting research for a project. It discusses choosing a topic that interests the reader and meets assignment requirements. It also covers finding and evaluating information from various sources, as well as thinking through the purpose, audience, and context of the research. The document emphasizes that research involves answering questions and sharing results with others. It stresses clarifying the assignment, managing time, and outlining the research process.
1) Animals are used in scientific research for various purposes like studying basic life processes, educational processes, experimental work on animal breeding and nutrition, diagnostic testing, and developing commercial products.
2) The welfare of research animals can be affected by some experiments that involve surgery or inducing painful conditions, as well as inadequate housing and husbandry. Researchers must seek to replace animal models, reduce animal usage to a minimum, and refine experiments to minimize pain and distress.
3) Standards for computer ethics and research ethics aim to prevent harm, ensure informed consent and privacy, and avoid conflicts of interest and other problems like plagiarism, fabrication, and exploitation of vulnerable groups. Upholding ethical guidelines is important for responsible conduct of
CHEM 2P21 Information Exercise Winter 2020 ppt slidesBrock University
This document provides instructions for using ChemDraw software to draw chemical structures and insert them into Word documents. It also lists several journal articles and patents related to pharmaceutical compounds and antibiotic development. The learning outcomes mention searching various databases to find information on chemical synthesis, commercial suppliers, and scholarly articles on topics like antibacterial drugs and green chemistry.
This document provides an overview of research methods. It discusses that research has grown out of educational practices aimed at improving instruction. The objectives of the chapter are then outlined, including defining research and differentiating it from problem-solving. Several types of research are classified, such as by purpose (predictive, directive, illuminative), goal (basic/pure vs. applied), and level of investigation (exploratory, descriptive, experimental). Characteristics of good research are also summarized, such as being systematic, controlled, empirical, and analytical.
This document discusses research ethics and outlines key concepts in the field. It describes how researchers were not properly considering subjects' interests, leading to problems like lack of informed consent. In response, the US government established regulations and the Institutional Review Board system to oversee research ethics. The Belmont Report identified core ethics principles of respect for persons, beneficence, and justice. Researchers must apply these principles, get informed consent, minimize risks and select subjects fairly. The roles of the IRB, OHRP and FDA in enforcing research ethics standards are also summarized.
This document discusses research ethics and outlines key concepts. It describes two types of ethical reasoning - deductive/principle-based and inductive/case-based. The Belmont Report established three core ethical principles for research involving human subjects: respect for persons, beneficence, and justice. It also discusses past ethical issues in research like lack of informed consent and the establishment of Institutional Review Boards to protect research participants according to federal regulations. The role of the IRB is to ensure research adheres to ethical standards and sound scientific principles.
Dahl-presentation - ethics and research.pptjagannath67
This document discusses research ethics and provides an overview of key concepts and principles. It covers two types of ethical reasoning - deductive/principle-based and inductive/case-based. Major topics include the Belmont Report, roles of the IRB and federal regulations. The Belmont Report established three core principles: respect for persons, beneficence, and justice. The document also presents three case studies and discusses norms for ethical scientific research involving human subjects.
Dahl-presentation - ethics and research.pptJames624783
This document discusses research ethics and provides an overview of key concepts and principles. It covers two types of ethical reasoning - deductive/principle-based and inductive/case-based. Major topics include the Belmont Report, roles of the IRB and federal regulations. The Belmont Report established three core ethical principles: respect for persons, beneficence, and justice. The document also presents three case studies on research plans to analyze related ethical issues.
Dahl-presentation - ethics and research.pptcsnehasingh13
This document discusses research ethics and provides an overview of key concepts and principles. It describes two approaches to ethical decision making - deductive/principle-based reasoning and inductive/case-based reasoning. The Belmont Report established three core ethical principles for research involving human subjects: respect for persons, beneficence, and justice. The document also outlines federal regulations and the role of Institutional Review Boards in protecting research participants. It analyzes several case studies and identifies ethical issues researchers should consider.
This document discusses research ethics and outlines key concepts in the field. It describes how researchers were not properly considering subjects' interests, leading to problems like lack of informed consent. To address this, the US government established regulations and the Institutional Review Board (IRB) system in 1974. The Belmont Report from 1979 established three core ethical principles of respect for persons, beneficence, and justice. Researchers must follow federal regulations and obtain IRB approval to ensure ethical research conduct and protection of human subjects.
The document outlines a lesson plan on research that includes explaining the importance of research in daily life, describing the characteristics and processes of research, differentiating between quantitative and qualitative research, and providing examples of different types of research. It covers topics such as the definition of research, the importance of research, the research process, ethics in research, and the differences between quantitative and qualitative research methodologies. The goal is for students to understand research and be able to apply research concepts and methods.
The document discusses several key issues regarding research ethics:
1. Ethical norms in research promote goals like knowledge, truth, and cooperation between researchers. They also help ensure accountability and build public support.
2. Many professional organizations and government agencies have established codes and policies on research ethics to address issues like honesty, objectivity, integrity, and protecting human and animal subjects.
3. Researchers must make ethical decisions by carefully applying rules and considering how their actions may affect others. They should avoid misconduct but also recognize unwritten norms around attribution, conflicts of interest, and sharing information and resources.
This document provides a curriculum vitae for Dr. C. K. K. Nair, including his contact information, educational background, areas of specialization, academic and professional experience, research interests, publications, awards, and more. Some key details include:
- Dr. Nair has over 47 years of experience in biochemistry, molecular biology, and radiation biology.
- He has a Ph.D. in biochemistry from the University of Bombay and has taught at several universities.
- His research focuses on areas like DNA repair, radiation biology, natural drugs, and nanotechnology applications.
- He has over 200 publications, guided 13 Ph.D. students, and received several awards
Dr. Mohamed Eddaoudi, an assistant professor in the chemistry department, is highly cited in his field. He has received prestigious grants and awards for his research. Dr. Edward Turos' research on nanoparticles for drug delivery was featured in a magazine. A Nobel Prize winner gave a lecture about protein degradation. The department was represented at several conferences, and faculty and students received recognition for their work. The document provides updates on faculty, students, alumni and funds in the chemistry department.
Gardens In Healthcare Facilities: Uses, Therapeutic Benefits, And Design Reco...angeliaGeo
The document summarizes a study of gardens in healthcare facilities that included:
1) Reviewing relevant research on the therapeutic benefits of natural environments.
2) Conducting case studies of gardens at 4 hospitals, including observations and interviews to understand usage.
3) Developing design recommendations based on the case studies to promote the therapeutic use of gardens.
This document discusses research projects for PharmD students. It emphasizes that research and problem solving are important for pharmacists and the pharmacy profession. Pharmacists can conduct research to help guide drug therapy and should understand the research process to interpret knowledge generated by others. The document provides guidance to students on formulating a research problem, including reviewing literature, developing a logical research problem statement, and considering factors like interest, magnitude, measurement and expertise when selecting a problem. It aims to help students develop skills for their PharmD research projects.
This document provides an overview of bibliometrics and conducting scholarly research. It discusses formulating hypotheses, identifying different types of scholarly articles, and searching techniques like using Boolean operators and subject headings. Specific topics covered include placebos, the placebo effect, turning questions into search statements, and the hierarchy of evidence. Practice exercises are provided on searching bibliographic databases and evaluating sources.
Discussion Ethical Dimensions of Research StudiesIn the best-se.docxlefrancoishazlett
Discussion: Ethical Dimensions of Research Studies
In the best-selling book, The Immortal Life of Henrietta Lacks (Skloot, 2010), the author highlights the true story of an African-American woman who died in 1951 from cervical cancer. What makes her story unique is that prior to her death, cells from her tumor were removed and successfully grown in a petri dish. This was the first time scientists were able to successfully replicate cells outside the body, and it is estimated that billions of Lacks’ cells have been used in medical research. However, Henrietta Lacks was never asked for permission to take a sample and her family was never made aware of the widespread use of her cells. Although the culturing of her cells has been pivotal for advancing research, strong ethical concerns later arose about using these cells without patient or family approval.
This week’s readings describe historical examples of unethical research, such as a study of syphilis among African-American men in which treatment was withheld and a study in which live cancer cells were injected into elderly patients. Today, stricter controls that seek to protect study participants are placed on researchers, but breaches still occur. Careful attention must be given toward preventing unethical behavior. In this Discussion, you explore ethical considerations and issues in research.
To prepare:
Select a current health-related case involving research ethics. (If none come to mind, browse the Internet to familiarize yourself with recent cases.)
As you review the case that you have selected, reflect on the ethical principles discussed in “What Are the Major Ethical Issues in Conducting Research?” article found in this week’s Learning Resources. Which principles were breached in the case you have identified?
Post a description of the case that you selected and the ethical issues involved. Analyze the ethical principles that were breached by the researchers or organizations in your selected case as well as the possible cause of the breach(es). Suggest how the research might have been conducted differently to avoid or minimize the ethical problems. Discuss how research can be done on sensitive issues while still protecting the rights of the research subjects.
Read a selection of your colleagues’ responses.
Respond to at least two of your colleagues on two different days using one or more of the following approaches:
Ask a probing question, substantiated with additional background information, and evidence.
Offer and support an alternative perspective using readings from the classroom or from your own review of the literature in the Walden Library.
Make a suggestion based on additional evidence drawn from readings or after synthesizing multiple postings.
Required Readings
Polit, D. F., & Beck, C. T. (2017). Nursing research: Generating and assessing evidence for nursing practice (10th ed.). Philadelphia, PA: Wolters Kluwer.
Chapter 3, “Key Concepts and Steps in Qualitative and Qu.
DOC1 - National Toxicology Program - Toxicology and Carcinogenesis 4 MIToxiColaOrg
Este es el único estudio realizado en seres vivos para evaluar el potencial toxicológico y cancerígeno del compuesto 4-Metilidimadazol que se encuentra en el colorante Caramelo IV usado por Coca Cola, las bebidas de Cola y otros productos. Fue realizado por el Programa Nacional de Toxicología del Servicio de Salud Pública de los Estados Unidos en 2007. Para evaluar el riesgo que pueden presentar para la salud humana diversos compuestos, se realizan estudios en animales, considerando que si hay un efecto negativo en su salud, estos compuestos no deberían ser consumidos por las personas. El estudio se realizó en ratas y ratones durante dos años y su conclusión fue: "Concluimos que el 4-Metilidimadazol causa cáncer de pulmón en ratones machos y hembras. El 4-Metilidimazol se puede asociar también con el desarrollo de leucemia en ratas hembras".
Developing and Analyzing Research Questions: Strategies for Environmental Hea...John Pell
The document discusses strategies for developing and analyzing research questions for environmental health studies. It introduces the Stases method for refining the scope of a research question by considering agreed upon points, points of contention, and which to address. It then outlines the six categories of the Stases method: existence, definition, cause, value, action, and jurisdiction. The document also describes the FINER and PICOT frameworks for assessing research questions. FINER considers feasibility, interest, novelty, ethics, and relevance, while PICOT breaks down questions into population, intervention, comparison, outcome, and temporality. Examples are provided for applying these frameworks to research objectives and questions.
Essay tests allow for the assessment of higher-order thinking skills as they are classified as non-objective tests. In an essay test, students are requested to write one or more paragraphs on a specified topic to organize their thoughts and inform an audience. Stecklein identified 14 types of abilities that can be measured by essay items, including comparisons, development and defense of opinions, explanations, summaries, analysis, knowledge of relationships, and inferential thinking. When grading essay papers, rules of thumb include phrasing the directions to guide students on key concepts and informing students of the criteria that will be used, such as coherence, accuracy, use of keywords, and clarity.
This resume summarizes Sean Ekins' experience and qualifications. He has over 17 years of experience in drug discovery from large pharmaceutical companies to small biotechs. He is an expert in computational and in vitro tools for accelerating drug discovery and reducing compound attrition. He has held leadership roles at several companies and currently works as an independent consultant advising various organizations. He is also an active researcher and writer with over 200 publications.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
CHEM 2P21 Information Exercise Winter 2020 ppt slidesBrock University
This document provides instructions for using ChemDraw software to draw chemical structures and insert them into Word documents. It also lists several journal articles and patents related to pharmaceutical compounds and antibiotic development. The learning outcomes mention searching various databases to find information on chemical synthesis, commercial suppliers, and scholarly articles on topics like antibacterial drugs and green chemistry.
This document provides an overview of research methods. It discusses that research has grown out of educational practices aimed at improving instruction. The objectives of the chapter are then outlined, including defining research and differentiating it from problem-solving. Several types of research are classified, such as by purpose (predictive, directive, illuminative), goal (basic/pure vs. applied), and level of investigation (exploratory, descriptive, experimental). Characteristics of good research are also summarized, such as being systematic, controlled, empirical, and analytical.
This document discusses research ethics and outlines key concepts in the field. It describes how researchers were not properly considering subjects' interests, leading to problems like lack of informed consent. In response, the US government established regulations and the Institutional Review Board system to oversee research ethics. The Belmont Report identified core ethics principles of respect for persons, beneficence, and justice. Researchers must apply these principles, get informed consent, minimize risks and select subjects fairly. The roles of the IRB, OHRP and FDA in enforcing research ethics standards are also summarized.
This document discusses research ethics and outlines key concepts. It describes two types of ethical reasoning - deductive/principle-based and inductive/case-based. The Belmont Report established three core ethical principles for research involving human subjects: respect for persons, beneficence, and justice. It also discusses past ethical issues in research like lack of informed consent and the establishment of Institutional Review Boards to protect research participants according to federal regulations. The role of the IRB is to ensure research adheres to ethical standards and sound scientific principles.
Dahl-presentation - ethics and research.pptjagannath67
This document discusses research ethics and provides an overview of key concepts and principles. It covers two types of ethical reasoning - deductive/principle-based and inductive/case-based. Major topics include the Belmont Report, roles of the IRB and federal regulations. The Belmont Report established three core principles: respect for persons, beneficence, and justice. The document also presents three case studies and discusses norms for ethical scientific research involving human subjects.
Dahl-presentation - ethics and research.pptJames624783
This document discusses research ethics and provides an overview of key concepts and principles. It covers two types of ethical reasoning - deductive/principle-based and inductive/case-based. Major topics include the Belmont Report, roles of the IRB and federal regulations. The Belmont Report established three core ethical principles: respect for persons, beneficence, and justice. The document also presents three case studies on research plans to analyze related ethical issues.
Dahl-presentation - ethics and research.pptcsnehasingh13
This document discusses research ethics and provides an overview of key concepts and principles. It describes two approaches to ethical decision making - deductive/principle-based reasoning and inductive/case-based reasoning. The Belmont Report established three core ethical principles for research involving human subjects: respect for persons, beneficence, and justice. The document also outlines federal regulations and the role of Institutional Review Boards in protecting research participants. It analyzes several case studies and identifies ethical issues researchers should consider.
This document discusses research ethics and outlines key concepts in the field. It describes how researchers were not properly considering subjects' interests, leading to problems like lack of informed consent. To address this, the US government established regulations and the Institutional Review Board (IRB) system in 1974. The Belmont Report from 1979 established three core ethical principles of respect for persons, beneficence, and justice. Researchers must follow federal regulations and obtain IRB approval to ensure ethical research conduct and protection of human subjects.
The document outlines a lesson plan on research that includes explaining the importance of research in daily life, describing the characteristics and processes of research, differentiating between quantitative and qualitative research, and providing examples of different types of research. It covers topics such as the definition of research, the importance of research, the research process, ethics in research, and the differences between quantitative and qualitative research methodologies. The goal is for students to understand research and be able to apply research concepts and methods.
The document discusses several key issues regarding research ethics:
1. Ethical norms in research promote goals like knowledge, truth, and cooperation between researchers. They also help ensure accountability and build public support.
2. Many professional organizations and government agencies have established codes and policies on research ethics to address issues like honesty, objectivity, integrity, and protecting human and animal subjects.
3. Researchers must make ethical decisions by carefully applying rules and considering how their actions may affect others. They should avoid misconduct but also recognize unwritten norms around attribution, conflicts of interest, and sharing information and resources.
This document provides a curriculum vitae for Dr. C. K. K. Nair, including his contact information, educational background, areas of specialization, academic and professional experience, research interests, publications, awards, and more. Some key details include:
- Dr. Nair has over 47 years of experience in biochemistry, molecular biology, and radiation biology.
- He has a Ph.D. in biochemistry from the University of Bombay and has taught at several universities.
- His research focuses on areas like DNA repair, radiation biology, natural drugs, and nanotechnology applications.
- He has over 200 publications, guided 13 Ph.D. students, and received several awards
Dr. Mohamed Eddaoudi, an assistant professor in the chemistry department, is highly cited in his field. He has received prestigious grants and awards for his research. Dr. Edward Turos' research on nanoparticles for drug delivery was featured in a magazine. A Nobel Prize winner gave a lecture about protein degradation. The department was represented at several conferences, and faculty and students received recognition for their work. The document provides updates on faculty, students, alumni and funds in the chemistry department.
Gardens In Healthcare Facilities: Uses, Therapeutic Benefits, And Design Reco...angeliaGeo
The document summarizes a study of gardens in healthcare facilities that included:
1) Reviewing relevant research on the therapeutic benefits of natural environments.
2) Conducting case studies of gardens at 4 hospitals, including observations and interviews to understand usage.
3) Developing design recommendations based on the case studies to promote the therapeutic use of gardens.
This document discusses research projects for PharmD students. It emphasizes that research and problem solving are important for pharmacists and the pharmacy profession. Pharmacists can conduct research to help guide drug therapy and should understand the research process to interpret knowledge generated by others. The document provides guidance to students on formulating a research problem, including reviewing literature, developing a logical research problem statement, and considering factors like interest, magnitude, measurement and expertise when selecting a problem. It aims to help students develop skills for their PharmD research projects.
This document provides an overview of bibliometrics and conducting scholarly research. It discusses formulating hypotheses, identifying different types of scholarly articles, and searching techniques like using Boolean operators and subject headings. Specific topics covered include placebos, the placebo effect, turning questions into search statements, and the hierarchy of evidence. Practice exercises are provided on searching bibliographic databases and evaluating sources.
Discussion Ethical Dimensions of Research StudiesIn the best-se.docxlefrancoishazlett
Discussion: Ethical Dimensions of Research Studies
In the best-selling book, The Immortal Life of Henrietta Lacks (Skloot, 2010), the author highlights the true story of an African-American woman who died in 1951 from cervical cancer. What makes her story unique is that prior to her death, cells from her tumor were removed and successfully grown in a petri dish. This was the first time scientists were able to successfully replicate cells outside the body, and it is estimated that billions of Lacks’ cells have been used in medical research. However, Henrietta Lacks was never asked for permission to take a sample and her family was never made aware of the widespread use of her cells. Although the culturing of her cells has been pivotal for advancing research, strong ethical concerns later arose about using these cells without patient or family approval.
This week’s readings describe historical examples of unethical research, such as a study of syphilis among African-American men in which treatment was withheld and a study in which live cancer cells were injected into elderly patients. Today, stricter controls that seek to protect study participants are placed on researchers, but breaches still occur. Careful attention must be given toward preventing unethical behavior. In this Discussion, you explore ethical considerations and issues in research.
To prepare:
Select a current health-related case involving research ethics. (If none come to mind, browse the Internet to familiarize yourself with recent cases.)
As you review the case that you have selected, reflect on the ethical principles discussed in “What Are the Major Ethical Issues in Conducting Research?” article found in this week’s Learning Resources. Which principles were breached in the case you have identified?
Post a description of the case that you selected and the ethical issues involved. Analyze the ethical principles that were breached by the researchers or organizations in your selected case as well as the possible cause of the breach(es). Suggest how the research might have been conducted differently to avoid or minimize the ethical problems. Discuss how research can be done on sensitive issues while still protecting the rights of the research subjects.
Read a selection of your colleagues’ responses.
Respond to at least two of your colleagues on two different days using one or more of the following approaches:
Ask a probing question, substantiated with additional background information, and evidence.
Offer and support an alternative perspective using readings from the classroom or from your own review of the literature in the Walden Library.
Make a suggestion based on additional evidence drawn from readings or after synthesizing multiple postings.
Required Readings
Polit, D. F., & Beck, C. T. (2017). Nursing research: Generating and assessing evidence for nursing practice (10th ed.). Philadelphia, PA: Wolters Kluwer.
Chapter 3, “Key Concepts and Steps in Qualitative and Qu.
DOC1 - National Toxicology Program - Toxicology and Carcinogenesis 4 MIToxiColaOrg
Este es el único estudio realizado en seres vivos para evaluar el potencial toxicológico y cancerígeno del compuesto 4-Metilidimadazol que se encuentra en el colorante Caramelo IV usado por Coca Cola, las bebidas de Cola y otros productos. Fue realizado por el Programa Nacional de Toxicología del Servicio de Salud Pública de los Estados Unidos en 2007. Para evaluar el riesgo que pueden presentar para la salud humana diversos compuestos, se realizan estudios en animales, considerando que si hay un efecto negativo en su salud, estos compuestos no deberían ser consumidos por las personas. El estudio se realizó en ratas y ratones durante dos años y su conclusión fue: "Concluimos que el 4-Metilidimadazol causa cáncer de pulmón en ratones machos y hembras. El 4-Metilidimazol se puede asociar también con el desarrollo de leucemia en ratas hembras".
Developing and Analyzing Research Questions: Strategies for Environmental Hea...John Pell
The document discusses strategies for developing and analyzing research questions for environmental health studies. It introduces the Stases method for refining the scope of a research question by considering agreed upon points, points of contention, and which to address. It then outlines the six categories of the Stases method: existence, definition, cause, value, action, and jurisdiction. The document also describes the FINER and PICOT frameworks for assessing research questions. FINER considers feasibility, interest, novelty, ethics, and relevance, while PICOT breaks down questions into population, intervention, comparison, outcome, and temporality. Examples are provided for applying these frameworks to research objectives and questions.
Essay tests allow for the assessment of higher-order thinking skills as they are classified as non-objective tests. In an essay test, students are requested to write one or more paragraphs on a specified topic to organize their thoughts and inform an audience. Stecklein identified 14 types of abilities that can be measured by essay items, including comparisons, development and defense of opinions, explanations, summaries, analysis, knowledge of relationships, and inferential thinking. When grading essay papers, rules of thumb include phrasing the directions to guide students on key concepts and informing students of the criteria that will be used, such as coherence, accuracy, use of keywords, and clarity.
This resume summarizes Sean Ekins' experience and qualifications. He has over 17 years of experience in drug discovery from large pharmaceutical companies to small biotechs. He is an expert in computational and in vitro tools for accelerating drug discovery and reducing compound attrition. He has held leadership roles at several companies and currently works as an independent consultant advising various organizations. He is also an active researcher and writer with over 200 publications.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...Leonel Morgado
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...Advanced-Concepts-Team
Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...Travis Hills MN
By harnessing the power of High Flux Vacuum Membrane Distillation, Travis Hills from MN envisions a future where clean and safe drinking water is accessible to all, regardless of geographical location or economic status.
Immersive Learning That Works: Research Grounding and Paths ForwardLeonel Morgado
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
Farming systems analysis: what have we learnt?.pptx
1 c.v. dellaria-acc full.1
1. 16.01.04
JOSEPH F. DELLARIA, JR.
10423 Kilbirnie Rd. ▪ Woodbury, MN 55129 ▪ (651) 436-6494
jfdellaria@perceptiverealities.com
CAREER PROFILE
Demonstrated ability to successfully navigate complex chemistry and organizational issues. Productive and
creative synthetic organic chemist with extensive experience in successfully directing, managing and
synthesizing complex organic compounds for drug discovery. Selected competencies fall into five areas:
Proven ability to create and lead teams that influences organizational direction.
Expediting Innovation Discovery: Conceived and created a novel process to qualify and prioritize ideas
in early phase discovery efforts. It finds “Better Ideas Faster,” saves time, and resources. The process is
proven for science-based projects, identifying new organizational processes, and making personal
decisions.
Patent Strategy Development: Worked in conjunction with patent counsels to create and implement
patent strategies for novel chemical entities in 9 unique therapeutic areas. This led to 63 patents.
Innovative Synthesis of New Compounds: discovered three new reactions and published 30 papers
describing new methods to efficiently prepare potent, biologically active compounds.
Extensive Understanding of Bioavailability Issues: participated and/or lead teams in the identification of
potent and bioavailable NCEs.
RESULTS:
Patents 64 issued U.S. patents in 9 unique therapeutic areas
Medicinal Chemistry Responsible for the discovery of the lead compound for an IND
in post-surgical scarring (effort was terminated with the sale of
the division)
Discovered back-up compounds in four therapeutic areas (Renin,
5-LO and Matrix Metalloproteinase, IRMs for cancer)
Directed the medicinal chemistry efforts of over 40 chemists over
the course of my career (bachelors, masters, and Ph.D.s)
Published Papers 30 Publications in major refereed journals
Presentations and Invited Lectures 22 professional presentations
11 invited university and college lectures
Books “The IDEA Formula
PROFESSIONAL EXPERIENCE
Perceptive Realities, LLC, Woodbury, MN 2007-present
Founder and Principal
Consulting firm dedicated to finding Better Ideas Faster through:
Building and implementing custom tailored processes for qualifying and prioritizing early R&D ideas
(Innovation Discovery Process®).
o Saves time and money by learning how to identify and stop ideas that cannot work at the earliest
possible time.
o Expedites the rate of discovering innovative ideas for late stage New Product Development.
Training to create and implement internally administered Innovation Discovery Processes®.
2. Joseph F. Dellaria, Jr.
2
Medicinal/Process Chemistry Consulting October, 2008 – October 2011
3M Pharmaceuticals, St. Paul, MN 2000 – 2007
Lead Research Specialist
Led a group of 11-14 chemists—Ph.D., M.S., and B.S.—in the design, synthesis and patenting of new
compounds in the Immune Response Modifier class of compounds.
Devised and executed a department wide plan to synthesize compounds and file 26 patents in 6 months.
Co-inventor on 19 granted U.S. patents for new Immune Response Modifying compounds.
Initiated and co-lead a team effort to design and implement the process used to select new projects for
the Pharmaceutical Discovery Division. 7 out of 50 ideas were selected for further scientific
investigation.
Lead Chemist on the Discovery Opportunities Team which oversaw allocating resources and scientific
strategy for potential new research programs.
Designed and played a leading role in implementing the hiring process to hire over thirty new
employees over a three year period.
Co-led the exploratory Multi-Drug Resistance Project. Set overall research direction, priorities, and
directed medicinal chemistry effort. Lead the team to make a data-driven no-go decision saving
$1K/year in research expenses.
Served as the departmental liaison for the design and construction of a new state-of-the-art $2 million
medicinal chemistry laboratory. Responsible for working with engineers and contractors to identify and
resolve numerous construction issues.
Abbott Labs, Chicago, IL 1984 – 2000
Associate Research Fellow / Sr. Group Leader, 1992 – 2000
Led teams of 6-8 chemists in discovering new compounds for the inhibition of four unique therapeutic
targets (5-Lipoxygenase, Cyclooxygenase II, Matrix Metalloproteinase, and Urokinase).
Identified potent (nanomolar to sub-nanomolar) inhibitors in each area.
Set and executed patent strategies for each area.
22 U.S. patents were granted during this time.
Maintained an active lab presence as time permitted.
Promoted to the first step of the Scientific Ladder (Associate Research Fellow, Volwiler Society, Aug.
1992).
Research Investigator, 1989 – 1992
Responsible for overseeing the work of two assistants and three summer students.
3 U.S. patents were granted during this period.
Designed and synthesized new amide-linked compounds for the inhibition of 5-Lipoxygenase.
EDUCATION
N.I.H. Post-doctoral Fellow: California Institute of Technology, Pasadena, CA and
Harvard University, Cambridge, MA. Research Advisor: Professor David A. Evans.
3. Joseph F. Dellaria, Jr.
3
Ph.D., Organic Chemistry, University of Minnesota, Minneapolis, MN. Research
Advisor: Professor T.R. Hoye.
Bachelor of Arts, Chemistry, Hope College, Holland, MI. Research Advisor: Michael P.
Doyle.
PROFESSIONAL SOCIETY
American Chemical Society
HONORS AND AWARDS
National Institute of Health Postdoctoral Fellow
L.I. Smith Outstanding Graduate Student Award, U. of MN
Graduate School Dissertation Fellowship, U. of MN
E.I. DuPont Research Award, Hope College
Member Phi Beta Kappa, Hope College
PATENTS
64) Stoermer, Doris; Dellaria, Jr.; Joseph F.; Amos, David T.; Zimmermann, Bernhard M;
Dressel, Luke T.; Bonk, Jason D.; “Substituted imidazoquinolines, imidazopyridines, and
imidazonaphthyridines”, U.S. 9,006,264, 04/14/2015.
63) Bonk, Jason D.; Dellaria, Jr.; Joseph F.; “Arylalkenyl and arylalkynyl substituted
imidazoquinolines”, U.S. 8,802,853, 08/12/2014.
62) Krepski, Larry R.; Dellaria, Jr.; Joseph F.; Marszalek, Gregory J.; “Hydroxylamine and
Oxime Substituted Imidazoquinolines, Imidazopyridines, And Imidazonaphthyridines”, U.S.
8,778,963, 7/15/2014.
61) Bonk, Jason D.; Dellaria, Jr.; Joseph F.; “Imidazoquinolinyl sulfonamides”, U.S. 8,735,421,
5/27/2014.
60) Krepski, Larry R.; Dellaria, Jr.; Joseph F.; Duffy, Daniel, E.; Radmer, Matthew R.; Amos,
David T.; Zimmermann, Bernhard M.; Moser, William H.; “Amide substituted
imidazopyridines, imidazoquinolines, and imidazonaphthyridines”, U.S. 8,697,873, 4/15/2014.
59) Krepski, Larry R.; Dellaria, Jr.; Joseph F.; Duffy, Daniel, E.; Radmer, Matthew R.; Amos,
David T.; “Substituted imidazo ring systems and methods”, U.S. 8,691,837, 4/8/2014.
58) Kshirsagar, Tushar A.; Amos, David T.; Dellaria, Jr.; Joseph F.; Heppner, Philip D.; Langer,
Scott E.; Zimmermann, Bernhard M.; “Oxime substituted imidazo-containing compounds”,
U.S. 8,673,932, 3/18/2014.
4. Joseph F. Dellaria, Jr.
4
57) Kshirsagar, Tushar A.; Lundquist, Jr., Gregory D.; Amos, David T.; Dellaria, Jr., Joseph F.;
Zimmermann, Bernhard M.; Heppner, Philip D.; “Hydroxylamine substituted Imidazo-
quinolines”, U.S. 8,598,192, 12/03/2013.
56) Stoermer, Doris.; Dellaria, J. F.; Amos, David T.; Zimmermann, Bernhard M.; Dressel, Luke
T.; Bonk, Jason, D.; Radmer; Matthew R.; “Substituted imidazoquinolines, imidazopyridines,
and imidazonaphthyridines”, U.S. 8,541,438, 09/24/2013.
55) Kshirsagar, Tushar A.; Lundquist, Gregory D.; Dellaria, J. F.; Radmer; Matthew R.;
Zimmermann, Bernhard M.; “Oxime and hydroxylamine substituted imidazo[4,5-c] ring
compounds and methods”, U.S. 7,968,563, 06/28/2011.
54) Radmer; Matthew R.; Moser, William H.; Moseman, Joan T.; Dellaria, J. F. “Sulfone
Substituted Imidazo Ring Ethers”, U.S. 7,939,526, 05/10/2011.
53) Kshirsagar, Tushar A.; Lundquist, Gregory D.; Amos, David T.; Dellaria, J. F.; Zimmermann,
Bernhard M.; Heppner, Philip D. “Oxime Substituted Imidazoquinolines”, U.S. 7,897,767,
03/01/2011.
52) Stoermer, Doris; Dellaria, J. F.; Amos, David T.; Zimmermann, Bernhard M.; Dressel, Luke
T.; Bonk, Jason D.; Radmer, Matthew R. “Substituted Imidazoquinolines, Imidazopyridines,
and Imidazonaphthyridines” U.S. 7,884,207, 02/08/2011.
51) Kshirsagar, Tushar A.; Amos, David T.; Dellaria, J. F.; Heppner, P. D.; Langer, Scott E.;
Zimmermann, B. M. “Hydroxylamine Substituted Imidazoquinolines”, U.S. 7,648,997,
01/19/2010.
50) Dellaria, J. F.; Radmer, M. R.; Merrill, B. A.; “Thioether Substituted Imidazopyridines”, U.S.
7,288,550, 10/30/2007.
49) Dellaria, J. F.; Radmer, M. R. “Thioether Substituted Imidazopyridines”, U.S. 7,276,515,
10/2/2007.
48) Dellaria, J. F.; Lindstrom, K. J.; Dressel, L. T.; Heppner, P. D.; Jacobsen, J. R.; Moseman, J.
T.; Moser, W. H.; Radmer, M. R.; Stoermer, D. “Ether Substituted Imidazopyridines”, U.S.
7,220,758, 05/22/2007.
47) Dellaria, J. F.; Lindstrom, K. J.; Dressel, L. T.; Duffy, D. E.; Heppner, P. D.; Jacobsen, J. R.;
Moseman, J. T.; Moser, W. H.; Radmer, M. R.; Stoermer, D.; Zimmermann, B. M. “Ether
substituted imidazopyridines”, U.S. 7,125,890, 10/24/2006.
46) Heppner, P. D.; Charles, L. J.; Dellaria, J. F.; Merrill, B. A.; Mickelson, J. W. “Aryl Ether
Substituted Imidazoquinolines", U.S. 6,989,389, 1/24/2006.
45) Dellaria, J. F.; Mickelson, J. W. “Aryl Ether Substituted Imidazoquinolines", U.S. 6,953,804,
10/11/2005.
44) Bonk, J. D.; Dellaria, J. F.; Merrill, B. A.; Radmer, M. R. “Thioether Substituted
Imidazoquinolines", U.S. 6,949,649, 09/27/2005.
43) Dellaria, J. F.; Merrill, B. A.; Radmer, M. R. “Thioether Substituted Imidazoquinolines", U.S.
6,921,826, 07/26/2005.
42) Dellaria, J. F.; Lindstrom, K. J.; Dressel, L. T.; Heppner, P. D.; Jacobsen, J. R.; Radmer, M.
R.; Stoermer, D. “Ether Substituted Imidazopyridines", U.S. 6,797,718, 09/28/2004.
5. Joseph F. Dellaria, Jr.
5
41) Dellaria, J. F.; Haraldson, C. A.; Lindstrom, K. J.; Merrill, B. A.; “Amide Substituted
Imidazopyridines", U.S. 6,720,422, 04/13/2004.
40) Dellaria, J. F.; Haraldson, C. A., Heppner; P. D.; Lindstrom, K. J.; Merrill, B. A. “Urea
Substituted Imidazopyridines", U.S. 6,720,334, 04/13/2004.
39) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Amide
Substituted Imidazopyridines", U.S. 6,720,333, 04/13/2004.
38) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Urea
Substituted Imidazopyridines ", U.S. 6,716,988, 04/06/2004.
37) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A.
“Sulfonamido Substituted Imiazopyridines", U.S. 6,696,465, 02/24/2004.
36) Heppner, P. D.; Charles, L. J.; Dellaria, J. F.; Merrill, B. A.; Mickelson, J. W. “Aryl Ether
Substituted Imidazoquinolines", U.S. 6,677,348, 01/13/2004.
35) Charles, L. J.; Dellaria, J. F.; Heppner, P. D.; Merrill, B. A.; Mickelson, J. W. “Aryl Ether
Substituted Imidazoquinolines", U.S. 6,670,372, 12/30/2003.
34) Bonk, J. D.; Dellaria, J. F.; Merrill, B. A.; Radmer, M. R.; “Thioether Substituted
Imidazopyridines", U.S. 6,667,312, 12/16/2003.
33) Dellaria, J. F.; Merrill, B. A.; Radmer, M. R. “Thioether Substituted Imidazopyridines", U.S.
6,664,264, 12/16/2003.
32) Charles, L. J.; Dellaria, J. F.; Griesgraber, G. W.; Heppner, P. D.; Manske, K. J.; Mickelson, J.
W.; Rice, M. J. “Heteroaryl Ether Substituted Imidazoquinolines”, U.S. 6,664,260, 12/16/2003.
31) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Urea
Substituted Imidazopyridines", U.S. 6,545,017, 4/8/2003.
30) Dellaria, J. F.; Haraldson, C. A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Amide
Substituted Imidazopyridines", U.S. 6,545,016, 4/8/2003..
29) Dellaria, J. F.; Haraldson, C.A.; Heppner, P. D.; Lindstrom, K. J.; Merrill, B. A. “Sulfonamido
Substituted Imidazopyridines", U.S. 6,525,064, 2/25/2003.
28) Curtin, M. L.; Dai, Y.; Davidsen, S. K.; Dellaria, J. F.; Florjancic, A. S.; Gong, J.; Guo, Y.;
Heyman, H. R.; Howard, R.; Holms, J. H.; Michaelides, M. R.; Stacey, J. R.; Steinman, D. H.;
Wada, C. K.; Xu, L. "Preparation of Hydroxamates as Matrix Metalloproteinase Inhibitors",
U.S. 6,294,573, 2001.
27) Dellaria, J. F. "Benzothiophene-based Urokinase Inhibitors", U.S. 6,207,701, 2001.
26) Dellaria, J. F.; Gane, T. H. "Prostaglandin Synthase-2 Inhibitors", U.S. 5,776,984, 07/07/98.
25) Dellaria, J. F.; Gane, T. H. "Prostaglandin Synthase-2 Inhibitors", U.S. 5,681,842, 1997.
24) Dellaria, J. F.; Chernesky, L. J. "Heteroatom Substituted Propanyl Derivatives Having 5-
Lipoxygenase Inhibitory Activity", U.S. 5,516,795, 1996.
23) Dellaria, J. F.; Brooks, D. W.; Sallin, K. J. ; Moore, J. L. "Arylamidoalkyl-N-hydroxyurea
Compounds Having Lipoxygenase Inhibitory Activity", U.S. 5,514,702, 1996.
6. Joseph F. Dellaria, Jr.
6
22) Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "Pyran-4-ylmethyl Substituted
Arylalkylaryl-, Arylalkenylaryl-, and Arylalkynylary Urea Inhibitors of 5-Lipoxygenase", U. S.
5,484,786, 1996.
21) Chernesky, L. J.; Dellaria, J. F. "1,2-Dialkoxylethanes as 5-Lipoxygenase Inhibitors", U.S.
5,475,009, 1995.
20) Brooks, D. W.; Carter, G. W.; Dellaria, J. F.; Maki, R. G.; Rodriquez, K. E. "Indole
Derivatives Which Inhibit Leukotriene Biosynthesis", U.S. 5,459,150, 1995.
19) Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(4-Alkoxypyran-4-yl)
Substituted Ether, Arylalkyl-, Arylalkenyl-, and Arylalkynyl)urea Inhibitors of 5-
Liopxygenase", U. S. 5,446,062, 1995.
18) Dellaria, J. F.; Ratajczyk, J. R.; Brooks, C. D. W.; Basha, A. "Polyether Napthalenic Lignan
Lactones as Inhibitors of 5-Lipoxygenase", U.S. 5,446,055, 1995.
17) Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(4-Alkoxypyran-4-yl)
Substituted Arylalkylaryl-, Arylalkenylaryl-, and Alrylalkynylarylurea Inhibitors of 5-
Lipoxygenase", U. S. 5,432,194, 1995.
16) Dellaria, Joseph F.; Ratajczyk, J. D.; Brooks, C. D.W.; Basha, A. “[Alkoxy-, alkenyloxy-,
alkynyloxy-, and phenylmethyloxyalkoxycycloalkyl or alkoxycycloheteroalkyl]naphtho[2,3-c]
furan-1(3H)-one inhibitors of 5-lipoxygenase”, U.S. 5,426,111, 06/20/95.
15) Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(Trans-1,4-
dialkoxycyclohexyl) Substituted Arylalkylaryl-, Arylalkenylaryl-, and Alrylalkynyl-arylurea
Inhibitors of 5-Liopxygenase", U.S. 5,407,959, 1995.
14) Dellaria, J. F.; Brooks, D. W.; Dorn, L. J. "Phenylmethyl Derivatives Having 5-Lipoxygenase
Inhibitory Activity", U.S. 5,354,865, 1994.
13) Dellaria, J. F.; Brooks, D. W.; Moore, J. L. "Ether Containing Inhibitors of 5-Lipoxygenase",
U.S. 5,350,765, 1994.
12) Dellaria, J. F.; Basha, A.; Black, L.; Chernesky, L. J.; Lee, W. "(4-Alkoxypyran-4-yl)
Substituted arylalkylaryl-, arylalkenylaryl-, and alrylalkynylarylurea inhibitors of 5-
Lipoxygenase", U.S. 5,346,914, 1994.
11) Dellaria, J. F.; Brooks, D. W.; Moore, J. L. "Ether Containing Inhibitors of 5-Lipoxygenase",
U.S. 5,268,379, 1993.
10) Brooks, D. W.; Dellaria, J. F.; Summers, J. B. "Lipoxygenase Inhibiting Compounds Derived
From Nonsteroidal Antiinflammatory Carboxylic Acids”, U.S. 5,220,059, 1993.
9) Dellaria, J. F.; Brooks, D. W.; Sallin, K. J. ; Moore, J. L. "Arylamidoalkyl-N-hydroxyurea
Compounds Having Lipoxygenase Inhibitory Activity", U.S. 5,214,204, 1993.
8) De, B.; Zydowsky, T. N.; Baker, W. R.; Dellaria, J. F.; Rosenberg, S. H.; Jae, H. S.
“Heterocyclic peptide renin inhibitors”, U.S. 5,164,388, 11/17/92.
7) Brooks, D. W.; Dellaria, J. F.; Maki, R. G.; Rodriquez, K. E.: Carter, G. W. "Indole
Derivatives Which Inhibit Leukotriene Biosynthesis", U.S. 5,095,031, 1992.
7. Joseph F. Dellaria, Jr.
7
6) Brooks, D. W.; Summers, J. B.; Gunn, B. P.; Dellaria, J. F.; Holms, J. H.; Maki, R. G.;
Martin, J. G.; Moore, J. L.; Rodriques, K. E.; Stewart, A. O. , "Heteroaryl N-Hydroxy Amides
and Ureas With Polar Substituents As 5-Lipoxygenase Inhibitors", U.S. 4,992,464, 1991.
5) Rosenberg, S. H.; Dellaria, J. F.; Fung, A. K. L.; Kempf, D. J.; Luly, J. R.; Plattner, J. J. "Renin
Inhibiting Compounds", U.S. 4,857,507, 1989.
4) Dellaria, J. F.; Fung, A. K. L; Kempf, D. J.; Luly, J. R.; Plattner, J. J.;; Rosenberg, S. H.; Sham,
H. L. "Renin Inhibiting Analogs", U. S. 4,826,958, 1989.
3) Luly, J. R.; Dellaria, J. F.; Fung, A. K. L.; Kempf, D. J.; Plattner, J. J.; Rosenberg, S. H.; Sham,
H. L. "Renin Inhibiting Compounds", U.S. 4,826,815, 1989.
2) Luly, J. R.; Plattner, J. J.; Dellaria, J. F. "Renin Inhibiting Compounds", U.S. 4,652,551, 1987.
1) Luly, J. R.; Plattner, J. J.; Dellaria, J. F. "Renin Inhibiting Compounds", U.S. 4,645,759, 1987.
Publications
32) Dellaria, Joseph F. “Clearing The “Fog Of Innovation”: Evaluating Ideas Accurately By
Recognizing and Controlling Perceptions.” International Journal of Innovation Sciences, 2009,
Volume 1 (2), pgs. 73-86.
31) Dellaria, Joe. “What You See Is What You Get: Water Visibility and Stream Trout”
Midwest Fly Fishing, 2009 (March), Volume 14, Issue 1, pages 14-15, 27.
30) Dellaria, Joseph F. “Telescoping Light for Perfect Sight”, Wood, 2007, 117, p.10.
29) Bruncko, M.; McClellan, W. J.; Wendt, M. D.; Sauer, D. R.; Geyer, A.; Dalton, C. R.;
Kaminski, M. A.; Weitzberg, M.; Gong, J.; Dellaria, J. F.; Mantei, R.; Zhao, X.; Nienaber, V. L.;
Stewart, K.; Klinghofer, V.; Bouska, J.; Rockway, T. W.; Giranda, V. L. “Naphthamidine
Urokinase, Plasminogen Activator Inhibitors with Improved Pharmacokinetic Properties”, Biorg.
Med. Chem. Lett., 2005, 15, 93-98.
28) Curtin, M. L.; Florjancic, A. S.; Heyman, H. R.; Michaelides, M. R.; Garland, R. B.; Holms, J.
H.; Steinman, D. H.; Dellaria, J. F.; Gong, J.; Wada, C.K.; Guo, Y.; Elmore, I. B.; Tapang, P.;
Albert, D. H.; Magoc, T. J.; Marcotte, P. A.; Bouska, J. J.;Goodfellow, C. L.; Bauch, J. L.; Marsh,
K. C.; Morgan, D. W.; Davidsen, S. K. “Discovery and Characterization of the Potent, Selective,
and Orally Bioavailable, MMP Inhibitor ABT-770”, Biorg. Med. Chem. Lett., 2001, 11 (12),
1557-1560.
27) Michaelides, M. R.; Dellaria, J. F.; Gong, J.; Holms, J. H.; Bouska, J. J.; Stacey, J.; Wada, C.K.;
Heyman, H. R.; Curtin, M. L.; Guo, Y.; Goodfellow, C. L.; Elmore, I. B.; Albert, D. H.; Magoc, T.
J.; Marcotte, P. A.; Garland, R. B.; Morgan, D. W.; Davidsen, S. K. “Biaryl Ether Retohydroxamtes
as Potent Long-lived Orally Bioavailable MMP Inhibitors”, Biorg. Med. Chem. Lett., 2001, 11
(12), 1553-1556.
8. Joseph F. Dellaria, Jr.
8
26) Kolasa, T.; Brooks, C. D. W.; Rodriques, K. E.; Summers, J. B.; Dellaria, J. F.; Hulkower, K.
I.; Bouska, J.; Bell, R. L.; Carter, G. W. "Nonsteroidal Anti-Inflammatory Drugs As Scaffolds For
The Design Of 5-Lipoxygenase Inhibitors", J. Med. Chem., 1997, 40 (5), 819-824.
25) Dellaria*, J. F.; Sallin, K. J. ; Rodriques, K. "Synthesis of New Amide-linked N-hydroxyurea
5-Lipoxygenase Inhibitors by an Intramolecular Oxygen to Nitrogen Acyl Transfer", Biorg. Med.
Chem. Lett., 1993, 3 (2), 305-309.
24) Luly*, J. R.; Dellaria, J. F.; Davidsen, S.K. “Anti-Inflammatory Patents Highlights From the
First Half of 1992”, Current Opinion in Therapeutic Patents, 1992, 2(10), 1577.
23) Dellaria*, J. F.; Sallin, K. J. "Wittig Olefination in the Absence of an Exogenous Base: a New
Synthesis of -Substituted Primary Allylic Amines", Tetrahedron Lett., 1990, 31, 2661.
22) Rosenberg*, S. H., Dellaria*, J. F.; Kempf*, D. J.; Hutchins, C. W.; Woods, K. W.; Maki, R.
G.; de Lara, E.; Spina, K. P.; Stein H. H.; Cohen, J.; Baker, W. R.; Plattner, J. J.; Kleinert, H. D.;
Perun, T. J. "Potent, Low Molecular Weight Renin Inhibitors Containing a C-Terminal Heterocycle:
Hydrogen Bonding at the Active Site", J. Med. Chem., 1990, 32, 1582.
21) Dellaria*, J. F.; Maki, R. G.; Stein,H. H.; Cohen, J. "New Inhibitors of Human Renin That
Contain Novel Phospho-Statine Derived Leu-Val Replacements" , J. Med. Chem., 1990, 32, 534.
20) Dellaria*, J. F.; Denissen, J. F.; Kerdesky, F.; Maki, R. M.; Nellans, H.N. "An Iterative
Synthesis of Radiolabelled Polyethylene Oligomers", J. Label. Cmpds. Radiopharm., 1989, 27
(12), 1438-1450.
19) Dellaria*, J. F.; Santarsiero, B. D. "The Enantioselective Synthesis of Amino Acid
Derivatives via the Stereoselective Alkylation of a Homochiral Glycine Enolate Synthon", J. Org.
Chem., 1989, 54, 3916-3926.
18) Evans*, D. A., Britton, T. C., Dorow, R. L., Dellaria, J. F. "The Asymmetric Synthesis of -
Amino and -Hydrazino Acid Derivatives via The Stereoselective Amination of Chiral Enolates
with Azodicarboxylate Esters", Tetrahedron, 1988, 44(17), 5525-5540.
17) Plattner*, J. J.; Marcotte, P. A.; Kleinert, H. D.; Stein, H.H.; Greer, J.; Bolis, G.; Fung, A. K.
L.; Bopp, B. A.; Luly, J. R.; Sham, H. L.; Kempf, D. J.; Rosenberg, S. H.; Dellaria, J. F.; De, B.;
Merits, I.; Perun, T. J. "Renin Inhibitors. Dipeptide Analogues of Angiotensinogen Utilizing a
Structurally Modified Phenylalanine Residue to Impart Proteolytic Stability" J. Med. Chem., 1988,
31, 2277-2288.
16) Zydowsky, T. M.; Dellaria*, J. F.; Nellans, H. N. "Efficient and Versatile Synthesis of
Dipeptide Isosteres Containing Gamma- or Delta-Lactams" , J. Org. Chem, 1988, 53, 5607-5616.
15) Dellaria*, J. F.; Santarsiero, B. D. "Stereoselective Alkylation of Chiral Glycine Enolate
Synthons. The Enantioselective Synthesis of -Amino Acid Derivatives" Tetrahedron Lett.,
1988, 29, 6079-6082.
14) Luly*, J. R.; Bolis, G.; BaMaung, N.; Soderquist, J.; Dellaria, J. F.; Stein, H.; Cohen, J.; Perun,
T. J.; Greer, J.; Plattner, J. J. "New Inhibitors of Human Renin That Contain Novel Leu-Val
Replacements. Examination of the P1 Site" , J. Med. Chem., 1988, 31, 532-539.
9. Joseph F. Dellaria, Jr.
9
13) Dellaria*, J. F.; Maki, R. G.; Bopp, B. A.; Cohen, J.; Kleinert, H.D .; Luly, J. R.; Merits, I.;
Plattner, J. J.; Stein, H. H. "Optimization and in Vivo Evaluations of a Series of Small, Potent, and
Specific Renin Inhibitors Containing a Novel Leu-Val Replacement" , J. Med. Chem., 1987, 30,
2137.
12) Luly*, J. R.; Dellaria, J. F.; Plattner, J. J.; Soderquist, J. L.; Yi, N. "A Synthesis of Protected
Aminoalkyl Epoxides from Alpha-Amino Acids" , J. Org. Chem., 1987, 52, 1487.
11) Dellaria*, J. F.; Maki, R. G. "The Enantio- and Diastereoselective Synthesis of the First
Phospho-Statine Derivative" , Tetrahedron Lett., 1986, 27, 2337.
10) Dellaria*, J. F.; Nordeen, C.; Swett, L. R. "The Facile and Efficient Preparation of Phenolic
and Thiol Esters" , Synth. Commun. , 1986, 16, 1043.
9) Evans*, D. A.; Britton, T. C.; Dorow, R. L.; Dellaria, J. F. "Stereoselective Amination of Chiral
Enolates. A New Approach to the Asymmetric Synthesis of Alpha-Hydrazino and Alpha-Amino
Acids" , J. Am. Chem. Soc., 1986,108, 6395.
8) Luly*, J. R.; Plattner, J. J.; Stein, H. H.; Yi, N.; Cohen, J.; Tricarico, K.; Dellaria, J. F. "Renin
Inhibitors: Peptide Analogs of Angiotensinogen Which Display Potent and Specific Inhibition of
Human Renin" , Pharmacologist, 1985, 27, 260.
7) Hoye*, T. R.; Caruso, A. J.; Dellaria, J. F.; Kurth, M. J. "Two Syntheses of dl-Aplysistatin" , J.
Am. Chem. Soc., 1982, 104, 6704.
6) Hoye*, T. R.; Bottorff, K. J.; Caruso, A. J.; Dellaria, J. F. "Regio- and Stereoselectivity in the
Ene Reaction of N-Phenyl-1,2,4-triazoline-3,5-dione With Alpha,Beta-Unsaturated Carbonyl
Substrates" , J. Org. Chem., 1980, 45, 4287.
5) Doyle*, M. P.; Buhro, W. E.; Dellaria, J. F. "A Facile Synthesis of 1,2-Disubstituted
Cyclopropyl-carbonyl Compounds of High Isomeric Purity" , Tetrahedron Lett., 1979, 4429.
4) Doyle*, M. P.; Elliott, R. C.; Dellaria, J. F. "Ring-size Effects in Lewis Acid Promoted
Reactions of n-(1-Phenylcyclopropyl)alkanoyl Chlorides" , J. Org. Chem., 1978, 43, 4459.
3) Doyle*, M. P.; Dellaria, J. F.; Siegfried, B.; Bishop, S. W. "Reductive Deamination of
Arylamines to Aromatic Hydrocarbons" , J. Org. Chem., 1977, 42, 3494.
2) Doyle*, M. P.; Siegfried, B.; Dellaria, J. F. "Copper(II) Halide Catalyzed Conversion of Aryl
Amines to Aryl Halides" , J. Org. Chem., 1977, 42, 2426.
1) Doyle*, M. P.; Siegfried, B.; Elliott, R. C.; Dellaria, J. F. "A Convenient and Effective
Variation of the Meerwein Arylation Reaction" , J. Org. Chem., 1977, 42, 2431.
PRESENTED PAPERS
22) Dellaria, Joseph F. “Shaping and Harnessing Your Innovation Process: the Interplay Between
Perception and Reality”, Front End of Innovation Conference, Pre-Conference Symposium 2,
Boston, Massachusetts, May 8-11, 2007.
10. Joseph F. Dellaria, Jr.
10
21) Kshirsagar, Tushar A.; Griesgraber, George W.; Stoermer, Doris; Amos, David T.; Lindstrom,
Kyle J.; Rice, Michael J.; Crooks, Stephen L.; Bonk, Jason D.; Dellaria, Joseph F.; Heppner,
Philip D.; Gerster, John F.; Merrill, Bryon A.; Johannessen, Sarah C.; Zimmermann, Bernhard M.;
Marszalek, Gregory; Dresssel, Luke T.; Haraldson, Chad A.; Squire, David J.; Wurst, Joshua R.;
Radmer, Matthew R.; Manske, Karl J.; Spessard, Sarah J.; Langer, Scott E.; Karp, Gregory P.;
Gibson, Sheila J.; Wurst, Lindsay R. “Imidazo[4,5-c]quinoline-based TLR7 and TLR8 immune
response modifiers: Structure-activity-relationships relating to potency, selectivity, and therapeutic
applications.” Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United
States, Sept. 10-14, 2006 (2006), MEDI-573.
20) Krepski, Larry R.; Manske, Karl J.; Griesgraber, George W.; Duffy, Daniel E.; Moseman, Joan
T.; Dressel, Luke T.; Stoermer, Doris; Heppner, Philip D.; Kshirsagar, Tushar A.; Dellaria, Joseph
F.; Gibson, Sheila J.; Wurst, Lindsay R. “Synthesis and SAR of TLR7 and TLR8 small molecule
immune response modifiers: Novel alkylamino and alkoxy functionalized imidazo[4,5-
c]quinolines.” Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United
States, Sept. 10-14, 2006 (2006), MEDI-218.
19) Rockway, T. W.; McClellan, W. J.; Dellaria, J. F.; Gong, J.; Mantei, R. A.; Wendt, M.; Zhao,
X.; Weitzberg, M.; Sauer, D.; Bruncko, M.; Dalton, C.; Kaminski, M.; Giranda, V.; Butler, C.;
Linghofer, V.; Joseph, M.; Nienaber, V.; Stewart, K. “Structure-based Design of Novel Urokinase
Inhibitors Derived from 2-Naphthamidine” 220th American Chemical Society National Meeting,
New Orleans, LA, Aug 20-244, 2000, MEDI-ABSTRACT #030.
18) Dellaria,* J. F.; Moore, J. L.; Hulkower, K. I.; Bouska, J.; Grayson, G. K.; Harris, R. R.: Bell,
R. L.; Brooks, C. D. W.; Carter, G. W. "Novel -Unsaturated Ethers Of 4-Methoxy
tetrahydropyran Are Orally Active 5-Lipoxygenase Inhibitors ." 211th American Chemical Society
National Meeting, New Orleans, LA, March 24-28, 1996, MEDI-ABSTRACT #246.
17) Black, * L. A.; Dellaria, J. F., Brooks,C. D. W., Bell, R. L., Harris, R.; Bouska, J.; Bures, M.
G. "Dialkoxycycloalkanes as Leukotriene Biosynthesis Inhibitors" 1989 International Chemical
Congress of Pacific Basin Societies, Honolulu, Hawaii, Dec 21, 1995, ORGN-ABSTRACT #532.
16) Dellaria, * J. F., Moore, J. L., Hulkower, K. I., Bouska, J., Bell, R. L., Brooks,C. D. W.,
Carter, G. W. "New Orally Active 5-Lipoxygenase Inhibitors: Unsaturated Ethers Of 4-
Methoxytetrahydropyran" 6th Interscience World Conference on Inflammation, Antirheumatics,
Analgesics, Immunomodulators, Geneva, Switzerland, March 28-30, 1995, Abstract # 53.
15) Dellaria,* J. F.; Sallin, K. J.; Moore, J. L.; Bell, R. L.; Lanni, C.; Bouska, J.; Young, P. R.;
Brooks, D. W.; Carter, G. W. "Amide-linked N-Hydroxyureas: A New Class of Potent, Long-lived,
and Orally Active 5-Lipoxygenase Inhibitors" 204th American Chemical Society National Meeting,
Washington, DC, August 23-28, 1992, MEDI-ABSTRACT #104.
14) Moore,* J. L.; Brooks, D. W.; Kolasa, T.; Rodriques, K. E.; Dellaria, J. F.; Lanni, C.; Young,
P. R.; Bell, R. L.; Carter, G. W. “5-Lipoxygenase Inhibitory Activity of Alkyl Hydroxyureas”
Abstracts 23rd National Med.Chem.Sym., Buffalo, NY., June 14-18, 1992, Abstract #49.
13) Zydowsky,* T. M.; Dellaria, J. F.; deLara, E.; Nellans, H. N.; Baker, W. R.; Barlow, J.;
Calzadilla, S.; Cohen, J.; Kleinert, H.; Klinghofer, V.; Polakowski, J.; Stein, H.; Verburg, K.;
Perun, T. J. “Synthesis of Renin Inhibitors Containing Conformationally Constrained Gamma- or
Delta-lactams as P-3 Site Replacements” XIIth International Symposium on Medicinal Chemistry,
Switzerland, September 13-17, 1992, 66, Abstract #OC-04.4.
11. Joseph F. Dellaria, Jr.
11
12) Dellaria,* J. F.; Brooks, D. W.; Summers, J. B.; Sallin, K. J.; DeNinno, S. L.; Martin, M. B.;
Martin, J. G.;. G.; Moore, J. L.; Holms, J. H.; Lanni, C.; Bouska, J.; Young, SP. R.; Bell, R. L.;
Carter, G. W. "A-69412, a Long Lived, Orally Active, and Selective 5-Lipoxygenase Inhibitor" 4th
Chemical Congress of North America, New York, New York, August 25-30, 1991. MEDI-
ABSTRACT #176.
11) Dellaria,* J. F.; Sallin, K. J. "Allylic Amines, Via In situ Ylide Formation from N-acyl
Aziridines and Triphenylphosphine" 32nd Organic Chemistry Symposium, University of
Minnesota, Minneapolis, Minnesota, June 16-20, 1991, Abstract #A-11.
10) Dellaria,* J. F.; Brooks, D. W.; Summers, J. B.; DeNinno, S. L.; Martin, M. B.; Martin, J. G.;.
G.; Stewart, A. O.; Sallin, K. J.; Bouska, J.; Young, SP. R.; Bell, R. L.; Carter, G. W. "Thiophene-
Derived Inhibitors of 5-Lipoxygenase: Small, Potent, and Bioavailable N-Hydroxy Ureas" 199th
American Chemical Society National Meeting, Boston, Massachusetts, April 22-27, 1990. Abstr.
Pap. Am. Chem. Soc. 1990, 199(0). MEDI-ABSTRACT #76.
9) Brooks,* D. W.; Summers, J. B.; Gunn, B. P.; Dellaria, J. F.; Holms, J. H.; Maki, R. G.; Martin,
J. G.; Martin M. b.; Moore J. L.; Rodriquez, K. E.; Stewart, A. O.; Albert, D. H.; Bell, R. L.;
Bouska, J. B.; Dyer, R. D.; Malo, P. E; Young, P. R.; Rubin, P. Kesterson, J.; Carter, G. W.
"Abbott-64077, a Promising Therapeutic Agent for Treating Leukotriene Mediated Diseases", 199th
American Chemical Society National Meeting, Boston, Massachusetts, April 22-27, 1990. Abstr.
Pap. Am. Chem. Soc. 1990, 199(0). MEDI-ABSTRACT #148.
8) Rosenberg*, S. H.; Dellaria, J. F.; Kempf, D. J.; Woods, K. W.; Maki, R. G.; de Lara, E.;
Kleinert, H. D.;, Stein, H. H.; Cohen, J.; Plattner, J. J.; Baker, W. R.; Perun, T. J. "Renin Inhibitors
Containing A C-terminal Heterocycle", In Proceedings of the 11th Peptide Symposium; Rivier, J. E.
; Marshall, G. R., Eds; Escom: Leiden, 1990; pp402-403.
7) Dellaria*, J. F.; Sallin, K. J.; Maki, R. G.; De Ninno, S. L. "A New Primary Allylic Amine
Synthesis: In Situ Formation And Trapping Of An Ylide From The Reaction Of An N-Acyl
Aziridine, Triphenylphosphine, And An Aldehyde", 1989 International Chemical Congress of
Pacific Basin Societies, Honolulu, Hawaii, Dec 21, 1989, ORGN-ABSTRACT #532.
6) Dellaria*, J. F.; Maki, R. G.; Stein, H. H.; Cohen, J. "Phospho-Statine Derived Renin
Inhibitors" 194th American Chemical Society National Meeting, New Orleans, Louisiana, Sept. 2,
1987. Abstr. Pap. Am. Chem. Soc. 1987, 194(0). MEDI-ABSTRACT #86.
5) Luly*, J. R.; Soderquist, J. L.; Yi, N.; Plattner, J. J.; Dellaria, J. F.; Kleinert, H. D.; Stein, H. H.;
Perun, T. J. "Design and Synthesis of Novel Inhibitors of Renin" , 192nd American Chemical
Society National Meeting, Anaheim, California, September 7-12, 1986. Abstr. Pap. Am. Chem.
Soc., 1986, 192(0). MEDI-ABSTRACT #7.
4) Luly*, J. R.; Dellaria, J. F.; Plattner, J. J.; Soderquist, J. L.; Yi, N. "The Wittig Olefination of
Alpha-Amino Aldehydes with Minimal Racemization. Synthesis of Protected Aminomethyl
Epoxides" , 191st American Chemical Society National Meeting, New York, NY, April 13-18,
1986. Abstr. Pap. Am. Chem. Soc. 1986, 191(0). ORG-ABSTRACT # 42.
3) Luly*, J. R.; Soderquist, J. L.; Yi, N.; Plattner, J. J.; Dellaria, J. F.; Kleinert, H. D.; Maki, R.;
Stein, H. H.; Bopp, B. A.; Perun, T. J. "Low Molecular Weight, Nanomolar Renin Inhibitors" ,
191st American Chemical Society National Meeting, New York, NY, April 13-18, 1986. Abstr.
Pap. Am Chem. Soc. 1986, 191(0). MEDI-ABSTRACT #9.
12. Joseph F. Dellaria, Jr.
12
2) Plattner*, J. J.; Fung, A. K. L.; Stein, H.; Kleinert, H. D.; Marcotte, P.; Smital, J.; Dellaria,J. F.;
Sham, H. L.; Luly, J. R.; Rosenberg, S. H.; Kempf, D. J.; Greer, J.; Perun, T. J. "Specific Inhibition
of Human Renin by a Small Peptide, Transition-State Analogs" , 191st American Chemical Society
National Meeting, New York, NY, April 13-18, 1986. Abstr. Pap. Am. Chem. Soc. 1986,191(0),
MEDI-ABSTRACT #28.
1) Dellaria*, J. F.; Evans, D. A. "The Enantioselective Synthesis of Alpha-Amino Acids
Employing a New Chiral Glycine Enolate Synthon" International Symposium of the Chemistry of
Natural Products, Edmonton, Alberta, Canada, June 23-26, 1985. Abstract #-CO-13.
INVITED LECTURES
11) “Part A. New Targets Requiring New Chemistry, Part B. Innovation, Perceptions, and
Information Poor Situations,C. Careers In Chemistry,” University of California, Davis, November
5, 2010.
10) "Medicinal Chemistry: A Mother Of Invention: Uses of Azridine Olefination and
Peptidomimetic Synthesis in Drug Discovery”, Macalester College, St. Paul, Minnesota, November
6, 2002.
9) "Medicinal Chemistry: A Mother Of Invention: Uses of Azridine Olefination and
Peptidomimetic Synthesis in Drug Discovery”, 2001 St. Louis Award Symposium, University of
Missouri-St. Louis, St. Louis, Missouri, April 20, 2001.
8) "Medicinal Chemistry: A Mother Of Invention" University of Kansas, Lawrence, Kansas,
September 9, 1993.
7) "Medicinal Chemistry: A Mother Of Invention" North Dakota State University , Fargo, ND,
November 9, 1989.
6) "Medicinal Chemistry: A Mother Of Invention" University of Minnesota, Minneapolis, MN,
November 8, 1989.
5) "Chemistry Enroute to Renin Inhibitors" University of California, Davis, February 23, 1989.
4) "Optimization of Renin Inhibitors Containing a Novel Leu-Val Replacements and Other
Pharmacological Evaluations" Reno, Nevada, American Association of Pharmaceutical Scientists
Western Regional Meeting, February 27, 1989.
3) "Chemistry Enroute to Renin Inhibitors" University of Nevada, Reno, March 1, 1989.
2) "In Search of Amide Bond Replacements" University of California, Davis, Chemistry
Department Industrial Symposium Program, October 10, 1986.
1) "Cardiovascular Drugs and Some Related Chemistry", Associated Colleges of the Chicago Area,
Argonne Labs, Chicago, Illinois, October 21, 1986.