This document reviews the transcriptional programming of dendritic cell subsets. It discusses:
1) Dendritic cells are a heterogeneous group divided into subsets based on location and surface markers, including conventional dendritic cells, plasmacytoid dendritic cells, Langerhans cells, and monocyte-derived dendritic cells.
2) The differentiation of dendritic cell subsets is controlled by cytokines and transcription factors. Hematopoietic progenitors in the bone marrow differentiate into precursor cells that migrate and further differentiate into the different dendritic cell subsets in response to local environmental cues.
3) Transcription factors play a key role in determining the specification and differentiation of dendritic cell subsets. Defects
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
This is grand rounds presentation about the role of MIC-A antibodies in renal transplantation. I gave this presentation back in 2008, during the second year of my fellowship at the University of Pittsburgh Medical Center.
Cell adhesion, both cell-cell and cell-ECM, can influence whether a c.pdfahntagencies
Cell adhesion, both cell-cell and cell-ECM, can influence whether a cell will proceed through
cell division or die by apoptosis. Compare/contrast the influence on cell survival and cell
division between cell-cell and cell-ECM adhesion. What signal in behavior is an integrin sending
to a cell when the integrin is binding its ligand? Explain your answer. What signal in behavior is
a cadherin sending to a cell when the cadherin is binding to its ligand? Explain your answer.
Compare and contrast how normal cells and cancer cells interpret cell adhesion (either cell-cell
and cell-ECM) to a change in cell behavior.
Solution
Answer B
Integrins and cadherins are adhesive molecules that are also called as cell adhesion molecules or
CAM. Cell matrix adhesion is brought over by integrins. Integrins are the receptors that bring
about ECM adhesion. Integrins activate signal transduction pathways, once they are activated by
ligand binding. These signal transduction pathways mediate cell signals for cell cycle
regulations, intracellular cytoskeleton organisation and new receptor movements to the cell
membranes.
AnswerC
Integrins and cadherins are adhesive molecules that are also called as cell adhesion molecules or
CAM. Junction adherin and cell cell interactions are generally carried out by cadherins. The
cadherins release a beta catenin that plays a role in cell cell adhesion and carries out cadherins
mediated cell division at the plasma membrane. Their name cadherin comes from their
dependency on Ca2+ ions required to function. There are different classes of cadherins. It is
generally seen that that cells containing a specific cadherin subtype tend to cluster together to the
exclusion of other types, both in cell culture and during development. When E cadherin is
expressed there is a release signal for the epithelial cadherin, followed by the expression of N
cadherin which is present for neural development. When the N cadherin is expressed E cadherin
is reduced , finally when there is development of notochord and so mites, E-P and N , cadherins
are expressed.
Answer D
In cancer cells , many of the stem cells show loosened attachment and higher motility. This is
generally seen in the cases where the cancer is highly invasive or malignant, affecting more than
one part of the body. The molecular adhesion fingerprint is altered in cases where the tumour
calls show high mobility showing a high need to dissociate.
Note- could not answer the first part due to lack of appropriate descriptive evidences. Thank you..
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
This is grand rounds presentation about the role of MIC-A antibodies in renal transplantation. I gave this presentation back in 2008, during the second year of my fellowship at the University of Pittsburgh Medical Center.
Cell adhesion, both cell-cell and cell-ECM, can influence whether a c.pdfahntagencies
Cell adhesion, both cell-cell and cell-ECM, can influence whether a cell will proceed through
cell division or die by apoptosis. Compare/contrast the influence on cell survival and cell
division between cell-cell and cell-ECM adhesion. What signal in behavior is an integrin sending
to a cell when the integrin is binding its ligand? Explain your answer. What signal in behavior is
a cadherin sending to a cell when the cadherin is binding to its ligand? Explain your answer.
Compare and contrast how normal cells and cancer cells interpret cell adhesion (either cell-cell
and cell-ECM) to a change in cell behavior.
Solution
Answer B
Integrins and cadherins are adhesive molecules that are also called as cell adhesion molecules or
CAM. Cell matrix adhesion is brought over by integrins. Integrins are the receptors that bring
about ECM adhesion. Integrins activate signal transduction pathways, once they are activated by
ligand binding. These signal transduction pathways mediate cell signals for cell cycle
regulations, intracellular cytoskeleton organisation and new receptor movements to the cell
membranes.
AnswerC
Integrins and cadherins are adhesive molecules that are also called as cell adhesion molecules or
CAM. Junction adherin and cell cell interactions are generally carried out by cadherins. The
cadherins release a beta catenin that plays a role in cell cell adhesion and carries out cadherins
mediated cell division at the plasma membrane. Their name cadherin comes from their
dependency on Ca2+ ions required to function. There are different classes of cadherins. It is
generally seen that that cells containing a specific cadherin subtype tend to cluster together to the
exclusion of other types, both in cell culture and during development. When E cadherin is
expressed there is a release signal for the epithelial cadherin, followed by the expression of N
cadherin which is present for neural development. When the N cadherin is expressed E cadherin
is reduced , finally when there is development of notochord and so mites, E-P and N , cadherins
are expressed.
Answer D
In cancer cells , many of the stem cells show loosened attachment and higher motility. This is
generally seen in the cases where the cancer is highly invasive or malignant, affecting more than
one part of the body. The molecular adhesion fingerprint is altered in cases where the tumour
calls show high mobility showing a high need to dissociate.
Note- could not answer the first part due to lack of appropriate descriptive evidences. Thank you..
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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