This document discusses how the speaker's genetics affect their response to caffeine and alcohol. It describes two genetic markers - a SNP related to caffeine metabolism that affects risk of heart attack from coffee consumption, and an SNP related to alcohol flushing that results in unpleasant reactions to even small amounts of alcohol like nausea. It notes how the speaker's subjective and objective experiences with caffeine and alcohol differ based on carrying these genetic variants, such as greater agitation from caffeine or longer recovery from alcohol.

3. "People with the slower version of the CYP1A2 enzyme who also drank at least two to three cups of coffee per day had a significantly increased risk of a non-fatal heart attack ...fast metabolizers, on the other hand, may have actually reduced their heart attack risk by drinking coffee." Cornelis MC et al. (2006) . “Coffee, CYP1A2 genotype, and risk of myocardial infarction.” JAMA 295(10):1135-41.

4. CAFFEINE EFFECTS: SUBJECTIVE VS. OBJECTIVE CUPS OF COFFEE (DECAF) DEGREE OF AGITATION

6. "The ALDH2 gene encodes a protein ...responsible for the second step of ethanol processing: the conversion of the highly toxic acetaldehyde to the harmless acetic acid (vinegar)...Having two copies of this version results in an extremely unpleasant experience when drinking"

7. ALCOHOL EFFECTS: SUBJECTIVE VS. OBJECTIVE NUMBER OF DRINKS DEGREE OF INTOXICATION & ILLNESS (VIOLENT NAUSEA)

8. ALCOHOL EFFECTS: RECOVERY TIME NUMBER OF DRINKS DAYS TO NORMALCY

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