This document summarizes key factors for leading cultures that deliver high quality healthcare. It discusses the importance of having an inspirational vision focused on quality, clear aligned goals at all levels, good people management and employee engagement, continuous learning and quality improvement, teamwork and cooperation, and a values-based collective leadership strategy. Specific success factors highlighted include developing a compelling strategic narrative, inclusive leadership styles, empowering staff to lead change, learning organizations, multi-disciplinary teamwork, and shared/collective leadership approaches. Research evidence is presented showing benefits such as lower patient mortality, reduced errors and staff injuries when these cultural factors are implemented.