This document describes the Outpatient Quality Improvement Network (OQUIN) initiative in South Carolina to improve cardiovascular health through interprofessional collaboration. OQUIN provided medical summary data to practices to monitor patient outcomes and drive quality improvements. This led to South Carolina improving from 33rd to 17th in cardiovascular health. The Center of Pediatric Medicine used Lean Six Sigma methodology in an initiative to increase measurement of patient heights and weights to calculate BMI for obesity identification. Through defining the problem, measuring baseline performance, analyzing causes, improving processes, and controlling gains, rates of missing BMI data decreased from 22.45% to 1.46%. The project highlighted the benefits of interprofessional teams bringing different perspectives to problem solving and mutual goal setting.