EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# REGIONAL PERSPECTIVES #
Genome Quebec, Canada:
Personalised medicine – Reaching the patient?
Marc LePage
President and CEO Genome Quebec
=======================================
http://www.eurobioforum.eu
KCA Big Data and Immunotherapeutics Symposium, August 31st, 2018, SydneyMichael Evtushenko
Kids Cancer Alliance warmly invites you to this symposium featuring the latest developments in big data analytics, bioinformatics and, immunotherapeutic targeting.
An all-day symposium on the genomics of childhood cancer and germline predisposition, immune epitope targeting and CAR T cell therapeutics, and, single-cell transcriptomic and proteomic diagnostics in cancer.
For more details please contact Dr Michael Evtushenko MEvtushenko@ccia.unsw.edu.au
EuroBioForum 2013 - Day 1 | Katherine PayneEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# MARKET PERSPECTIVES #
Towards market access for personalised medicines: opportunities and recommendations
Katherine Payne
Professor of Health Economics, Health Sciences - Economics, University of Manchester
Member EuroBioForum Strategic Advisory Board
=======================================
http://www.eurobioforum.eu
KCA Big Data and Immunotherapeutics Symposium, August 31st, 2018, SydneyMichael Evtushenko
Kids Cancer Alliance warmly invites you to this symposium featuring the latest developments in big data analytics, bioinformatics and, immunotherapeutic targeting.
An all-day symposium on the genomics of childhood cancer and germline predisposition, immune epitope targeting and CAR T cell therapeutics, and, single-cell transcriptomic and proteomic diagnostics in cancer.
For more details please contact Dr Michael Evtushenko MEvtushenko@ccia.unsw.edu.au
EuroBioForum 2013 - Day 1 | Katherine PayneEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# MARKET PERSPECTIVES #
Towards market access for personalised medicines: opportunities and recommendations
Katherine Payne
Professor of Health Economics, Health Sciences - Economics, University of Manchester
Member EuroBioForum Strategic Advisory Board
=======================================
http://www.eurobioforum.eu
EuroBioForum 2013 - Day 1 | Emmanuelle BenzimraEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# MARKET PERSPECTIVES #
Navigating the Challenges of Personalised Medicine Access in Europe
Emmanuelle Benzimra
General Delegate at EPEMED, The European Personalised Medicine Association
=======================================
http://www.eurobioforum.eu
EuroBioForum 2013 - Day 1 | Sergey SuchkovEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Russia:
Introduction into PPPM as a new paradigm of public health care service and an example of the ready-to-use Clinical Model in the Area of Medicine
Sergey Suchkov
Professor in Medicine and Immunology at Moscow State Medical & Dental University & I.M. Sechenov Moscow Medical Academy
=======================================
http://www.eurobioforum.eu
How to tackle the future financial challenges in Personalised Medicine in Eur...EuroBioForum
Presentation of Dr Wouter Spek, Managing director of EuroBioForum for the European Personalised Medicine Association (EPEMED) 2013 Spring series of webinars on 24 April 2013.
EuroBioForum 2013 - Day 1 | Pierre MeulienEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Canada:
Genomics and personalised health in Canada
Dr Pierre Meulien, President and CEO at Genome Canada
=======================================
http://www.eurobioforum.eu
Tumour models London 1-3 December 2015 AgendaDiane McKenna
Tumour Models London 2015, now in its 4th year,is the leading meeting dedicated to improve preclinical predictability and translational success of oncology discoveries. Tackling clinical failures rates, preclinical strategies and translational challenges, this Summit will enable you to translate your discoveries from model to human studies with superior predictability to future proof clinical success. [Read More…]
Patients Phase I Clinical Trials – Secured Multi Site Model for Key Populatio...SGS
Patient trials are receiving more focus in the early phase landscape. SGS strategy is to create robust and transparent capabilities to offer customized solutions for a wide range of patient trial requests. Enrollment potential, operational, excellence and completeness
in control are the key concerns for sponsors in this field. Beyond our CPU capabilities, we employ a network of Phase I Patient Units.
These units are located in hospitals both in Belgium and in the CEE region, where SGS own medical and support staff are present to ensure quality and professionalism in trial execution and SOPs are harmonized for full-scope transparency. Additional or alternative
solutions involve our regular cooperation and partnership with carefully selected recruitment expert CROs in order to access highly challenging patient pools or unique geographical locations.
Contact Us: clinicalresearch@sgs.com
Visit our Website: http://www.sgs.com/cro
Follow Us on LinkedIn: http://bit.ly/SGSLifeSciences
- Discover new methods for managing clinical next-gen data with insights from Pfizer, Boston Children’s Hospital and AstraZeneca
- Uncover and critique the latest technologies out there for you to use in clinical trials. Mayo Clinic, Merck and Harvard Medical School let you into their trade secrets
- Hear the genomics strategies that Roche, Millennium and Regeneron are using for discovery and validation of clinically actionable biomarkers
-Bristol-Myers Squibb, Takeda and Partners Healthcare the role that NGS can play when implementing an effective strategy in the lab to speed up CDx development
- Learn how to integrate molecular details into medical decision making, with fresh data from Washington University School of Medicine and Genzyme
EuroBioForum 2013 - Day 1 | Emmanuelle BenzimraEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# MARKET PERSPECTIVES #
Navigating the Challenges of Personalised Medicine Access in Europe
Emmanuelle Benzimra
General Delegate at EPEMED, The European Personalised Medicine Association
=======================================
http://www.eurobioforum.eu
EuroBioForum 2013 - Day 1 | Sergey SuchkovEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Russia:
Introduction into PPPM as a new paradigm of public health care service and an example of the ready-to-use Clinical Model in the Area of Medicine
Sergey Suchkov
Professor in Medicine and Immunology at Moscow State Medical & Dental University & I.M. Sechenov Moscow Medical Academy
=======================================
http://www.eurobioforum.eu
How to tackle the future financial challenges in Personalised Medicine in Eur...EuroBioForum
Presentation of Dr Wouter Spek, Managing director of EuroBioForum for the European Personalised Medicine Association (EPEMED) 2013 Spring series of webinars on 24 April 2013.
EuroBioForum 2013 - Day 1 | Pierre MeulienEuroBioForum
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Canada:
Genomics and personalised health in Canada
Dr Pierre Meulien, President and CEO at Genome Canada
=======================================
http://www.eurobioforum.eu
Tumour models London 1-3 December 2015 AgendaDiane McKenna
Tumour Models London 2015, now in its 4th year,is the leading meeting dedicated to improve preclinical predictability and translational success of oncology discoveries. Tackling clinical failures rates, preclinical strategies and translational challenges, this Summit will enable you to translate your discoveries from model to human studies with superior predictability to future proof clinical success. [Read More…]
Patients Phase I Clinical Trials – Secured Multi Site Model for Key Populatio...SGS
Patient trials are receiving more focus in the early phase landscape. SGS strategy is to create robust and transparent capabilities to offer customized solutions for a wide range of patient trial requests. Enrollment potential, operational, excellence and completeness
in control are the key concerns for sponsors in this field. Beyond our CPU capabilities, we employ a network of Phase I Patient Units.
These units are located in hospitals both in Belgium and in the CEE region, where SGS own medical and support staff are present to ensure quality and professionalism in trial execution and SOPs are harmonized for full-scope transparency. Additional or alternative
solutions involve our regular cooperation and partnership with carefully selected recruitment expert CROs in order to access highly challenging patient pools or unique geographical locations.
Contact Us: clinicalresearch@sgs.com
Visit our Website: http://www.sgs.com/cro
Follow Us on LinkedIn: http://bit.ly/SGSLifeSciences
- Discover new methods for managing clinical next-gen data with insights from Pfizer, Boston Children’s Hospital and AstraZeneca
- Uncover and critique the latest technologies out there for you to use in clinical trials. Mayo Clinic, Merck and Harvard Medical School let you into their trade secrets
- Hear the genomics strategies that Roche, Millennium and Regeneron are using for discovery and validation of clinically actionable biomarkers
-Bristol-Myers Squibb, Takeda and Partners Healthcare the role that NGS can play when implementing an effective strategy in the lab to speed up CDx development
- Learn how to integrate molecular details into medical decision making, with fresh data from Washington University School of Medicine and Genzyme
Produced by:
Clinical Research Centre, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, 93586, Kuching, Sarawak | Phone: 082-276820 / 082-276666 ext 1074 / 1075 | Fax: 082-276823 | E-mail: leelen.crc@gmail.com, ireneg.crc@gmail.com | To contribute (news & event, publication, article of interest, etc), please call us or email to leelen.crc@gmail.com or ireneg.crc@gmail.com
For more information please visit our website. http://www.crc.gov.my/crcSarawak/
2022-11-23 DTL Future of data-driven life sciences, Utrecht, Alain van Gool.pdfAlain van Gool
A pitch on directions to improve experimental reproducibility, illustrated by examples of past experiences. I made the plee to move from 'Proudly invented here' to 'Proudly copyied from', to re-use each other's eperiences in successes and failures.
Outlining the proces and lessons learned in organising the technological infrastructure at the Radboud university medical center, to shape the Radboudumc Technology Centers, supporting our mission in enabling personalized healthcare.
QPS is a GCP/GLP-compliant CRO that supports discovery, preclinical, and clinical drug development. We provide quality services in DMPK, Toxicology, Translational Medicine Research, Early Stage and Phase II - IV Clinical Research to clients worldwide. Our regional laboratories are located at our headquarters in Newark, DE, USA; Springfield, MO, USA; Groningen, The Netherlands; Hyderabad, India; and Taipei, Taiwan.
Pitches from the 10 finalist teams selected to compete for the £100,000 Grand Prize of the inaugural OneStart competition in 2013, hosted by the Oxbridge Biotech Roundtable and SR One.
Learn more about this year's competition: http://oxbridgebiotech.com/onestart
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Working across disciplines for our health benefit - From successful strategies for biotech and nanotech to Nanotech for Health in Flanders
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
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Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
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Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
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Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
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25% of the population with heightened sensitivity to taste, especially bitterness
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RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
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EuroBioForum 2013 - Day 2 | Marc Lapage
1. PERSONALIZED MEDICINE:
OPPORTUNITIES IN QUÉBEC
Marc LePage, President and CEO, Génome Québec
EuroBioForum 2nd Annual Conference 2013
May 28, 2013
Munich, Germany
2. 1- Génome Québec in brief
2- Platforms
3- Personalized medicine portfolio
4- What do we offer?
5- What are we looking for?
6- Personalized medicine projects (4-minute video)
OUTLINES
May 28, 2013 2Marc LePage, President and CEO
3. Launched in 2000
Large-scale genomics research
$750 million invested / 80 projects
Health, Forestry, Agriculture, Environment, etc.
Operates genomics platform
750 researchers at all major universities
90 employees
GÉNOME QUÉBEC IN BRIEF
May 28, 2013 3Marc LePage, President and CEO
4. May 28, 2013 4
McGILL UNIVERSITY AND GÉNOME QUÉBEC
INNOVATION CENTRE
175 employees:
110 McGill (research): 15 research teams
65 Génome Québec (management of services): average
experience of GQ team > 4.5 years
Number of users: > 800 research teams
Annual revenues: $12 million
Marc LePage, President and CEO
5. May 28, 2013 5
TECHNOLOGIES AND APPLICATIONS
Whole genome sequencing
Exome sequencing (custom capture)
RNA-Seq
ChIP-Seq
Epigenetics , methylation
Transcriptomics, expression
Genotyping (GWAS and custom)
Validation (low throughput sequencing and genotyping)
Bioinformatics
Data analysis
Marc LePage, President and CEO
6. May 28, 2013 6
INNOVATION CENTRE TODAY
52%33%
15%
Geographical distributionof revenues of the
InnovationCentre for 2011-2012
Québec
Rest of Canada
International
Marc LePage, President and CEO
7. May 28, 2013 7
INTERNATIONAL DISTRIBUTION OF USERS
23 countries (2011-2012)
Mostly in Europe!
Marc LePage, President and CEO
8. May 28, 2013 8
COGS
MAJOR CANADA/EUROPAN UNION COLLABORATION
Marc LePage, President and CEO
9. May 28, 2013 9
INNOVATION CENTRE AND EUROPEAN UNION
Citation
“I am heading one of the largest genotype projects globally and
a large part of our nearly 250,000 samples have been
genotyped at the McGill University and Génome Québec
Innovation Centre. We are very impressed with the expertise
and professionalism of the personnel, their project management
approach and the capacity to deliver large-scale projects in a
timely manner with very high quality standards.”
Per Hall, MD, PhD; Medical Epidemiology and Biostatistics,
Karolinska Institute,and Head of the COGS International Consortium
Marc LePage, President and CEO
10. May 28, 2013 10
PERSONALIZED MEDICINE PORTFOLIO
Principal
Investigator
Institution Project Title
Total Budget
($)
Patrick Cossette
Centre hospitalier universitaire de
l’Université de Montréal (CHUM)
Personalized medicine in the treatment of epilepsy 10,833,759
Nada Jabado
Research Institute of the
McGill University Health Centre
Biomarkers for pediatric glioblastoma through
genomics and epigenomics
5,074,844
Claude Perreault
Hôpital Maisonneuve-Rosemont
and the Institute for Research in
Immunology and Cancer of
Université de Montréal
Personalized cancer immunotherapy 13,486,784
John D. Rioux
Montreal Heart Institute of
Université de Montréal
Inflammatory bowel diseases Genomic Medicine
Consortium (iGenoMed)
9,892,162
François Rousseau
Université Laval and
CHU de Québec
Personalized genomics for prenatal aneuploidy
screening using maternal blood (PEGASUS)
10,459,731
Guy Sauvageau
Institute for Research in
Immunology and Cancer of
Université de Montréal
Innovative chemo-genomic tools to improve clinical
outcome in acute myeloid leukemia
11,325,631
Jacques Simard
Université Laval and
CHU de Québec
Personalized risk stratification for the prevention and
early detection of breast cancer
11,382,455
Jean-Claude Tardif
Montreal Heart Institute of
Université de Montréal
Personalized medicine strategies for molecular
diagnostics and targeted therapeutics of cardiovascular
diseases
9,443,002
4 collaborations 6,666,950
Marc LePage, President and CEO
11. May 28, 2013 11
WHAT DO WE OFFER?
International collaborations
Access to genomics platform (sequencing, genotyping)
CARTaGENE/Genizon: Population cohorts of Québec
« Colloque sur la médecine personnalisée: Parce que les
solutions sont dans nos gènes »
Investigators and health policy meeting that will be held
October 1, 2013, in Québec City
Marc LePage, President and CEO
12. May 28, 2013 12
WHAT DO WE WANT?
Today
Translational strategies: successful models and approaches
Collaborators, cohorts
Tomorrow
Clinical genomics: lessons learned
Genomics and prevention (healthy lifestyle habits…)
Marc LePage, President and CEO
13. May 28, 2013 13
PERSONALIZED MEDICINE PROJECTS
Marc LePage, President and CEO