The Heart

Anatomy & Physiology Bio 2402 Lecture Dr shabeel pn dr shabeel pn

Review: ,[object Object],[object Object]

Review of Cardiac Blood Flow ,[object Object]

Sequence of blood flow ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Two systems: ,[object Object],[object Object]

Review of Cardiac Blood Flow ,[object Object],[object Object]

Control system - Autorhythmic Fibers ,[object Object],[object Object]

Control system - role of instability of RMP ,[object Object],[object Object],[object Object],[object Object],[object Object]

Atrial (Bainbridge) Reflex ,[object Object],[object Object],[object Object]

Control system - ,[object Object]

Control system - ,[object Object],[object Object]

Control system - ,[object Object],[object Object],[object Object]

Intrinsic Conduction System ,[object Object],[object Object],[object Object],[object Object]

Pacemaker and Action Potentials of the Heart

Sequence of Excitation ,[object Object],[object Object],[object Object]

Heart Excitation Related to ECG SA node generates impulse; atrial excitation begins Impulse delayed at AV node Impulse passes to heart apex; ventricular excitation begins Ventricular excitation complete SA node AV node Purkinje fibers Bundle branches Figure 18.17

Heart Excitation Related to ECG SA node generates impulse; atrial excitation begins SA node

Heart Excitation Related to ECG Impulse delayed at AV node AV node

Heart Excitation Related to ECG Impulse passes to heart apex; ventricular excitation begins Bundle branches

Heart Excitation Related to ECG Ventricular excitation complete Purkinje fibers

Extrinsic Innervation ,[object Object],[object Object]

ECG – What it means ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Heart Sounds - valves ,[object Object],[object Object],[object Object]

Cardiac Cycle ,[object Object],[object Object],[object Object]

Phases of Cardiac Cycle ,[object Object],[object Object],[object Object]

Phases of Cardiac Cycle ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cardiac Output (CO) and Reserve ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cardiac Output (CO) - Example ,[object Object],[object Object]

Stroke Volume ,[object Object],[object Object],[object Object]

What affects Stroke Volume? ,[object Object],[object Object],[object Object]

Frank-Starling Law of the Heart ,[object Object],[object Object],[object Object]

Chemical Regulation of Heart ,[object Object],[object Object],[object Object]

Regulation of Heart Rate: Autonomic Nervous System ,[object Object],[object Object],[object Object]

Heart Contractility and Norepinephrine ,[object Object],GTP GDP Inactive protein kinase A Active protein kinase A ATP cAMP GTP SR Ca 2+ channel Ca 2+ Ca 2+ binds to Troponin Enhanced actin-myosin interaction Extracellular fluid Cytoplasm Adenylate cyclase Ca 2+ channel Ca 2+  1 -Adrenergic receptor Norepinephrine Ca 2+ uptake pump Sarcoplasmic reticulum (SR) Cardiac muscle force and velocity 1 3 2 Figure 18.22

Extrinsic Factors Influencing Stroke Volume ,[object Object],[object Object],[object Object],[object Object]

Extrinsic Factors Influencing Stroke Volume ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cardiac Output ,[object Object],[object Object],[object Object]

Control system - Clinical Applications ,[object Object],[object Object]

Control system - Clinical Applications ,[object Object],[object Object],[object Object],[object Object]

Control system - Clinical Applications ,[object Object]

Control system - Clinical Applications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical: What is a “Heart attack”? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical Application – CHF Congestive Heart Failure ,[object Object],[object Object],[object Object],[object Object],[object Object]

Age-Related Changes Affecting the Heart ,[object Object],[object Object],[object Object],[object Object]

Developmental Aspects of the Heart ,[object Object]

Developmental Aspects of the Heart ,[object Object],[object Object]

Fetal Heart Development ,[object Object],[object Object],[object Object]

The Heart

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The Heart

Editor's Notes