URINARY ANTISEPTIC DRUGS

1. Drugs used on Urinary
System
Presented By:
Ms. Sayali Dilip Powar
(Master of Pharmacy )
5/14/2020
1

2. Content
• Diuretics
• Antidiuretics
• Urinary Antiseptics
• Cholinergics & Anticholinergics
• Acidifiers
• Alkalanizers.
5/14/2020 2
Composition
 Action
 Dosage
 Route
 Indications,
Contraindications
 Drug Interactions
 Side Effects,
Adverse, Effects,
Toxicity
 Role Of Nurse

3. Content
URINARY
ANTISEPTICS
5/14/2020 3
Composition
 Action
 Dosage
 Route
 Indications,
Contraindications
 Drug Interactions
 Side Effects,
Adverse, Effects,
Toxicity
 Role Of Nurse

4. Urinary Antiseptics
Drugs used for urinary tract infects which kill or
inhibit the growth of microorganism
5/14/2020 4

5. CLASSIFICATION
5/14/2020 5
• Urinary antiseptic drugs
1) Nitrofurantoin
2) Methenamine
3) Nalidixic acid
4) Phenazopyridine

6. Nitrofurantoin
5/14/2020 6
 USE: It is used as an urinary antiseptic in the treatment of urinary tract infection. It
is primarily bacteriostatic. In higher doses it may act as bacteriocidal in acidic
urine.
 DOSE: It is available as 50 mg ,100mg in tablet form
 INDICATION: cystitis ,pyelitis , post operative infection of urinary tract.
 CONTRAINDICATION: Hypersensitivity ,Pregnancy ,lactation ,anuria ,renal
disease.
 DRUG INTERACTION: a) Anticholinergics. b) Magnesium trisilicate antacids.
 ADVERSE REACTION: CNS: headache ,dizziness ,drowsiness G.I: anorexia
,nausea ,vomiting ,abdominal pain ,diarrhea. RESPIRATORY REACTION: cough
,chest pain ,dyspnea , asthmatic attack in pt with history of asthma. OTHERS:
hypersensitivity reaction.

7. Methenamine
5/14/2020 7
 USE: Methenamine is an urinary anti infective drug. This drug do not exert any
antimicrobial action in blood and body tissue and kidneys.
 DOSAGE FORM:. It is available as 500 mg ,1 gm tablet ,suspension
containing 250 mg ,500 mg per 5ml.
 INDICATION: UTI caused by E.Coli ,Enterobacter.
 CONTRAINDICATION: Hypersensitivity reaction ,dehydration, pregnancy
,lactation and renal disease.
 SIDE EFFECT: Headache ,rash ,urticaria ,nausea ,anorexia ,abdomen pain
,hematuria ,dysuria ,bladder irrigation ,stomatitis and fever

8. Nalidixic acid
5/14/2020 8
USE: It is a urinary tract anti infective drug. Nalidixic acid is antibacterial drug. It
is used in the treatment of urinary tract infection and gastro-intestinal infections.
DOSAGE: Adult dose orally 1 gm 6 hourly orally for 7 days. -- FOR CHILD: 55
mg per kg body weight for 7 days. -- it is not recommended below 3 months age
child.
INDICATION: Acute and chronic urinary tract infection ,cystitis ,prostitis
,urethritis ,pyelonephritis .
CONTR-INDICATION: hypersensitivity ,pregnancy ,convulsion disorder ,liver
disorder ,child below 3 months age. And elderly patients.
 SIDE-EFFECT: Nausea , vomiting ,abdominal pain ,dizziness ,headache
,drowsiness ,insomnia , convulsion ,rash ,urticaria ,blurred vision and central nervous
system disturbances.
DRUG-INTERACTION: it reduces the effect of antacids.

9. Phenazopyridine
5/14/2020 9
 USE:Phenazopyridine act as an analgesic It has local anesthetic effect on
urinary tract mucosa. It relief of burning sensation ,dysuria , urgency due to
cystitis.
 TRADE NAME: TABLET PYRIDIUM DOSAGE:ADULT DOSE- 100 mg to
400 mg ,8 hourly orally after meals ,orally.
 INDICATIONS: pain with urinary tract irritation ,infection ,burning
maturation ,dysuria ,cystitis.
 CONTRAINDICATION: liver dysfunction , pregnancy ,uremia ,renal
impairment ,contraindicated for children below 12 years ,hypersensitivity
,lactation.
 SIDE-EFFECT: nausea ,vomiting ,headache .leukopenia ,hemolytic anemia
,heart burn ,anorexia ,rash ,purities.

10. MECHANISM OF ACTION
5/14/2020 10
There are bacteriostatic drug.
They inhibit the growth of different
species of bacteria in urine.

11. ROLE OF NURSES
5/14/2020 11
• Assess the insomnia ,vertigo ,headache and
drowsiness in pt.
• In case of long term therapy complete blood cell
count should be done to check the anemia in pt.
Assess fever ,rash and urticaria in pt To take
medicine with food or milk.
• The drug may cause drowsiness to advice patient
not to drive vehicle.
• Advice pt of possible adverse reaction that drug
color urine red or orange and may stain clothing.

12. 5/14/2020 12