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“Between B Cells and T Cells: transcription factor EFB-1”
And “Understanding the Effects of Genes On Human
Traits”
Daniela...
Introduction
The transcription is the
process responsable to
the sintesis of the
molecular of RNA from
the genetic informa...
Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily. July ,23 ,2013
The receptor EBF-1 wa...
Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily, july,23,2013
Decided to use mice for...
.
Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily, July, 23,2013
After three months t...
.
Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily, July, 23,2013
http://vivesana.blog...
PERSONAL OPINION
.
I believe this
discovery can be very
important in different
pathologies and long
term this new
knowledg...
Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31,2013
A new methodology for insight into the
most...
Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31, 2013
The focus of this new methodology known as...
Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31, 2013
Thanks to this methodology, we can now bet...
Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31, 2013
Understanding the genome and their
influen...
PERSONAL OPINION
Personally feel that this
methodology would be a
breakthrough and personalized
medicine would be ideal fo...
.
The goal of medicine today is not supplying
drugs that can produce damage to other
organs, the goal is to identify the p...
The medical objective is to know the DNA of every person and to know
that at one point influences is very important as tra...
Many studies related to the human genome genomic
influences have shown many common complex diseases
such as asthma, diabet...
MEDICAL UTILITY
Both events have great
medical importance both
differentiation of the
immune system such as
knowledge of t...
BIBLIOGRAPHY
-Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB.
Facultad de Medicina, 2012. 78-84.P
-Robert...
Biomol presentacion 1
Biomol presentacion 1
Biomol presentacion 1
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Biomol presentacion 1

  1. 1. “Between B Cells and T Cells: transcription factor EFB-1” And “Understanding the Effects of Genes On Human Traits” Daniela Marín Rivera Medicine student III Semester Molecular Biology
  2. 2. Introduction The transcription is the process responsable to the sintesis of the molecular of RNA from the genetic information contained in a DNA. This point is important because the different s trancriptions factors can to change the response on the cell.
  3. 3. Between B and T cells : transcription factor EBF-1 reminds who they are Sciencedaily. July ,23 ,2013 The receptor EBF-1 was described previously by Rudolf Grosschedl and his colleagues were able to prove as early as 1995, but its only significance level was immune cells inactivation of T in his presence.
  4. 4. Between B and T cells : transcription factor EBF-1 reminds who they are Sciencedaily, july,23,2013 Decided to use mice for further experiments on the mechanisms of this transcription factor and took samples of mice in late phase of development and transferred to mice lacking immune system and inactived the factor transcription EFB-1 Image taken from: http://www.bioblogia.com/2011/02/los-ratones-que-carecen-de-las- bacterias-normales-del-intestino-tienen-diferencias-en-el-desarrollo- cerebral-y-el-comportamiento/
  5. 5. . Between B and T cells : transcription factor EBF-1 reminds who they are Sciencedaily, July, 23,2013 After three months they managed to identify the presence of B cells in these mice but discovered they had forgotten their identity by the factor inactivation of transcription. And in place of B cells were T cells and natural murderers, still important this new finding, and considering it as a breakthrough in order to control certain pathologies.
  6. 6. . Between B and T cells : transcription factor EBF-1 reminds who they are Sciencedaily, July, 23,2013 http://vivesana.blogspot.com/2013/03/document al-ruleta-genetica-el-juego-de.html Knowing the activity of this transcription factor could be very useful because it can induce the cell to change identity and take another route of action. Image taken from :
  7. 7. PERSONAL OPINION . I believe this discovery can be very important in different pathologies and long term this new knowledge allows cells to be reprogrammed as pathological loss of specific types of cells. http://edith- jules.blogspot.com/2011_02_01_archive.html Image taken from :
  8. 8. Understanding the Effects of Genes On Human Traits Sciencedaily, july, 31,2013 A new methodology for insight into the most common diseases in the human would be a new way of developing medicine, and to understand the genetic influences for such serious diseases locate an effective treatment for each person.
  9. 9. Understanding the Effects of Genes On Human Traits Sciencedaily, july, 31, 2013 The focus of this new methodology known as personalized medicine will be on the effects of disease-associated genomic variants on DNA-to-RNA transcription, instead of the challenging question of effects on RNA-to- protein translation. http://anestesiar.org/2010/citocromo-p450- cyp450-y-farmacogenetica/ Image taken from :
  10. 10. Understanding the Effects of Genes On Human Traits Sciencedaily, july, 31, 2013 Thanks to this methodology, we can now better understand the effect of genetic variants on translation of RNA to protein - a powerful way of developing biomarkers for personalized medicine and new therapies.
  11. 11. Understanding the Effects of Genes On Human Traits Sciencedaily, july, 31, 2013 Understanding the genome and their influence will be the objective of this research there and generate appropriate treatments in diseases affecting the majority of the population. http://laterapiacelular.com/terapia-celular/ Image taken from :
  12. 12. PERSONAL OPINION Personally feel that this methodology would be a breakthrough and personalized medicine would be ideal for any country, however the costs of studying any disease from the genome would be very high and difficult to achieve but I think that the methodology would be very useful and would be achieved control multiple common diseases in the population.
  13. 13. . The goal of medicine today is not supplying drugs that can produce damage to other organs, the goal is to identify the problem from the genome and from there find appropriate solutions.
  14. 14. The medical objective is to know the DNA of every person and to know that at one point influences is very important as transcription and interaction with transcription factors thus generating a variety of possibilities for each person in their cure. MEDICAL UTILITY http://es.123rf.com/photo_11420525_las-palabras-curar-el-cancer-en- las-cadenas-de-adn-que-representan-la-importancia-de-la- investigacio.html Image taken from :
  15. 15. Many studies related to the human genome genomic influences have shown many common complex diseases such as asthma, diabetes, cancer or concerted ezquizofrenia and is indispensable as this variant affects the health. MEDICAL UTILITY
  16. 16. MEDICAL UTILITY Both events have great medical importance both differentiation of the immune system such as knowledge of the genome and in the immune system for example could be the cure for diseases of a type of cell and induce the system to produce inactivated factor transcription However, discovering a genetic variant predisposing to a disease is only a first step. To apply this knowledge towards prevention or cure, including tailoring treatment to the patient's genetic profile, needs to know how this genetic variant affects health
  17. 17. BIBLIOGRAPHY -Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB. Facultad de Medicina, 2012. 78-84.P -Robert Nechanitzky, Duygu Akbas, Stefanie Scherer, Ildiko Györy, Thomas Hoyler, Senthilkumar Ramamoorthy, Andreas Diefenbach, Rudolf Grosschedl. Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nature Immunology, 2013. -http://www.sciencedaily.com/releases/2013/07/130723113745.htm -Quan Li, Angeliki Makri, Yang Lu, Luc Marchand, Rosemarie Grabs, Marylene Rousseau, Houria Ounissi-Benkalha, Jerry Pelletier, Francis Robert, Eef Harmsen, Thomas J. Hudson, Tomi Pastinen, Constantin Polychronakos, Hui-Qi Qu.Genome-wide search for exonic variants affecting translational efficiency. Nature Communications, 2013; 4 DOI -http://www.sciencedaily.com/releases/2013/07/130731164757.htm

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