2. MUMPS VIRUS
Mumps virus is the cause of acute,
benign viral parotitis.
RNA virus
(Genus: Rubulavirus of the Paramyxoviridae family)
Only one serotype is known.
{Hence, lifelong immunity after the infection}
3. Disease Mechanisms
• Cell-mediated immunity is essential for control of infection and responsible for
causing some of the symptoms. Antibody is not sufficient because of virus’s ability
to spread cell to cell.
Spread by respiratory droplets
Replicates in T Lymphocytes
Hematogenous spread
Infection of Parotid gland and Other organs.
Mumps Parotitis
5. EPIDEMIOLOGY
I. Virus has large enveloped virion that is easily inactivated by dryness and acid.
II. Contagion period precedes symptoms.
III. Virus may cause asymptomatic shedding.
IV. Host range is limited to humans.
V. Only one serotype exists.
VI. Immunity is lifelong.
12. Laboratory diagnosis
No Laboratory confirmation needed.
Atypical infection needs laboratory diagnosis.
• Virus isolated from;
Saliva, Urine, Pharynx, Secretions from Stensen duct and CSF.
• Serology: mumps-specific IgM antibody.
• Enzyme-linked immunosorbent assay, Immunofluorescence tests, and
hemagglutination inhibition can be used to detect the mumps virus, antigen, or
antibody
13. Treatment
No specific Antiviral therapy.
Antipyretics are administered for fever.
Bed rest
And the Diet should be adjusted to patient’s ability to
chew.
14. Modes of Prevention
• Live attenuated vaccine (Jeryl Lynn strain),
Administered as a part of MMR vaccine.
• Keep distance from infected person.
