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Blood indices
1. Blood Indices
Dr. Sai Sailesh Kumar G
Associate Professor
Department of Physiology
RDGMC
DR Sai Sailesh Kumar G 1
2. Case study
An 18 year old male subject complained of
generalized weakness and fatigue. On clinical
examination, yellowish discoloration was visible on
skin and conjunctivae. His plasma bilirubin level was
2mg%. Van den Bergh reaction was indirect positive.
What is the diagnosis. Enlist any three causes for the
same.
DR Sai Sailesh Kumar G 2
3. Case study
Hemolytic or pre-hepatic jaundice
Sickle cell anemia
Congenital spherocytosis
Thalassemia
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5. Introduction
The features of RBC such as volume, number, color
indicate the quality of blood
These features are referred as blood indices
The blood indices are calculated from packed cell
volume, hemoglobin concentration and red cell count
The blood indices are
1. Mean corpuscular volume (MCV)
2. Mean corpuscular hemoglobin (MCH)
3. Mean corpuscular hemoglobin concentration (MCHC)
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6. Mean corpuscular volume
MCV is the average volume of the red cells
It is calculated by dividing PCV in 100 mL of
blood by RBC count in 100 mL of blood
It is expressed in femtolitres (fL)
Normal value is 87-90 fL
RBCs are called as normocytes when the volume
is with in normal range
Cell with MCV >95 fL – Macrocytes
Cell with MCV <80 fL - Microcytes
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7. Mean corpuscular volume
MCV is increased in megaloblastic anemia due
to deficiency of folic acid
MCV is increased in pernicious anemia due to
deficiency of vitamin B12
MCV is decreased in iron deficiency anemia
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8. Mean corpuscular hemoglobin
MCH is the average mass of hemoglobin in
picogram contained in each red cell
It is calculated by dividing hemoglobin content in
100 mL of blood by RBC count in 100 mL of blood
Normal value is 27-32 pg (picogram)
RBCs are referred as normochromic if MCH is 27-32
pg
Cell with <25pg of MCH – hypochromic
MCH is decreased in microcytic hypochromic
anemia (iron deficiency anemia)
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9. Mean corpuscular hemoglobin
concentration
MCHC is expressed as percentage
It is the amount of hemoglobin per 100 mL of RBC
Normal value is 32-38 %
RBCs are referred as normochromic if MCHC is with
in the normal range
Decreased MCHC- hypochromic
MCHC is decreased in microcytic hypochromic
anemia (iron deficiency anemia)
MCHC in pernicious anemia???
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10. Mean corpuscular hemoglobin
concentration
Anemia never be hyperchromic
MCHC can never ne >38%
In pernicious anemia- Macrocytic hypochromic/
normochromic anemia
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11. Color index
It is calculated by dividing percentage of Hb with
percentage of RBC
Normal color index is 1
In hypochromic anemia- CI is low
In macrocytic anemia – CI is increased
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