Duchenne Muscular Dystrophy (DMD) is a disease that manifests in muscle weakness. It exhibits X-linked recessive inheritance pattern. The dystrophin gene is large and can have many different mutations along the DNA. From the following mutations between the gene sequence (DNA template strand) of a healthy male and an affected brother determine if they would affect the production of mRNA or the sequence of the protein. Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons. LO37 Explain the consequences of mutations in different regions of a gene Mutation 3: Position +1535 (intron 5) Healthy individual C Affected individual A mRNA not produced, no protein mRNA produced, normal protein mRWA produced, no protein produced mRMA produced whort protein.

1. Duchenne Muscular Dystrophy (DMD) is a disease that manifests in muscle weakness. It
exhibits X-linked recessive inheritance pattern. The dystrophin gene is large and can have many
different mutations along the DNA. From the following mutations between the gene sequence
(DNA template strand) of a healthy male and an affected brother determine if they would affect
the production of mRNA or the sequence of the protein. Base your analysis on the position of the
mutation in the transcription unit, and the impact of the change on the codons. LO37 Explain the
consequences of mutations in different regions of a gene Mutation 3: Position +1535 (intron 5)
Healthy individual C Affected individual A mRNA not produced, no protein mRNA produced,
normal protein mRWA produced, no protein produced mRMA produced whort protein