This document provides a literature review of research on anti-inflammatory properties and chemoprofiles of compounds like imidazolidines. It summarizes several studies that synthesized novel imidazolidine derivatives and evaluated their anti-inflammatory and analgesic effects in animal models and tests. Many of the studies found that imidazolidine compounds demonstrated anti-inflammatory properties and reduced inflammation, potentially providing an alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) with fewer side effects.

1. Agnihotri,S.,Wakode,S.,Agnihotri,A.,2010. Anoverview onantiinflammatory propertiesand
chemo-profilesof plantsusedin traditionalmedicine.IndianJ.Nat.ProductsResour.1 (2),150–
167
.
Allison,M.C.,Howatson,A.G.,Torrance,C.J.,Lee,F.D., Russell, R.I.G.,1992. Gastrointestinal damage
associatedwiththe use of nonsteroidalantiinflammatorydrugs.N.Engl.J.Med.327 (11),
749–754
.
Ashley,N.T.,Weil,Z.M.,Nelson,R.J.,2012. Inflammation:mechanisms,
costs andnatural variation.Annu.Rev.Ecol.Evol.Syst.43,
385–406
.
Buttgereit,F.,Burmester,G.,Simon,L.S.,2001. Gastrointestestinal
toxicside effectsof non-steroidal anti-inflammatorydrugsand
cyclooxygenase-2-specificinhibitors.Am.J.Med.110, 135–195
.
Caterina,M.C.,Perillo, I.A.,Boiani,L.,Pezaroglo,H.,Cerecetto,H.,
Gonzalez,M.,Salerno,A.,2008. Imidazolidinesasnew antiTrypanosoma
cruzi agents:biologicalevaluationandstructureactivity
relationships.Bioorg.Med.Chem.16(5),2226–2234
.
Cioli,V.,Putzolu,S., Rossi,V.,Barcellona,P.S.,Corradino,C.,1979.
The role of directtissue contactinthe productionof gastrointestinal
ulcerby anti-inflammatorydrugsinrats.Toxicol.Appl.
Pharmacol.50, 283–289
.
Fernandes,E.S.,Passos,G.F.,Medeiros,R.,2007. Anti-inflammatory
effectsof compoundsalpha-humulene and(-)-trans-caryophyllene

2. isolatedfromthe essential oil of Cordiaverbenacea.Eur.J.
Pharmcol.569, 228–236
. Franzotti,E.M.,Santos,C.V.,Rodrigues,H.M.,Mourao,R.H.,
Andrade,M.R.,Antoniolli, A.R.,2000.Anti-inflammatory,analgesic
activityandacute toxicityof SidacordifoliaL.(Malva
branca).J. Ethnopharmacol.72, 273–277.
Gautam, R.,Jachak, S.M.,2009. Recentdevelopmentsinantiinflammatory
natural products.Med. Res.Rev.29 (5),767–820
.
Gupta, M., Mazumder,U.K.,Gomathi,P.,Selvan,V.T.,2006.
Antiinflammatoryevaluationof leavesof Plumeriaacuminate.
BMC Comp.Alter.Med.6, 36
.
Hunskaar,S., Hole,K.,1987. The formalintestinmice:dissociation
betweeninflammatoryandnon-inflammatorypain.Pain30,103–
114
.
Husain,A.,Bhutani,R.,Kumar,D., Shin,D.S.,2013. Synthesisand
biological evaluationof novel substituted-Imidazolidinederivatives.
J. Kor.Chem.Soc.57 (2),227–233
. Khan,M.S., Chawla,G.,2002. Tetrahydroimidazoles-A promising
groupof expectedNSAIDS-theirsynthesisandanti-inflammatory
activity.IndianJ.Chem.41B, 653–663
.
Khan,M.S., Gupta,M., 2003. Synthesisandevaluationof antiinflammatory
and analgesicactivityof some new1,3-diphenyl-2aryltetrahydroimidazoles.
IndianJ.Chem.42B, 2086–2090

3. .
Khan,M., Husain,A.,Sharma,S., Rashid,M., 2012. Microbiological
evaluationof 4-substituted-imidazolidine derivatives.IndianJ.
Pharm.Sci. 74, 80–83
.
Kulkarni,S.K.,Jain,N.K.,2005.Coxibs:the new super aspirinsor
unsafe painkillers?IndianJ.Pharmacol.37,86–89
.
Lanza, F.L.,1998. A guideline forthe treatmentandpreventionof
NSAID-inducedulcers.Am.J.Gastroenterol.93,2037–2046.
Lipinski,C.A.,Lombardo,F.,Dominy,B.W.,Feeney,P.J.,1997.
Experimentalandcomputational approachestoestimate solubility
and permeabilityindrugdiscoveryanddevelopmentsettings.Adv.
Drug. DeliverRev.23,4–25
.
Mantovani,A.,Pierotti,M.A.,2008. Cancer and inflammation:a
complex relationship.CancerLett.267, 180–181
.
Marki, F.,Buch, O.,Delini-Stula,A.,Kraetz,J.,Petermann,H.,
Radeka,E., Schweizer,A.,Thomann,P.,Truog,A.,1984.
Sulfonyliminoimidazolidines,anewclassof oral hypoglycemic
agents,Toxicityandgeneral pharmacologyof 1-[p-[2-(crotonylamino)-ethyl]-phenylsulfonyl]-3-
cyclohexy
l-2-imino- imidazolidine
(CGP11 112. Arzneimittelforschung34(3),247–252
.
Neves,J.K.,filteryourcurrentsearchBotelho,SP.,filteryourcurrentsearchMelo,CM.,filteryour
currentsearch Pereira,VR.,filter

4. your currentsearchLima, MC., filteryourcurrentsearch Pitta,
IR.,filteryour currentsearchAlbuquerque,MC.,filteryour
currentsearch Galdino,Sl.,2010. Biological andimmunological
activityof newimidazolidinesagainstadultwormsof Schistosoma
mansoni.filteryourcurrentsearchParasitol.Res.107(3), 531–538. Patel,M.V.,Bell,R.,Majest,S.,
Henry,R., Kolasa,T.,2004. Synthesis
of 4,5-Diaryl-1H-pyrazole-3-olderivativesaspotential COX-2
inhibitors.J.Org.Chem.69, 7058–7065
.
Ricciotti,E.,Fitzgerald,G.A.,2011. Prostaglandinsand
Inflammation.Arterioscler.Thromb.Vasc.Biol.31(5), 986–1000
.
Robert,J.G.,Daryl,S.W.,Paul,J.B.,Elena,F.,Anton,D.M., Shilina,
A.R.,Sac-Pham,T.,2010. Synthesisandbiological activity of a
seriesof tetrasubstituted-imidazolesasP2X7 antagonists.Bioorg.
Med. Chem.Lett.20 (16),4951–4954
.
Saczewski,J.,Hudson,A.L.,Rybczynska,A.,2009.2-[(arylmethoxy)imino]imidazolidines
withpotential biological activities.
Acta Poloniae Pharmaceutia-DrugResearch.66(6),671–679
.
Seigmund,E.,Cadmus,R.,Lu,G., 1957. A methodforevaluating
bothnon-narcoticandnarcotic analgesics.Proc.Soc.Exp.Biol.95,
729–731
.
Sharma,V.,Khan,M.S., 2001. Synthesisof novel tetrahydroimidazole
derivativesandstudiesfortheirbiologicalproperties.Eur.J.Med.
Chem.36, 651–658

5. .
Tan, T.M., Chen,Y.,Kong,K.H.,Bai, J.,Li, Y.,Lim, S.G.,1992.
NSAID,ulcerandprostaglandins.J.Rhematol.19,68–73
.
Verrico,M.M., Weber,R.J.,McKaveney,T.P., Ansani,N.T.,Towers,
A.L.,2003. Adverse drugeventsinvolvingCOX-2inhibitors.Ann.
Pharmacother.37 (9), 1203–1213
. Winter,C.A.,Risley,E.A.,Nuss,G.W.,1962. Carrageenin-induced
edemainhindpawof the rat as an assay for anti-inflammatory
drugs. Proc. Soc. Exp.Biol.111, 544–547
.
Zhao,Y., Abraham,M.H., Le,J., Hersey,A.,Luscombe,C.N.,Beck,
G., Sherborne,B.,Cooper,I.,2002. Rate-limitedstepsof human
oral absorptionandQSARstudies.Pharm.Res.19 (10),1446–
1457
.