According to the study, higher levels of physical activity are linked to a decreased risk of various health consequences, and the risk reduction increases as physical activity level increases. Based on these findings, the authors recommend that public health policies and interventions focus on promoting physical activity to reduce the risk of these diseases. Read more @ https://pubrica.com/academy/meta-analysis/critical-review-of-meta-analysis-conducted-in-this-paper/ Visit us @ https://pubrica.com/services/research-services/systematic-review/

1. An Academic presentation by
Dr. Nancy Agnes, Head, Technical
Operations, Pubrica
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Email: sales@pubrica.com
A CRITICAL REVIEW OF META-ANALYSIS
CONDUCTED IN THIS PAPER, "PHYSICAL
ACTIVITY AND RISK OF BREAST CANCER,
COLON CANCER, DIABETES, ISCHEMIC
HEART DISEASE.

2. INTRODUCTION
• The systematic review and meta-analysis by Kyu et al. (2016) on
physical activity and the risk of breast cancer, colon cancer, diabetes,
ischemic heart disease, and ischemic stroke is a comprehensive study
that evaluated data from 174 prospective cohort studies.
• Overall, the study found that higher levels of physical activity
correlated with a lower risk of all five health outcomes, and the risk
reduction was more significant with higher levels of physical activity.
• This blog provides the relationship between Physical activity and the
risk of breast cancer, colon cancer, diabetes, and ischemic heart
disease.

3. STRENGTH OF THE STUDY:
• One strength of the study is the large number of studies
included in the meta-analysis research, which increases
the biostatistical power and generalizability of the results.
• The study also used a dose-response meta-analysis
approach to evaluate the correlation between physical
activity and the risk of each health outcome, which
provides more nuanced information on the optimal level
of physical activity for disease prevention.
Contd...

4. LIMITATIONS OF THE STUDY:
• However, there are also several limitations of the study
that should be considered.
• One limitation is the heterogeneity of the included studies
in terms of the measurement of physical activity and
health outcomes, which may have influenced the
accuracy and generalizability of the results.
• Additionally, while the study attempted to account for
potential confounding variables, such as age, sex, and
smoking status, there may still be residual confounding
that was not accounted for in the analysis strategy in
research.
Contd...

5. • Another limitation is that the study focused exclusively
on the connection between physical activity and the risk
of these five health outcomes and did not consider other
potential health benefits or harms of meta-clinical
research on physical activity.
• Additionally, the study did not consider the potential
impact of different types or intensities of physical activity
on disease risk, which could be important for informing
public health recommendations.
Contd...

6. • Overall, the study by Kyu et al. provides important evidence on the relationship between physical
activity and the risk of several primary healthcare outcomes.
• To completely understand the relationship between physical activity and health and improve
public health policies and treatments, further research is required, however, according to the
study's limitations.

8. • The systematic review and meta-analysis by Kyu et al. (2016) provide substantial evidence of the
relationship between physical activity and the risk of several primary health outcomes, including
breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke.
• According to the study, higher levels of physical activity are linked to a decreased risk of various
health consequences, and the risk reduction increases as physical activity level increases. Based
on these findings, the authors recommend that public health policies and interventions focus on
promoting physical activity to reduce the risk of these diseases.
FUTURE RECOMMENDATIONS

9. • They specifically advise people to do at least 150 minutes
of moderate-intensity aerobic physical activity or 75
minutes of vigorous-intensity aerobic physical activity
each week, along with muscle-strengthening exercises at
least two days per week.
• Additionally, the authors suggest that further research is
needed to understand better the relationship between
physical activity and health outcomes, particularly
concerning the intensities, types, and durations of
physical activity most beneficial for disease prevention.

10. • They also suggest that more research is needed to identify the mechanisms underlying the
relationship between physical activity and health outcomes, which could help to develop more
targeted disease prevention interventions.

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